more than 900 medicines and vaccines in against...

Few things cause more fear and apprehension than a cancer diagnosis. But today—because of early detection and a steady stream of new and improved treatments—cancer increasingly can be managed and even beaten. But patients and their families are looking for more and bet-ter treatments, and America’s biopharmaceuti-cal research companies are responding.

Biopharmaceutical researchers are now work-ing on 981 medicines for cancer. Many are high-tech weapons to fight the disease, while some involve innovative research into using existing medicines in new ways.

Researchers’ deep commitment to patients and advancing science is at the core of the remark-able progress made in fighting cancer. In re-cent years we have seen significant declines in cancer deaths. The number of cancer survivors living in the United States has increased from 3 million in 1971 to nearly 12 million in 2008. The increase in survivors is attributed in large measure to earlier diagnosis and detection and better treatments and follow-up care.

America’s biopharmaceutical research com-panies are working on many new cutting-edge

approaches to fight cancer. They include:

• A medicine that interferes with the me-tabolism of cancer cells by depriving them of the energy provided by glucose.

• A medicine for acute myeloid leukemia (AML) that inhibits cancer cells with a mutation found in about a third of AML sufferers.

• A therapy that uses nanotechnology to target the delivery of medicines to cancer cells, potentially overcoming some limita-tions of existing treatments.

Despite recent progress, cancer remains the second leading cause of death by disease in the United States, exceeded only by heart disease. In 2012, some 577,190 Americans are expected to die of cancer—more than 1,500 people a day. The hundreds of new medicines to treat cancer now being developed are our best hope for lessening the burden of cancer to patients, their families and society.

More Than 900 Medicines and Vaccines in Clinical Testing Offer New Hope in the Fight Against Cancer

Medicines in Development

CanCerpresented by america’s biopharmaceutical research companies

2012 RepoRt

111

66

121117

94

Lym

phom

a

Col

orec

tal C

ance

rLu

ng C

ance

r

Pros

tate

Can

cer

Brea

st C

ance

r

67

Skin

Can

cer

Medicines in Development

for Selected Cancer Types

More Than

1.6 million New Cases of Cancer Are Expected This Year

Medicines in Development Cancer 20122

**For more information about a specific medicine in this report, please call the telephone number listed.

Lung Cancer

Liver Cancer

Leukemia

Kidney Cancer

Head/Neck Cancer

Colorectal Cancer

Cervical Cancer

Breast Cancer

Brain Cancer

Bladder Cancer 9

62

66

111

8

25

35

120

36

121

Multiple Myeloma

Lymphoma 117

57

Ovarian Cancer 63

Cancer-Related Conditions

Stomach Cancer

Solid Tumors

Skin Cancer

Sarcoma

Prostate Cancer

Pancreatic Cancer

94

58

21

67

280

23

38

Unspecified Cancer

Other Cancers 102

72

* Some medicines are listed in more than one category.

Medicines in Development for Cancer*

Medicines in Development for Cancer

Bladder CanCer

product Name Sponsor Indication Development Status*

Abraxane®albumin-bound paclitaxel

CelgeneSummit, NJ

second-line bladder cancer (see also breast, lung, ovarian, pancreatic, skin)

Phase II(908) 673-9000

AEZS-108 AEterna ZentarisBasking Ridge, NJ

(see also ovarian, prostate, other) Phase II(908) 626-5428

BC-819 (gene therapy)

BioCancell TherapeuticsJerusalem, Israel

(see also ovarian, pancreatic) Phase IIwww.biocancell.com

EN3488(mycobacterium cell wall-DNA complex)

Endo PharmaceuticalsChadds Ford, PA

non-muscle invasive bladder cancer(Fast Track)

Phase III(610) 558-9800

Medicines in Development Cancer 2012 3

Bladder CanCe

product Name Sponsor Indication Development Status

eoquin®apaziquone

AllerganIrvine, CASpectrum PharmaceuticalsIrvine, CA

non-invasive bladder cancer(Fast Track)

Phase III(949) 788-6700

Folotyn®pralatrexate(orphan Drug)

Allos TherapeuticsWestminster, CO

(see also breast, lung, lymphoma) Phase II(303) 426-6262

icrucumab(LY3012212/IMC-18F1)

Eli LillyIndianapolis, INImCloneBridgewater, NJ

(see also breast, colorectal) Phase II(800) 545-5979

tesetaxel GentaBerkeley Heights, NJ

second-line bladder cancer (see also breast, prostate, skin, stomach)

Phase II(908) 286-9800

VB4-845 Viventia BiotechnologiesMississauga, Canada

(see also head/neck) Phase II(905) 362-2973

Brain CanCer


8H9 I-131 mAb United TherapeuticsSilver Spring, MD

(see also sarcoma, other) Phase I(301) 608-9292

ABT-888(veliparib)(PARP inhibitor)

Abbott LaboratoriesAbbott Park, IL

(see also breast, colorectal, lung, lymphoma, ovarian, prostate, skin, other)

Phase I(847) 937-6100

AC480(pan-HER inhibitor)

Ambit BiosciencesSan Diego, CA

glioma(see also breast, lung)

Phase I(858) 334-2100

AEE788 Novartis PharmaceuticalsEast Hanover, NJ

glioblastoma Phase I/II(888) 669-6682

afatinib(BIBW2992)

Boehringer IngelheimPharmaceuticalsRidgefield, CT

glioblastoma(see also breast, head/neck, lung)

Phase I/II(800) 243-0127

APN301(ch14.18 mAb/interleukin-2 fusion protein)

Apeiron BiologicsVienna, Austria

neuroblastoma in children(see also skin)

Phase II completedwww.apeiron-biologics.com



Brain CanCer


AR-67 Arno TherapeuticsFlemington, NJ

glioblastoma(see also leukemia, solid tumors)

Phase II(862) 703-7170

ARC-100 Archer BiosciencesNew York, NY

glioblastoma (recurrent)(see also breast, prostate, skin)--------------------------------------------------neuroblastoma (combination therapy)--------------------------------------------------medulloblastoma (combination therapy)

Phase II(646) 747-9090-------------------------------------------Phase I/II(646) 747-9090-------------------------------------------Phase I(646) 747-9090

AT-101(oral pan Bcl-2 inhibitor)

Ascenta TherapeuticsMalvern, PA

glioblastoma(see also leukemia, lung, lymphoma, prostate, stomach)

Phase II(610) 408-0301

Avastin®bevacizumab

GenentechSouth San Francisco, CA

first-line glioblastoma multiforme (see also breast, colorectal, lung, ovarian, other)

Phase III(800) 626-3553

Azedra™metaiodobenzylguanidine I-131(orphan Drug)

Molecular Insights PharmaceuticalsCambridge, MA

neuroblastoma (pediatric) (Fast Track), paraganglioma, pheochromocytoma (Fast Track)

Phase II(617) 492-5554

bafetinib CytRx Los Angeles, CA

second-line brain cancer (see also leukemia, prostate)

Phase I(310) 826-5648

BKM120(PI3K inhibitor)

Novartis PharmaceuticalsEast Hanover, NJ

glioblastoma(see also breast, lung, other)

Phase I/II(888) 669-6682

ch14.18 mAb(orphan Drug)

United TherapeuticsSilver Spring, MD

neuroblastoma (children) Phase III(301) 608-9292

cilengitide(orphan Drug)

EMD SeronoRockland, MA

newly-diagnosed glioblastoma(combination therapy)(see also prostate)

Phase III(800) 283-8088

cintredekin besudotox(orphan Drug)

INSYS TherapeuticsPhoenix, AZ

glioma (adolescents and children)(Fast Track)

Phase I(602) 910-2617

Cotara®monoclonal antibody TNT-1 (orphan Drug)

Peregrine PharmaceuticalsTustin, CA

recurrent glioblastoma(Fast Track)

Phase II(714) 508-6000

CPP-1X(eflornithine)

Cancer Prevention PharmaceuticalsTucson, AZ

neuroblastoma Phase I(520) 908-7774



Brain CanCer


crenolanib (CP-868-596)

AROG PharmaceuticalsDallas, TX

glioma (adults)(see also stomach)--------------------------------------------------glioma (pediatric)

Phase II(214) 594-0002-------------------------------------------Phase I(214) 594-0002

DCVax®-Brainbrain cancer vaccine(orphan Drug)

Northwest BiotherapeuticsBethesda, MD

glioblastoma Phase II(240) 497-9024

E7050 EisaiWoodcliff Lake, NJ

second-line glioblastoma (see also head/neck, liver, skin, solid tumors, stomach)

Phase I/II(888) 422-4743

E7080(lenvatinib)

EisaiWoodcliff Lake, NJ

glioma(see also skin, other)

Phase II(888) 422-4743

EPO-806(patupilone)


brain metastases from lung cancer(see also prostate)

Phase II(888) 669-6682

G-100 prophage cancer vaccine(vitespen)(orphan Drug)

AgenusLexington, MA

newly-diagnosed glioma Phase II(781) 674-4400

G-200 prophage cancer vaccine(vitespen)(orphan Drug)

AgenusLexington, MA

recurrent glioma Phase II(781) 674-4400

GliAtak™gene therapy(orphan Drug)

AdvantageneAuburndale, MA

glioma

--------------------------------------------------brain cancer (children)

Phase II(617) 916-5445-------------------------------------------Phase I(617) 916-5445

GMB-Vaxdendritic cell cancer vaccine

Activartis BiotechVienna, Austria

first-line glioblastoma Phase IIwww.activartis.com

GRN1005(LRP directed peptide-drugconjugate)

GeronMenlo Park, CA

brain metastases

--------------------------------------------------glioma

Phase II(650) 473-7700-------------------------------------------Phase I completed(650) 473-7700

GSK2118436(BRaf protein kinase inhibitor)

