medication safety: a prescription for...
TRANSCRIPT
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Medication Safety: A
Prescription for Prevention
Chad Kawakami Pharm.D., BCPS, CDE
Assistant Professor of Pharmacy Practice
The Daniel K. Inouye College of Pharmacy
Jonathan Kataoka Pharm.D. Candidate
Robert McHugh Pharm.D. Candidate
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Objectives
● Understand the definition of prescription drug misuse
● Know the risk factors involved in prescription drug misuse
● List misuse prevention tactics that help aid in proper drug use
● Understand the different disposal methods, and understand when each method is most
appropriate
● List the common problems associated with each medication form
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Objective
● List devices that can help medication compliance
● Understand the pros and cons regarding OTC medications
● List common drugs that geriatrics tend to take, the adverse effects, and
cautions regarding these drugs
● Realize the dangers that may occur when taking combination or multi-
symptom products
● Be able to utilize and describe the drug facts label
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Older Adults Take More
Medicine → Consume 1/3 of all prescription meds
→ One in four older adults has used
psychoactive meds with abuse potential
→ Prescription drug misuse and abuse
is a growing problem
→ May be as high as 11% of older adult
population
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Definitions
Prescription Drug Misuse
→ The use of a medication other than as
directed
– May be accidental or willful
Prescription Drug Abuse
→ Intentionally taking medications that are not
medically necessary
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Misuse can Lead to Abuse
→ Patient behavior
→ Prescriber behavior
→ Both
The pathway from appropriate use, through misuse to abuse can result from
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Prescription Drug MisusePatient Behavior
→ Taking more of a drug than prescribed
→ Missing doses
→ Taking the wrong drug
→ Using a drug for other than the prescribed reason
→ Sharing or borrowing drugs
→ Using drugs that have expired
→ Combining drugs with alcohol or other substances
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Prescription Drug MisusePrescriber Behavior
→ Medications w/o indication
→ Multiple drugs from same class
→ Dose too high; duration too long
→ High risk drugs or inappropriate for elderly
→ Inadequate instructions for taking meds
→ Failure to question about use of alcohol or other
drugs with abuse potential
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Prescription Drug Misuse is UNSAFE
→ Treatment failure
→ Increased health resource utilization
– ER visits
– Hospitalizations
It might lead to prescription drug ABUSE
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Prescription Drug Misuse
Risk Factors → Number of medications
→ Multiple prescribers
→ Inappropriate prescribing
→ Limited English language proficiency
→ Low health literacy
→ Memory problems
→ Hearing/Vision impairments
→ Treating symptoms and not the cause
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How Much is Too Many?
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Prevention Tactics→ Improving medication adherence.
→ Making sure that older adults understand how to take medications and what to avoid when taking a prescription medication.
→ Encouraging older adults to share concerns and ask questions about their medication.
→ Encouraging older adults to inform health care providers of all medications they take regularly.
→ Encouraging older adults to keep a current medication list.
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Prevention Tactics
→ Provide medication aids
→ Address communication barriers
→ Community informational and intervention support programs
→ Educate prescribers
→ Adequate treatment of underlying conditions
→ Standardized screening
→ Transitional care and medication review
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Quality of Prescribing“No man is an island”
Quality of Prescribing requires a team effort to avoid ADE and optimize therapy to improve a patient's QOL
In an article published by AAFP titled “Appropriate Prescribing of Medications: An Eight-Step Approach,” the
authors combined WHO suggested steps with their own to create a safer and more effective prescribing
strategy:
1. Evaluate and Define the patient’s problem
2. Specify the therapeutic objective
3. Select the appropriate drug therapy
4. Initiate therapy with appropriate details and consider
nonpharmacologic therapies
1. Give information, instructions, and warnings
2. Evaluate therapy regularly
3. Consider drug cost
4. Use Electronic Devices (RX software, and access to a
Electronic drug references)
BUT WHAT’S MISSING????
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Quality of Prescribing
While these steps are thorough and address many of the potential pitfalls and mistakes in prescribing
medications to the elderly with chronic disease, the steps fail to mention the prescribers most valuable
resource: the whole medical team.
Every member of the medical team should contribute to the 8 steps.
