medicare model guidelines draft v8.0 1 of 97...anti-inflammatory agents diclofenac sodium/...

Medicare Model Guidelines Draft v8.0 1 of 97

USP Category USP Class Example Drugs Combination Drug Product

Track Changes

Analgesics CatNonsteroidal Anti-inflammatory Drugs

Class

Celecoxib noDiclofenac Potassium noDiclofenac Epolamine noDiflunisal noEtodolac noFenoprofen Calcium noFlurbiprofen noIbuprofen noIndomethacin noKetoprofen noKetorolac Tromethamine noMeclofenamate Sodium noMefenamic Acid noMeloxicam noNabumetone noNaproxen noOxaprozin noPiroxicam noSulindac noTolmetin Sodium no

Opioid Analgesics, Long-acting Class

Buprenorphine noFentanyl noFentanyl Citrate noFentanyl Hydrochloride no Manufacturer Discontinued

* This list is illustrative of Part D eligible drugs only, and does not infer CMS coverage.


Hydrocodone Bitartrate noHydromorphone Hydrochloride no

Levorphanol Tartrate noMethadone Hydrochloride noMorphine Sulfate noOxycodone Hydrochloride noOxymorphone Hydrochloride noTapentadol Hydrochloride noTramadol Hydrochloride no

Opioid Analgesics, Short-acting Class

Butorphanol Tartrate noCodeine Phosphate noFentanyl Citrate noHydromorphone Hydrochloride no

Meperidine Hydrochloride noMorphine Sulfate no Additional Placement Nalbuphine Hydrochloride noOxycodone Hydrochloride noOxymorphone Hydrochloride noPentazocine Lactate no Manufacturer DiscontinuedTapentadol Hydrochloride noTramadol Hydrochloride no

Analgesics Combinations Class New class to include analgesic combination drug products

Acetaminophen/ Codeine Phosphate

yes

Benzhydrocodone/ A t i h

yes



Hydrocodone Bitartrate/ Acetaminophen

yes

Hydrocodone Bitartrate/ Ibuprofen yes

Morphine Sulfate/ Naltrexone Hydrochloride

yes

Oxycodone Hydrochloride/ Acetaminophen

yes

Oxycodone Hydrochloride/ Aspirin yes

Oxycodone Hydrochloride/ Ibuprofen

yes

Tramadol Hydrochloride/ Acetaminophen

yes

Butalbital/ Acetaminophen yesButalbital/ Acetaminophen/ Caffeine

yes

Butalbital/ Acetaminophen/ Caffeine/ Codeine Phosphate

yes

Butalbital/ Aspirin/ Caffeine yesButalbital/ Aspirin/ Caffeine/ Codeine

yes

Anesthetics CatLocal Anesthetics Class

Lidocaine Hydrochloride noLidocaine/ Epinephrine yesLidocaine/ Prilocaine yesLidocaine/ Tetracaine yes



Anti-Addiction/ Substance Abuse Treatment Agents

Cat

Alcohol Deterrents/Anti-craving Class

Acamprosate Calcium noDisulfiram noNaltrexone Hydrochloride no

Opioid Dependence Treatments Opioid Dependence

Class Renamed class to "Opioid Dependence" to avoid redundancy in category name, since the concept of "treatment agents" is already included

Buprenorphine noBuprenorphine/ Naloxone Hydrochloride

yes

Lofexidine noNaltrexone Hydrochloride no

Opioid Reversal Agents ClassNaloxone Hydrochloride no

Smoking Cessation Agents ClassBupropion Hydrochloride noNicotine Polacrilex noVarenicline Tartrate no

Antibacterials CatAntibacterials Aminoglycosides ClassAntibacterials Amikacin Sulfate noAntibacterials Gentamicin Sulfate noAntibacterials Neomycin Sulfate noAntibacterials Paromomycin Sulfate noAntibacterials Plazomicin noAntibacterials Streptomycin Sulfate noAntibacterials Tobramycin Sulfate no



Antibacterials Beta-lactam, Cephalosporins ClassAntibacterials Antibacterials Cefadroxil noAntibacterials Cefazolin noAntibacterials Cephalexin noAntibacterials Antibacterials Cefaclor noAntibacterials Cefoxitin Sodium noAntibacterials Cefprozil noAntibacterials Cefuroxime Axetil noAntibacterials Sodium noAntibacterials Antibacterials Cefdinir noAntibacterials Cefixime noAntibacterials Cefotaxime Sodium noAntibacterials Cefpodoxime Proxetil noAntibacterials Ceftazidime noAntibacterials Ceftazidime/ Avibactam yesAntibacterials Ceftibuten Dihydrate no Manufacturer DiscontinuedAntibacterials Ceftriaxone Sodium noAntibacterials Antibacterials Cefepime Hydrochloride noAntibacterials Antibacterials Ceftaroline Fosamil noAntibacterials Ceftolozane Sulfate/ Tazobactam yes

Antibacterials Beta-lactam, Penicillins ClassAntibacterials Antibacterials Amoxicillin noAntibacterials Amoxicillin/ Clavulanate yesAntibacterials Ampicillin no



Antibacterials Ampicillin Sodium/ Sulbactam S di

yesAntibacterials Antibacterials Piperacillin Sodium/ Tazobactam

Sodium yes

Antibacterials Antibacterials Penicillin G Benzathine noAntibacterials Penicillin G Potassium noAntibacterials Penicillin G Procaine noAntibacterials Penicillin G Sodium noAntibacterials Penicillin G Benzathine/ Penicillin

G Procaine yes

Antibacterials Penicillin V Potassium noAntibacterials Antibacterials Dicloxacillin Sodium noAntibacterials Nafcillin Sodium noAntibacterials Oxacillin Sodium noAntibacterials Beta-lactam, Other Carbapenems Class Renamed class to add specification

Antibacterials Aztreonam no Moved example drug to USP Class, "Antibacterials, Other"

Antibacterials Doripenem no Manufacturer DiscontinuedAntibacterials Ertapenem Sodium noAntibacterials Imipenem/ Cilastatin Sodium yes

Imipenem/ Cilastatin/ Relebactam yes New FDA approved drug, 7/16/19

Antibacterials Meropenem noAntibacterials Meropenem/ Vaborbactam yesAntibacterials Macrolides ClassAntibacterials Azithromycin noAntibacterials Clarithromycin noAntibacterials Erythromycin no



Antibacterials Erythromycin Ethylsuccinate noAntibacterials Erythromycin Lactobionate noAntibacterials Erythromycin Stearate noAntibacterials Fidaxomicin noAntibacterials Quinolones ClassAntibacterials Besifloxacin Hydrochloride noAntibacterials Ciprofloxacin noAntibacterials Delafloxacin Meglumine noAntibacterials Finafloxacin no Manufacturer DiscontinuedAntibacterials Gatifloxacin noAntibacterials Gemifloxacin Mesylate noAntibacterials Levofloxacin noAntibacterials Moxifloxacin Hydrochloride noAntibacterials Ofloxacin noAntibacterials Sulfonamides ClassAntibacterials Sulfacetamide Sodium noAntibacterials Sulfadiazine noAntibacterials Sulfamethoxazole/ Trimethoprim yes

Antibacterials Tetracyclines ClassAntibacterials Demeclocycline Hydrochloride no

Antibacterials Doxycycline Calcium noAntibacterials Doxycycline Hyclate no

Eravacycline noAntibacterials Minocycline Hydrochloride noAntibacterials Omadacycline noAntibacterials Sarecycline noAntibacterials Tetracycline Hydrochloride noAntibacterials Antibacterials, Other ClassAntibacterials



Antibacterials Silver Sulfadiazine noAntibacterials Antibacterials Trimethoprim noAntibacterials

Dalbavancin noAntibacterials Vancomycin Hydrochloride noAntibacterials Antibacterials Clindamycin Hydrochloride noAntibacterials Clindamycin Palmitate

Hydrochlorideno

Antibacterials Lincomycin Hydrochloride noAntibacterials Antibacterials Nitrofurantoin noAntibacterials Antibacterials Linezolid noAntibacterials Tedizolid Phosphate noAntibacterials Antibacterials Acetic Acid no

Aztreonam no Moved example drug from USP Class, "Beta-lactam, Other"

Antibacterials Bacitracin noAntibacterials Chloramphenicol Sodium

S i tno

Antibacterials Daptomycin noAntibacterials Fosfomycin Tromethamine noAntibacterials Mafenide Acetate noAntibacterials Methenamine Hippurate noAntibacterials Metronidazole noAntibacterials Mupirocin Calcium noAntibacterials Polymyxin B Sulfate noAntibacterials Retapamulin noAntibacterials Rifaximin no



Antibacterials Secnidazole noAntibacterials Tinidazole noAntibacterials Tigecycline noAnticonvulsants CatAnticonvulsants Calcium Channel Modifying Agents Class

Anticonvulsants Ethosuximide noAnticonvulsants Methsuximide noAnticonvulsants Gamma-aminobutyric Acid (GABA)

Augmenting Agents Class

Anticonvulsants Anticonvulsants Clobazam noAnticonvulsants Clonazepam noAnticonvulsants Clorazepate Dipotassium noAnticonvulsants Diazepam noAnticonvulsants Lorazepam noAnticonvulsants Anticonvulsants Phenobarbital noAnticonvulsants Primidone noAnticonvulsants Anticonvulsants Gabapentin noAnticonvulsants Pregabalin noAnticonvulsants Tiagabine noAnticonvulsants Vigabatrin no

Glutamate Reducing Agents Class Removed class due to multiple mechanism of actions of example drugs. Example drugs with multiple mechanism of actions moved to USP Class, "Anticonvulsants, Other.“ Examples drugs moved to USP Class, "Anticonvulsants, Other."