GlaxoSmithKlineRsch. Triangle Park, NC

brain metastases from melanoma(see also lung, skin)

Phase II(888) 825-5249

Hycamtin®topotecan


metastatic brain cancer Phase III(888) 825-5249




Brain CanCer


ICT-107(dendritic cell vaccine)(orphan Drug)

ImmunoCellular TherapeuticsWoodland Hills, CA

glioblastoma Phase II(818) 992-2907

Levulan® pDtaminolevulinic acid

DUSA PharmaceuticalsWilmington, MA

Phase II(978) 657-7500

lonafarnib MerckWhitehouse Station, NJ

glioblastoma Phase I(800) 672-6372

Lucanix®belagenpumatucel-L

NovaRxSan Diego, CA

glioma(see also lung)

Phase I(858) 522-8600

macitentan Actelion Pharmaceuticals USSouth San Francisco, CA

glioblastoma (combination therapy) Phase I(650) 624-6900

MEDI-575(anti-PDGFR-alpha mAb)

AstraZenecaWilmington, DEMedImmuneGaithersburg, MD

glioblastoma(see also lung)

Phase II(800) 236-9933(301) 398-0000

mibefradil(T-type calcium channel inhibitor)(orphan Drug)

Tau TherapeuticsCharlottesville, VA


motexafin gadolinium PharmacyclicsSunnyvale, CA

glioblastoma (combination therapy) Phase II(408) 774-0330

nimotuzumab(orphan Drug)

YM Biosciences USALehigh Valley, PA

metastatic brain cancer, recurrent glioma (pediatric)(see also breast, prostate)

Phase II(610) 560-0600

olaratumab(LY3012207)

Eli LillyIndianapolis, INImClone SystemsBridgewater, NJ

glioblastoma(see also ovarian)

Phase II(800) 545-5979

opaxio™paclitaxel poliglumex

Cell TherapeuticsSeattle, WA

glioma, glioblastoma(see also lung, ovarian, stomach, other)

Phase II(800) 215-2355

perifosine AEterna ZentarisBasking Ridge, NJ

refractory metastatic glioma(see also colorectal, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428



Brain CanCer


PLX3397(CSF-1R kinase inhibitor)

PlexxikonBerkeley, CA

recurrent glioblastoma(see also leukemia, lymphoma, solid tumors)

Phase II(510) 647-4000

Poly-ICLC(orphan Drug)

OncovirWashington, DC

anaplastic astrocytoma (adolescents and children), glioblastoma (adolescents and children)

Phase IIwww.oncovir.com

PX-866 OncothyreonSeattle, WA

second-line glioblastoma (see also head/neck, lung, prostate)

Phase II(206) 801-2100

Reolysin®reovirus

Oncolytics BiotechCalgary, Canada

glioma(see also colorectal, head/neck, lung, ovarian, pancreatic, sarcoma,skin, solid tumors)

Phase I/II(403) 670-7377

rindopepimut(orphan Drug)

Celldex TherapeuticsNeedham, MA

first-line glioblastoma (Fast Track)--------------------------------------------------second-line glioblastoma (Fast Track)

Phase III(781) 433-0771-------------------------------------------Phase II(781) 433-0771

SB-313-xTZ Sangamo BiosciencesRichmond, CA


SBG Biotec PharmaconTromsø, Norway

neuroblastoma (pediatric) Phase I/II completedwww.biotec.no

SL-701(brain cancer vaccine)

Stemline TherapeuticsNew York, NY

glioma (adults)

--------------------------------------------------glioma (children)

Phase I/II(212) 831-1111-------------------------------------------Phase I/II(212) 831-1111

SpRYCeL®dasatinib

Bristol-Myers SquibbPrinceton, NJ

glioblastoma(see also breast, pancreatic, prostate, other)

in clinical trials(800) 332-2056

tarceva®erlotinib(orphan Drug)

GenentechSouth San Francisco, CAOSI PharmaceuticalsFarmingdale, NY

late-stage brain metastases, recurrent ependymoma (children), glioblastoma(see also breast, head/neck, leukemia, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

terameprocol Erimos PharmaceuticalsHouston, TX

glioma (intravenous)(see also cervical, head/neck, solid tumors, other)

Phase I/II(713) 541-2000

TGF-ß R1 inhibitor(LY2157299)

Eli LillyIndianapolis, IN

(see also liver) Phase II(800) 545-5979


Brain CanCer


TH-302 Threshold PharmaceuticalsSouth San Francisco, CA

astrocytoma(see also leukemia, multiple myeloma, pancreatic, sarcoma)

Phase II(650) 474-8200

Toca 511/Toca FC(cytosine deaminase gene therapy)

TocagenSan Diego, CA

glioblastoma Phase I/II(858) 412-8400

trans-sodium crocetinate (TSC)(orphan Drug)

Diffusion PharmaceuticalsCharlottesville, VA

gliobastoma Phase I/II(434) 220-0718

TVI-Brain-1(cellular immunotherapyvaccine)

TVAX BiomedicalLenexa, KS

glioma Phase II(913) 492-2221

VAL-083 Del Mar PharmaceuticalsVancouver, Canada

grade IV malignant glioma Phase I/II(604) 629-5989

VB-111 VBL TherapeuticsOr Yehuda, Israel

glioblastoma(see also other)

Phase I/IIwww.vblrx.com

Xeloda®capecitabine


newly-diagnosed glioma (adolescents and children)(see also colorectal, liver, stomach)

Phase I(800) 626-3553

Zelboraf®vemurafenib

GenentechSouth San Francisco, CAPlexxikonBerkeley, CA

brain metastases(see also colorectal, other)

Phase II(800) 626-3553

Breast CanCer


18F-fluorothymidine MerckWhitehouse Station, NJ

breast cancer (diagnosis) Phase II(800) 672-6372


CelgeneSummit, NJ

first-line metastatic breast cancer(see also bladder, lung, ovarian,pancreatic, skin)

Phase II(908) 673-9000

ABT-888 (veliparib)(PARP inhibitor)


(see also brain, colorectal, lung, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100



(see also brain, lung) Phase I(858) 334-2100



Breast CanCer


acolbifene(4th-generation SERM)

EndoCeuticsQuebec, Canada

Phase II(418) 653-0033

AE37 peptide vaccine Antigen ExpressWorcester, MA

(see also ovarian) Phase II(508) 852-8783

afatinib(BIBW2992)


second-line metastatic breast cancer(see also brain, head/neck, lung)--------------------------------------------------first-line breast cancer


afimoxifene ASCEND TherapeuticsHerndon, VA

breast cancer (prevention) Phase II(703) 471-4744

Afinitor®everolimus


HER2-positive breast cancer(see also kidney, lymphoma)

Phase III(888) 669-6682

AFP464 KiraxBonita Springs, FL

Phase II(239) 444-5400

amrubicin CelgeneSummit, NJ

late-stage breast cancer (see also lung)

Phase I/II(908) 673-9000

ARC-100 Archer BiosciencesNew York, NY

(see also brain, prostate, skin) Phase II(646) 747-9090

ARRY-380(HER2 inhibitor)

Array BioPharmaBoulder, CO

Phase I(877) 633-2436

AUY922(Hsp90 inhibitor)


breast cancer (monotherapy)(see also colorectal, lung, multiple myeloma, stomach)--------------------------------------------------breast cancer (combination therapy)

Phase II(888) 669-6682

-------------------------------------------Phase I/II(888) 669-6682



Breast CanCer




adjuvant HER2-negative breast can-cer, adjuvant HER2-positive breast cancer, adjuvant triple negative breast cancer(see also brain, colorectal, lung, ovarian, other)

Phase III(800) 626-3553

AZD8931(erbB kinase inhibitor)

AstraZenecaWilmington, DE

advanced breast cancer (combination therapy)(see also solid tumors)

Phase II(800) 236-9933

BAY 86-5044 (lonaprisan)

Bayer HealthCare PharmaceuticalsWayne, NJ

metastatic breast cancer Phase II completed(888) 842-2937

BIIB 2024 Biogen IdecCambridge, MA

(see also stomach) Phase II completed(617) 679-2000

BKM120(PI3K inhibitor)


second-line breast cancer(see also brain, lung, other)

Phase I/II(888) 669-6682

breast cancer vaccine (dendritic cell vaccine)

Quantum ImmunologicsTampa, FL

Phase I/II(866) 213-4594

brostallicin Cell TherapeuticsSeattle, WA

triple-negative breast cancer Phase I(800) 215-2355

BTSCAN Molecular Targeting TechnologiesWest Chester, PA

breast cancer (diagnosis) Phase I(610) 738-7938

BZL-101 BionovoEmeryville, CA

Phase I(510) 601-2000

cabozantinib(XL184)

ExelixisSouth San Francisco, CA

(see also kidney, lung, ovarian, prostate, other)

Phase II(650) 837-7000

cancer vaccine MabVax TherapeuticsSan Diego, CA

(see also sarcoma) Phase I(858) 259-9405

CDX-011(glembatumumab vedotin)

Celldex TherapeuticsNeedham, MA

breast cancer (Fast Track)(see also skin)

Phase II(781) 433-0771

CV-301(cancer vaccine)

BN ImmunoTherapeuticsMountain View, CA

metastatic breast cancer Phase II(650) 681-4660

D-1MT NewLink GeneticsAmes, IA

second-line metastatic breast cancer(see also solid tumors)

Phase I/II(515) 296-5555



Breast CanCer


dalotuzumab(MK-0646)

MerckWhitehouse Station, NJ

second-line breast cancer (combination therapy)(see also lung, pancreatic, other)--------------------------------------------------first-line breast cancer

Phase II(800) 672-6372

-------------------------------------------Phase I(800) 672-6372

DPX-0907 ImmunovaccineHalifax, Canada

(see also ovarian, prostate) Phase I(902) 492-1819

eniluracil Adherex TechnologiesRsch. Triangle Park, NC

metastatic breast cancer(combination therapy)

