meeren et al the journal of neuroscience, february 15, 2002, 22(4):
TRANSCRIPT
Meeren et al The Journal of Neuroscience, February 15, 2002, 22(4):
VPM VPL
18.4
8.8
29.3
3.1
9.9
Hindpaw
UpperLip Nose
“FOCUS”
SmIThalamus
B. whole seizure
4.9
A. first 500 msec
VPM
2.9
8.1
11.7
30.0
4.3
6.1
VPL
UpperLipNose
“FOCUS”
SmIThalamus
Hindpaw
20-30
40-5030-4070-80
50-60
60-70Association (%)
Evolution of absence seizures: a summary
Meeren, Pijn, van Luijtelaar, Coenen and Lopes da Silva, J. Neurosci 2002,22:1480-95
Cortico-Cortical. Intra-Thalamic and Cortico-Thalamic relations
Focus does not mean a “point source”, just that the local neuronal population has a lower threshold for initiating seizures.
During the seizures it becomes just a part of the oscillating network..
The oscillations constitute an emergent property of the whole system.
Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsyAyten A Gurbanova,1 Rezzan Aker,1 Kemal Berkman,1 Filiz Yilmaz Onat,1 Clementana M van Rijn,2 and Gilles van Luijtelaar2*
Br J Pharmacol. 2006 August; 148(8): 1076–1082.
4th International Workshop on Seizure Prediction
Kansas City, Missouri – June 4 -7, 2009
Ictogenesis: Focus or Network?
Center of Neuroscience
Swammerdam Institute for Life Sciences
University of Amsterdam
Fernando Lopes da Silva
Cortical Focus Drives Widespread Corticothalamic Networksduring Spontaneous Absence Seizures in RatsH. K. M. Meeren, J. P. M. Pijn†, E. L. J. M. Van Luijtelaar, A. M. L. Coenen, and F. H. Lopes da Silva, The Journal of Neuroscience, February 15, 2002
Ayten A Gurbanova, Rezzan Aker, Kemal Berkman, Filiz Yilmaz Onat, Clementana M van Rijn, and Gilles van Luijtelaar. Effect of systemic and intracortical administration of phenytoin in two genetic models of absence epilepsy. Br J Pharmacol. 2006 August; 148(8): 1076–1082.
