Dr. H. Nelson AguilaDr. H. Nelson AguilaCenter to Reduce Cancer Health DisparitiesCenter to Reduce Cancer Health Disparities

July 14, 2008July 14, 2008

Minority Institution/ Cancer Center Minority Institution/ Cancer Center PartnershipPartnership

Cancer Health Disparities Summit ’08

Eliminating Cancer Health Disparities Through

Science, Training and Community

Cancer Health Disparities Summit ’08

Eliminating Cancer Health Disparities Through

Science, Training and Community

MI/CCP Partnership Model

Reduce Cancer Health Disparities

• Build research capacity and training at MSIs• Create stable, long-term collaborations between MSIs and CCs in research, training, career

development, and outreach• Improve effectiveness of CC research, education and outreach for underserved

populations• Export successful approaches for addressing disparities to all CCs and other key networks

and consortiums

Education

Minority Training

Community Trust and Participation

MSICancer Research Expertise

State-of-the-Art Cancer Facilities

State-of-the-Art Cancer Treatments

CC

U54 - 7 partnershipsU56 - 10 partnershipsP20 - 9 partnerships

U54 - 7 partnershipsU56 - 10 partnershipsP20 - 9 partnerships

Current Distribution of NCI-Sponsored MI/CCPCurrent Distribution of NCI-Sponsored MI/CCP

GuamUniv. of Puerto Rico

Ponce School of Med

MI/CCP Partnership Program Structure

MI/CCP Program Structure

RESEARCH, TRAINING, OUTREACH, EDUCATION

MINORITYSERVINGINSTITUTION

CANCER CENTER

P20Feasibility Studies

F31, Career Awards, R03, R21,

R01, R25, T32, P01

U56Cooperative

Comprehensive Planning Grant

U54Comprehensive

Grant

F31/32/33, Career Awards, R03, R21,

R01, R25, T32, P01

MI/CCP P20 MechanismPAR-07-230

Next submission due date: April 15, 2009

Primary Objective: To provide support for cancer projects and Programs for a limited duration of time to perform feasibility studies/obtain preliminary data/submission of competitive grant applications.

Target Areas: Research; Training and Career Development; Education

Duration: Up to 4 years

Funding: Direct Cost up to $275K per partnership/year: Administrative and Developmental Costs planning; priority setting; implementation)

Final Objective: Submission of competitive grant applications (i.e. R series, K series, T32, R25T, F31, R25E) funded by NIH/NCI and/or comparable grant funding organizations.

0

3060

90120

150180

Num

ber o

f Can

cer

Res

earc

h St

udie

s

2001-2003 27 11

2004-2007 170 61

All Project Types

CHD Projects

Project Types Cancer Types Total

Breast Prostate Head & Neck Lung CRC Gynecologic

Pilot 31 23 19 16 19 15 123Full 15 10 3 5 6 5 47Total 46 33 22 21 25 20 170

U54/ U56 ResearchProjects

U54/U56 ResearchPublications

Aurora B Kinase Maintains Chromatin Organization During the Ml and Mll Transition in Surf Clam Oocytes

Cell Cycle 5:2648, 2006

BRCA1 Antitumor activity in breast, ovarian, and prostate cancers

Oncogene 26:6031, 2007

Breast Cancer Education for Native American Women

Clinical J Oncology Nursing 9(6): 689, 2005

Cispaltin and Fluoruracil Alone or with Docetaxel in Head and Neck Cancer

N Engl J Med 357:1705, 2007

Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors

Science 315: 1133, 2007

U54/U56 ResearchCompetitive Grants

0

30

60

90

120

150N

umbe

r of G

rant

s

2001-2003 2 1 0

2004-2007 137 77 6

Submitted Funded Pending

U54/ U56 Training, Career Development and Education

21 Med Students25 Med Fellows

34 Post-Docs

72 Junior Faculty

21 High School Students

178 Master Students157 Pre-Docs

35 Post-Bac338 Undergrad

881 Trainees70 New MSI Faculty13 New CC Faculty

881 Trainees70 New MSI Faculty13 New CC Faculty

Education• Curricula to build critical mass of diverse investigators in cancer

research through competitive R25 grants, institutional support and leveraged funds

• New Mexico State University at Las Cruces and the Fred Hutchinson Cancer Research Center

• Biology 385: An Introduction to Cancer

• University of the District of Columbia and The Lombardi CCC (R25 grant)• Master’s Degree in Cancer Biology, Prevention, and Control

• Tuskegee University, University of AL at Birmingham CC, Morehouse School of Medicine

• Foundations of Cancer Biology (BIOL 0540)• Biosciences Research and Ethics (IBSC 0601)