Phase II(919) 636-4530

entinostat Syndax PharmaceuticalsWaltham, MA

(see also colorectal, kidney, leukemia, lung, lymphoma)

Phase II(781) 419-1400

etirinotecan pegol (NKTR-102)

Nektar TherapeuticsSan Francisco, CA

metastatic breast cancer(see also colorectal, ovarian, solid tumors)

Phase III(855) 482-6587

EZN-2208(PEG-SN38, firtecan pegol)

Enzon PharmaceuticalsPiscataway, NJ

metastatic breast cancer(see also colorectal, solid tumors)

Phase II(973) 980-4500

Faslodex®fulvestrant


first-line advanced breast cancer Phase III(800) 236-9933

folate binding protein (E39) vaccine

Galena BiopharmaLake Oswego, OR

(see also ovarian, other) Phase I(855) 855-4253

Folotyn®pralatrexate

Allos TherapeuticsWestminster, CO

(see also bladder, lung, lymphoma) Phase II(303) 426-6262

ganetespib (Hsp90i)

Synta PharmaceuticalsLexington, MA

(see also colorectal, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

ganitumab(AMG 479)

AmgenThousand Oaks, CA

combination therapy(see also colorectal, lung, pancreatic, sarcoma)

Phase II(800) 772-6436

GDC-0980(PI3 kinase/mTOR dual inhibitor)


hormone receptor-positive breast cancer(see also lymphoma, solid tumors)

Phase II(800) 626-3553

GSK2302024A(WT1 antigen-specific cancerimmunotherapeutic)


neoadjuvant breast cancer Phase I/II(888) 825-5249

GVAX® Breastcancer vaccine

BioSante PharmaceuticalsLincolnshire, IL

Phase I(847) 478-0500



Breast CanCer


HER2 antigen-specific cancerimmunotherapeutic


Phase II(888) 825-5249



metastatic breast cancer(see also bladder, colorectal)

Phase II(800) 545-5979

imetelstat GeronMenlo Park, CA

metastatic breast cancer(combination therapy)(see also leukemia, lung, multiple myeloma)

Phase II(650) 473-7700

IMT-1012 immunotherapeuticvaccine

ImmunotopeDoylestown, PA

(see also ovarian) Phase I(215) 253-4180

indibulin(ZIO-301)

ZIOPHARM OncologyNew York, NY

late-stage breast cancer Phase I/II(646) 214-0700

iniparib(BSI-201)

Sanofi USBridgewater, NJ

neoadjuvant breast cancer(see also lung, ovarian)

Phase II(800) 981-2491

KW-2450 Kyowa Hakko Kirin PharmaPrinceton, NJ

first-line breast cancer, second-line breast cancer

Phase I/II(609) 919-1100

LFA102(anti-prolactin receptor anti-body)

Novartis PharmaceuticalsEast Hanover, NJXOMABerkeley, CA

(see also prostate) Phase I(888) 669-6682

LGK974(WNT signaling pathway inhibitor)


(see also skin) Phase I(888) 669-6682

linifanib Abbott LaboratoriesAbbott Park, IL

breast cancer (combination therapy)(see also colorectal, kidney, liver, lung)

Phase II(847) 937-6100

liposome encapsulated paclitaxel (LEP-ETU)

Insys TherapeuticsPhoenix, AZ

Phase II(602) 910-2617

litronesib(LY2523355)


metastatic breast cancer(see also lung)

Phase II(800) 545-5979

LOR-2040 Lorus TherapeuticsToronto, Canada

metastatic breast cancer(see also colorectal, kidney, leukemia, prostate)

Phase II(416) 798-1200

Lymphoseek®Tc-99m tilmanocept

Navidea PharmaceuticalsDublin, OH

breast cancer (diagnosis)(see also head/neck, skin)

application submitted(614) 793-7500



Breast CanCer


maraciclatide GE HealthcareWaukesha, WI

breast cancer (diagnosis) in clinical trialswww.gehealthcare.com

MK-0752(notch signaling pathway inhibitor)


early-stage breast cancer, late-stage breast cancer(see also other)

Phase I(800) 672-6372

MK-2206(c-akt inhibitor)


HER2-positive breast cancer(see also other)

Phase I(800) 672-6372

MM-111 Merrimack PharmaceuticalsCambridge, MA

breast cancer (combination therapy) Phase I/II(617) 441-1000

MM-302(anti-HER2 antibody doxorubicin conjugate)

Merrimack PharmaceuticalsCambridge, MA

Phase I(617) 441-1000

motesanib AmgenThousand Oaks, CA

(see also colorectal, lung, other) Phase I/II(800) 772-6436

MVA-BN® HeR2(HER-2/neu-based MVA vaccine)

BN ImmunoTherapeuticsMountain View, CA

Phase I(650) 681-4660

Myocet™doxorubicin liposomal

Sopherion TherapeuticsPrinceton, NJ

first-line breast cancer (combination therapy) (Fast Track)

Phase III(609) 986-2020

NeuVax™cancer vaccine E75

Galena BiopharmaLake Oswego, OR

early-stage breast cancer(prevention of relapse)(see also prostate)

Phase III(855) 855-4253

Nexavar®sorafenib


(see also colorectal, head/neck, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

nimotuzumab YM Biosciences USALehigh Valley, PA

(see also brain, prostate) Phase I(610) 560-0600

NK-012 Nippon KayakuTokyo, Japan

(see also lung) Phase IIwww.nipponkayaku.co.jp

OBP-301 Oncolys BiopharmaTokyo, Japan

(see also head/neck, liver, lung) Phase Iwww.oncolys.com

OGX-427 OncoGenex PharmaceuticalsBothell, WA

(see also lung, ovarian) Phase I(425) 686-1500



Breast CanCer


onartuzumab GenentechSouth San Francisco, CA

metastatic breast cancer (combination therapy)(see also colorectal, lung)

Phase II(800) 626-3553

OPT-822/OPT-821 Optimer BiotechnologySan Diego, CA

Phase II/III(858) 909-0736

PB-272 (neratinib) Puma BiotechnologyLos Angeles, CA

second-line breast cancer, neoadjuvant breast cancer

Phase II(424) 248-6500

pertuzumab GenentechSouth San Francisco, CA

first-line metastatic breast cancer

--------------------------------------------------second-line late-stage breast cancer

application submitted(800) 626-3553-------------------------------------------Phase II(800) 626-3553

pertuzumab companion diagnostic(HER2 FISH pharmDx™)

DakoGlostrup, DenmarkGenentechSouth San Francisco, CA

breast cancer (diagnostic) Phase IIIwww.dako.com(800) 626-3553

pertuzumab companiondiagnostic(HercepTest™)


breast cancer (diagnosis) Phase IIIwww.dako.com(800) 626-3553

pixantrone Cell TherapeuticsSeattle, WA

breast cancer (Fast Track)(see also lymphoma)

Phase II(800) 215-2355

PTC299 PTC TherapeuticsSouth Plainfield, NJ

(see also solid tumors, other) Phase I/II(908) 222-7000

Quinamed®amonafide

CephalonFrazer, PA

(see also ovarian, prostate) Phase II(610) 344-0200

ramucirumab(IMC-1121B)

Eli LillyIndianapolis, INImClone SystemsBridgewater, NJ

metastatic breast cancer(see also colorectal, stomach)

Phase III(800) 545-5979

Reximmune-C®personalized cancer vaccine

Epeius BiotechnologiesSan Marino, CA

Phase I/II(626) 441-6695

Rexin-G® Epeius BiotechnologiesSan Marino, CA

metastatic breast cancer(see also pancreatic, sarcoma)

Phase I/II(626) 441-6695



Breast CanCer


ridaforolimus ARIAD PharmaceuticalsCambridge, MAMerckWhitehouse Station, NJ

metastatic breast cancer(see also kidney, lung, prostate, sarcoma, other)

Phase II(800) 672-6372

rucaparib Clovis OncologyBoulder, CO

(see also ovarian) Phase II(303) 625-5000

sagopilone Bayer HealthCare PharmaceuticalsWayne, NJ

(see also ovarian, prostate) Phase II completed(888) 842-2937

samarium SM-153 lexidronaminjection

EUSA PharmaLanghorne, PA

(see also multiple myeloma, prostate, sarcoma, other)

Phase II(800) 833-3533

SAR245408 (XL147)(oral PI3K inhibitor)

Sanofi USBridgewater, NJExelixis South San Francisco, CA

(see also other) Phase II(800) 981-2491(650) 837-7000

SAR245409 (XL765)(PI3K/mTOR inhibitor)

Sanofi USBridgewater, NJExelixis South San Francisco, CA

(see also lymphoma) Phase II(800) 981-2491(650) 837-7000

SAR256212 (MM-121)(anti-ErbB3 mAb)

Merrimack PharmaceuticalsCambridge, MASanofi USBridgewater, NJ

(see also lung, ovarian) Phase II(800) 981-2491

SF1 (sonodynamic therapy) SonneMedBoston, MA

advanced breast cancer Phase I/IIwww.sonnemed.com

SpRYCeL®dasatinib


(see also brain, pancreatic, prostate, other)


SR 16234 SRI InternationalMenlo Park, CA

Phase II(650) 859-2000

tarceva®erlotinib


(see also brain, head/neck, leukemia, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

tesetaxel GentaBerkeley Heights, NJ

first-line breast cancer (see also bladder, prostate, skin, stomach)

Phase II(908) 286-9800



Breast CanCer


thermoDox®doxorubicin liposomal

CelsionLawrenceville, NJ

recurrent breast cancer(see also colorectal, liver)

Phase I/II(609) 896-9100

tigatuzumab(anti-DR5 antibody)

