Metabolism and Cell Structure ATP and Energy Important Coenzymes in Metabolic

Pathways Coenzyme NAD+

Coenzyme FAD Coenzyme A

Metabolic Pathways

Metabolic Pathways

Metabolism involves: Catabolic reactions that break down large,

complex molecules to provide energy and smaller molecules.

Metabolism

Anabolic reactions that use ATP energy to build larger molecules.

Stages of Metabolism

Catabolic reactions are organized as stages: In Stage 1, digestion breaks down large molecules

into smaller ones that enter the bloodstream. In Stage 2, molecules in the cells are broken down

to two- and three-carbon compounds. In Stage 3, compounds are oxidized in the citric

acid cycle to provide energy.

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Cell StructureMetabolic reaction occur in specific sites within cells.

Cell Components and Function

ATP and Energy In cells, energy is stored in adenosine triphosphate

(ATP).

Hydrolysis of ATP

The hydrolysis of ATP to ADP releases 7.3 kcal (31 kJ/mole). ATP ADP + Pi + 7.3 kcal (31 kJ/mole)

The hydrolysis of ADP to AMP releases 7.3 kcal (31 kJ/mole). ADP AMP + Pi + 7.3 kcal (31 kJ/mole)

Hydrolysis of ATP to ADP and ADP to AMP

ATP and Muscle Contraction

Muscle fibers contains filaments of actin and myosin.

When a nerve impulse increases Ca+2, the filaments slide closer together to contract muscle.

The hydrolysis of ATP in muscle provides the energy for contraction.

As Ca+2 and ATP decrease, the filaments return to the relaxed position.

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Coenzyme NAD+

In cells, the oxidation of compounds provides 2H as 2H+ and 2e- that reduce coenzymes.

NAD+ (Nicotinamide Adenine Dinucleotide) participates in reactions that produce a carbon-oxygen double bond (C=O).Oxidation O

||CH3—CH2—OH CH3—C—H + 2H+ + 2e-

ReductionNAD+ + 2H+ + 2e- NADH + H+

Structure of Coenzyme NAD+

NAD+ (nicotinamide adenine dinucleotide) contains ADP, ribose, and nicotinamide.

NAD+ reduces to NADH when the nicotinamide group accepts H+ and 2e-

Coenzyme FAD FAD participates in reactions that produce a

carbon-carbon double bond (C=C).

Oxidation —CH2—CH2— —CH=CH— + 2H+ + 2e-

ReductionFAD + 2H+ + 2e- FADH2

Structure of Coenzyme FAD

FAD (flavin adenine dinucleotide) contains ADP and riboflavin (vitamin B2)

FAD reduces to FADH2 when flavin accepts 2H+ and 2e-

Coenzyme A CoA activates acyl groups such as the two-carbon

acetyl group for transfer. O O || ||

CH3—C— + HS—CoA CH3—C—S—CoA