Anticonvulsants Sodium Channel Agents ClassAnticonvulsants Carbamazepine no



Anticonvulsants Eslicarbazepine noEthotoin no

Anticonvulsants Fosphenytoin noAnticonvulsants Lacosamide noAnticonvulsants Oxcarbazepine noAnticonvulsants Phenytoin noAnticonvulsants Rufinamide noAnticonvulsants Zonisamide noAnticonvulsants Anticonvulsants, Other ClassAnticonvulsants Cannabidiol noAnticonvulsants Anticonvulsants Brivaracetam noAnticonvulsants Levetiracetam noAnticonvulsants Anticonvulsants Divalproex noAnticonvulsants Felbamate noAnticonvulsants Lamotrigine noAnticonvulsants Perampanel noAnticonvulsants Stiripentol noAnticonvulsants Topiramate noAnticonvulsants Valproic Acid noAntidementia Agents CatAntidementia Agents Cholinesterase Inhibitors ClassAntidementia Agents Donepezil Hydrochloride noAntidementia Agents Galantamine Hydrobromide noAntidementia Agents Rivastigmine no

Rivastigmine Tartrate noAntidementia Agents N-methyl-D-aspartate (NMDA)

Receptor Antagonist Class

Antidementia Agents Memantine Hydrochloride noAntidementia Agents Antidementia Agents, Other Class



Antidementia Agents Memantine/ Donepezil H d hl id

yesAntidementia Agents Ergoloid Mesylates noAntidepressants CatAntidepressants Monoamine Oxidase Inhibitors ClassAntidepressants Isocarboxazid no Gap drug found on FRFAntidepressants Phenelzine Sulfate noAntidepressants Selegiline noAntidepressants Tranylcypromine Sulfate noAntidepressants SSRIs/SNRIs (Selective Serotonin

Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors)

Class

Antidepressants Citalopram Hydrobromide noAntidepressants Desvenlafaxine noAntidepressants Desvenlafaxine Succinate noAntidepressants Duloxetine Hydrochloride noAntidepressants Escitalopram Oxalate noAntidepressants Fluoxetine Hydrochloride noAntidepressants Fluvoxamine Maleate noAntidepressants Levomilnacipran Hydrochloride no

Antidepressants Maprotiline Hydrochloride no Example drug moved to USP Class, "Antidepressants, Other."

Antidepressants Nefazodone Hydrochloride noAntidepressants Paroxetine Hydrochloride noAntidepressants Sertraline Hydrochloride noAntidepressants Trazodone Hydrochloride noAntidepressants Venlafaxine Hydrochloride noAntidepressants Vilazodone Hydrochloride noAntidepressants Vortioxetine Hydrobromide noAntidepressants Tricyclics Class



Antidepressants Amitriptyline Hydrochloride noAntidepressants Amoxapine noAntidepressants Clomipramine Hydrochloride noAntidepressants Desipramine Hydrochloride noAntidepressants Doxepin Hydrochloride noAntidepressants Imipramine Hydrochloride noAntidepressants Imipramine Pamoate noAntidepressants Nortriptyline Hydrochloride noAntidepressants Protriptyline Hydrochloride noAntidepressants Trimipramine Maleate noAntidepressants Antidepressants, Other ClassAntidepressants Bupropion Hydrochloride noAntidepressants Mirtazapine noAntidepressants Antidepressants Aripiprazole noAntidepressants Quetiapine Fumarate no

Esketamine Hydrochloride no New FDA approved drug, 3/5/19

Antidepressants Antidepressants Chlordiazepoxide/ Amitriptyline

Hydrochloride yes

Antidepressants Olanzapine/ Fluoxetine yesAntidepressants Perphenazine/ Amitriptyline

Hydrochloride yes

Antiemetics CatAntiemetics Emetogenic Therapy Adjuncts ClassAntiemetics Antiemetics Rolapitant noAntiemetics Antiemetics Dolasetron Mesylate no Manufacturer DiscontinuedAntiemetics Granisetron Hydrochloride no



Antiemetics Ondansetron noAntiemetics Ondansetron Hydrochloride noAntiemetics Palonosetron Hydrochloride noAntiemetics Antiemetics Aprepitant no

Fosnetupitant/ Palonosetron no New FDA approved drug 4/19/18Antiemetics Netupitant/ Palonosetron yesAntiemetics Antiemetics Dronabinol noAntiemetics Nabilone noAntiemetics Antiemetics, Other ClassAntiemetics Chlorpromazine Hydrochloride no

Antiemetics Diphenhydramine Hydrochloride no

Antiemetics Doxylamine Succinate/ Pyridoxine Hydrochloride

yes

Antiemetics Hydroxyzine Hydrochloride noAntiemetics Meclizine Hydrochloride noAntiemetics Metoclopramide noAntiemetics Perphenazine noAntiemetics Prochlorperazine Edisylate noAntiemetics Prochlorperazine Maleate noAntiemetics Promethazine Hydrochloride noAntiemetics Scopolamine noAntiemetics Trimethobenzamide Hydrochloride no

Antifungals CatAntifungals Antifungals Naftifine Hydrochloride noAntifungals Terbinafine Hydrochloride no



Antifungals Antifungals Butoconazole Nitrate noAntifungals Clotrimazole noAntifungals Econazole Nitrate noAntifungals Efinaconazole noAntifungals Fluconazole noAntifungals Isavuconazonium Sulfate noAntifungals Itraconazole noAntifungals Ketoconazole noAntifungals Luliconazole noAntifungals Miconazole Nitrate noAntifungals Oxiconazole Nitrate noAntifungals Posaconazole noAntifungals Sertaconazole Nitrate noAntifungals Sulconazole Nitrate noAntifungals Terconazole noAntifungals Voriconazole noAntifungals Antifungals Anidulafungin noAntifungals Caspofungin Acetate noAntifungals Micafungin Sodium noAntifungals Antifungals Amphotericin B noAntifungals Natamycin no Removed placement. Placement exists under USP Class,

"Ophthalmic Anti-Infectives."Antifungals Nystatin noAntifungals Antifungals Butenafine Hydrochloride noAntifungals Ciclopirox Olamine noAntifungals Flucytosine noAntifungals Griseofulvin no



Antifungals Tavaborole noAntigout Agents CatAntigout Agents Antigout Agents Probenecid noAntigout Agents Antigout Agents Allopurinol noAntigout Agents Febuxostat noAntigout Agents Antigout Agents Colchicine noAntigout Agents Lesinurad no Manufacturer DiscontinuedAntigout Agents Pegloticase noAntigout Agents Antigout Agents Lesinurad/ Allopurinol yes Manufacturer DiscontinuedAntigout Agents Probenecid/ Colchicine yesAnti-inflammatory Agents Cat

Anti-inflammatory Agents Glucocorticoids Class

Anti-inflammatory Agents Nonsteroidal Anti-inflammatory Drugs

Class

Anti-inflammatory Agents Celecoxib no

Anti-inflammatory Agents Diclofenac Potassium no

Anti-inflammatory Agents Diclofenac Epolamine no

Anti-inflammatory Agents Diclofenac Sodium/ Misoprostol yes

Anti-inflammatory Agents Diflunisal no



Anti-inflammatory Agents Etodolac no

Anti-inflammatory Agents Fenoprofen Calcium no

Anti-inflammatory Agents Flurbiprofen no

Anti-inflammatory Agents Ibuprofen no

Anti-inflammatory Agents Ibuprofen/ Famotidine yes

Anti-inflammatory Agents Indomethacin no

Anti-inflammatory Agents Ketoprofen no

Anti-inflammatory Agents Ketorolac Tromethamine no

Anti-inflammatory Agents Meclofenamate Sodium no

Anti-inflammatory Agents Mefenamic Acid no

Anti-inflammatory Agents Meloxicam no

Anti-inflammatory Agents Nabumetone no

Anti-inflammatory Agents Naproxen Sodium no

Anti-inflammatory Agents Naproxen/ Esomeprazole Magnesium

yes

Anti-inflammatory Agents Oxaprozin no



Anti-inflammatory Agents Piroxicam no

Anti-inflammatory Agents Sulindac no

Anti-inflammatory Agents Tolmetin Sodium no

Antimigraine Agents CatAntimigraine Agents Ergot Alkaloids ClassAntimigraine Agents Dihydroergotamine Mesylate noAntimigraine Agents Ergotamine Tartrate noAntimigraine Agents Serotonin (5-HT) 1b/1d Receptor

Agonists Class

Antimigraine Agents Almotriptan Malate noAntimigraine Agents Eletriptan Hydrobromide noAntimigraine Agents Frovatriptan Succinate noAntimigraine Agents Naratriptan Hydrochloride noAntimigraine Agents Rizatriptan Benzoate noAntimigraine Agents Sumatriptan noAntimigraine Agents Sumatriptan/ Naproxen Sodium yes

Antimigraine Agents Zolmitriptan noAntimigraine Agents Prophylactic ClassAntimigraine Agents Antimigraine Agents Erenumab noAntimigraine Agents Fremanezumab noAntimigraine Agents Galcanezumab noAntimigraine Agents Antimigraine Agents Timolol Maleate noAntimigraine Agents Antimigraine Agents Divalproex Sodium noAntimigraine Agents Topiramate no



Antimigraine Agents Valproic Acid noAntimyasthenic Agents CatAntimyasthenic Agents Parasympathomimetics ClassAntimyasthenic Agents Guanidine Hydrochloride noAntimyasthenic Agents Pyridostigmine Bromide noAntimycobacterials CatAntimycobacterials Antituberculars ClassAntimycobacterials Aminosalicylic Acid noAntimycobacterials Bedaquiline Fumarate noAntimycobacterials Capreomycin Sulfate noAntimycobacterials Cycloserine noAntimycobacterials Ethambutol Hydrochloride noAntimycobacterials Ethionamide noAntimycobacterials Isoniazid noAntimycobacterials Pyrazinamide noAntimycobacterials Rifampin noAntimycobacterials Rifapentine noAntimycobacterials Rifampin/ Isoniazid yesAntimycobacterials Rifampin/ Isoniazid/ Pyrazinamide yes