Daiichi SankyoParsippany, NJ

(see also colorectal, liver, lymphoma, ovarian, pancreatic)

Phase II(973) 944-2600

tivozanib(ASP4130/AV-951)

Astellas Pharma USDeerfield, ILAVEO PharmaceuticalsCambridge, MA

breast cancer (combination therapy)(see also colorectal, kidney)

Phase I/II(800) 695-4321(617) 299-5000

TKI258(dovitinib)


metastatic breast cancer(see also kidney, multiple myeloma, prostate, skin, other)

Phase II(888) 669-6682

trabectedin Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

metastatic breast cancer (see also ovarian, prostate, sarcoma)

Phase III(800) 817-5286

trastuzumab-DM1(RG3502)


Phase III(800) 626-3553

trastuzumab-DM1 companion diagnostic(HercepTest™)



trastuzumab-DM1 companion diagnostic(HER2 FISH pharmDx™)



TRC 105(ENG protein inhibitor)

TRACON PharmaceuticalsSan Diego, CA

(see also ovarian, prostate, other) Phase I/II(858) 550-0780

trebananib (AMG386)


(see also colorectal, kidney, liver, ovarian, stomach, other)

Phase II(800) 772-6436

tykerb®lapatinib


inflammatory breast cancer (see also colorectal, head/neck, stomach)--------------------------------------------------adjuvant breast cancer, first-line metastatic breast cancer--------------------------------------------------neoadjuvant breast cancer


-------------------------------------------Phase III(888) 825-5249-------------------------------------------Phase II(888) 825-5249

upamostat (WX-671)

WilexMunich, Germany

Phase IIwww.wilex.de



Breast CanCer


varlitinib ASLAN PharmaceuticalsSingapore

Phase IIwww.aslanpharma.com

VeriStrat®companion diagnostic testEGFR-TKI

BiodesixBoulder, CO

advanced breast cancer (diagnosis-outcome test in HER2-overexpressing tumors)

Phase III(303) 417-0500

YM155(sepantronium)

Astellas Pharma USDeerfield, IL

(see also lymphoma) Phase II(800) 695-4321

Zolinza®vorinostat


(see also leukemia, lung, lymphoma, multiple myeloma, other)

Phase II(800) 672-6273

Zytiga®abiraterone

Janssen BiotechHorsham, PA

second-line metastatic breast cancer(see also prostate)

Phase II(800) 526-7736

CerviCal CanCer


ADXS-HPV AdvaxisPrinceton, NJ

cervical cancer, cervical intraepithelial neoplasia

Phase II(609) 452-9813

PM-00104 PharmaMarMadrid, Spain

(see also sarcoma, other) Phase IIwww.pharmamar.com

PV701(replication-competent oncolytic virus)

Wellstat BiologicsGaithersburg, MD

(see also colorectal) Phase II(240) 683-2500


cervical intraepithelial neoplasia (intravaginal)(see also brain, head/neck, solid tumors, other)

Phase II(713) 541-2000

V503(HPV virus-like particle (VLP) vaccine)


prevention of cervical cancer, prevention of vulvovaginal cancer

Phase III(800) 672-6372

V505(HPV vaccine)


prevention of cervical cancer Phase II completed(800) 672-6372



CerviCal CanCer


verpasep caltespen(cancer vaccine)

Akela PharmaAustin, TX

cervical intraepithelial neoplasia Phase I completed(512) 834-0449

VGX-3100(DNA cancer vaccine)

Inovio PharmaceuticalsBlue Bell, PA

cervical intraepithelial neoplasia Phase II(877) 446-6846

ColoreCtal CanCer




(see also brain, breast, lung, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100

Aptocine™talaporfin

Light Sciences OncologyBellevue, WA

metastatic colorectal cancer Phase III(425) 957-8900



second-line colorectal cancer (combination therapy)(see also breast, lung, multiplemyeloma, stomach)

Phase I(888) 669-6682



metastatic colorectal cancer (treatment beyond progression) (see also brain, breast, lung, ovarian, other)

Phase III(800) 626-3553

AVX701(CEA cancer immunotherapy)

AlphaVaxRsch. Triangle Park, NC

colorectal cancer prevention in patients with advanced or metastatic CEA-expressing malignancies

Phase I/II(919) 595-0400

belinostat Spectrum PharmaceuticalsHenderson, NV

colorectal cancer (combination therapy)(see also leukemia, liver, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300

brivanib(VEGFR/FGFR kinase inhibitor)


metastatic colorectal cancer(see also liver, sarcoma)

Phase II(800) 332-2056

CPX-1(irinotecan/floxuridine)

Celator PharmaceuticalsPrinceton, NJ

Phase II completed(609) 243-0123

CT-011 CureTechYavne, Israel

first-line metastatic colorectal cancer (combination therapy)(see also leukemia, lymphoma)

Phase IIwww.curetechbio.com


Phase II(888) 422-4743



ColoreCtal CanCer


efatutazone Daiichi SankyoParsippany, NJ

metastatic colorectal cancer(see also lung, other)

Phase II(973) 944-2600

EGEN-001 EGENHuntsville, AL

(see also ovarian, other) Phase I/II(256) 512-0077

EGFR antagonist companion diagnostic

QIAGENValencia, CA

colorectal cancer (diagnosis) application submittedwww.qiagen.com

encapsulated cell therapy(macrobeads)

Rogosin InstituteNew York, NY

refractory metastatic colorectal cancer(see also pancreatic, prostate)

Phase II(212) 746-1566


metastatic colorectal cancer(combination therapy)(see also breast, kidney, leukemia, lung, lymphoma)

Phase II(781) 419-1400

eRBItUX®cetuximab

Bristol-Myers SquibbPrinceton, NJEli LillyIndianapolis, IN

first-line colorectal cancer(see also stomach)

in clinical trials(800) 332-2056(800) 545-5979

etirinotecan pegol(NKTR-102)

Nektar TherapeuticsSan Francisco, CA

second-line colorectal cancer(see also breast, ovarian, solid tumors)

Phase II/III(855) 482-6587

EZN-2208(PEG-SN38, firtecan pegol)

Enzon PharmaceuticalsPiscataway, NJ

metastatic colorectal cancer(see also breast, solid tumors)

Phase II(973) 980-4500

FANG™ Vaccineautologous tumor cell vaccine

GradalisCarrollton, TX

(see also ovarian, skin) Phase II(214) 442-8100

ganetespib (Hsp90i)


refractory, metastatic colorectal cancer(see also breast, leukemia, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

ganitumab(AMG 479)


second-line metastatic colorectal cancer (combination therapy)(see also breast, lung, pancreatic, sarcoma)

Phase II(800) 772-6436

GI-4000(cancer vaccine)

GlobeImmuneLouisville, CO

(see also lung, pancreatic) Phase II(303) 625-2700



ColoreCtal CanCer


GM-CT-01 Galectin TherapeuticsNewton, MA

colorectal cancer (combination therapy)

Phase II(617) 559-0033

GS-6624(monoclonal antibody)

Gilead SciencesFoster City, CA

(see also pancreatic) Phase II(800) 445-3235

GVAX® Colorectalcancer vaccine


Phase I(847) 478-0500



(see also bladder, breast) Phase II(800) 545-5979

IMO-2055(TLR9 agonist)

Idera PharmaceuticalsCambridge, MA

(see also head/neck, lung) Phase I(617) 679-5000

Imprime pGG® BiotheraEagan, MN

(see also leukemia, lung, skin) Phase III(651) 675-0300

JX-594 (pexastimogene devacirepvec)

Jennerex BiotherapeuticsSan Francisco, CA

(see also liver) Phase I/II(415) 281-8886

KRN-330 Kyowa Hakko Kirin PharmaPrinceton, NJ

colorectal cancer (combination therapy)--------------------------------------------------colorectal cancer (monotherapy)

Phase I/II(609) 919-1100-------------------------------------------Phase I(609) 919-1100

labetuzumab I-131(IMMU-111)

ImmunomedicsMorris Plains, NJ

Phase II(973) 605-8200

labetuzumab-SN-38(IMMU-130)


Phase I(973) 605-8200

LGX818(RAF inhibitor)


metastatic colorectal cancer(see also skin)

Phase I(888) 669-6682


second-line colorectal cancer(see also breast, kidney, liver, lung)

Phase II(847) 937-6100

LOR-2040 Lorus TherapeuticsToronto, Canada

metastatic colorectal cancer(see also breast, kidney, leukemia, prostate)

Phase II(416) 798-1200

motesanib AmgenThousand Oaks, CA

(see also breast, lung, other) Phase I(800) 772-6436



ColoreCtal CanCer


Nexavar®sorafenib


metastatic colorectal cancer (see also breast, head/neck, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase II(888) 842-2937

NPC-1C(ensituximab)

Neogenix OncologyRockville, MD

metastatic colorectal cancer(see also pancreatic)

Phase I(301) 917-6893

onartuzumab GenentechSouth San Francisco, CA

(see also breast, lung) Phase II(800) 626-3553

oncoVAX®active specific immunotherapy

VaccinogenFrederick, MD

(Fast Track) Phase I/II(301) 668-8400


refractory metastatic colorectal cancer (combination therapy)(Fast Track)(see also brain, kidney, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase III(908) 626-5428

PHY906 PhytoCeuticaNew Haven, CT

(see also liver, pancreatic, cancer-related)

Phase I/II(203) 777-3462

picoplatin Ponaird PharmaceuticalsSeattle, WA

(see also lung, ovarian, prostate) Phase II(206) 281-7001

polyclonal antibody stimulator Cancer AdvancesDurham, NC

(see also pancreatic, stomach) Phase II(919) 361-2162

PV701(replication-competent oncolytic virus)

Wellstat BiologicsGaithersburg, MD

(see also cervical) Phase II(240) 683-2500

ramucirumab(IMC-1121B)


(see also breast, stomach) Phase III(800) 545-5979

regorafenib Bayer HealthCare PharmaceuticalsWayne, NJ

metastatic colorectal cancer (Fast Track)(see also kidney, lung, solid tumors, stomach)

Phase III(888) 842-2837

Reolysin®reovirus


(see also brain, head/neck, lung, ovarian, pancreatic, sarcoma,skin, solid tumors)

Phase I(403) 670-7377



ColoreCtal CanCer


RG7160(EGFR inhibitor)

RocheNutley, NJ

second-line metastatic colorectal cancer (combination therapy)

Phase II(973) 235-5000

RG7414(EGFL7 inhibitor)


(see also lung) Phase II(800) 626-3553

RIGScan™tumor-specific, radio-labeled monoclonal antibody targeting agent

Navidea BiopharmaceuticalsDublin, OH

metastatic colorectal cancer (diagnosis)


robatumumab MerckWhitehouse Station, NJ

(see also sarcoma, solid tumors) Phase II completed(800) 672-6372

Sym004 SymphogenLyngby, Denmark

metastatic colorectal cancer Phase IIwww.symphogen.com

TAS-102 Taiho Pharma U.S.A.Princeton, NJ

Phase I(609) 750-5300

telatinib ACT BiotechSan Francisco, CA

(see also stomach) Phase I(415) 230-3900

TF2(pretargeted radioimmuno-therapy)


colorectal cancer Phase I(973) 605-8200

thermoDox®doxorubicin liposomal


adjuvant inoperable/unresectable, metastatic colorectal cancer(see also breast, liver)

Phase II(609) 896-9100



(see also breast, liver, lymphoma, ovarian, pancreatic)

Phase I(973) 944-2600

tivantinib (ARQ 197)

ArQuleWoburn, MADaiichi SankyoParsippany, NJ

(see also kidney, liver, lung, pancreatic, sarcoma, other)

Phase I/II(781) 994-0300(973) 944-2600



colorectal cancer (combination therapy)(see also breast, kidney)

Phase II(800) 695-4321(617) 299-5000

trebananib (AMG386)


(see also breast, kidney, liver, ovarian, stomach, other)

Phase II(800) 772-6436

tykerb®lapatinib


metastatic colorectal cancer(see also breast, head/neck, stomach)

Phase II(888) 825-5249



ColoreCtal CanCer


Vectibix®panitumumab


first-line and second-line colorectal cancer (see also head/neck)




first-line and second-line metastatic colorectal cancer (combination therapy)(see also brain, liver, stomach)


Zaltrap™aflibercept

Regeneron PharmaceuticalsTarrytown, NYSanofi USBridgewater, NJ

second-line metastatic colorectal cancer(see also prostate)

application submitted(914) 345-7400(800) 981-2491

Zelboraf®vemurafenib

GenentechSouth San Francisco, CAPlexxikonBerkeley, CA

(see also brain, other) Phase I(800) 626-3553

Head/neCk CanCer


ACE-041(dalantercept)

Acceleron PharmaCambridge, MA

(see also multiple myeloma) Phase II(617) 649-9200

afatinib(BIBW2992)


second-line head/neck cancer(see also breast, brain, lung)

Phase II(800) 243-0127

AP5346 Access PharmaceuticalsDallas, TX

Phase II(214) 905-5100


(see also brain, liver, skin, solid tumors, stomach)

Phase I/II(888) 422-4743

foretinib(GSK1363089)


(see also kidney, liver, lung) Phase II completed(888) 825-5249

GL-0810(orphan Drug)

GliknikBaltimore, MD

Phase Iwww.gliknik.com

GL-0817(orphan Drug)

GliknikBaltimore, MD

(see also multiple myeloma) Phase Iwww.gliknik.com

HF-10 Takara BioShiga, Japan

Phase Iwww.takara-bio.com



Head/neCk CanCer


IMO-2055(TLR9 agonist)

Idera PharmaceuticalsCambridge, MA

second-line head and neck cancer(combination therapy)(see also colorectal, lung)

Phase II(617) 679-5000

IRX-2 IRX TherapeuticsNew York, NY

(Fast Track) Phase II(212) 582-1199

Lymphoseek®Tc-99m tilmanocept

Navidea PharmaceuticalsDublin, OH

head and neck cancer (diagnosis)(see also breast, skin)

Phase III(614) 793-7500

Multikine®leukocyte interleukin(orphan Drug)

CEL-SCIVienna, VA

first-line head and neck cancer Phase III(703) 506-9460

Nexavar®sorafenib


(see also breast, colorectal, kidney, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase II(888) 842-2937


(see also breast, liver, lung) Phase Iwww.oncolys.com

PX-866 OncothyreonSeattle, WA

head and neck cancer (combination therapy)(see also brain, lung, prostate)

Phase II(206) 801-2100

Reolysin®reovirus


metastatic head and neck cancer (combination therapy)(see also brain, colorectal, lung, ovarian, pancreatic, sarcoma, skin, solid tumors)

Phase III(403) 670-7377

RG7597(EGFR antagonist)


Phase II(800) 626-3553

seliciclib(CYC202)

Cyclacel PharmaceuticalsBerkeley Heights, NJ

nasopharyngeal cancer (see also solid tumors)

Phase II(908) 517-7330

tarceva®erlotinib


first-line head/neck cancer (combination therapy)(see also brain, breast, leukemia,liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

TAS-106 Taiho Pharma U.S.A.Princeton, NJ

Phase II(609) 750-5300



Head/neCk CanCer



head and neck cancer (intratumoral)(see also brain, cervical, solid tumors, other)

Phase I(713) 541-2000

tNFerade™golnerminogene pradenovec

GenVecGaithersburg, MD

(see also prostate, skin, stomach) Phase I/II completed(877) 943-6832

tykerb®lapatinib


head and neck squamous cell carcinoma (resectable disease)(see also breast, colorectal, stomach)

Phase III(888) 825-5249

VB4-845(orphan Drug)

Viventia BiotechnologiesMississauga, Canada

(Fast Track)(see also bladder)

Phase II(905) 362-2973

Vectibix®panitumumab


first-line head and neck cancer(see also colorectal)--------------------------------------------------second-line head and neck cancer


kidney CanCer


Afinitor®everolimus


hepatocellular carcinoma(see also breast, lymphoma)

Phase II(888) 669-6682

AGS-003(personalized dendritic cell vaccine)

Argos TherapeuticsDurham, NC

renal cancer (combination therapy)(Fast Track)--------------------------------------------------metastatic renal cancer (monotherapy)

Phase II(919) 287-6300-------------------------------------------Phase II(919) 287-6300

AMG 172 AmgenThousand Oaks, CA

Phase I(800) 772-6436

anti-PD1 (BMS-936558)


renal cell carcinoma(see also lung, skin)

Phase II(800) 332-2056

BNC105 BionomicsThebarton, Australia

Phase IIwww.bionomics.com.au

cabozantinib(XL184)

ExelixisSouth San Francisco, CA

renal cell carcinoma(see also breast, lung, ovarian, prostate, other)

Phase I(650) 837-7000



kidney CanCer


CVX 060 (PF-04856884)(Ang2 antagonist)

PfizerNew York, NY

renal cell carcinoma(see also solid tumors)

Phase II(860) 732-5156

CYT107(interleukin-7)

CytherisRockville, MD

(see also skin) Phase I(301) 231-0451


(see also breast, colorectal, leukemia, lung, lymphoma)

Phase I/II(781) 419-1400



(see also head/neck, liver, lung) Phase II(888) 825-5249

IMA901(cancer vaccine)

immatics biotechnologiesTüebingen, Germany

renal cancer Phase IIIwww.immatics.com

Inlyta®axitinib(orphan Drug)

PfizerNew York, NY

advanced renal cell carcinoma in treatment-naive patients(see also liver, other)

Phase III(860) 732-5156

Istodax®romidepsin

CelgeneSummit, NJ

renal cancer(see also pancreatic, prostate, other)

Phase II(908) 673-9000

LBH589 (panobinostat)


renal cancer(see also leukemia, multiple myeloma, prostate, solid tumors)

Phase II(888) 669-6682


renal cancer (see also breast, colorectal, liver, lung)

Phase II(847) 937-6100

LOR-2040(orphan Drug)

Lorus TherapeuticsToronto, Canada

metastatic renal cancer(see also breast, colorectal, leukemia, prostate)

Phase II(416) 798-1200

naptumomab estafenatox Active BiotechLund, Sweden

(see also lung, pancreatic) Phase I completedwww.activebiotech.com

Nexavar®sorafenib


renal cell carcinoma (adjuvant therapy)(see also breast, colorectal, head/neck, leukemia, liver, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

oncophage®vitespen(orphan Drug)

AgenusLexington, MA

renal cell carcinoma (Fast Track) Phase II(781) 674-4400

OSI-027(TORC1/TORC2 inhibitor)

OSI PharmaceuticalsFarmingdale, NY

renal cancer(see also lymphoma)

Phase II(631) 962-0600



kidney CanCer



metastatic renal cancer(see also brain, colorectal, leukemia, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428

Redectane®girentuximab I-124 companion diagnostic


renal cancer (diagnosis) Phase III completedwww.wilex.de

regorafenib Bayer HealthCare PharmaceuticalsWayne, NJ

renal cancer(see also colorectal, lung, solid tumors, stomach)

Phase II(888) 842-2837

Rencarex®girentuximab(orphan Drug)


clear cell renal cell carcinoma(Fast Track)

Phase IIIwww.wilex.de

ridaforolimus ARIAD PharmaceuticalsCambridge, MAMerckWhitehouse Station, NJ

(see also breast, lung, prostate, sarcoma, other)

Phase I(800) 672-6372

SGN-75(vorsetuzumab mafodotin)