● Nurses
● Pharmacists
● Specialist
● Mental Health Care Providers
● Social Workers
● Family Members TEAMWORK
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Help fight
Prescription Drug Misuse & Abuse
CLEAN OUT THE
MEDICINE
CABINET!!
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Safe Disposal of Medications
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Importance of Safe Disposal
● Keeping medications when they are not needed also keeps unnecessary
health risks in the household
● Every year, more than 71,000 children (18 years old and younger) are seen in
the emergency room due to accidental overdoses of prescription and OTC
medications
● Ensuring proper disposal of medications can help reduce accidental exposure
(and also intentional misuse)
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Accidental Exposure Cases
● 2-year old male taken to ER due to methadone intake. Was treated in the ER with
appropriate actions such as activated charcoal, and was discharged. Later that day,
child had no heartbeat and not breathing. Resuscitation attempts were not effective
and child died.
● 4-year old female not breathing at grandparents home. Resuscitation attempts were
not effective and child died. Autopsy showed that child ingested a transdermal fentanyl
patch. Child probably found a used patch in the house trash.
● 2-year old female was found staggering and rubbing mouth. Child also developed
tiredness and abdominal pain. Brought to ER, but found no signs of distress. The next
day under parent’s care, child was found unresponsive. Child pronounced dead at
hospital. Blood test was found positive for oxycodone.
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Disposal Methods
Three Safe Methods:
● Drug Take-Back Programs or Authorized Collectors
● Household Trash
● Flushing in Sink or Toilet
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Drug Take-Back Programs and Authorized Collectors
• Recommended for all medications allowed in the program when possible• DEA-authorized personnel receive prescription drugs and safely/securely
dispose of them• National Prescription Drug Take-Back events are periodically hosted by
DEA– Free and anonymous– Takes back solid dosage forms, such as tablets and capsules– Does not accept needles and syringes
• Some places are DEA-authorized to collect medications, and may include retail pharmacies, hospitals, clinics, and law enforcement
• Some authorized collectors may provide mail-back envelopes or have drop-boxes
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Drug Take-Back Event
Where - Blaisdell Exhibition Hall
When - September 22-24, 2017,
8:30am-12:30pm each day
Who - Anyone
Cost - Nothing!
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National Prescription Drug
Take-Back Day
https://www.deadiversion.usdoj.gov/
drug_disposal/takeback/index.html
● Occurs biannually (Around April
and October)
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National Prescription Drug
Take Back Day
●Who: Everyone
●What: Unused or Expired
Medications
●When: Saturday, October 28th,
2017 from 10:00 am to 2:00 pm
●Where: visit www.dea.gov or call 1-
800-9539 for a collection site.
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Controlled Substance Public Disposal Locator
https://apps.deadiversion.usdoj.gov/pubdispsearch/spring/main?execution=e1s1
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Other Method: Disposal Envelopes
● $4.20 (Amazon price)
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Disposal by Household Trash
● Recommended for most drugs if a drug take-back program is not available
● Usually not done for narcotics because a child or pet may still accidentally get
the disposed drug
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Disposal by Flushing
● Recommended for certain controlled-substances (especially narcotics) if a
drug take-back program is not available
● The label or patient information sheet that came with the medication should
indicate if the medication can be flushed
● Flushing prevents accidental ingestion of these harmful and fatal medications
● Not done for all medications due to environmental concerns (water treatment
plants were not made to remove medicines in mind)
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Disposal by Flushing
• Substances include:• Buprenorphine• Diazepam (rectal gel)• Fentanyl• Hydrocodone• Hydromorphone
• Methadone
• Methylphenidate
• Morphine
• Oxycodone
• Oxymorphone
• For a full list of brands please visit:
• https://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSafely/EnsuringSafeUseofMedicine/SafeDisposalofMedicines/ucm186187.htm#medicines
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Medication Disposal
DisposeMyMeds.org→ An online resource to help find medication disposal programs at the local
independent community pharmacy near you
Drug Take Back Network→ Information on permanent and regularly recurring drug take-back events
www.takebacknetwork.com/local_efforts.html
SMARxT Disposal→ http://www.mnsmartdisposal.net/
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Medication Forms
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Medication Forms● Oral
○ Multiple medications can make organizing and remembering when to take which meds difficult
○ Size of capsules and tablets can make swallowing difficult
○ Specifics with dosing (example: with or without food)