Antimycobacterials Antimycobacterials, Other ClassAntimycobacterials Dapsone noAntimycobacterials Rifabutin noAntineoplastics CatAntineoplastics Alkylating Agents ClassAntineoplastics Antineoplastics Altretamine no Manufacturer DiscontinuedAntineoplastics Antineoplastics Chlorambucil noAntineoplastics Mechlorethamine Hydrochloride no



Antineoplastics Melphalan noAntineoplastics Antineoplastics Lomustine noAntineoplastics Antineoplastics Busulfan noAntineoplastics Cyclophosphamide noAntineoplastics Procarbazine Hydrochloride noAntineoplastics Temozolomide noAntineoplastics Trabectedin noAntineoplastics Antiandrogens ClassAntineoplastics Antineoplastics Apalutamide no

Daroflutamide New FDA approved, 7/30/19Antineoplastics Enzalutamide noAntineoplastics Bicalutamide noAntineoplastics Flutamide noAntineoplastics Nilutamide noAntineoplastics Antineoplastics Abiraterone Acetate noAntineoplastics Antiangiogenic Agents ClassAntineoplastics Lenalidomide noAntineoplastics Pomalidomide noAntineoplastics Thalidomide noAntineoplastics Antiestrogens/Modifiers ClassAntineoplastics Antineoplastics Estramustine Phosphate Sodium no

Antineoplastics Fulvestrant noAntineoplastics Antineoplastics Tamoxifen Citrate noAntineoplastics Toremifene Citrate no



Antineoplastics Antimetabolites ClassAntineoplastics Antineoplastics Capecitabine noAntineoplastics Mercaptopurine noAntineoplastics Thioguanine noAntineoplastics Antineoplastics Hydroxyurea noAntineoplastics Aromatase Inhibitors, 3rd

Generation Class

Antineoplastics Anastrozole noAntineoplastics Exemestane noAntineoplastics Letrozole noAntineoplastics Enzyme Inhibitors ClassAntineoplastics Etoposide noAntineoplastics Topotecan noAntineoplastics Molecular Target Inhibitors Class

Antineoplastics Gefitinib noAntineoplastics Antineoplastics Binimetinib noAntineoplastics Cobimetinib Fumarate noAntineoplastics Antineoplastics Alectinib noAntineoplastics Brigatinib noAntineoplastics Ceritinib noAntineoplastics Crizotinib no

Lorlatinib no New FDA approved drug, 11/2/18Antineoplastics Antineoplastics Dabrafenib Mesylate noAntineoplastics Encorafenib noAntineoplastics Trametinib Dimethyl Sulfoxide no



Antineoplastics Vemurafenib noAntineoplastics Antineoplastics Acalabrutinib no New FDA approved drug,10/31/17 Antineoplastics Ibrutinib noAntineoplastics Antineoplastics Abemaciclib no New FDA approved drug, 09/28/17Antineoplastics Palbociclib noAntineoplastics Ribociclib no New FDA approved drug, 3/13/17Antineoplastics Antineoplastics Ramucirumab noAntineoplastics Antineoplastics Afatinib Dimaleate noAntineoplastics Dacomitinib noAntineoplastics Erlotinib Hydrochloride no

Neratinib no New FDA approved drug, 7/17/17Antineoplastics Osimertinib Mesylate no

Erdafitinib no New FDA approved drug, 4/12/19

Antineoplastics Glasdegib no New FDA approved drug, 11/21/18

Antineoplastics Sonidegib Phosphate noAntineoplastics Vismodegib noAntineoplastics Antineoplastics Ivosidenib no New FDA approved drug, 7/20/18Antineoplastics Antineoplastics Ruxolitinib Phosphate no New FDA approved drug, 05/24/19Antineoplastics

Cabazitaxel noAntineoplastics

Antineoplastics Everolimus no



Antineoplastics Antineoplastics Bosutinib Monohydrate noAntineoplastics Dasatinib noAntineoplastics Imatinib Mesylate noAntineoplastics Nilotinib Hydrochloride

Monohydrateno

Antineoplastics Ponatinib Hydrochloride noAntineoplastics Antineoplastics Lapatinib Ditosylate noAntineoplastics Axitinib noAntineoplastics Cabozantinib S-Malate no

EntrectinibAntineoplastics Lenvatinib Mesylate no

Pexidartinib New FDA approved drug 8/2/19Antineoplastics Pazopanib Hydrochloride noAntineoplastics Regorafenib noAntineoplastics Sorafenib Tosylate noAntineoplastics Sunitinib Malate noAntineoplastics Vandetanib noAntineoplastics

Gilteritinib no New FDA approved drug, 11/28/18Antineoplastics Midostaurin no

Larotrectinib no New FDA approved drug, 11/26/18

Antineoplastics Alpelisib no New FDA approved drug, 05/24/19

Antineoplastics Copanlisib no New FDA approved drug, 09/14/17Antineoplastics Duvelisib no New FDA approved drug, 09/24/18Antineoplastics Idelalisib noAntineoplastics Antineoplastics Niraparib no New FDA approved drug, 03/27/17



Antineoplastics Olaparib noAntineoplastics Rucaparib no New FDA approved drug, 12/19/16Antineoplastics Talazoparib no New FDA approved drug, 10/16/18Antineoplastics Antineoplastics Venetoclax noAntineoplastics Antineoplastics Belinostat noAntineoplastics Panobinostat Lactate noAntineoplastics Monoclonal Antibody/Antibody-

D C j t Class

Antineoplastics Moxetumomab Pasudotox no New FDA approved drug, 9/13/18Antineoplastics Antineoplastics Bevacizumab no

Mogamulizumab no New FDA approved drug 8/8/19

Antineoplastics Antineoplastics Blinatumomab noAntineoplastics Antineoplastics Daratumumab noAntineoplastics Antineoplastics Dinutuximab noAntineoplastics Antineoplastics Elotuzumab noAntineoplastics Antineoplastics Ipilimumab noAntineoplastics Antineoplastics Pertuzumab no

Trastuzumab/ Hyaluronidase no New FDA approved drug, 02/28/19Antineoplastics Antineoplastics Cetuximab noAntineoplastics



Antineoplastics Olaratumab noAntineoplastics Antineoplastics Atezolizumab noAntineoplastics Avelumab noAntineoplastics Cemiplimab noAntineoplastics Durvalumab noAntineoplastics Nivolumab noAntineoplastics Pembrolizumab noAntineoplastics Antineoplastics Obinutuzumab noAntineoplastics Ofatumumab noAntineoplastics Rituximab noAntineoplastics Rituximab/ Hyaluronidase yesAntineoplastics Antineoplastics Ado-Trastuzumab Emtansine noAntineoplastics Brentuximab Vedotin no

Gemtuzumab Ozogamicin no New FDA approved drug, 09/01/17 Antineoplastics Inotuzumab Ozogamicin no

Polatuzumab Vedotin no New FDA approved drug, 06/10/19Antineoplastics Retinoids ClassAntineoplastics Alitretinoin noAntineoplastics Bexarotene noAntineoplastics Tretinoin noAntineoplastics Treatment Adjuncts ClassAntineoplastics Allopurinol noAntineoplastics Mesna noAntineoplastics Rasburicase noAntineoplastics Antineoplastics, Other Class

Methotrexate no Additional placementPemetrexed Disodium no New FDA approved drug, 5/23/19



Antineoplastics Aldesleukin noAntineoplastics Asparaginase-erwinia no

Calaspargase Pegol no New FDA approved drug, 12/20/18Antineoplastics Denileukin Diftitox noAntineoplastics Enasidenib no New FDA approved drug, 08/01/17Antineoplastics Fludarabine Phosphate noAntineoplastics Ixazomib Citrate noAntineoplastics Letrozole/ Ribociclib yes New FDA approved drug, 05/04/17Antineoplastics Leucovorin no

Levoleucovorin Calcium no New FDA approved drug 10/19/18Antineoplastics Mitoxantrone Hydrochloride no

Permetrexed Disodium new FDA approved drug, 5/23/19Antineoplastics Pegaspargase no

Selinexor no New FDA approved drug, 7/3/19Tagraxofusp no New FDA approved drug, 12/21/18

Antineoplastics Trifluridine/ Tipiracil yes New FDA approved drug, 02/22/19Antineoplastics Vorinostat noAntiparasitics CatAntiparasitics Anthelmintics ClassAntiparasitics Albendazole noAntiparasitics Ivermectin noAntiparasitics Mebendazole noAntiparasitics Moxidectin noAntiparasitics Praziquantel no

Triclabendazole no New FDA approved drug 11/9/18Antiparasitics Antiprotozoals ClassAntiparasitics Antiparasitics Miltefosine noAntiparasitics



Antiparasitics Artemether/ Lumefantrine yesAntiparasitics Atovaquone/ Proguanil

Hydrochloride yes

Antiparasitics Chloroquine Phosphate noAntiparasitics Hydroxychloroquine Sulfate noAntiparasitics Mefloquine Hydrochloride noAntiparasitics Primaquine Phosphate noAntiparasitics Quinine Sulfate noAntiparasitics Tafenoquine Succinate no New FDA approved drug, 7/20/2018Antiparasitics Antiparasitics Atovaquone noAntiparasitics Benznidazole noAntiparasitics Nitazoxanide noAntiparasitics Pentamidine Isethionate noAntiparasitics Pyrimethamine noAntiparkinson Agents CatAntiparkinson Agents Anticholinergics ClassAntiparkinson Agents Benztropine Mesylate noAntiparkinson Agents Diphenhydramine Hydrochloride no

