Mitosis Virtual Lab and the mitotic index

During this activity you will…• Learn to identify the phases of mitosis in plant and animal cells

micrographs.• Calculate the mitotic index.• Learn about cyclins, mutagens, oncogenes and metastasis and their

relation to tumor formation

Evaluation: • Present:

1. Questions on part 1 of the virtual lab2. Calculate the mitotic index3. Research

Mitosis virtual labfind… “lab on mitosis”• https://bio.rutgers.edu/~gb101/lab2_mitosis/index2.html

The mitotic index

• The mitotic index measures cellular proliferation. • It is an important factor to predict both overall survival and response

to chemotherapy in most types of cancer. • Additionally, the mitotic index is simply a measurement to determine

the percentage of cells undergoing mitosis. • Durations of the cell cycle and mitosis vary in different cell types. • An elevated mitotic index indicates more cells are dividing, and thus

obvious in cancer cells.• The mitotic index may be elevated during necessary processes to life,

such as the normal growth of plants or animals, as well as cellular repair the sire of an injury.

http://en.wikipedia.org/wiki/Mitotic_index

Formula:

(P+M+A+T) — the sum of all cells in phase as prophase, metaphase, anaphase and telophase, respectively; N — total number of cells.

Part 2. Calculate the mitotic index in this micrograph

Part 3. Research:• Investigate how cyclins are involved in the control of the cell cycle• Investigate how mutagens, oncogenes and metástasis are involved in

the development of tumors.