mimics innovation suitedk.kisti.re.kr/files/notice-11.pdf · 2012-10-26 · 법의인류학db...

Mimics® Innovation Suitefor

Engineering on Anatomy

From CT/ MRI to 3D models of Human and Applications to bio-medical engineering

Empowering biomedical professionals

to improve quality of life through engineering on anatomy

Discovery of X-ray (1895)

3

W.C. Roentgen

The hand of Roentgen – The first X-ray image (1895)(Anatomical projection image)

CT vs MRI

4

CT ; slice images created using X-rayMRI ; slice images created using magnetic field

MRI

CT & MRI scan for 2D slice images

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CT Image( Bone)

MRI Image(Soft Tissue)

2-D Cross Sections

or

CT/MRI/MicroCT/CBCT & etc. Anatomical slice images / industrial sectional images

What to be needed..

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3 Core Competences

Medical image-based engineering

Additive manufacturing

Digital computer

aided design


• Mimics® Innovation Suite• Mimics®

• From CT/MRI to 3D modelling• Link to 3D printer• Link to FEA• Link to Virtual OP simulation• Link to 3D CAD• Etc.

• 3-matic®

• Meshing and modelling• 3D desing for patient-specific prosthesis

• Services

7

Software is what we develop,solutions are what we provide

“ “

Mimics and 3-matic basics

• Engineering on anatomy• Mimics extracts 3D information from image stacks• 3-matic allows further manipulation and design on 3D data

Medical Image Technology for Head

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Advanced Visualization

CT & MRI

Facial Texture Mapping & Soft

Tissue Simulation

Dental Implant Planning

CMF Surgery Simulation

Digital Bridge Design

Medical Image Technology for Head

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Individualized Cranioplasty Design

(Mimics & 3-matic)

FEA and CFD Modeling(Mimics &

ABAQUS/Fluent etc.)

Individualized Hearing Aid Design and Rapid

Manufacturing(RSM)

Meet Wang Na

11Case courtesy by Prof. Liu Yanpu; Dr. Bai Shizhu; Prof. Zhao Yimin; School of Stomatology, Fourth Military Medical University, Xi'an 710032, China

Giving a young woman a reason to smile

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Jaw Case

• Jaw reconstruction

Jaw Case

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16

Jaw Case

16

17

Jaw Case

17

Meet Simon

Personal touch

• Multidisciplinary team

• UCL Institute of Cardiovascular Science• Cardiorespiratory Unit at Great Ormond Street Hospital

Great Ormond Street Hospital for Children

NHS Trust

NHSUniversity College London HospitalsNHS Foundation Trust

NHS

Personal touch

UCL Institute for Cardiovascular Sciences

Mimics® Innovation Suite

Personal touch

• EXAMINING pulmonary outflow tract & arteries


Personal touch

• MODELING of device & anatomy using FEA• Device customization with Medtronic


Personal touch

• DESIGNING and 3D printing anatomical replica


Simon’s intervention

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MeasurePopulation analysis

Device fit Validation

Surgical simulation

DesignCustom implants &

guides Medical models

Benchtop modelsModeling FEA/CFD/MSM

Meshing Info extraction (materials, ...)

AccurateAnatomy

Segmentation

Segmentation

CT or MRI Scan 2-D Cross Sections Mimics

3D model

Segmentation

• To extract 3D information• Threshold based methods

• Contour based methods

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Mimics®

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Filter the images to reduce noise

Image processing

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Wrap and Smooth the 3D model to• Remove small gaps• Make the model smoother

Optimize 3D

Mimics®

3D Anatomy for fracture inspection

법의학관련 ; 추락사망시뼈의골절상태의 3D 모델

-Non-invasive Inspection possible in using CT/MRI & Mimics without further damage

- 3D Replica model to be created from RP system

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MeasurePopulation analysis

Device fit Validation

Surgical simulation


guides Medical models

Benchtop modelsModeling FEA/CFD/MSM


AccurateAnatomy

Segmentation

Anatomical Analysis

• Measurements• Distance, angle, volume• Anatomical landmarks• Export for analysis, Export to Matlab

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Mimics®

Anatomical Analysis

• Fit primitives• Sphere, line, cylinder, centerline,...• Statistics• Parameters for device design

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Mimics®

Anatomical Analysis

• Analyze...• Part Comparison• Thickness• Curvature

• ... and visualize as colormap

35Comparison ThicknessCurvature

3-matic ®

http://uc.materialise.com/mimics/sites/uc.materialise.com.mimics/files/data/whatsnew_3matic7.pdf�

http://uc.materialise.com/mimics/sites/uc.materialise.com.mimics/files/data/Feedbackform_beta.doc�

http://www.materialise.com/mwc2012�

http://uc.materialise.com/mimics/�

• Wall thickness analysis• Bone thick enough for screw?