● Inhaled (Powder and Aerosolized)
○ Specific instructions for proper administration can be complicated
○ New devices may not be “user friendly” to the elderly
● Rectal
○ Stigma associated with insertion
○ Proper administration instructions must be given
● Topical (lotions, gels, ointments)
○ Variable absorption and application rates
○ Many medications are not transdermal
○ Application to hard reach areas may be very difficult
● Injections
○ Painful
○ Problematic dosing and process - requires extra equipment
○ Dexterity and cognitive issues
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Devices
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Blister Packing
• Pharmacare– Minimal to NO additional cost to patient– Free Home Delivery
• Contact:– Reece Uyeno, Pharm.D., BCPS– (808) 840-4126– [email protected]
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Devices
There are many devices that can help elderly patients remain compliant to their medications:
● Pill Organizers - One of the oldest, most often-utilized methods
○ Pros: inexpensive, effective, simple
○ Cons: must be packed by hand, remember to take medications, can become confusing
● Bubble Packs - Can be completed by local pharmacies or other health care providers
○ Pros: packed at the pharmacy and approved by RPh, multiple packs for multiple times of day
○ Cons: cost, remember to take medications, cannot adjust medications mid-Rx
● Time Bottle Caps - Can be set to show when bottle was last opened or alarm each day to remind the
patient that it’s time to take his or her medication
○ Pros: will alarm when time to take medication, multiple settings available
○ Cons: hearing impaired, no idea if patient is over/under dosing him or herself
● Software/Apps - One of the newest items on the market to ensure safe and compliant use of
medications, involves portable electronics/smart phones
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Software/Apps
Pros:
● Not Just for patient but for family
● Multiple apps for mobile devices
● Multiple alarms with images
● Can be set up by family members
● Integrated Bluetooth caps can keep track of what medications
have been taken and when
Cons:
● Learning curb for geriatrics
● Must maintain battery
● Keep device on and near Bluetooth caps
● Can not be sure if patient is over- or under-dosing him or herself
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Over-The-Counter Medications
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Over-The-Counter (OTC) Medications
● Can be found in many outlets over at the shopping aisles
● Can be purchased without a prescription
● Considered safe enough to use without supervision of a physician or other
health care professional
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Over-The-Counter (OTC) Medications
Pros
● Convenient for the patient
● Cost-friendly for many common conditions
(allergy, cough, diarrhea, rash, etc.)
● Patients can purchase OTC products
independently based on their own judgment
Cons
● Common misconception that OTCs must
always be safe to use
● Dosing, adverse effects, and interactions
● Instructions are not always clear
● Possible unnecessary ingredients or even
unnecessary treatment
● Doctors not always informed on all OTC
products being taken
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Over-The-Counter (OTC) Medications
Because of the risks still found in OTC products, it is good practice to remember:
● Common generics and examples of brands
● Indications as to why a medication should be taken
● Adverse effects that may happen when taking the product
● Interactions that may occur with a product
● Cautions regarding other existent conditions
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NSAIDs
● Examples: ○ Aspirin (Bayer, Ecotrin)○ Ibuprofen (Advil, Motrin)○ Naproxen (Aleve, Midol ER)
● Indications: Pain, Headache, Fever, Inflammation
● Adverse Effects: Gastrointestinal Bleeding, Gastritis, Diarrhea, Nausea, Renal Failure, Tinnitus
● Interactions: ACEIs, Warfarin● Cautions: Cirrhosis, Renal Failure,
Congestive Heart Failure, Alcohol Use
● Note: Take with food to prevent upset stomach
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Acetaminophen
• Example: Tylenol• Indications: Pain, Headache,
Fever• Adverse Effects: Liver Toxicity• Interactions: Azoles,
Macrolides, Warfarin• Cautions: Cirrhosis, Alcohol
Use• Note: Multiple Products with
Acetaminophen • Max total for geriatrics = 3
grams/day
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Not just in Tylenol…
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OTC Combination and Multi-Symptom Products
• Some OTC products contain more than one active ingredient (contain more than one drug)
• Reasoning:• More effective in treating a single symptom
(combination product)• Example: Excedrin
• Migraine• Acetaminophen + Aspirin +
Caffeine• More effective in treating various different
symptoms (multi-symptom product)• Example: Adult Robitussin Multi-
Symptom Cold (Cough, Nasal Congestion, Mucus)
• Dextromethorphan, Guaifenesin, Phenylephrine
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Benefits and Safety Concerns
Benefits
● Convenience of less products
● Cost benefits
Safety Concerns
● Possible unneeded drug(s)
● Risk of taking one specific active
ingredient in multiple medicines at the
same time
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Do You See Any Potential Problems?
