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molecules involved in t cell activation

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Cell-mediated immune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation

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Ce ll-mediated im mune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation. Molecules involved in T cell activation. TCR. TCR complex. - PowerPoint PPT Presentation

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Page 1: Molecules involved in T cell activation

Cell-mediated immune response

Activation of T lymphocytes by intracellular microorganisms

Phases of T cell responseBiochemical pathways of T cell activation

Functional responses of T lymphocytes to antigens and costimulation

Page 2: Molecules involved in T cell activation
Page 3: Molecules involved in T cell activation
Page 4: Molecules involved in T cell activation
Page 5: Molecules involved in T cell activation
Page 6: Molecules involved in T cell activation
Page 7: Molecules involved in T cell activation
Page 8: Molecules involved in T cell activation

TCR

TCR complex

Molecules involved in T cell activation

Costimulators

Page 9: Molecules involved in T cell activation

Requirement for two signals in T cell activation

Page 10: Molecules involved in T cell activation
Page 11: Molecules involved in T cell activation

Molecules involved in T cell activation

Adhesion molecule

Coreceptor

Page 12: Molecules involved in T cell activation

Molecules involved in T cell activation

Accessory molecules

Page 13: Molecules involved in T cell activation

Molecules involved in T cell activation

Immunological synapse

Page 14: Molecules involved in T cell activation

Biochemical pathways ofT cell activation

Page 15: Molecules involved in T cell activation

Clustering of two or more

TCRs

Page 16: Molecules involved in T cell activation

Functional responses of T lymphocytes to antigens

and costimulation

Page 17: Molecules involved in T cell activation
Page 18: Molecules involved in T cell activation

Clonal expansion of T-limphocytes

Page 19: Molecules involved in T cell activation
Page 20: Molecules involved in T cell activation
Page 21: Molecules involved in T cell activation

Treg

Naivna CD4+TNaïveCD4+T

Th1

Th2

TGF-

TGF-+IL-6

IL-4

IL-12+IL-18

IFN-

IL-23…Th17

Diferentiation od CD4+ T-limphocytes

Page 22: Molecules involved in T cell activation

Th17

Th1

Treg

Naivna CD4+T

Th2

TGF-

TGF-+IL-6

IL-4

IL-12+IL-18

IL-23…

T-bet

GATA-3

RORt

FoxP3

IFN-

Th17

Diferentiation od CD4+ T-limphocytes

NaïveCD4+T

Page 23: Molecules involved in T cell activation

Diferentiation of naive

CD4+ T-cells

Page 24: Molecules involved in T cell activation

Diferentiation od CD8+ T-limphocytes

Page 25: Molecules involved in T cell activation
Page 26: Molecules involved in T cell activation

CD3 complex and chainsj.Main transcription factors in T cell activation are10.

T cell is not activatedi.Cytokine that is crucial for TH1 differentiation is9.

IL-12h.Activation of naive T-cells requires8.

CD3, CD4, CD8, CD28 and adhesion molecules

g.Adhesion molecules7.

CD28 and B7 moleculesf.If APC does not express costimulatory molecules

6.

NFAT, NF-B and AP1e.

T cell growth factor is 5.

two signalsd.

Costimulatory signals for T cell activation are provided by

4.

and chains of TCRc.

Accesory molecules involved in T cell activation are

3.

stabilize binding of T-cells to APC

b.

Signal transduction in T cells is mediated by2.

IL-2a.Recognition of antigen by T cells is mediated by1.

10.____9.____8.____7.____6.____5.____4.____3.____2.____1.____c j g f a i b d h e


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