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Advanta MOS™

MOS = Mannan Oligosaccharides

ADVANTA MOS™ is a prebiotic produced from a Mannan Oligosaccharide and Beta-glucan complex which has been extracted from the cell wall of molasses yeast (Saccharomyces cerevisiae). The soluble portions of the yeast cells are removed by a gentle digestion and the remaining insoluble cell wall fraction is then washed and spray dried.

FUNCTION OF BETA-GLUCAN AND MOSBeta-glucans are known for their capacity to bind to phagocytic cells thus making them more active in the immune system. At the same time, these activated cells produce a chemical known as cytokine which causes a chain reaction producing more phagocytic cells, thus creating a stronger immune system.

The action of MOS is based on its ability to bind to pathogen receptors or their toxin-receptor. MOS can bind and neutralize toxins in the intestinal lumen or prevent the binding of pathogens to intestinal epithelium.

IMMUNE SYSTEMThe effect of glucan is thought to be primarily due to stimulation of the reticulo endothelial system (RES), which in turn produces increased amounts of macrophages that play a key role in the body’s natural immune system. The precise function of the macrophages is to absorb and destroy invading particles through phagocytosis. Recent studies have demonstrated the beneficial effect of glucan in improving host resistance by enhancing both humoral and cellular immunity to certain malignant tumors, as well as to certain bacterial and viral infections (DiLUZIO, 1985; REED and NAGODAWITHANA, 1991).

Glucans are one of the most important structural elements of the cell wall (ROSENBERGER,1976), and are known to stimulate defense mechanisms in a range of higher organisms. Studies have demonstrated the value of phosphorylated glucans in combating a variety of conditions caused by bacteria, fungi, and viruses (RAA et al., 1992).

ADVANTA MOS™ is composed of an insoluble Mannan Oligosaccharide and Beta-glucan complex which has been extracted from the cell wall of molasses yeast (Saccharomyces cerevisiae). Saccharomyces cerevisiae cell wall is an important source of MOS, “Mannan Oligosaccharides”, which acts in the gut of animals, capturing hostile gut-wall-attacking bacteria like E. coli. MOS locks into the molecular structure of hostile bacteria and carries them safely outside the body.

ADVANTA MOS™ is an exclusive nutrition source for beneficial bacteria, such as Lactobacillus and Bifidobacteria.

ADVANTA MOS™ will agglutinate Salmonella and E. coli.

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Advanta MOS™

MOS = Mannan Oligosaccharides

MIXING INSTRUCTIONS

POULTRY CATTLE Broilers 1.0 kg/ton Calves 2.0 - 2.5 kg/ton Layers 1.0 kg/ton Dairy & Beef Cattle 1.0 - 2.0 kg/ton

PETS SWINE Dogs 0.5 kg/ton Piglets 2.0 kg/ton Cats 0.5 kg/ton Growing Pigs & Sows 1.0 kg/ton CAUTION: Care should be used in storing and handling this product. 1. Store in a clean, dry place. 2. Do not breathe ADVANTA MOS™ dust or expose to unprotected skin. 3. Take precautions not to cross contaminate supplemented feeds.

FEEDING RATECOWS 10 grams per head per day.

APPLICATIONFor manufacturing of complete feed for chickens, turkeys, swine, dairy cattle and beef cattle.

GUARANTEED ANALYSISCrude Protein (CP) . . . . . . . . . . . . Min. 28.0%Moisture . . . . . . . . . . . . . . . . . Max. 8.0%Crude Fiber . . . . . . . . . . . . . . . . Max. 4.0%

INGREDIENTSYeast Extract

CERTIFICATION OF ANALYSIS Available upon request.

PACKAGING 25-Kg multi-walled paper bags with poly liner.

Complex is flushed out through the intestines.

BeneficialBacteria

BeneficialBacteria

PathogenicBacteria

Binding Site

Binding Site

Binding Site

Binding Site

MOSPathogenicBacteria

• Beneficial bacteria and pathogenic bacteria have different binding sites. 

• Infection begins when pathogens bind to the intestinal walls.

