Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA)Genius Book Record Holder

Postdoctoral Fellow,

Department of Neuroimaging and Interventional Radiology

National Institute of Mental Health & Neuro Sciences (NIMHANS),

Bengaluru-560 029, India.

Email: nsr4069@nimhans.ac.in

For Pharma Graduates & GPAT Aspirants

Date: 11/07/2020

Medicinal ChemistryANS

Structures of direct acting parasympathomimetics

Direct acting parasympathomimetics

Structural Activity Relationship (SAR) of Ach:

Stereochemistry (conformers) of Ach:

2. Indirect Acting Parasympathomimetics (Anti-cholinesterases)

Structures of indirect acting parasympathomimetics

Reversible Agents Irreversible Agents

NH2

NH2

1. Mechanism of Ach on Hydrolysis process 2. Mechanism of Reversible inhibitor

3. Mechanism of Irreversible inhibitor 4. Reactivating AchE using 2-PAM

3. Sympathomimetics

3. Sympatholytics