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Active Ingredients
Tylenol Cold (per caplet)
• Acetaminophen 325 mg
• Dextromethorphan 10 mg
• Guaifenesin 200 mg
• Phenylephrine 5 mg
• Recommended dose is 2 caplets every 4 hours
Robitussin Severe Multi-Symptom Cough Cold + Flu (per 20 mL)
• Acetaminophen 650 mg
• Dextromethorphan 20 mg
• Guaifenesin 400 mg
• Phenylephrine 10 mg
• Recommended dose is 20 mL every 4 hours (6 doses per day)
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Acetaminophen Overdose
If both products taken together at the same time at the manufacturer’s
recommended dose:
● You would exceed the recommended maximum single dose of acetaminophen
● After three doses, you would exceed the recommended maximum daily dose of
acetaminophen
Always read the Drug Facts label on every OTC product!
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Pseudoephedrine
• Example: Sudafed • Indications:
– Nasal Congestion
• Adverse Effects: – Hypertension, Vasospasm, Arrhythmia, Tremors, Stroke, Seizures, Insomnia, Headaches, Hallucinations
• Interactions: – Beta-Blockers, Digoxin, Monoamine Oxidase Inhibitors
• Contraindications: – MAO use
• Cautions: – Hypertension, Heart Disease, Diabetes Mellitus, Closed-Angle Glaucoma, Thyroid Disease, Prostatic Hypertrophy,
Urinary Retention
• Note: Doesn’t need prescription but is behind-the-counter
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Topical Nasal Decongestants
● Examples: Oxymetazoline (Afrin),
Phenylephrine (Neo-Synephrine)
● Indications: Nasal Congestion
● Adverse Effects: Hypertension, Rhinitis
Medicamentosa
● Interactions: Beta-Blockers, Digoxin,
Monoamine Oxidase Inhibitors
● Cautions: Hypertension, Heart Disease,
Diabetes Mellitus, Closed-Angle
Glaucoma, Thyroid Disease, Prostatic
Hypertrophy, Urinary Retention
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First-Generation Antihistamines
● Examples: Diphenhydramine (Benadryl)
● Indications: Symptomatic Relief of Cough,
Cold, and Allergy
● Adverse Effects: Arrhythmia, Diaphoresis,
Dry Mouth, Mydriasis, Constipation,
Urinary Retention, Cognitive Dysfunction,
Seizures, Hallucinations, Sedation
● Interactions: Oxybutynin, Phenothiazine
Medications, TCAs, Antiparkinsonian
Medications
● Cautions: Closed-Angle Glaucoma, BPH,
Asthma, Dementia
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Laxatives
Surfactant Agents
● Examples:Docusate Sodium (Colace),
Mineral Oil
● Cautions: Aspiration (mineral oil)
Stimulant Agents
● Examples: Senna, Bisacodyl (Dulcolax)
● Adverse Effects: Cathartic Colon,
Electrolyte Imbalance
Osmotic Agents
● Examples: Magnesium Hydroxide,
Magnesium Sulfate
● Adverse Effects: Edema, Electrolyte
Imbalance
● Interactions: Digoxin, Thyroid Medications,
Quinolones, Azoles
● Cautions: Renal Failure, Bone Disease
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Important Notes• Remember to always read the Drug
Facts found on the OTC product for important information. This label contains invaluable information regarding the product.
• Active Ingredient: Be aware of this, especially if multiple OTC products are being used simultaneously
• Uses: Make sure you are using the correct product for the certain condition
• Warnings: Be sure to understand when not to take the product, and what adverse effects may happen while taking the product
• Inactive Ingredients: May contain something that a patient may be allergic to
• Directions: Always follow this• Other Information: storage, expiration
date, overdose instructions, etc.
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• Take steps to prescribe appropriately• Be aware of difficult to administer dosage forms
and take steps to mitigate errors• Use compliance aids as appropriate• Encourage proper medication disposal to prevent
accidental exposure
Directions: