melanocytes and melanosomes melanocytes are the cells that make melanosomes melanosomes are...
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MELANOCYTES AND MELANOSOMES
MELANOCYTES ARE THE CELLS THAT MAKE MELANOSOMES
MELANOSOMES ARE MEMBRANE-BOUND ORGANELLES THAT
SYNTHESIZE AND STORE MELANIN
EUMELANIN IS BLACK
MELANIN IS A COMPLEX POLYMER MADE FROM TYROSINE
BUT OTHER MELANINS CAN BE YELLOW TO RED
AFRICAN/AMERICAN ASIAN CAUCASIAN
AFRICAN/AMERICAN ASIAN CAUCASIAN
11% MELANOSOMES IN MEMBRANE- BOUND PACKETS
37% MELANOSOMES IN MEMBRANE- BOUND PACKETS
85% MELANOSOMES IN MEMBRANE- BOUND PACKETS
MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS
MELANOBLASTS DIVIDE TO FORM MELANOCYTES
LEUKODERMIA
AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM
INACTIVE TYROSINASE DUE TO MUTATION
INACTIVE TYROSINASE DUE TO MUTATION
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
INACTIVE TYROSINASE DUE TO MUTATION
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.
SO MISDIRECTED AT TRANS-GOLGI SYSTEM
MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.
LACK OF TYROSINE TRANSPORT SYSTEM IN MELANOSOME MEMBRANE.
INACTIVE TYROSINASE DUE TO MUTATION
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.
SO MISDIRECTED AT TRANS-GOLGI SYSTEM
MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.
INACTIVE TYROSINASE DUE TO MUTATION
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.
SO MISDIRECTED AT TRANS-GOLGI SYSTEM
MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.
LACK OF TRANSFER TO KERATINOCYTES
LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.
MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES
“MELANOSOME COMPLEX” IN KERATINOCYTE
MELANOCYTES BEING PHAGOCYTOSED BY A KERATINOCYTE
PHAGOCYTOSED MELANOSOMES ARE DISTRIBUTED
AS A CAP AT TOP OF THE NUCLEUS
LATEX BEADS TAKEN UP BY KERATINOCYTE AND FORMING A CAP ON TOP OF THE NUCLEUS
Keratinocyte Growth Factor Promotes Melanosome Transfer
to Keratinocytes
CULTURED MELANOCYTES (M) AND KERATINOCYTES (K)
MELANOSMES ARE GREEN (ANTI-TYROSINASE IMMUNOFLUORESCENCE LABELLING)
KERATINOCYTES ARE RED (ANTI-KERATIN IMMUNOFLUORESCENCE LABELLING)
CULTURED CELLS TREATED WITH KERATINOCYTE GROWTH FACTOR (KGF)
CULTURED CELLS EXPOSED TO UVB LIGHT
CULTURE TREATED WITH MELANOCYTE-STIMULATING HORMONE
(MSH)
BEGINNING OF A MALIGNANT MELANOMA (DUE TO UNCONTROLLED GROWTH OF MELANOCYTES)
LOW POWER HIGH POWER