• Part comparison• Pre- vs post-operative• CAD Design vs scan (TechCT)

36

Anatomical Analysis

법의인류학 DB 구축사업 (가톨릭대학교의과대학응용해부연구소)

- Mimics를이용- 연령대별 CT 영상수집- 모델제작 (머리뼈, 얼굴)- Mimics project file format (.mcs) & .stl 로 저장

Courtesy of Catholic University Medicine College

Measuring and Verification인체정보를이용한신원확인

- 머리뼈모델의계측템플릿제작- 표지점표지후 계측값자동출력

법의인류학 DB 구축사업(가톨릭대학교의과대학응용해부연구소)

Measuring and Verification인체정보를이용한신원확인

What if you cannot go patient specific?

39

People come in all shapes and sizes!• Anatomical differences based on size, gender, ethnicity,…..

-4 -3 -2 -1 0 1 2 3 4

-4 -3 -2 -1 0 1 2 3 4

Femur neck angle as a function of size

Statistical modeling

40Statistical model of Chinese Femur

Services

Segmentation and Measurement Services

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Neck angle Medial offset

Femur Head diameter

AP dimension

ML dimension

Services

population based variation

• The AP vs. ML dimension of a Korean population

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Ref: 1. Resected femoral anthropometry ... Korean Population (Anat Cell Biol. 2010 September; 43(3): 252–259. )

AP dimension

ML dimension

Creation of sub-population averages

• For analysis, optimization, simulation, design, bench top testing

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…

Virtual testing on population

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Virtual Surgery Implant Placement Fitment analysis onspecific population

Competition comparisonand analysis

The advantages

• Optimized product line• Lower inventory costs

• New market growth• Faster design cycle

• Competitive advantage• Market better fit

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The only implant that comes close!

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MeasureAnatomy analysis

Population analysis Validation


guides Benchtop models

Modeling FEA/CFD/MSM


Accurate Anatomy

Segmentation

Engineering on Anatomy-Custom Implant Design

• 3-matic: Design and meshing software dedicated for anatomical data

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Custom cranial plate

3-matic ®


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• Design and meshing software dedicated for anatomical data

Acetabular cup with custom flanges

3-matic ®

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Use ‘statistical average’ as a starting point

49Population Average -3σ (Population extreme)

Services

50


Contoured anatomical plates Custom surgical guides

3-matic ®

Custom guide design

• Surgical planning in Mimics• Cutting planes for osteotomies• Reposition bone parts

• How to transfer to OR? Surgical guides!• E.g. Knee guides Biomet and Zimmer

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Custom guide design benefits

• Accurately transfer surgical plan to OR• Less invasive, fast and accurate surgery

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Link to Tradtional CAD packages

• 3-matic is CAD on STLs• Reverse Engineering to use traditional CAD

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One continuous flow from CT to C0

“ “3-matic ®

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MeasureAnatomy analysis

Population analysis Validation


guides Benchtop models

Modeling FEA/CFD/MSM


Accurate Anatomy

Segmentation

FEA Preprocessing

• Prepare anatomical 3D mesh for FEA• Smooth/reduce/remesh surface

• Create and optimize volume mesh• Material properties derived from CT gray values

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Link to FEA Packages

Link to Musculoskeletal Modeling Packages

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Further down the road…

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Mimics® Innovation SuiteEngineering on cardiovascular anatomy

Image based applications

Other applicationsIntervention Simulation

Follow-up & comparisonAnatomy analysisSegmentation Physical models

FEA / CFDDevice analysis

Visualization vs Engineering

• Diagnostics vs anatomical selection• Anatomical selection/segmentation allows engineering on

anatomy• Triangulated surface models

Segmentation

• Advanced tools to select the anatomy you need• Image filters• Thresholding• (Dynamic) Region Growing• Flood fill• 2D/3D editing• Multiple slice editing• Interpolation• Livewire• …

3D visualization

• Visualizing the invisible• Transparency• Clipping• Volume rendering• Image registration• Movie generation