Antiparkinson Agents Trihexyphenidyl Hydrochloride noAntiparkinson Agents Dopamine Agonists ClassAntiparkinson Agents Apomorphine Hydrochloride noAntiparkinson Agents Bromocriptine Mesylate noAntiparkinson Agents Pramipexole Dihydrochloride noAntiparkinson Agents Ropinirole Hydrochloride noAntiparkinson Agents Rotigotine no



Antiparkinson Agents Dopamine Precursors/ L-Amino Acid Decarboxylase Inhibitors Dopamine Precursors and/or L-Amino Acid Decarboxylase Inhibitors

Class Renamed class to add specification

Antiparkinson Agents Carbidopa noAntiparkinson Agents Carbidopa/ Levodopa yes

Levodopa no New FDA approved drug, 12/21/18Antiparkinson Agents Monoamine Oxidase B (MAO-B)

Inhibitors Class

Antiparkinson Agents Rasagiline Mesylate noAntiparkinson Agents Safinamide no New FDA approved drug, 3/21/17Antiparkinson Agents Selegiline Hydrochloride noAntiparkinson Agents Antiparkinson Agents, Other ClassAntiparkinson Agents Carbidopa/ Levodopa/

E t yes

Antiparkinson Agents Carbidopa/ Levodopa/ Entacapone

Gap drug to include combination

Antiparkinson Agents Entacapone noAntiparkinson Agents Tolcapone noAntiparkinson Agents Antiparkinson Agents Amantadine Hydrochloride noAntipsychotics CatAntipsychotics 1st Generation/Typical ClassAntipsychotics Chlorpromazine Hydrochloride no

Antipsychotics Fluphenazine Hydrochloride noAntipsychotics Fluphenazine Decanoate noAntipsychotics Haloperidol noAntipsychotics Haloperidol Decanoate noAntipsychotics Loxapine Succinate noAntipsychotics Perphenazine no



Antipsychotics Pimozide noAntipsychotics Prochlorperazine Edisylate noAntipsychotics Prochlorperazine Maleate noAntipsychotics Thioridazine Hydrochloride noAntipsychotics Thiothixene Hydrochloride noAntipsychotics Trifluoperazine Hydrochloride noAntipsychotics 2nd Generation/Atypical ClassAntipsychotics Aripiprazole noAntipsychotics Asenapine noAntipsychotics Brexpiprazole noAntipsychotics Cariprazine Hydrochloride noAntipsychotics Iloperidone noAntipsychotics Lurasidone Hydrochloride noAntipsychotics Olanzapine noAntipsychotics Olanzapine Pamoate noAntipsychotics Pimavanserin Tartrate noAntipsychotics Quetiapine Fumarate noAntipsychotics Paliperidone noAntipsychotics Paliperidone Palmitate noAntipsychotics Risperidone noAntipsychotics Ziprasidone Hydrochloride noAntipsychotics Ziprasidone Mesylate noAntipsychotics Treatment-Resistant ClassAntipsychotics Clozapine noAntispasticity Agents CatAntispasticity Agents Baclofen noAntispasticity Agents Dantrolene Sodium noAntispasticity Agents Tizanidine Hydrochloride noAntivirals CatAntivirals Anti-cytomegalovirus (CMV) Agents Class



Antivirals Cidofovir noAntivirals Foscarnet Sodium noAntivirals Ganciclovir Sodium no

Letermovir no New FDA approved drug,11/08/17Antivirals Valganciclovir Hydrochloride noAntivirals Anti-hepatitis B (HBV) Agents ClassAntivirals Adefovir Dipivoxil noAntivirals Entecavir noAntivirals Lamivudine noAntivirals Ribavirin noAntivirals Tenofovir Alafenamide no New FDA approved drug, 11/10/16Antivirals Tenofovir Disoproxil Fumarate no

Interferon Alfa-2b, Recombinant no

Interferon Alfa-n3 noPeginterferon Alfa-2a noPeginterferon Alfa-2b no

Antivirals Anti-hepatitis C (HCV) Agents, Other

Class

Ribavirin no

Interferon Alfa-2b, Recombinant no

Interferon Alfa-n3 noPeginterferon Alfa-2a noPeginterferon Alfa-2b no

Anti-hepatitis C (HCV) Agents Direct Acting Agents

Class

Ribavirin no

Antivirals Daclatasvir no



Antivirals Sofosbuvir noAntivirals Antivirals Dasabuvir/ Ombitasvir/

Paritaprevir/ Ritonavir yes

Antivirals Elbasvir/ Grazoprevir yesAntivirals Glecaprevir/ Pibrentasvir yes New FDA approved drug, 08/03/17Antivirals Ledipasvir/ Sofosbuvir yesAntivirals Ombitasvir/ Paritaprevir/ Ritonavir yes

Antivirals Sofosbuvir/ Velpatasvir/ V il i

yesAntivirals Velpatasvir/ Sofosbuvir yesAntivirals Antiherpetic Agents ClassAntivirals Acyclovir noAntivirals Famciclovir noAntivirals Foscarnet Sodium noAntivirals Idoxuridine no Manufacturer DiscontinuedAntivirals Penciclovir Sodium noAntivirals Valacyclovir Hydrochloride noAntivirals Anti-HIV Agents, Non-nucleoside

Reverse Transcriptase Inhibitors (NNRTI)

Class

Antivirals Delavirdine Mesylate noAntivirals Doravirine noAntivirals Efavirenz noAntivirals Etravirine noAntivirals Nevirapine noAntivirals Rilpivirine Hydrochloride noAntivirals Anti-HIV Agents, Nucleoside and

Nucleotide Reverse Transcriptase Inhibitors (NRTI)

Class



Antivirals Abacavir Sulfate noAntivirals Didanosine noAntivirals Emtricitabine noAntivirals Lamivudine noAntivirals Stavudine noAntivirals Tenofovir Disoproxil Fumarate noAntivirals Zidovudine noAntivirals Anti-HIV Agents, Protease Inhibitors

(PI) Class

Antivirals Atazanavir Sulfate noAntivirals Darunavir noAntivirals Fosamprenavir Calcium noAntivirals Indinavir Sulfate noAntivirals Nelfinavir Mesylate noAntivirals Ritonavir noAntivirals Saquinavir Mesylate noAntivirals Tipranavir noAntivirals Anti-HIV Agents, Integrase

Inhibitors (INSTI) Class

Antivirals Dolutegravir Sodium noAntivirals Raltegravir Potassium noAntivirals Anti-HIV Agents, Other ClassAntivirals Ibalizumab noAntivirals Antivirals Cobicistat noAntivirals Enfuvirtide noAntivirals Maraviroc noAntivirals Anti-HIV Combinations Class New class to add Anti-HIV combination drug productsAntivirals Abacavir Sulfate/ Lamivudine yesAntivirals Abacavir Sulfate/ Lamivudine/

Zidovudine yes



Antivirals Abacavir/ Dolutegravir/ L i di

yesAntivirals Atazanavir/ Cobicistat yesAntivirals Bictegravir/ Emtricitabine/

Tenofovir Alafenamide yes

Antivirals Darunavir/ Cobicistat yesAntivirals Darunavir/ Cobicistat/

Emtricitabine/ Tenofovir Alafenamide Fumarate

yes

Dolutegravir/ Lamivudine yes New FDA approved drug, 4/8/19

Antivirals Dolutegravir/ Rilpivirine yesAntivirals Doravirine/ Lamivudine/ Tenofovir

Disproxil Fumarate yes

Antivirals Efavirenz/ Emtricitabine/ Tenofovir Disoproxil Fumarate

yes

Antivirals Efavirenz/ Lamivudine/ Tenofovir Disoproxil Fumarate

yes

Antivirals Elvitegravir/ Cobicistat/ Emtricitabine/ Tenofovir Alafenamide Fumarate

yes

Antivirals Elvitegravir/ Cobicistat/ Emtricitabine/ Tenofovir Disoproxil Fumarate

yes

Antivirals Emtricitabine/ Rilpivirine / Tenofovir Disoproxil Fumarate

yes

Antivirals Emtricitabine/ Rilpivirine/ Tenofovir Alafenamide Fumarate

yes

Antivirals Emtricitabine/ Tenofovir Alafenamide Fumarate

yes

Antivirals Emtricitabine/ Tenofovir Disoproxil Fumarate

yes



Antivirals Lamivudine/ Tenofovir Disoproxil Fumarate

yes

Antivirals Lamivudine/ Zidovudine yesAntivirals Lopinavir/ Ritonavir yesAntivirals Anti-influenza Agents ClassAntivirals Amantadine Hydrochloride noAntivirals Baloxavir Marboxil noAntivirals Oseltamivir Phosphate noAntivirals Peramivir noAntivirals Rimantadine Hydrochloride noAntivirals Zanamivir noAnxiolytics CatAnxiolytics SSRIs/SNRIs (Selective Serotonin

Reuptake Inhibitors/ Serotonin and Norepinephrine Reuptake Inhibitors)

Class

Anxiolytics Duloxetine Hydrochloride noAnxiolytics Escitalopram Oxalate noAnxiolytics Paroxetine Hydrochloride noAnxiolytics Sertraline Hydrochloride noAnxiolytics Venlafaxine Hydrochloride noAnxiolytics Benzodiazepines ClassAnxiolytics Alprazolam noAnxiolytics Chlordiazepoxide noAnxiolytics Clonazepam noAnxiolytics Clorazepate Dipotassium noAnxiolytics Diazepam noAnxiolytics Lorazepam noAnxiolytics Oxazepam noAnxiolytics Anxiolytics, Other Class



