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MENU Slide 2 depigmentating cosmetic treatment effective against blemishes Slide 3 antiaging range MENU cosmelan Introduction The cosmelan method cosmelan pack composition Treatment Results cosmelan Slide 4 antiaging range MENU Melanogenesis is the combined process of physical, biochemical and morphological skin factors for protecting itself against the action of sun radiations. It consists of melanin production in the melanocyte, this being a cell located at the basal layer of the epidermis, wherein it acts as a photoprotecting barrier. SYNTHESIS OF MELANIN DOPAQUINONE DOPA TYROSINE Tyrosinase (Cu) Oxidation Cyclisation EUMELANINS PHEOMELANINS DOPA DOPAQUINONE Melanogenesis: origin of skin depigmentation cosmelan Slide 5 antiaging range MENU cosmelan Once melanin has been synthesised, melanosomes are exported towards keratinocytes. In keratinocytes, melanosome membranes are disrupted and melanin protects cell DNA from ultraviolet radiations. The continuous desquamation and renewal process of skin corneocytes is the natural mechanism of cell renewal and the melanin removal pathway. Melanogenesis: origin of skin depigmentation MELANOCYTES EUMELANINS: Black or brown-coloured biopolymers. They are responsible for the darkest pigmentations. EUMELANINS: Black or brown-coloured biopolymers. They are responsible for the darkest pigmentations. PHEOMELANINS: Reddish or yellowish biopolymers. They are responsible for the lightest pigmentations. PHEOMELANINS: Reddish or yellowish biopolymers. They are responsible for the lightest pigmentations. Slide 6 antiaging range MENU cosmelan Human skin colour: skin phototypes The North American dermatologist Dr. T. Fitzpatrick established a classification of the skin type based on the quantity and type of melanins produced. It is the reference used worldwide. Slide 7 antiaging range MENU cosmelan The cosmelan method It has an intensive and integral depigmentating action. It is highly effective in all kinds of skin pigmentations. It can be initiated at any time of the year. It may be applied to any skin phototype. It has a broad safety margin. depigmentating cosmetic method effective against skin pigmentations The cosmelan method acts on those cells responsible for skin pigmentation by controlling pigment production at those areas where there is an excess thereof, thereby succeeding in removing or attenuating skin melanic unaesthetic pigmentations. Slide 8 antiaging range MENU cosmelan cosmelan 1 1 treatment session + home care treatment depigmentating cosmetic treatment effective against melanic pigmentations cosmelan 2 degreasing solution hydra vital factor K Pack composition Slide 9 antiaging range MENU cosmelan Pack composition cosmelan 1 10 g pot Mask with depigmentating active substances. Intensive and integral method against melanic pigmentations of any nature. Recommendations for use: Let act for the period of time as recommended according to the skin phototype. Phototypes I and II: 8 hours Phototypes III and IV: 10 hours Phototypes V and VI: 12 hours professional use degreasing solution Cleansing and degreasing of the skin in order to ensure a better absorption of the depigmentating substances of the treatment. It is applied at the beauty salon. 10 ml bottle. Slide 10 antiaging range MENU cosmelan Pack composition cosmelan 2 30 g pot. Maintenance cream with depigmentating active substances. It complements the depigmentating process initiated at the doctors office. Recommendations for use: Apply maintenance cream cosmelan 2 by using method 3,2,1. First 15 days: 3 applications. Morning/noon/night Next 15 days : 2 applications, Morning/night From the 2 nd month on: 1 application. Night (*) During the first stage of the home care treatment, avoid exposure to heat sources or direct light. home care use Cream for daily use that provides the necessary moisturising and nutrition. hydra vital factor k 50 ml tube. Slide 11 antiaging range MENU cosmelan Application protocol Stage prior to cosmelan treatment Make a clinical datasheet (anamnesis) All data of interest will be collected, including personal, habit-related and technical data (type of skin, type of lesions, associated concerns) and disorder-related factors. Make a personalised diagnosis With the aim to adapt the application protocol in accordance with each patients need. Fill the informed consent form Sharing with the patient the treatment process while at the same time making him/her commit him/herself to continue with the home care regimen (basic protocol). Photographic record Thereby ensuring that an objective evaluation can be made of the evolution of the result. Monitoring visits It is important to make monitoring visits