Helmholtz Institute Aachen, AME, Germany

4D visualization

• Visualizing the invisible dynamics

UCL Institute of Cardiovascular Sciences & Great Ormond Street Hospital for Children, London, UK

Anatomy analysis

• Wide range of measurements• E.g. calculate an accurate centerline

• User selects the structures of interest• Entire 3D tree is calculated automatically

• Centerline branches• Automated calculations• Measurements

• Output as text file• Cut endings

• In/outlets for CFD• Export as IGES or STEP

Anatomy analysis

Follow-up & comparison

• Segment data at different time points in the cardiac cycle• Use part comparison to analyze deformation

Follow-up & comparison

• Follow up on aneurysm evolution and pre- versus post-intervention comparison + statistics

Pre Post Comparison

Universitätsklinikum Mannheim – Institut für Klinische Radiologie und Nuklearmedizin

• Clinically relevant test models• Test guidewires/stents in realistic (flexible) model• Check the fit of ventricular assist devices (for children)• Realistic flow experiments

3D printing of physical models

Angela Noecker, Lemer Research Institute, The Cleveland Clinic Foundation

Gabriele Wurm, Medical School Hannover, Germany

• Clinically relevant models• Congenital malformations• Allows for physiscal pre-intervention study• Communication with parents/patients• Medical training


UCL Institute of Cardiovascular Sciences, & Great Ormond Street Hospital for Children, London, UK


• Bench testing• Design based on patient-specific data• Create realistic bench top testing models• Cyclic testing, fit/function testing, mock loops, etc.

• Device prototype analysis• Analyze true geometry• Simulate expansion• Virtual implantation• Flow analysis• Design modification

Device design analysis

• Quantification for regulatory approval process• Animal testing & first in man image analysis

• Pre-intervention planning & simulation• Sizing• Fit

• Post-intervention image analysis• Fit validation• Device/anatomy deformation• Motion over cardiac cycle


• Send 3D anatomical data to CAD• Algorithm geared to anatomy• Use your own CAD environment to insert your device• Fit your device into real patient data• Export as IGES


Intervention simulation

• Artificial heart• Abiomed verifies implantation of their artificial heart with Mimics

Source: www.abiomed.com ©

Data courtesy of Abiomed Inc.

http://www.medmovie.com/�


• Stent fit, sizing & morphing

• Analyze the position of the heart valve• Virtual implantation


Markus Bongert, University of Applied Sciences and Arts, Dortmund, Germany

Virtual analysis – FEA & CFD

Markus Bongert, University of Applied Sciences and Arts, Dortmund, Germany

• Analyse blood flow• Velocity• Pressure• Shear stress

• Validated with MR


• Patient specific CFD analysis of aneurysm• Result: wall stresses, flow patterns, particle velocity• Base intervention decision on rupture risk rather than on

diameter

Images courtesy of Dilana Hazer, University of Karlsruhe, Germany

• Advanced mesh generation control• Surface – & volume meshing• Mesh quality control• Non-manifold meshing• Separation of surfaces for boundary conditions


Other applications

Jules Poukens et al.Academic Hospital Maastricht, The Netherlands

Custom implant design Micro-CTFEA/CFD meshing

• The Mimics Innovation Suite is used in a wide variety of image based engineering

…and so much more…

Other applications - Services

• Biomedical engineering services• Let our engineers put their expertise to your use

• Segmentation• Population analysis• Functional medical models• Pre-clinical analysis using micro-CT

Cardiovascular

Research areas

91Prosthetics & Orthotics

Food processingOrthopedic

Pulmonary

Brain

Archeology

AnthropologyBiology

Astronomy

MusicPaper

Wood

Geology

Forensics

Speech Anatomy

Dental

Craniomaxillofacial

Paleontology

AutomotiveMaterials science

A wide variety of innovative research is using Materialise technology

for a better and healthier world

Empowering biomedical professionals

to improve quality of life through engineering on anatomy

Thank you, any questions?

93

“Engineering on

Anatomy”Analysis, design

and meshing on patient data

FDA and CEmarket

clearances

김인명 (In-Myung Kim)/ 퓨전테크 (FusionTech Co.)

Authorized Distributor of Materialisefor MIS (Mimics Innovation Suite)

[email protected]

mimics innovation suitedk.kisti.re.kr/files/notice-11.pdf · 2012-10-26 · 법의인류학db...

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