Anxiolytics Buspirone Hydrochloride noAnxiolytics Doxepin Hydrochloride noAnxiolytics Hydroxyzine Hydrochloride noAnxiolytics Hydroxyzine Pamoate noAnxiolytics Meprobamate noBipolar Agents CatBipolar Agents Mood Stabilizers ClassBipolar Agents Carbamazepine noBipolar Agents Divalproex Sodium noBipolar Agents Lamotrigine noBipolar Agents Lithium Carbonate noBipolar Agents Valproic Acid noBipolar Agents Bipolar Agents, Other ClassBipolar Agents Aripiprazole noBipolar Agents Asenapine noBipolar Agents Olanzapine noBipolar Agents Olanzapine Pamoate noBipolar Agents Quetiapine Fumarate noBipolar Agents Risperidone noBipolar Agents Ziprasidone Hydrochloride noBipolar Agents Ziprasidone Mesylate noBlood Glucose Regulators Cat

Blood Glucose Regulators Antidiabetic Agents Class

Blood Glucose Regulators

Blood Glucose Regulators Metformin Hydrochloride no




Blood Glucose Regulators Alogliptin no

Blood Glucose Regulators Linagliptin no

Blood Glucose Regulators Saxagliptin no

Blood Glucose Regulators Sitagliptin Phosphate no

Blood Glucose Regulators Blood Glucose Regulators Albiglutide no

Blood Glucose Regulators Dulaglutide no

Blood Glucose Regulators Exenatide no

Blood Glucose Regulators Liraglutide no

Blood Glucose Regulators Lixisenatide no

Blood Glucose Regulators Semaglutide no


Blood Glucose Regulators Canagliflozin no

Blood Glucose Regulators Dapagliflozin no

Blood Glucose Regulators Ertugliflozin no New FDA approved drug 12/19/17

Blood Glucose Regulators Empagliflozin no




Blood Glucose Regulators Chlorpropamide no Manufacturer Discontinued

Blood Glucose Regulators Glimepiride no

Blood Glucose Regulators Glipizide no

Blood Glucose Regulators Glyburide no

Blood Glucose Regulators Tolazamide no

Blood Glucose Regulators Tolbutamide no


Blood Glucose Regulators Pioglitazone Hydrochloride no

Blood Glucose Regulators Rosiglitazone Maleate no


Blood Glucose Regulators Acarbose no

Blood Glucose Regulators Miglitol no


Blood Glucose Regulators Nateglinide no



Blood Glucose Regulators Repaglinide no

Blood Glucose Regulators Pramlintide Acetate no

Blood Glucose Regulators Colesevelam Hydrochloride no

Blood Glucose Regulators Bromocriptine Mesylate no

Blood Glucose Regulators Antidiabetic Combinations Class New class to add antidiabetic combination drug products

Blood Glucose Regulators Alogliptin Benzoate/ Pioglitazone Hydrochloride

yes

Blood Glucose Regulators Alogliptin/ Metformin H d hl id

yesBlood Glucose Regulators Canagliflozin/ Metformin

Hydrochloride yes

Blood Glucose Regulators Dapagliflozin/ Metformin Hydrochloride

yes

Blood Glucose Regulators Dapagliflozin/ Saxagliptin yesDapagliflozin/ Saxagliptin/ Metformin Hydrochloride

yes New FDA approved drug, 5/2/19

Blood Glucose Regulators Empagliflozin/ Linagliptin yesBlood Glucose Regulators Empagliflozin/ Metformin

Hydrochloride yes New FDA approved drug,12/9/16

Blood Glucose Regulators Ertugliflozin/ Metformin H d hl id

yes New FDA approved drug,12/19/17Blood Glucose Regulators Ertugliflozin/ Sitagliptin yes New FDA approved drug, 12/19/17Blood Glucose Regulators Glipizide/ Metformin Hydrochloride yesBlood Glucose Regulators Glyburide/ Metformin

H d hl id yes

Blood Glucose Regulators Insulin Degludec/ Liraglutide yesBlood Glucose Regulators Insulin Glargine/ Lixisenatide yes



Blood Glucose Regulators Linagliptin/ Metformin H d hl id

yesBlood Glucose Regulators Pioglitazone Hydrochloride/

Glimepiride yes

Blood Glucose Regulators Pioglitazone Hydrochloride/ Metformin Hydrochloride

yes

Blood Glucose Regulators Repaglinide/ Metformin Hydrochloride

yes

Blood Glucose Regulators Saxagliptin/ Metformin H d hl id

yesBlood Glucose Regulators Sitagliptin/ Metformin

H d hl id yes

Blood Glucose Regulators Glycemic Agents Class

Blood Glucose Regulators Diazoxide no

Blood Glucose Regulators Glucagon no

Blood Glucose Regulators Insulins Class


Blood Glucose Regulators Insulin Aspart no

Blood Glucose Regulators Insulin Glulisine no

Blood Glucose Regulators Insulin Lispro no


Blood Glucose Regulators Insulin Human (Regular) no




Blood Glucose Regulators Isophane Insulin (Human) no


Blood Glucose Regulators Insulin Degludec no

Blood Glucose Regulators Insulin Detemir no

Blood Glucose Regulators Insulin Glargine no


Blood Glucose Regulators Insulin Aspart/ Insulin Degludec yes

Blood Glucose Regulators Insulin Aspart Rapid-acting/ Insulin Aspart Protamine

yes

Blood Glucose Regulators Insulin Lispro Rapid-acting/ Insulin Lispro Protamine

yes

Blood Glucose Regulators Insulin Human Regular/ Isophane Insulin

yes

Blood Products/ Modifiers/ Volume Expanders Blood Products and Modifiers

Cat Renamed category to remove, "Volume Expanders" since drugs that are volume expanders also modify blood products.

Blood Products and Modifiers

Anticoagulants Class


Blood Products and M difi

Dabigatran Etexilate Mesylate no




Desirudin no Manufacturer Discontinued



Apixaban no


Betrixaban no N


Rivaroxaban no


Edoxaban Tosylate no



Fondaparinux Sodium no



Heparin, porcine no



Dalteparin Sodium no


Enoxaparin Sodium no



Vorapaxar Sulfate no





Warfarin Sodium no


Hemostasis Agents Class



Tranexamic Acid no



6-Aminocaproic Acid no


Platelet Modifying Agents Class



Clopidogrel Bisulfate no


Prasugrel Hydrochloride no


Ticlopidine Hydrochloride no


Ticagrelor no

Aspirin noAvatrombopag no New FDA approve drug, 05/21/18Caplacizumab no New FDA approved drug, 02/06/19Cilostazol no



Dipyridamole noAspirin/ Dipyridamole yesFostamatinib no New FDA approved drug, 04/17/2018

Blood Formation Modifiers Blood Products and Modifiers, Other

Class Renamed class to "Blood Products and Modifiers, Other" to encompass additional drugs

Filgrastim noPegfilgrastim noSargramostim no Darbepoetin Alfa noEpoetin Alfa noMethoxy polyethylene glycol-epoetin beta

no

Anagrelide no Eltrombopag Olamine noLusutrombopag no New FDA approved drug, 07/31/2018Romiplostim no Plerixafor no

Cardiovascular Agents CatAlpha-adrenergic Agonists Class

Clonidine Hydrochloride noDroxidopa noGuanfacine Hydrochloride noMethyldopa noMethyldopate Hydrochloride no Manufacturer DiscontinuedMidodrine Hydrochloride no



Phenylephrine Hydrochloride noAlpha-adrenergic Blocking Agents Class

Doxazosin Mesylate noPhenoxybenzamine Hydrochloride no

Prazosin Hydrochloride noTerazosin Hydrochloride no

Angiotensin-converting Enzyme (ACE) Inhibitors

Class

Benazepril Hydrochloride noCaptopril noEnalapril Maleate noFosinopril Sodium noLisinopril noMoexipril Hydrochloride noPerindopril Erbumine noQuinapril Hydrochloride noRamipril noTrandolapril no

Angiotensin II Receptor Antagonists class

Azilsartan Medoxomil noCandesartan Cilexetil noEprosartan Mesylate noIrbesartan noLosartan Potassium noOlmesartan Medoxomil noTelmisartan noValsartan no

Antiarrhythmics class



Disopyramide Phosphate noFlecainide Acetate noMexiletine Hydrochloride noPropafenone Hydrochloride noQuinidine Sulfate no Acebutolol no Added example drug due to antiarrhythmic indicationPropranolol no Added example drug due to antiarrhythmic indication Amiodarone Hydrochloride noDofetilide noDronedarone noSotalol Hydrochloride no Diltiazem no Added example drug due to antiarrhythmic indicationVerapamil no Added example drug due to antiarrhythmic indication Digoxin no Added example drug due to antiarrhythmic indication

Beta-adrenergic Blocking Agents class

Atenolol noBetaxolol Hydrochloride noBisoprolol Fumarate noMetoprolol Succinate noMetoprolol Tartrate noNebivolol Hydrochloride no Nadolol noPropranolol Hydrochloride no



Timolol Maleate no Acebutolol Hydrochloride noCarteolol no Removed example drug due to dosage form, ophthalmic

solution. Additional placement in USP Category, "Ophthalmic Agents"

Pindolol noCarvedilol Phosphate noLabetalol Hydrochloride no

Calcium Channel Blocking Agents class Removed class and replaced with 2 new USP Classes, "Calcium Channel-Blocking Agents, Dihydropyridines," and "Calcium Channel Blocking Agents, Nondihydropyridines"

Amlodipine Besylate noFelodipine noIsradipine noNicardipine Hydrochloride noNifedipine noNimodipine noNisoldipine no

Diltiazem Hydrochloride noVerapamil Hydrochloride no

Calcium Channel Blocking Agents, Dihydropyridines

class New Class to provide therapeutic distinction

Amlodipine Besylate noFelodipine noIsradipine noNicardipine Hydrochloride noNifedipine no



Nimodipine noNisoldipine no

Calcium Channel Blocking Agents, Nondihydropyridines

class New Class to provide therapeutic distinction

Diltiazem Hydrochloride noVerapamil Hydrochloride no

Diuretics, Carbonic Anhydrase Inhibitors

class Removed class due to limited relevance to cardiovascular agents.

