modification of neural circuits with experience. experience gained… in utero development adulthood...
DESCRIPTION
Changes to Neuron Diversity in Utero Cellular Interaction Model –Neuron diversity reliant on the extent and type of intracellular signaling and genetics –These signaling cascades are sensitive to changes in physiological factors and environmental stressors (anxiety, diet deficiency) –This, in turn, can influence where these neurons migrate to in the cortex, for exampleTRANSCRIPT
Modification of Neural Circuits with Experience
Experience gained…
• In utero• Development• Adulthood
– By experience, we mean changes in the chemical and external environments
– Really hot research area (epigenetics)
Changes to Neuron Diversity in Utero
• Cellular Interaction Model– Neuron diversity reliant on the extent and type
of intracellular signaling and genetics– These signaling cascades are sensitive to
changes in physiological factors and environmental stressors (anxiety, diet deficiency)
– This, in turn, can influence where these neurons migrate to in the cortex , for example
Imprinting After Birth
Even in humans
During adolescence
The Importance of Time During Development
The Importance of Length During the Critical Period
Complementary Changes in Neuronal Architecture
Hebbian Theory• Neurons that wire together, fire together
Somatosensory Cortex of An Amputee
Whole System Changes During the Critical Period
Epigenetics: Environment + Genetics
• Diet, anxiety, aggression affects DNA transcription and translation
• Hugely popular in psychiatric research
Optional Reading
• From my blog “Dormivigilia”– www.dormivigilia.com
• Basic review of epigenetic factors and the effects of early-life stress on subsequent development and social relationships