with a periodicity adapted to the needs of the particular case. Slide 12 antiaging range MENU cosmelan Treatment protocol Analyse the skin with Woods light Woods light is a light beam emitted by a mercury lamp. Epidermal melasma: it becomes more obvious with light (dark fluorescence). Dermal melasma: it becomes attenuated/poor fluorescence. Mixed melasma: some areas become more obvious whereas others do not. Inapparent melasma: it vanishes with light (V or VI). Slide 13 antiaging range MENU cosmelan Treatment protocol cosmelan treatment protocol Cleanse and tone with hydra milk cleanser and hydratonic. Stage 2: degrease Degrease the skin by applying the exfoliating solution with a gauze, massaging from the forehead, cheeks and central area of the face. Stage 1: remove make-up and tone Slide 14 antiaging range MENU cosmelan Treatment protocol cosmelan treatment protocol Protect with mesolips protector those areas which, due to their sensitivity, should not be contacted with the mask. Stage 4: treat Apply cosmelan 1 mask with a gloved hand or with a spatula, applying a bigger amount onto the affected areas, taking care of the eye contour and the lips and gently spreading on the chin. Let act for the recommended time according to the skin phototype. The exposure time should be from 8 to 12 hours (as per the professionals judgment). Once the exposure time is over, remove with abundant water. Stage 3: protect Slide 15 antiaging range MENU cosmelan Treatment protocol cosmelan treatment protocol Apply cosmelan 2 maintenance cream following method 3-2-1. First 15 days: 3 applications. Morning/noon/night.* Next days: 2 applications Morning/night. From the first month on: 1 application. Night. (*) During the first stage of home care treatment, avoid exposure to heat sources or direct light. Stage 5: gradual inhibition Slide 16 antiaging range MENU cosmelan Treatment protocol cosmelan home care treatment protocol Apply hydra-vital factor k cream, indicated to return smoothness and elasticity. Apply moisturising sun protection several times daily depending on the light exposure. Stage 6: prescribe Slide 17 antiaging range MENU cosmelan Skin changes during treatment Oedema / Erythema They may be one of the treatment manifestations. They are transient. Desquamation It corresponds to the expected progression after conducting this treatment; depending on skin sensitivity, it may last for a few days. Burning / Stinging Depending on skin sensitivity, it may accompany the home care product application; it usually disappears once the moisturising product has been completely absorbed. Tightness sensation This sensation is attenuated by repeatedly applying products favouring the suitable moisturising. Slide 18 antiaging range MENU cosmelan Precautions and contraindications Solar erythema (avoid UV radiation exposure from the previous 15 days). Pregnancy and lactation. Dermatological diseases, persons who are allergic to some formulation ingredient. Treatments with isotretinoin, antibiotics, hydroquinone. Bacterial, viral, mycotic or herpetic infection. It is not advisable to combine it with other chemexfoliation and/or hair removal technique. The time of exposure to the professional mask will be subject to professionals judgment depending on the phototype and the skin characteristics and conditions. In order to extend the result over time, it is essential to complete the home care treatment cycle (gradual inhibition). Slide 19 antiaging range MENU cosmelan Results Skin renewal and embellishment from the 2 nd week of treatment. Attenuation, diminishing or disappearance of melanic pigmentations since one month of treatment. Reduction in small imperfections of the cutaneous relief, such as acne residual scars. Stimulation of capillary circulation and neoangiogenesis. Healthy, bright, rejuvenated and generally whitened skin effect. Slide 20 antiaging range MENU cosmelan Results | Clinical cases Before After Slide 21 antiaging range MENU Before After Results | Clinical cases cosmelan Slide 22 antiaging range MENU cosmelan Results | Clinical cases Before After Slide 23 antiaging range MENU cosmelan Results | Clinical cases Before After Slide 24 antiaging range MENU cosmelan Coadjuvant products for beauty salon treatment in subsequent sessions Cosmeceutical line with high vegetable stem cell concentrations. Pack content: stem Cell serum restructuractive. stem Cell crystal fiber mask. stem Cell active growth factor. Slide 25 antiaging range MENU cosmelan Coadjuvant products for beauty salon treatment in subsequent sessions Cosmeceutical line with high vitamin C concentrations. Pack content: energy C serum. energy C crystal fiber mask. energy C intensive cream. Slide 26 antiaging range MENU