Acetazolamide Sodium no Moved example drug to USP Class, "Cardiovascular Agents, Other". Additional placment in USP Category, "Ophthalmic Agents"

Methazolamide no Removed example drug due to indication. Additional placement in USP Category, "Ophthalmic Agents"

Diuretics, Loop classBumetanide noEthacrynate Sodium noEthacrynic Acid noFurosemide noTorsemide no

Diuretics, Potassium-sparing classAmiloride Hydrochloride noEplerenone noSpironolactone noTriamterene no

Diuretics, Thiazide classBendroflumethiazide no Manufacturer DiscontinuedChlorothiazide Sodium noChlorthalidone noHydrochlorothiazide noIndapamide noMethyclothiazide no



Metolazone noDyslipidemics, Fibric Acid Derivatives

class

Choline Fenofibrate noFenofibrate noFenofibric Acid noGemfibrozil no

Dyslipidemics, HMG CoA Reductase Inhibitors

class

Atorvastatin Calcium noFluvastatin Sodium noLovastatin noPitavastatin noPravastatin Sodium noRosuvastatin Calcium noSimvastatin no

Dyslipidemics, Other classCholestyramine noColesevelam Hydrochloride noColestipol Hydrochloride noEzetimibe noIcosapent Ethyl noLomitapide Mesylate noMipomersen Sodium no Manufacturer DiscontinuedNiacin noOmega-3-acid Ethyl Esters noOmega-3 Carboxylic Acids no Manufacturer Discontinued Ezetimibe/ Simvastatin yes Removed PG



Alirocumab no Example drug moved to new USP Class, "Dyslipidemics, PCSK9 Inhibitor."

Evolocumab no Example drug moved to new USP Class, "Dyslipidemics, PCSK9 Inhibitor."

Dyslipidemics, PCSK9 Inhibitor class New Class to provide therapeutic distinctionAlirocumab noEvolocumab no

Vasodilators, Direct-acting Arterial class Removed class, replaced with new USP Class, "Vasodilators"

Hydralazine Hydrochloride noMinoxidil no

Vasodilators, Direct-acting Arterial/Venous

class Removed class, replaced with new USP Class, "Vasodilators"

Isosorbide Dinitrate noIsosorbide Mononitrate noNitroglycerin no

Vasodilators class New USP class to consolidate two removed USP classes," Vasodilators, Direct-acting Arterial," and "Vasodilators, Direct-acting Arterial/Venous"

Hydralazine Hydrochloride noMinoxidil no Isosorbide Dinitrate noIsosorbide Mononitrate noNitroglycerin no

Cardiovascular Agents, Other Class Acetazolamide no Moved from deleted USP Class, "Diuretics, Carbonic

Anhydrase Inhibitors."Aliskiren Fumarate no



Digoxin noIvabradine Hydrochloride noMecamylamine Hydrochloride noPentoxifylline noRanolazine no

Cardiovascular Combinations Class New Class to add specificationAliskiren Hemifumarate/ Hydrochlorothiazide

yes

Amiloride Hydrochloride/ Hydrochlorothiazide

yes

Amlodipine Besylate/ Atorvastatin Calcium

yes

Amlodipine/ Benazepril Hydrochloride

yes

Amlodipine Besylate/ Celecoxib yes New FDA approved drug, 05/31/18

Amlodipine/ Olmesartan Medoxomil

yes

Amlodipine/ Valsartan yesAmlodipine/ Valsartan/ Hydrochlorothiazide

yes

Atenolol/ Chlorthalidone yesAzilsartan Kamedoxomil/ Chlorthalidone

yes

Benazepril Hydrochloride/ Hydrochlorothiazide

yes

Bisoprolol Fumarate/ Hydrochlorothiazide

yes

Candesartan Cilexetil/ Hydrochlorothiazide

yes

Captopril/ Hydrochlorothiazide yes



Enalapril Maleate/ Hydrochlorothiazide

yes

Ezetimibe/ Simvastatin yes Placed in Dyslipedmics, OtherFosinopril Sodium/ Hydrochlorothiazide

yes

Hydralazine Hydrochloride/ Isosorbide Dinitrate

yes

Irbesartan/ Hydrochlorothiazide yes

Lisinopril/ Hydrochlorothiazide yesLosartan Potassium/ Hydrochlorothiazide

yes

Methyldopa/ Hydrochlorothiazide yes

Metoprolol Succinate/ Hydrochlorothiazide

yes

Metoprolol Tartrate/ Hydrochlorothiazide

yes

Moexipril Hydrochloride/ Hydrochlorothiazide

yes

Nadolol/ Bendroflumethiazide yesNebivolol Hydrochloride/ Valsartan yes

Olmesartan Medoxmil/ Hydrochlorothiazide

yes

Olmesartan Medoxomil/ Amlodipine Besylate/ Hydrochlorothiazide

yes

Perindopril Arginine/ Amlodipine Besylate

yes



Propranolol Hydrochloride/ Hydrochlorothiazide

yes

Quinapril Hydrochloride/ Hydrochlorothiazide

yes

Sacubitril/ Valsartan yesSpironolactone/ Hydrochlorothiazide

yes

Telmisartan/ Amlodipine yesTelmisartan/ Hydrochlorothiazide yes

Trandolapril/ Verapamil Hydrochloride

yes

Triamterene/ Hydrochlorothiazide yes

Valsartan/ Hydrochlorothiazide yesCentral Nervous System Agents

Cat

Central Nervous System Agents

Attention Deficit Hyperactivity Disorder Agents, Amphetamines

Class


Amphetamine no


Dextroamphetamine Sulfate no


Dextroamphetamine Saccharate/ Amphetamine Aspartate/ Dextroamphetamine Sulfate/ Amphetamine Sulfate

yes





Lisdexamfetamine Dimesylate no


Methamphetamine Hydrochloride no


Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines

Class


Atomoxetine Hydrochloride no


Clonidine Hydrochloride no


Dexmethylphenidate Hydrochloride

no


Guanfacine Hydrochloride no


Methylphenidate Hydrochloride no


Fibromyalgia Agents Class


Duloxetine Hydrochloride no


Milnacipran Hydrochloride no


Pregabalin no

Multiple Sclerosis Agents Class Interferon Beta-1a noInterferon Beta-1b noPeginterferon Beta-1a no



Dalfampridine no Teriflunomide no Fingolimod Hydrochloride noSiponimod no New FDA approved drug, 3/26/19 Alemtuzumab noCladribine no New FDA approved drug, 3/29/19Dimethyl fumarate noGlatiramer Acetate noMitoxantrone Hydrochloride noNatalizumab noOcrelizumab noDaclizumab no Manufacturer Discontinued

Central Nervous System, Other ClassAmifampridine Phosphate no New FDA approved drug, 11/28/18Carbamazepine noDeutetrabenazine no New FDA approved drug, 04/03/17Dextromethorphan Hydrobromide/ Quinidine Sulfate

yes


Edaravone no


Gabapentin no


Gabapentin Enacarbil no


Tetrabenazine no




Riluzole no


Valbenazine no

Dental and Oral Agents CatDental and Oral Agents Cevimeline Hydrochloride noDental and Oral Agents Chlorhexidine Gluconate noDental and Oral Agents Doxycycline Hyclate noDental and Oral Agents Minocycline Hydrochloride noDental and Oral Agents Palifermin noDental and Oral Agents Pilocarpine Hydrochloride noDental and Oral Agents Prilocaine Hydrochloride noDental and Oral Agents Triamcinolone Acetonide noDermatological Agents CatDermatological Agents Acne and Rosacea Agents Class New class to add acne and rosacea agentsDermatological Agents Dermatological Agents Acitretin noDermatological Agents Adapalene noDermatological Agents Isotretinoin noDermatological Agents Tazarotene noDermatological Agents Tretinoin noDermatological Agents Dermatological Agents Azelaic Acid noDermatological Agents Brimonidine Tartrate noDermatological Agents Oxymetazoline noDermatological Agents Dermatological Agents Adapalene/ Benzoyl Peroxide yesDermatological Agents Clindamycin/ Benzoyl Peroxide yes

Dermatological Agents Clindamycin/ Tretinoin yes



Dermatological Agents Erythromycin/ Benzoyl Peroxide yes

Dermatological Agents Dermatitis and Pruritus Agents Class New class to add dermatitis and pruritus agentsDermatological Agents Dermatological Agents Alclometasone Dipropionate noDermatological Agents Clocortolone Pivalate noDermatological Agents Desonide noDermatological Agents Hydrocortisone noDermatological Agents Dermatological Agents Betamethasone Valerate noDermatological Agents Desoximetasone noDermatological Agents Fluocinolone Acetonide noDermatological Agents Flurandrenolide noDermatological Agents Fluticasone Propionate noDermatological Agents Hydrocortisone Butyrate noDermatological Agents Hydrocortisone Probutate noDermatological Agents Hydrocortisone Valerate noDermatological Agents Mometasone Furoate noDermatological Agents Triamcinolone Acetonide noDermatological Agents Dermatological Agents Amcinonide noDermatological Agents Betamethasone Dipropionate noDermatological Agents Desoximetasone noDermatological Agents Diflorasone Diacetate noDermatological Agents Fluocinolone Acetonide noDermatological Agents Fluocinonide noDermatological Agents Halcinonide noDermatological Agents Triamcinolone Acetonide noDermatological Agents Dermatological Agents Betamethasone Dipropionate noDermatological Agents Clobetasol Propionate no