INTESTINAL COLONIZATION

INTESTINAL COLONIZATIONWITH MOS SUPPLEMENTATION

Advanta MOS™

MOS = Mannan Oligosaccharides

TYPICAL ANALYSISTotal Glucomannans % 47 - 55Beta glucan % (Min.) 28.0Mannan Oligosaccharides % (Min.) 20.0Protein % (Min.) 28.0Ash % (Max.) 8.0Fiber % (Max.) 4.0Moisture (Max.) 8.0Form Fine PowderColor BeigeOdor Faint

pH 5.5

Total Plate Count (CFU/g) <15,000/gS. aureus NegativeE. coli NegativePs. Aeruginosa NegativeTotal Combined Mold & Yeast (CFU/g) < 100/gSalmonella Negative

MOS is effective in 93.4% of Salmonella species tested. MOS is effective in 95% of E. coli strains tested.

University of Sao PauloDr. Syndney Hartz Alves & Janio M. SanturioInitial Date: Feb 2007 Finish date: April 2007

N SPECIES SERUM GROUP AGL

1 Salmonella agona (1) B +

2 Salmonella agona (2) B +

3 Salmonella cerro (1) K +

4 Salmonella derby (1) B +

5 Salmonella derby (2) B +

6 Salmonella enterica subsp. enterica (1)

- +

7 Salmonella enterica subsp. enterica (2)

- ++

8 Salmonella enterica subsp. enterica (3)

- +

9 Salmonella enteritidis (1) - ++

10 Salmonella enteritidis (2) - ++

11 Salmonella enteritidis (3) - ++

12 Salmonella infantis (1) C1 +

13 Salmonella infantis (2) C1 +

14 Salmonella livingstone (1) C1 +

15 Salmonella livingstone (2) C1 +

16 Salmonella mbandaka (1) C1 ++

17 Salmonella mbandaka (2) C1 ++

18 Salmonella ohio (1) C1 ++

19 Salmonella ohio (2) C1 ++

20 Salmonella panama (1) D1 ++

21 Salmonella rissen (1) C1 +

22 Salmonella rissen (2) C1 +

23 Salmonella saintpaul (1) B +

24 Salmonella saintpaul (2) B ++

25 Salmonella saintpaul (3) B ++

26 Salmonella schwarzengrund (1) B +

27 Salmonella schwarzengrund (2) B ++

28 Salmonella schwarzengrund (3) B ++

29 Salmonella senftemberg (1) E4 +

30 Salmonella senftemberg (2) E4 +

31 Salmonella worthington (1) G2 +

32 Salmonella worthington (2) G2 +

33 Salmonella worthington (3) G2 ++

34 Salmonella worthington (4) G2 +

35 Salmonella worthington (5) G2 ++

36 Salmonella saintpaul (4) B ++

37 Salmonella saintpaul (5) B +

38 Salmonella saintpaul (6) B ++

N SPECIES SERUM GROUP AGL

39 Salmonella saintpaul (7) B +

40 Salmonella saintpaul (8) B ++

41 Salmonella pullorum - +

42 Salmonella worthington (6) G2 +

43 Salmonella panama (2) D1 +

44 Salmonella kingston (1) B +

45 Salmonella anatum (1) E1 +

46 Salmonella heidelberg (1) B ++

47 Salmonella orion E1 ++

48 Salmonella agona (3) B +

49 E. coli 8355 - +

50 E. coli 8358 - ++

51 E. coli F-18 LT - ++

52 E. coli 4246 - ++

53 E. coli i4648 - ++

54 E. coli 8929 - +

55 E. coli 7387 - +

56 E. coli 7389 - +

57 E. coli 8356 - +

58 E. coli 6743 - +

59 E. coli T1 6 - +

60 E. coli T2 41 - +

61 E. coli T3 44 - +

62 E. coli T4 36 - +

63 E. coli T5 12 - +

64 E. coli T6 10 - +

65 E. coli T6 42 - +

ABILITY OF ADVANTA MOS™ TO CAUSE AGGLUTINATION IN VARIOUS SPECIES OF SALMONELLA AND STRAINS OF E.COLI

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