melanogel touch all kinds of skin post_procedure fast skin repair all kinds of skin Post-treatment Repairing cream with anti-oedematous and anti-erythematous properties. continuous maintenance post-treatment Depigmentating occasional treatment of melanic pigmentations. continuous maintenance post-treatment anti-stress face mask all kinds of skin Soothing and repairing mask. It fights against oxidative stress effects hydra-vital face mask dry and dehydrated skins continuous maintenance post-treatment Hydronutritious and revitalising facial mask. continuous maintenance post-treatment proteoglycans ampoules normal and dry skins Nutritional solution. It prevents and combats the appearance of expression wrinkles. cosmelan Coadjuvant products for home care treatment moisturising sun protection sensitive,combination and oily skins continuous maintenance post-treatment Facial sun cream. Very high protection | SPF50 + Slide 27 antiaging range MENU Cosmeceutical line with high vegetable stem cell concentrations. Cosmeceutical line with whitening and improving action formulated with [meso]white complex. continuous maintenance post-treatment Cosmeceutical line with high vitamin C concentrations. continuous maintenance post-treatment continuous maintenance post-treatment cosmelan Coadjuvant products for home care treatment Slide 28 antiaging range MENU 1.Which is cosmelan mechanism of action? It acts in a non-cytotoxic manner, inhibiting both the production and the transfer of melanin pigments. It produces a superficial chemexfoliation, thereby allowing attenuation and/or removal of more or less deep superficial hyperpigmentations. 2. Which sensations does the patient usually experiment along the 8-hour time of exposure to cosmelan 1 mask? The symptoms may vary between individuals; nevertheless, a slight itching or stinging sensation and tightness can be felt. 3.Which changes does the skin usually undergo in the days following application of cosmelan 1 mask? Although symptoms vary between individuals, there is usually a slight desquamation, together with some itching, stinging and tightness. cosmelan FAQs Slide 29 antiaging range MENU 4.Is it necessary to take any precaution during treatment? Besides being a necessary requirement in order to avoid post-inflammatory hyperpigmentations, the continuous use of a high-filter solar protection is essential when facing light exposure or any nature, since both natural and artificial light can stimulate melanin synthesis. If because of his/her labour activities one is subject to direct light sources, it is necessary to repeat the sun protection application regularly. During the first week post-treatment, it is advisable to avoid the following activities: swimming in pools, sauna, exposure to direct heat sources, outdoor sports. 5.For how long is it recommended to perform the home care treatment? It is recommended to perform the application for at least 4 months, which may be extended up to 9 months depending on the progression of each individual case. cosmelan FAQs Slide 30 antiaging range MENU 6.In which cases is it recommended to complement cosmelan and depigmentating treatment with tmt system no. 7? Once the cosmelan treatment is over, the professional will assess the possibility to complement the depigmentating effect with the tmt system no. 7 treatment for those hyperpigmentations that because of their more deep location will persist. 7. After how long will the result of the treatment be noticed? One month after having been applying cosmelan 2 mask, we can appreciate an attenuation of hyperpigmentations and the disappearance of the most superficial ones, besides an evident improvement in the skin, with unification of the tone. 8. During the 4 months of home care treatiment with cosmelan, can techniques such as biostimulation be used? Once at the single night application stage, the skin can be treated by means of any treatment, provided it is not photodynamica. cosmelan FAQs Slide 31 antiaging range MENU 9.Can cosmelan 2 be used indefinitely after conducting a treatment with cosmelan? In order to prolong the associated benefits of skin embellishment, cosmelan 2 is often indefinitely maintained as antiaging treatment with longer intervals between applications. 10.How can the intake of certain drugs and/or nutritional supplements affect the treatment result? Many drugs have photosensitising effects on the skin; nutritional supplements contain ingredients that may interfere with the melanin synthesis metabolism. The regular intake of both is to be considered when predicting the efficiency of any depigmentating treatment. Therefore, it is essential to gather as much information as possible through the anamnesis. cosmelan FAQs Slide 32 MENU