Dermatological Agents Diflorasone Diacetate noDermatological Agents Halobetasol Propionate noDermatological Agents Dermatological Agents Ammonium Lactate noDermatological Agents Crisaborole no New FDA approved drug, 12/14/16Dermatological Agents Doxepin Hydrochloride noDermatological Agents Pimecrolimus noDermatological Agents Selenium Sulfide no

Tacrolimus noDermatological Agents Topical Anti-infectives Class New class to add topical anti-infectivesDermatological Agents Dermatological Agents Clindamycin Phosphate noDermatological Agents Erythromycin noDermatological Agents Benzoyl Peroxide noDermatological Agents Dapsone noDermatological Agents Ozenoxacin no New FDA approved drug, 12/11/17Dermatological Agents Dermatological Agents Butenafine Hydrochloride noDermatological Agents Ciclopirox Olamine noDermatological Agents Efinaconazole noDermatological Agents Ketoconazole noDermatological Agents Tavaborole noDermatological Agents Terbinafine Hydrochloride noDermatological Agents Dermatological Agents Acyclovir noDermatological Agents Penciclovir noDermatological Agents Pediculicides/Scabicides Class USP Class moved from USP Category, "Antiparasitics." Dermatological Agents Crotamiton noDermatological Agents Ivermectin noDermatological Agents Lindane noDermatological Agents Malathion no



Dermatological Agents Spinosad noDermatological Agents Dermatological Agents, Other Class New class to add miscellaneous dermatological agentsDermatological Agents Dermatological Agents AbobotulinumyoxinA noDermatological Agents Bimatoprost noDermatological Agents Deoxycholic Acid noDermatological Agents Eflornithine noDermatological Agents Finasteride noDermatological Agents Glycopyrronium noDermatological Agents OnabotulinumtoxinA no

PrabotulinumtoxinA no New FDA approved drug, 02/01/19Dermatological Agents Dermatological Agents Anthralin noDermatological Agents Apremilast noDermatological Agents Calcipotriene noDermatological Agents Calcitriol noDermatological Agents Methoxsalen noDermatological Agents Dermatological Agents Diclofenac Sodium noDermatological Agents Fluorouracil noDermatological Agents Imiquimod noDermatological Agents Ingenol mebutate noDermatological Agents Podofilox noDermatological Agents Sinecatechins noDermatological Agents Dermatological Agents Becaplermin noDermatological Agents Collagenase noDermatological Agents Silver Sulfadiazine noDermatological Agents Dermatological Agents Acyclovir/ Hydrocortisone yes



Dermatological Agents Calcipotriene/ Betamethasone Dipropionate

yes

Dermatological Agents Clotrimazole/ Betamethasone Dipropionate

yes

Dermatological Agents Fluocinolone Acetonide/ Hydroquinone/ Tretinoin

yes

Dermatological Agents Hydrocortisone Acetate/ Pramoxine Hydrochloride

yes

Dermatological Agents Neomycin/ Polymyxin B Sulfates/ Bacitracin Zinc/ Hydrocortisone

yes

Dermatological Agents Neomycin Sulfate/ Fluocinolone Acetonide

yes

Dermatological Agents Nystatin/ Triamcinolone Acetonide yes

Electrolytes/Minerals/Metals/ Vitamins

Cat

Electrolytes/Minerals/Metals/

Electrolyte/Mineral/Metal Modifiers Class



Deferasirox no


Deferiprone no



Penicillamine no


Succimer no




Tolvaptan no


Trientine Hydrochloride no



Prussian Blue no


Zinc Acetate no


Electrolyte/Mineral Replacement Class


Ammonium Chloride no


Carglumic Acid no


Chromic Chloride no


Citric Acid/ Potassium Citrate/ Sodium Citrate

yes


Fluoride Sodium no


Fluoride Stannous no


Magnesium Chloride no


Magnesium Sulfate no


Manganese Chloride no




Potassium Acetate no


Potassium Bicarbonate no


Potassium Chloride no


Potassium Citrate no


Potassium Gluconate no


Potassium Phosphates no

Electrolytes/Minerals/Metal/

Potassium Citrate/ Citric Acid yesElectrolytes/Minerals/Metal

/Potassium Citrate/ Sodium Citrate yes


Potassium Phosphate/ Sodium Phosphate

yes


Sodium Acetate no


Sodium Bicarbonate no


Sodium Lactate no


Sodium Chloride no


Sodium Ferric Gluconate Complex no


Phosphate Binders Class


Calcium Acetate no




Ferric Citrate no


Lanthanum Carbonate no


Sevelamer Hydrochloride no


Sodium Zirconium Cyclosilicate no


Sucroferric Oxyhydroxide no


Potassium Binders Class


Patiromer Sorbitex Calcium no


Sodium Polystyrene Sulfonate no


Vitamins Class


Prenatal no

Gastrointestinal Agents Cat

Gastrointestinal Agents Anti-Diarrheal Agents Class New class to add anti-diarrheal agents

Gastrointestinal Agents Alosetron Hydrochloride no

Gastrointestinal Agents Crofelemer no

Gastrointestinal Agents Eluxadoline no



Gastrointestinal Agents Loperamide Hydrochloride no

Rifamycin no New FDA approved drug, 11/16/18Gastrointestinal Agents Rifaximin no

Gastrointestinal Agents Telotristat Ethyl no New FDA approved drug, 02/28/17

Gastrointestinal Agents

Gastrointestinal Agents Difenoxin/ Atropine Sulfate yes

Gastrointestinal Agents Diphenoxylate Hydrochloride/ Atropine Sulfate

yes

Gastrointestinal Agents Antispasmodics, Gastrointestinal Class

Gastrointestinal Agents Dicyclomine Hydrochloride no

Gastrointestinal Agents Glycopyrrolate no

Gastrointestinal Agents Mepenzolate Bromide no Manufacturer Discontinued

Gastrointestinal Agents Methscopolamine Bromide no

Gastrointestinal Agents Scopolamine no

Gastrointestinal Agents Anti-Constipation Agents Class New class to add anti-constipation agents


Gastrointestinal Agents Lactulose no



Gastrointestinal Agents Polyethylene Glycol 3350 NF no

Te Tenaparor New FDA approved drug, 09/12/19Gastrointestinal Agents

Gastrointestinal Agents Lubiprostone no

Gastrointestinal Agents Methylnaltrexone no

Gastrointestinal Agents Naloxegol Oxalate no

Gastrointestinal Agents Naldemedine no


Gastrointestinal Agents Linaclotide no

Gastrointestinal Agents Plecanatide no New FDA approved drug,1/19/17

Prucalopride no New FDA approved drug, 12/14/18Gastrointestinal Agents Histamine2 (H2) Receptor

Antagonists Class

Gastrointestinal Agents Cimetidine Hydrochloride no

Gastrointestinal Agents Famotidine no

Gastrointestinal Agents Nizatidine no

Gastrointestinal Agents Ranitidine Hydrochloride no



Irritable Bowel Syndrome Agents Class Removed class due to broaden class name to effect rather than disease state. Example drugs moved to new classes, Anti-Diarrheal agents and Anti-Constipation Agents.

Laxatives Class Removed class to broaden class name to Anti-Constipation Agents.

Gastrointestinal Agents Protectants Class

Gastrointestinal Agents Misoprostol no

Gastrointestinal Agents Sucralfate no

Gastrointestinal Agents Proton Pump Inhibitors Class

Gastrointestinal Agents Dexlansoprazole no

Gastrointestinal Agents Esomeprazole Magnesium no

Strontium noGastrointestinal Agents Lansoprazole no

Gastrointestinal Agents Omeprazole no

Gastrointestinal Agents Omeprazole/ Sodium Bicarbonate yes

Gastrointestinal Agents Pantoprazole Sodium no

Gastrointestinal Agents Rabeprazole Sodium no

Gastrointestinal Agents Gastrointestinal Agents, Other Class



Gastrointestinal Agents Alvimopan no

Gastrointestinal Agents Bezlotoxumab no

Gastrointestinal Agents Chenodiol no

Gastrointestinal Agents Metoclopramide no

Gastrointestinal Agents Metreleptin no

Gastrointestinal Agents Rifaximin no

Gastrointestinal Agents Ursodiol no

Moved PGBismuth Subcitrate Potassium/ Metronidazole/ Tetracycline Hydrochloride

yes Example drug incorporated to account for combinations

Lansoprazole/ Amoxicillin/ Clarithromycin


Omeprazole/ Clarithromycin/ Amoxicillin



Gastrointestinal Agents Glutamine no

Gastrointestinal Agents Somatropin no

Gastrointestinal Agents Teduglutide no




Gastrointestinal Agents Polyethylene Glycol 3350/ Sodium Chloride/ Potassium Chloride/ Sodium Bicarbonate/ Sodium Sulfate

yes

Gastrointestinal Agents Polyethylene Glycol 3350/ Sodium Chloride/ Sodium Bicarbonate/ Potassium Chloride

yes

Gastrointestinal Agents Polyethylene Glycol 3350/ Sodium Chloride/ Sodium Bicarbonate/ Potassium Chloride/ Bisacodyl

yes

Gastrointestinal Agents Polyethylene Glycol 3350/ Sodium Sulfate/ Sodium Chloride/ Potassium Chloride/ Ascorbic Acid/ Sodium Ascorbate

yes

Gastrointestinal Agents Sodium Picosulfate/ Magnesium Oxide/ Anhydrous Citric Acid

yes

Genetic or Enzyme Disorder: Replacement, Modifiers, Treatment

Cat

Genetic or Enzyme Disorder


Inotersen no


Patisiran no



Tafamidis no New FDA approved drug, 5/3/19Tafamidis Meglumine no New FDA approved drug, 5/3/19