Seattle GeneticsBothell, WA

renal cancer(see also lymphoma)

Phase I(425) 527-4000

Sutent®sunitinib(orphan Drug)

PfizerNew York, NY

renal cell carcinoma (adjuvant therapy)

Phase III(860) 732-5156

tivantinib (ARQ 197)

ArQuleWoburn, MADaiichi SankyoParsippany, NJ

(see also colorectal, liver, lung, pancreatic, sarcoma, other)

Phase II(781) 994-0300(973) 944-2600



first-line renal cancer (see also breast, colorectal)

--------------------------------------------------renal cancer(combination therapy)

Phase III(800) 695-4321(617) 299-5000-------------------------------------------Phase I(800) 695-4321(617) 299-5000

TKI258(dovitinib)


(see also breast, multiple myeloma, prostate, skin, other)

Phase III(888) 669-6682

torisel®temsirolimus(orphan Drug)

PfizerNew York, NY

renal cell carcinoma Phase III(860) 732-5156

trebananib (AMG386)


renal cancer(see also breast, colorectal, liver, ovarian, stomach, other)

Phase II(800) 772-6436



kidney CanCer


TVI-Kidney-1(cellular immunotherapyvaccine)

TVAX BiomedicalLenexa, KS

renal cell carcinoma Phase II completed(913) 492-2221

veglin (VEGF antisense)

VasGene TherapeuticsLos Angeles, CA

(see also lung, skin) Phase I(323) 221-7818

Votrient™pazopanib


(see also ovarian, other) Phase III(888) 825-5249

leukemia


ABIO-0501 (TALL104)

Abiogen PharmaPisa, Italy

chronic myeloid leukemia (CML) Phase IIwww.abiogen.it

AC220(quizartinib)

Ambit BiosciencesSan Diego, CAAstellas Pharma USDeerfield, IL

second-line and third-line acute myeloid leukemia (AML) (monotherapy)(see also solid tumors)--------------------------------------------------acute lymphocytic leukemia (ALL) (combination therapy), first-line AML

Phase II(858) 334-2100(800) 695-4321

-------------------------------------------Phase I(858) 334-2100(800) 695-4321

AC430(JAK2 inhibitor)


Phase I(858) 334-2100

Adcetris™brentuximab vedotin

Millennium PharmaceuticalsCambridge, MASeattle GeneticsBothell, WA

(see also lymphoma) Phase II(800) 390-5663(425) 527-4000

AEG35156(XIAP inhibitor)

Aegera TherapeuticsMontreal, Canada

AML(see also lymphoma)--------------------------------------------------chronic lymphocytic leukemia (CLL)

Phase II(514) 288-5532-------------------------------------------Phase I/II(514) 288-5532

AFX-9154 Afecta PharmaceuticalsIrvine, CA




leukemia


AGS-005 Argos TherapeuticsDurham, NC

CLL Phase I/II(919) 287-6300

ALD-151 AldagenDurham, NC

Phase I(919) 484-2571

ALXN6000(samalizumab)

Alexion PharmaceuticalsCheshire, CT

CLL(see also multiple myeloma)

Phase I/II completed(203) 272-2596

aminopterin Syntrix BiosystemsAuburn, WA

ALL Phase II completed(253) 833-8009

anti-CD22/CD19 mAb-toxinconjugate

Abiogen PharmaPisa, Italy

ALL Phase Iwww.abiogen.com


CLL(see also lymphoma, multiple myeloma)

Phase I/II(862) 703-7170


myelodysplastic syndromes(see also brain, solid tumors)

Phase II(862) 703-7170

Arranon®nelarabine(orphan Drug)


first-line ALL(see also lymphoma)--------------------------------------------------second-line ALL

Phase III(888) 669-6682-------------------------------------------Phase I/II(888) 669-6682

ARRY-520(KSP inhibitor)

Array BioPharmaBoulder, CO

AML(see also multiple myeloma, solid tumors)

Phase II(877) 633-2436

Arzerra®ofatumumab(orphan Drug)


first-line CLL (combination therapy)(see also lymphoma)

Phase III(888) 825-5249



CLL(see also brain, lung, lymphoma, prostate, stomach)

Phase II(610) 408-0301

AT-406/Debio-1143 Ascenta TherapeuticsMalvern, PADebiopharmLausanne, Switzerland

AML(see also lymphoma)

Phase I(610) 408-0301www.debiopharm.com



leukemia


AT7519(CDK inhibitor)

Astex PharmaceuticalsDublin, CA

CLL(see also lymphoma, multiple myeloma, solid tumors)

Phase II(925) 560-0100

AT9283(aurora/Jak2 inhibitor)(orphan Drug)


AML(see also lymphoma, multiple myeloma, solid tumors)

Phase I/II(925) 560-0100

AVL-292(Btk inhibitor)

CelgeneSummit, NJ

second-line CLL (combination therapy)(see also lymphoma, unspecified)

Phase I(908) 673-9000

AZD1208(Pim kinase inhibitor)


AML Phase I(800) 236-9933

bafetinib(orphan Drug)

CytRx Los Angeles, CA

second-line CLL (see also brain, prostate)--------------------------------------------------ALL, CML

Phase II(310) 826-5648-------------------------------------------Phase I(310) 826-5648

Bcl-2 inhibitor(ABT-199/GDC-0199)

Abbott LaboratoriesAbbott Park, ILGenentechSouth San Francisco, CA

CLL(see also lymphoma)

Phase I(847) 937-6100(800) 626-3553


AML(see also colorectal, liver, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300

BI-811283(aurora kinase B inhibitor)


AML(see also solid tumors)

Phase I/II(800) 243-0127

BI-836826 Boehringer IngelheimPharmaceuticalsRidgefield, CT

CLL Phase I(800) 243-0127

bosutinib PfizerNew York, NY

previously treated CML application submitted(860) 732-5156

cenersen(orphan Drug)

EleosOmaha, NE

AML Phase II completed(402) 393-3034

Ceplene®histamine dihydrochloride injection(orphan Drug)

EpiCeptTarrytown, NY

AML application submitted(914) 606-3500



leukemia


CLL immunotherapeutic vaccine MaxCyteGaithersburg, MD

CLL Phase I/II(301) 944-1700

Clolar®clofarabine injection (orphan Drug)

GenzymeCambridge, MA

AML (adults) Phase III(617) 252-7500

CNDO-109(tumor activated NK cells)

Coronado BiosciencesBurlington, MA

AML Phase I(781) 238-6621

CPX-351(cytarabine/daunorubicin)(orphan Drug)

Celator PharmaceuticalsPrinceton, NJ

AML Phase II(609) 243-0123

CT-011 CureTechYavne, Israel

second-line AML (combination therapy)(see also colorectal, lymphoma)

Phase IIwww.curetechbio.com

CWP232291 JW PharmaceuticalSeoul, South Korea

AML Phase I

Dacogen®decitabine

EisaiWoodcliff Lake, NJ

AML

--------------------------------------------------pediatric AML


danusertib Nerviano Medical SciencesNerviano, Italy

CML Phase IIwww.nervianoms.com

DCC-2036 Deciphera PharmaceuticalsLawrence, KS

ALL, CML

--------------------------------------------------AML

Phase I/II(785) 830-2100-------------------------------------------Phase I(785) 830-2100

DCDS-4501A GenentechSouth San Francisco, CA


Phase I(800) 626-3553

DCDT-2980S GenentechSouth San Francisco, CA

recurrent CLL(see also lymphoma)

Phase I(800) 626-3553

elacyt™elacytarabine(orphan Drug)

Clavis PharmaOslo, Norway

late-stage AML(Fast Track)--------------------------------------------------early-stage AML

Phase IIIwww.clavispharma.com-------------------------------------------Phase IIwww.clavispharma.com



leukemia


elesclomol Synta PharmaceuticalsLexington, MA

AML(see also lung, ovarian)

Phase I(781) 274-8200


(see also breast, colorectal, kidney, lung, lymphoma)

Phase II(781) 419-1400

epratuzumab(orphan Drug)

ImmunomedicsMorris Plains, NJUCBAtlanta, GA

ALL in children (combination therapy)(see also lymphoma)

Phase II(973) 605-8200

forodesine(orphan Drug)

BioCryst PharmaceuticalsDurham, NC


Phase II(919) 859-1302

ganetespib (Hsp90i)


ALL, AML, CML(see also breast, colorectal, liver, lung, multiple myeloma, pancreatic, prostate, skin, stomach)--------------------------------------------------myelodysplastic syndromes

Phase I/II(781) 274-8200

-------------------------------------------Phase I(781) 274-8200

GNKG-168 SBI BiotechTokyo, Japan

CLL Phase Iwww.sbibiotech.jp

GRNVAC1(dendritic cell vaccine)

Argos TherapeuticsDurham, NCGeronMenlo Park, CA

AML(see also prostate)

Phase II(650) 473-7700

GS-1101(PI3K delta inhibitor)

Gilead SciencesFoster City, CA

second-line CLL (see also lymphoma)

Phase III(800) 445-3235

GSK2110183(protein kinase B inhibitor)


(see also multiple myeloma) Phase II(888) 825-5249

GSK2130579A(WT1 antigen-specific cancer immunotherapeutic)


AML Phase II(888) 825-5249

GVAX® Leukemiacancer vaccine(orphan Drug)


AML, CML Phase II(847) 478-0500

HuM195-Ac-225(lintuzumab Ac-225)

Actinium PharmaceuticalsNewark, NJ

AML Phase I(973) 344-6500



leukemia


HuM195-Bi-213(lintuzumab Bi-213)

Actinium PharmaceuticalsNewark, NJ

AML Phase I/II(973) 344-6500

HuM195/rGel(lintuzumab-gelonin conjugate)

