Mol Cell. 2014 Sep 9. pii: S1097-2765

RNA-Seq Identifies an Extensive Network of Conserved Neural-Enriched Exons Regulated by nSR100

△PSI:displaying an absolute percent spliced in change

doxycycline

Mol Cell. 2014 Sep 9. pii: S1097-2765

RNA-Seq Identifies an Extensive Network of Conserved Neural-Enriched Exons Regulated by nSR100

Mol Cell. 2014 Sep 9. pii: S1097-2765

UGC-Containing Motifs Are Enriched Adjacent to Target Exons and Are Directly Bound by nSR100 In Vivo

Mol Cell. 2014 Sep 9. pii: S1097-2765

UGC-Containing Motifs Are Enriched Adjacent to Target Exons and Are Directly Bound by nSR100 In Vivo

PAR-iCLIP

IP

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Binds Directly Upstream of Suboptimal 30 Splice Sites to Promote Neural Exon Inclusion

Polypyrimidine tract

Branch point

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Binds Directly Upstream of Suboptimal 30 Splice Sites to Promote Neural Exon Inclusion

Polypyrimidine tract

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Interaction Partners Are Enriched in Early-Acting Splicing Complex Proteins

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Interaction Partners Are Enriched in Early-Acting Splicing Complex Proteins

mg/ml

Mol Cell. 2014 Sep 9. pii: S1097-2765

Opposing Regulation of Neural Exons by PTBP1 and nSR100

Mouse cortex tissues development

E,embryonic; P, postnatal

Mol Cell. 2014 Sep 9. pii: S1097-2765

Opposing Regulation of Neural Exons by PTBP1 and nSR100

ESC: embryonic stem cellsNESC: neuroepithelial stem cellsRadial NP:radial neural progenitorsDIV: days in vitro

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion

Mol Cell. 2014 Sep 9. pii: S1097-2765

nSR100 Directly Overcomes PTBP1-Mediated Repression to Promote Exon Inclusion

50,100,200ng

100,200ng 200

+50,100,200ng