• Northern Arizona University and Arizona Cancer Center• Chemical Carcinogenesis (MS level course)• Patient Navigation program for Native American students

• San Francisco State University and UCSF Hellen Diller Family CCC (state funding)

• Ph.D. Program for Nurses in clinical nursing oncology

Dr. Marcia Cruz-Correa (Assistant Professor) – UPRCC / MDACC • K22CA115193 – Clinicopathology of IGF2 Loss of Imprinting in Colon Neoplasia• R03CA130034 – Familial Colorectal Cancer in Puerto Rico: A Feasibility Study

Dr. James Lillard (Assistant Professor) – TU / MSM / UAB• DOD New Investigator Award – CCL25-CCR9 Prostate Cancer Cell Survival and Metastasis

Dr. Alecia Malin Fair (Assistant Professor) – MMC / VUCC• ACS Career Development Award (MRSGT-07-008-01-CPHPS) – Mammography Follow-up in Minority and Medically Underserved Women

Dr. Maribel Vazquez (Associate Professor) – CCNY / MSKCC•R21GM71703 – Mycrosystems to manipulate fibroblast chemotaxis•R21CA118255 – A mu migration assay for temporal protein localization

Training and Career DevelopmentMSI Junior Investigator Successes

MI/CCP- AACR ForumShowcased the Accomplishments of the MI/CCP Junior

Investigators April 14, 2008

• Basic Research - Dr. LaMonica V. Stewart, Meharry Medical College, Nashville, TN

• Clinical Research - Dr. Barbara H. Jung, University of California San Diego, La Jolla, CA

• Population Research - Dr. Gary Bennett, Harvard School of Public Health, Boston, MA

• Investing in the Future - Dr. Rachael Leon Guerrero, University of Guam, Mangilao, GU

• Using hypothesis driven interventions, Arizona CC and NAU are working with Native Americans, and the Hawaii CC and University of Guam are working with Pacific Islander populations, to increase cancer screenings through print and electronic mediums.

• Partnering with local community coalitions, MMC/VICC and TSU is reaching African American and Hispanic communities through cancer prevention workshops and symposiums. The purpose is to develop community-based participatory research.

U54/U56 Outreach

Next steps and challenges

• Increase publications and grant submissions • Evaluation of the impact of the MI/CCP program

(NCI and Partnerships)• Increase training and mentoring of students and

junior investigators• Tracking and evaluation of training and

educational programs• Improve communication among partnerships• Increasing outreach activities• Increasing clinical activities• Develop new funding mechanisms (NCI)

Selected MI/CCP Presentations

• July 141:00 – 2:30Session 6: Models of Training ProgramsDr. Marian Manciu – P20 UT El Paso/ UT Hlth. Sci. Ctr. San AntonioDr. Louis Canfield – U54 AZCC/ Northern Arizona UniversityDr. Christi Patten – P20 Mayo Clinic/ Dine College

• 2:45 – 4:00Session 2: Recruitment and Retention IssuesDr. Samuel Adunyah – U54 MMC/ VICCSession 3: Role of Physical Activity and Nutritional FactorsDr. Rachel Leon-Guerrero – U56 Univ. of Guam/ Hawaii CCSession 6: Cancer Health Disparities: Epidemiology & Risks FactorsDr. Pamela Hull – U54 MMC/ VICC (TSU)

Selected MI/CCP Presentations

• July 151:00 – 2:30Session 3: A Greater Understanding of Breast & Cervical CancerDr. Tu-Uyn Nguyen – U56 UCSF CC/ SFSUSession 5: Innovative Research MethodsDr. Alecia Fair (Malin) – U54 MMC/ VICC

• 2:45 – 4:00Session 1: Cancer Therapeutics & Radiopharmaceuticals Res.Dr. Marcia Cruz-Correa – U54 UPRCC/ MD Anderson

Contacts

Dr. Nelson Aguila Dr. Peter OgunbiyiProgram Director Program Directoraguilah@mail.nih.gov ogunbyp@mail.nih.gov

Telephone301-496-7344

http://crchd.cancer.gov

P20 Program Accomplishments (FY01 – FY08)

P20 NumbersStudents trained 234Faculty career development 36Faculty hired 3Courses developed 9Publications 49Publications (under review) 20Applications submitted 23Grants awarded 12

Total of 17 Partnerships

P20 Accomplishments

• Students Trained• 146 Undergraduate• 65 Graduate• 23 Medical/ Dental

• New Courses • Cancer Biology 101• Cancer Causes & Prevention• Cancer Biology & Bioinformatics• Tumor Biology• Bioethics

• Cancers in Minority Populations– Breast– Prostate– Colorectal– Cervical

• Grants Awarded– R01– P20– U56– U54– DoD– Private Foundation