Targa TherapeuticsSan Diego, CA

AML, CML, myelodysplasticsyndromes

Phase I(858) 483-6600

ibrutinib(PCI-32765)

Janssen BiotechHorsham, PAPharmacyclicsSunnyvale, CA

CLL(see also lymphoma, multiple myeloma)

Phase I/II(800) 526-7736(408) 774-0330

imatinib sublingual Kedem PharmaceuticalsMesa, AZ

CML in clinical trials(604) 324-4244

imetelstat GeronMenlo Park, CA

CLL(see also breast, lung, multiple myeloma)

Phase I/II(650) 473-7700

Imprime pGG® BiotheraEagan, MN

CLL(see also colorectal, lung, skin)

Phase I/II(651) 675-0300

INNO-305(WT-1 vaccine)

CytRxLos Angeles, CA

AML, myelodysplastic syndromes(see also solid tumors)

Phase I(310) 826-5648

inotuzumab ozogamicin PfizerNew York, NY

ALL(see also lymphoma)

Phase I(860) 732-5156

ISF35(recombinant immunotherapeutic vaccine)

MemgenSan Diego, CA

CLL (monotherapy)(see also lymphoma)--------------------------------------------------refractory metastatic CLL (combination therapy)

Phase II(858) 524-5400-------------------------------------------Phase I(858) 524-5400

JNJ-26481585(quisinostat)

Johnson & Johnson PharmaceuticalResearch & DevelopmentRaritan, NJ

myelodysplastic syndromes, metastatic leukemia(see also lymphoma)

Phase I(800) 817-5286

JVRS-100(lipid-DNA complex vaccine)

Colby PharmaceuticalSan Jose, CA

Phase I(650) 333-3152

KX2-391 Kinex PharmaceuticalsBuffalo, NY

AML in the elderly(see also prostate)

Phase I(716) 898-8626



leukemia


LBH589 (panobinostat)


ALL, AML, myelodysplastic syndromes(see also kidney, multiple myeloma, prostate, solid tumors)

Phase II(888) 669-6682

LDE225(erismodegib)


CML (combination therapy)(see also pancreatic, solid tumors, skin)

Phase I(888) 669-6682

lestaurtinib(orphan Drug)

CephalonFrazer, PA

AML Phase II(610) 344-0200

leukemia DNA vaccine Inovio PharmaceuticalsBlue Bell, PAUniversity of SouthamptonSouthampton, United Kingdom

AML, CML Phase II(877) 446-6846

LG740(activated T-cells)

LentigenGaithersburg, MDUniversity of PennsylvaniaPhiladelphia, PA

ALL, B-cell prolymphocytic leukemia, CLL(see also lymphoma)

Phase I(301) 527-4200

LOR-2040(orphan Drug)

Lorus TherapeuticsToronto, Canada

AML (combination therapy)(see also breast, colorectal, kidney, prostate)--------------------------------------------------CML, myelodysplastic syndromes

Phase II(416) 798-1200

-------------------------------------------Phase I (416) 798-1701

lurbinectedin PharmaMarMadrid, Spain

(see also solid tumors) Phase Iwww.pharmamar.com

Marqibo®vincristine liposomal(orphan Drug)

Talon TherapeuticsSan Mateo, CA

relapsed or refractory Philadelphia chromosome-negative ALL (Fast Track)(see also lymphoma, skin, other)--------------------------------------------------ALL in the elderly (Fast Track)


-------------------------------------------Phase III(650) 588-6404

milatuzumab ImmunomedicsMorris Plains, NJ

CLL (monotherapy)(see also lymphoma, multiple myeloma)

Phase I/II(973) 605-8200

MK-7956(dinaciclib)(orphan Drug)



Phase II(800) 672-6372



leukemia


MK-8242 MerckWhitehouse Station, NJ


Phase I(800) 672-6372

mocetinostat(MGCD0103, HDAC inhibitor)

MethylGeneMontreal, Canada

CLL(see also lymphoma, solid tumors)

Phase II completed(514) 337-3333

Mozobil®plerixafor

GenzymeCambridge, MA

AML Phase I(617) 252-7500

navitoclax(ABT-263)


first-line CLL (combination therapy)(see also lung, lymphoma)--------------------------------------------------CLL, lymphoid leukemia

Phase II(847) 937-6100-------------------------------------------Phase I(847) 937-6100

Nexavar®sorafenib


AML, myelodysplastic syndromes(see also breast, colorectal, head/neck, kidney, liver, lung, multiple myeloma, ovarian, other)

Phase I/II(888) 842-2937

obatoclax(orphan Drug)

CephalonFrazer, PA

CLL(see also lung, lymphoma, multiple myeloma)


obinutuzumab(GA101/RG7159)

Biogen IdecWeston, MAGenentechSouth San Francisco, CA

first-line CLL (combination therapy)(see also lymphoma)

Phase III(781) 464-2000(800) 626-3553

omapro™omacetaxine(orphan Drug)

CephalonFrazer, PA

second-line CML(see also solid tumors)--------------------------------------------------AML, myelodysplastic syndromes


ON 013105 Onconova TherapeuticsNewtown, PA

ALL(see also lymphoma)

Phase I(267) 759-3680

oral azacitidine(orphan Drug)

CelgeneSummit, NJ

myelodysplastic syndromes(Fast Track) (see also lung, lymphoma, solid tumors)--------------------------------------------------AML, CML

Phase II(908) 673-9000

-------------------------------------------Phase I(908) 673-9000



leukemia


oral clofaribine GenzymeCambridge, MA

myelodysplastic syndromes Phase I(617) 252-7500

OVI-123(orphan Drug)

OncoVista Innovative TherapiesSan Antonio, TX

TdT-positive leukemia Phase I(210) 677-6000

OXi4503 OXiGENESouth San Francisco, CA

AML, myelodysplastic syndromes Phase I(650) 635-7000


refractory metastatic CLL(see also brain, colorectal, kidney, lung, lymphoma, multiple myeloma, sarcoma, solid tumors, stomach)

Phase II(908) 626-5428

PKC412(midostaurin)


AML Phase III(888) 669-6682

PLX3397(CSF-1R kinase inhibitor)

PlexxikonBerkeley, CA

recurrent or refractory AML(see also brain, lymphoma, solid tumors)

Phase I/II(510) 647-4000

ponatinib(orphan Drug)

ARIAD PharmaceuticalsCambridge, MA

Philadelphia-positive ALL, CML

--------------------------------------------------AML

Phase II(617) 494-0400-------------------------------------------Phase I(617) 494-0400

PR104 ProactaLa Jolla, CA

AML Phase I/II(858) 642-0386

Revlimid®lenalidomide(orphan Drug)

CelgeneSummit, NJ

CLL, myelodysplastic syndromes(see also lymphoma)

Phase III(908) 673-9000

rigosertib(orphan Drug)

Onconova TherapeuticsNewtown, PA

myelodysplastic syndromes (intravenous)(see also lymphoma, ovarian, pancreatic)--------------------------------------------------CLL

--------------------------------------------------AML

--------------------------------------------------myelodysplastic syndromes (oral)

Phase III(267) 759-3680

-------------------------------------------Phase II(267) 759-3680-------------------------------------------Phase I/II(267) 759-3680-------------------------------------------Phase I(267) 759-3680



leukemia


sapacitabine (CYC682)(orphan Drug)

Cyclacel PharmaceuticalsBerkeley Heights, NJ

first-line AML (see also lung, solid tumors)--------------------------------------------------CLL (combination therapy),myelodysplastic syndromes


SB989 (pracinostat)

S*BIOOakland, CA

myelodysplastic syndromes(see also solid tumors, other)

Phase I(650) 730-2860

SB1518 (pacritinib)

S*BIOOakland, CA

myelodysplastic syndromes

--------------------------------------------------myeloid leukemia

Phase II(650) 730-2860-------------------------------------------Phase I/II(650) 730-2860

SF1126(orphan Drug)

Semafore PharmaceuticalsIndianapolis, IN

CLL(see also multiple myeloma, solid tumors)

Phase I(317) 876-3075

SGI110(DNMT inhibitor)


AML, myelodysplastic syndromes Phase I/II(925) 560-0100

SL-401(recombinant fusion protein)(orphan Drug)

Stemline TherapeuticsNew York, NY

AML, myelodysplastic syndromes Phase I/II(646) 502-2310

tamibarotene(orphan Drug)

CytRxLos Angeles, CA

acute promyelocytic leukemia (APL) (Fast Track)(see also lung)--------------------------------------------------APL (combination therapy)

Phase II(310) 826-5648

-------------------------------------------Phase I(310) 826-5648

tarceva®erlotinib

GenentechSouth San Francisco, CAOSI OncologyFarmingdale, NY

myelodysplastic syndromes(see also brain, breast, head/neck, liver, lung, other)

Phase II(800) 626-3553(631) 962-0600

tasigna®nilotinib(orphan Drug)


CML (adolescents and children), ALL (adolescents and children)(see also skin, stomach)

Phase II(888) 669-6682

temodar®temozolomide


AML(see also lung)

Phase II(800) 672-6372

TH-302 Threshold PharmaceuticalsSouth San Francisco, CA

(see also brain, multiple myeloma, pancreatic, sarcoma)

Phase I(650) 474-8200

thiarabine Access PharmaceuticalsDallas, TX

(see also lymphoma) Phase I/II(215) 904-5100



leukemia


TL-32711(birinapant)

TetraLogic PharmaceuticalsMalvern, PA


Phase I/II(610) 889-9900

tosedostat(orphan Drug)

Chroma TherapeuticsOxon, United Kingdom

AML Phase IIwww.chromatherapeutics.com

trametinib GlaxoSmithKlineRsch. Triangle Park, NC

relapsed or refractory leukemia(see also brain, lung, lymphoma, multiple myeloma, pancreatic, skin)

