methodology of human risk assesment
DESCRIPTION
Methodology of Human Risk Assesment. Dr. Manfred Wentz Director, Hohenstein Institutes (USA) Head, Oeko-Tex Certification Body (USA) AAFA – Environmental Committee Meeting November 10, 2008 - Washington, D.C. Sustainability of Global Textile Market Triple Bottom Line (TBL) – Willard (2002). - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/1.jpg)
Dr. Manfred WentzDirector, Hohenstein Institutes (USA)
Head, Oeko-Tex Certification Body (USA)
AAFA – Environmental Committee Meeting
November 10, 2008 - Washington, D.C.
Methodology of
Human Risk Assesment
11/10/20081 M. Wentz, Oeko-Tex (USA) - AAFA/RSL
![Page 2: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/2.jpg)
Sustainability of Global Textile MarketTriple Bottom Line (TBL) – Willard (2002)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL2
![Page 3: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/3.jpg)
Environmental Sustainability
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL3
![Page 4: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/4.jpg)
M. Wentz, Oeko-Tex (USA) - AAFA/RSL4 11/10/20084
Concept of Textile Ecology
![Page 5: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/5.jpg)
M. Wentz, Oeko-Tex (USA) - AAFA/RSL5
Human Health Risk Assessment
Human Ecology Challenges (EPA)
Life stage
Low Dose
Acute
Cumulative
Characterizing uncertainty
(weight of evidence)
Estimating risk from diverse exposure
scenarios:
Applying novel biological data:
Improving human exposure assessment
Toxic genomic
11/10/2008
![Page 6: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/6.jpg)
What is a “Poison” ?“Dose makes the Poison”
“All things are poison, and nothing is without poison. It is the dose only that
makes a thing not a poison.”
Paracelsus (1494-1541)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL6
![Page 7: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/7.jpg)
Toxics - Basic Definitions
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL7
![Page 8: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/8.jpg)
Risk - Basic Definitions
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL8
![Page 9: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/9.jpg)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL9
Exposure and Toxicity
![Page 10: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/10.jpg)
Types of Toxic Effects on Humans
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL10
![Page 11: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/11.jpg)
M. Wentz, Oeko-Tex (USA) - AAFA/RSL11
Risk Assessment and ManagementNational Research Council (1983, 1996)
11/10/200811
![Page 12: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/12.jpg)
Typical Assays for Human Risk Assessment
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL12
Assay Subjects EndpointDose
CriterionExtrapolati
on
Ames BacteriaGenetic Damage
In Vitro Screening
Acute Rodents Death50%
Lethality(LD50)
None
Subacute Rodents MultipleSafe Level
(NOAEL, MTD)
Safety Factor
Cancer -chronic
Rodents CancerAcceptableRisk Level
Mathematical
Epidemiology
-chronicHumans Multiple Variable None
![Page 13: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/13.jpg)
General Risk Assessment Process
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL13
![Page 14: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/14.jpg)
EPA- Design for the Environment (DfE)Voluntary Stakeholder Program
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL14
![Page 15: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/15.jpg)
Chemical and Pesticides Results Measures (CAPRM) 145 Environmental Indicators (EPA/OPPTS-FSU Project)
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL15
Human Health
Ecological Health
Chemical and Pesticides
Food Safety
Product Safety
Transboundary Movement
Product Steward ship
Pollution Prevention
![Page 16: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/16.jpg)
CAPRM /EPA Hierarchy of Indicators
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL16
![Page 17: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/17.jpg)
Complex Process of Regulatory DecisionsSource: EPA
11/10/2008M. Wentz, Oeko-Tex (USA) - AAFA/RSL17
![Page 18: Methodology of Human Risk Assesment](https://reader035.vdocuments.site/reader035/viewer/2022062304/568145bf550346895db2cac0/html5/thumbnails/18.jpg)
M. Wentz, Oeko-Tex (USA) - AAFA/RSL18
Factors Affecting Risk Perception“Perception is Reality”
Increased Public Concern Decreased Public Concern
11/10/200818