Phase III(888) 825-5249

treanda®bendamustine

CephalonFrazer, PA

ALL in children, AML in children(see also lymphoma, multiple myeloma)

Phase I/II(610) 344-0200

treosulfan MedacWedel, Germany

ALL, AML, myelodysplastic syndromes

Phase IIwww.medac.de

TRU-016(humanized anti-CD37 therapeutic)

Emergent BioSolutionsRockville, MD


Phase II(301) 795-1800

Velcade®bortezomib

Millennium PharmaceuticalsCambridge, MA

second-line T-cell prolymphocytic leukemia (see also lymphoma, other, cancer-related)

Phase II(800) 390-5663

veltuzumab(orphan Drug)



Phase I/II(973) 605-8200

Vidaza®azacitidine(orphan Drug)

CelgeneSummit, NJ

AML in the elderly(see also lymphoma)

Phase III(908) 673-9000

vosaroxin(orphan Drug)

Sunesis PharmaceuticalsSouth San Francisco, CA

second-line AML(Fast Track)(see also ovarian)--------------------------------------------------AML in the elderly

Phase III(650) 266-3739

-------------------------------------------Phase II(650) 266-3739

XmAb® 5574(MOR208, anti-CD19 mAb)

MorphoSysPlanegg, GermanyXencorMonrovia, CA

recurrent CLL Phase Iwww.morphosys.com(626) 305-5900

Zolinza®vorinostat


AML, myelodysplastic syndromes(see also breast, lung, lymphoma, multiple myeloma, other)

Phase II(800) 672-6273



liver CanCer


ALN-VSP Alnylam PharmaceuticalsCambridge, MA

Phase I(617) 551-8200

bavituximab Peregrine PharmaceuticalsTustin, CA

(see also lung, pancreatic) Phase I/II(715) 508-6000

BAY 86-9766(MEK inhibitor)

Ardea BiosciencesSan Diego, CABayer HealthCare PharmaceuticalsWayne, NJ

first-line liver cancer (combination therapy)(see also pancreatic)

Phase II(888) 842-2937


inoperable/unresectable liver cancer(see also colorectal, leukemia, lung, lymphoma, ovarian, other)

Phase I/II(702) 835-6300

BIIB 022 Biogen IdecCambridge, MA

(see also lung) Phase I completed(617) 679-2000

brivanib(VEGFR/FGFR kinase inhibitor)


first-line liver cancer, liver cancer (TACE)(see also colorectal, sarcoma)

Phase III(800) 332-2056

cixutumumab(LY3012217/IMC-A12)


(see also lung) Phase II(800) 545-5979

darinaparsin(ZIO-101)

ZIOPHARM OncologyNew York, NY

(see also lymphoma, multiple myeloma, solid tumors)

Phase II(646) 214-0700

DC Bead®doxorubicin-eluting beads

Bayer HealthCare PharmaceuticalsWayne, NJBiocompatiblesSurrey, United Kingdom

Phase II(888) 842-2937


(see also brain, head/neck, skin, solid tumors, stomach)

Phase I/II(888) 422-4743



(see also head/neck, kidney, lung) Phase I(888) 825-5249

ganetespib (Hsp90i)


(see also breast, colorectal, leukemia, lung, multiple myeloma, pancreatic, prostate, skin, stomach)

Phase II(781) 274-8200

Inlyta®axitinib

PfizerNew York, NY

(see also kidney, other) Phase II(860) 732-5156

irinotecan eluting beads Biocompatibles InternationalSurrey, United Kingdom

liver metastases from colorectal cancer

Phase IIwww.biocompatibles.com



liver CanCer


JX-594 (pexastimogene devacirepvec)(orphan Drug)

Jennerex BiotherapeuticsSan Francisco, CA

(see also colorectal) Phase II(415) 281-8886

lansoprazole (orphan Drug)

Apricus BiosciencesSan Diego, CA

first-line liver cancer Phase II(858) 220-8041


first-line liver cancer (monotherapy)(see also breast, colorectal, kidney, lung)

Phase III(847) 937-6100

mapatumumab Human Genome SciencesRockville, MD

liver cancer (combination therapy)(see also lung, multiple myeloma)

Phase II(301) 309-8504

MB07133(HepDirect HepB inhibitor)

Ligand PharmaceuticalsLa Jolla, CA

inoperable/unresectable liver cancer Phase I/II completed(858) 550-7500

melphalan drug delivery system Delcath SystemsNew York, NY

inoperable/unresectable liver cancer application submitted(212) 489-2100

muparfostat (PI-88) Progen PharmaceuticalsQueensland, Australia

liver cancer (Fast Track)(see also skin)

Phase IIIwww.progen.com.au

Nexavar®sorafenib(orphan Drug)


heptocellular carcinoma (adjuvant therapy)(see also breast, colorectal, head/neck, kidney, leukemia, lung, multiple myeloma, ovarian, other)

Phase III(888) 842-2937

NV-1020 CatherexPhiladelphia, PA

Phase I/II completed


(see also breast, head/neck, lung) Phase Iwww.oncolys.com

PEG arginine deiminase (ADI-PEG 20)

Polaris PharmaceuticalsSan Diego, CA

hepatocellular carcinoma(see also prostate, skin, other)

Phase III(858) 452-6688

PHY906 PhytoCeuticaNew Haven, CT

(see also colorectal, pancreatic, cancer-related)


PV-10(rose bengal sodium)(orphan Drug)

Provectus PharmaceuticalsKnoxville, TN

liver cancer, liver metastases(see also skin)

Phase I(866) 594-5999

RG7686 RocheNutley, NJ

metastatic liver cancer(combination therapy)

Phase II(973) 235-5000



liver CanCer


tarceva®erlotinib


first-line inoperable/unresectable liver cancer (combination therapy)(see also brain, breast, head/neck, leukemia, lung, other)--------------------------------------------------second-line liver cancer (combination therapy)

Phase III(800) 626-3553(631) 962-0600

-------------------------------------------Phase II(800) 626-3553(631) 962-0600

TGF-ß R1 inhibitor(LY2157299)


(see also brain) Phase II(800) 545-5979

thermoDox®doxorubicin liposomal(orphan Drug)


first-line inoperable/unresectable liver cancer (Fast Track)(see also breast, colorectal)

Phase III(609) 896-9100



(see also breast, colorectal, lymphoma, ovarian, pancreatic)

Phase II(973) 944-2600

tivantinib (ARQ 197) ArQuleWoburn, MADaiichi SankyoParsippany, NJ

second-line liver cancer (see also colorectal, kidney, lung, pancreatic, sarcoma, other)--------------------------------------------------liver cancer (combination therapy)

Phase II(781) 994-0300(973) 944-2600------------------------------------------Phase I(781) 994-0300(973) 944-2600

trebananib (AMG386)


(see also breast, colorectal, kidney, ovarian, stomach, other)

Phase II(800) 772-6436



biliary cancer (combination therapy)(see also brain, colorectal, stomach)

Phase II(800) 626-3553

Zadaxin®thymalfasin alfa 1(orphan Drug)

SciClone PharmaceuticalsFoster City, CA

(see also skin) Phase II/III(650) 358-3456



lung CanCer



CelgeneSummit, NJ

first-line non-small-cell lung cancer (NSCLC)(see also bladder, breast, ovarian, pancreatic, skin)




NSCLC(see also brain, breast, colorectal, lymphoma, ovarian, prostate, skin, other)

Phase II(847) 937-6100



NCSLC(see also brain, breast)

Phase I(858) 334-2100

Actimid®pomalidomide

CelgeneSummit, NJ

small-cell lung cancer (SCLC)(see also lymphoma, multiple myeloma, pancreatic)

Phase I/II(908) 673-9000

afatinib(BIBW2992)


first-line NSCLC(see also brain, breast, head/neck)--------------------------------------------------second-line NSCLC (Fast Track)

Phase III(800) 243-0127-------------------------------------------Phase II/III(800) 243-0127

Alimta®pemetrexed


first-line and maintenance NSCLC Phase III(800) 545-5979

AMG888/U3-1287(anti-HER3 antibody)

AmgenThousand Oaks, CADaiichi SankyoParsippany, NJ

NSCLC Phase II(800) 772-6436(973) 944-2600

amrubicin(orphan Drug)

CelgeneSummit, NJ

SCLC (Fast Track)(see also breast)--------------------------------------------------first-line SCLC


amuvatinib(MP470)


SCLC (combination therapy)(see also lymphoma)

Phase II(925) 560-0100

anti-PD1 (BMS-936558)


(see also kidney, skin) Phase II(800) 332-2056

AP26113 ARIAD PharmaceuticalsCambridge, MA

NSCLC Phase I(617) 494-0400

apricoxib(TG01)

Tragara PharmaceuticalsSan Diego, CA

second-line NSCLC (combination therapy)(see also pancreatic)

Phase II(858) 350-6900



lung CanCer


astuprotimut-R(MAGE-A3 antigen-specific cancer immunotherapeutic)


adjuvant NSCLC (see also skin)

Phase III(888) 825-5249



NSCLC (combination therapy), SCLC (combination therapy) (see also brain, leukemia, lymphoma, prostate, stomach)

Phase II(610) 408-0301



third-line NSCLC(see also breast, colorectal, multiple myeloma, stomach)--------------------------------------------------second-line late-stage NSCLC(combination therapy)

Phase II(888) 669-6682

-------------------------------------------Phase I/II(888) 669-6682



adjuvant NSCLC (see also brain, breast, colorectal, ovarian, other)

Phase III(800) 626-3553

bavituximab Peregrine PharmaceuticalsTustin, CA

first-line NSCLC, second-line NSCLC(see also liver, pancreatic)

Phase II(715) 508-6000


mesothelioma(see also colorectal, leukemia, liver, lymphoma, ovarian, other)--------------------------------------------------NSCLC

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