Burosumab no


Genetic or Enzyme Di d

Alpha-1 Proteinase Inhibitor, H

noGenetic or Enzyme Disorder


Cerliponase alfa no



Cholic Acid no



Cysteamine Bitartrate no



Eteplirsen no



Agalsidase Beta no




Migalastat Hydrochloride no



Imiglucerase no


Taliglucerase Alfa no


Velaglucerase Alfa no



Eliglustat no


Miglustat no




Nitisinone no



Betaine Hydrochloride no



Idursulfase no





Dichlorphenamide no



Asfotase Alfa no



Sebelipase Alfa no




Galsulfase no


Laronidase no


Elosulfase Alfa no



Pancrelipase no



Pegvaliase no New FDA approved drug, 05/24/18




Sapropterin Dihydrochloride no



Elapegademase no New FDA approved drug, 10/05/18


Pegademase Bovine no



Glutamine no



Sacrosidase no



Sodium Phenylbutyrate no


Glycerol Phenylbutyrate no


Obeticholic Acid no

Genitourinary Agents CatGenitourinary Agents Antispasmodics, Urinary ClassGenitourinary Agents Genitourinary Agents Mirabegron no New FDA approved drug, 10/12/18Genitourinary Agents Genitourinary Agents Darifenacin Hydrobromide no



Genitourinary Agents Fesoterodine Fumarate noGenitourinary Agents Flavoxate Hydrochloride noGenitourinary Agents Oxybutynin Chloride noGenitourinary Agents Solifenacin Succinate noGenitourinary Agents Tolterodine Tartrate noGenitourinary Agents Trospium Chloride noGenitourinary Agents Benign Prostatic Hypertrophy

Agents Class

Genitourinary Agents Genitourinary Agents Alfuzosin Hydrochloride noGenitourinary Agents Doxazosin Mesylate noGenitourinary Agents Prazosin Hydrochloride noGenitourinary Agents Silodosin noGenitourinary Agents Tamsulosin Hydrochloride noGenitourinary Agents Terazosin Hydrochloride noGenitourinary Agents Genitourinary Agents Dutasteride noGenitourinary Agents Dutasteride/ Tamsulosin

Hydrochloride yes

Genitourinary Agents Finasteride noGenitourinary Agents Genitourinary Agents Tadalafil noGenitourinary Agents Genitourinary Agents, Other ClassGenitourinary Agents Bethanechol noGenitourinary Agents Penicillamine noGenitourinary Agents Pentosan Polysulfate Sodium noHormonal Agents, Stimulant/ Replacement/ Modifying (Adrenal)

Cat

Hormonal



Hormonal Corticotropin noHormonal Hormonal Betamethasone Acetate/

Betamethasone Sodium Phosphate

yes

Hormonal Budesonide noHormonal Cortisone Acetate noHormonal Deflazacort no New FDA approved drug, 2/9/17Hormonal Dexamethasone Acetate noHormonal Dexamethasone Sodium

Phosphateno

Hormonal Hydrocortisone Acetate noHormonal Hydrocortisone Sodium Succinate noHormonal Methylprednisolone Acetate noHormonal Methylprednisolone Sodium

S i tno

Hormonal Prednisolone Acetate noHormonal Prednisolone Sodium Phosphate no

Hormonal Prednisone noHormonal Triamcinolone Acetonide noHormonal Triamcinolone Diacetate no Manufacturer DiscontinuedHormonal Triamcinolone Hexacetonide noHormonal Hormonal Fludrocortisone Acetate noHormonal Agents, Stimulant/Replacement/ Modifying (Pituitary)

Cat

Hormonal Hormonal Chorionic Gonadotropin noHormonal Choriogonadotropin Alfa noHormonal



Hormonal Somatropin, Recombinant noHormonal Tesamorelin Acetate noHormonal Hormonal Mecasermin Rinfabate noHormonal Hormonal Desmopressin Acetate noHormonal noHormonal Agents, Stimulant/ Replacement/ Modifying (Prostaglandins)

Cat

Hormonal Alprostadil noHormonal Carboprost Tromethamine noHormonal Misoprostol noHormonal Agents, Stimulant/ Replacement/ Modifying (Sex Hormones/ Modifiers)

Cat

Hormonal Anabolic Steroids ClassHormonal Oxandrolone noHormonal Oxymetholone noHormonal Androgens ClassHormonal Danazol noHormonal Fluoxymesterone noHormonal Methyltestosterone noHormonal Testosterone Cypionate noHormonal Testosterone Enanthate noHormonal Estrogens ClassHormonal Estradiol Acetate no



Hormonal Estradiol Cypionate noHormonal Estradiol Valerate noHormonal Conjugated Estrogens noHormonal Esterified Estrogens noHormonal Estropipate noHormonal Ethinyl Estradiol no

Progesterone Agonists/Antagonists Class Removed class, example drug not FRF eligible

UlipristalHormonal Progestins ClassHormonal Hydroxyprogesterone Caproate no

Hormonal Levonorgestrel noHormonal Medroxyprogesterone Acetate noHormonal Megestrol Acetate noHormonal Norethindrone Acetate noHormonal Progesterone noHormonal Selective Estrogen Receptor

M dif i A t Class

Hormonal Conjugated Estrogens/ B d if

yesHormonal noHormonal Raloxifene Hydrochloride noHormonal Ospemifene noHormonal Hormonal Agents, Stimulant/

Replacement/ Modifying (Sex Hormones/ Modifiers), Other

Class New class to add combination drug products

Hormonal Estradiol/ Norgestimate yesHormonal Estradiol/ Levonorgestrel yesHormonal Estradiol/ Norethindrone Acetate yes

Estradiol/ Progesterone no New FDA approved drug, 10/28/18



Hormonal Agents, Stimulant/Replacement/ Modifying (Thyroid)

Cat

Hormonal Levothyroxine Sodium noHormonal Liothyronine Sodium noHormonal Liotrix no Manufacturer DiscontinuedHormonal Agents, Suppressant (Adrenal)

Cat

Hormonal Mitotane noHormonal Agents, Suppressant (Pituitary)

Cat

Hormonal Hormonal Bromocriptine Mesylate noHormonal Cabergoline noHormonal Hormonal Goserelin Acetate noHormonal Leuprolide Acetate noHormonal Nafarelin Acetate noHormonal Triptorelin Pamoate noHormonal Hormonal Degarelix Acetate noHormonal Elagolix noHormonal Hormonal Pegvisomant noHormonal Hormonal Lanreotide Acetate noHormonal Octreotide Acetate noHormonal Pasireotide Diaspartate noHormonal Pamoate noHormonal Agents, Suppressant (Thyroid)

Cat



Hormonal Antithyroid Agents ClassHormonal Methimazole noHormonal Propylthiouracil noImmunological Agents CatImmunological Agents Angioedema Agents ClassImmunological Agents Immunological Agents Icatibant Acetate noImmunological Agents Immunological Agents C1 esterase inhibitor (human) noImmunological Agents C1 esterase inhibitor

( bi t) no

Immunological Agents Immunological Agents Lanadelumab noImmunological Agents Immune Suppressants ClassImmunological AgentsImmunological Agents Mycophenolic Acid noImmunological AgentsImmunological Agents Tacrolimus noImmunological Agents Cyclosporine noImmunological AgentsImmunological Agents Baricitinib no New FDA approved drug, 05/31/18Immunological Agents Tofacitinib Citrate noImmunological AgentsImmunological Agents Sirolimus noImmunological AgentsImmunological Agents Mercaptopurine noImmunological Agents Abatacept noImmunological Agents Anakinra noImmunological Agents Belatacept noImmunological Agents Everolimus noImmunological Agents Methotrexate Sodium noImmunological Agents Pimecrolimus no



Immunological AgentsImmunological Agents Azathioprine noImmunological AgentsImmunological Agents Adalimumab noImmunological Agents Certolizumab Pegol noImmunological Agents Etanercept noImmunological Agents Golimumab noImmunological Agents Infliximab no

Class

Anti-thymocyte Globulin noImmune Globulin Intramuscular (Human)

no

Immune Globulin Intravenous (Human)

no

ClassImmunological AgentsImmunological Agents Belimumab noImmunological AgentsImmunological Agents Interferon Gamma-1b,

Recombinantno

Immunological AgentsImmunological Agents Brodalumab no New FDA approved drug, 02/15/19Immunological Agents Canakinumab noImmunological Agents Dupilumab noImmunological Agents Guselkumab noImmunological Agents Ixekizumab noImmunological Agents Rilonacept noImmunological Agents Risankizumab no New FDA approved drug, 04/23/19Immunological Agents Sarilumab noImmunological Agents Secukinumab no



Immunological Agents Siltuximab noTildrakizumab no New FDA approved drug, 03/20/18Tocilizumab no

Auranofin noApremilast noEculizumab no

Immunological Agents Emapalumab no New FDA approved drug, 11/20/18Immunological Agents Leflunomide noImmunological Agents Natalizumab noImmunological Agents Omalizumab noImmunological Agents Ravulizumab no New FDA approved drug, 12/21/18Immunological Agents Vedolizumab noImmunological AgentsImmunological Agents Sweet Vernal/ Orchard/ Perennial

Rye/ Timothy/ Kentucky Blue Grass Mixed Pollens Allergen Extract

yes

Immunological Agents Vaccines ClassImmunological Agents Immunological Agents Adenovirus Type 4 and Type 7

Vaccine Live Oral yes

Immunological Agents Anthrax Vaccine Adsorbed noImmunological Agents Immunological Agents Cholera Vaccine Live Oral noImmunological Agents Immunological Agents Diphtheria and Tetanus Toxoids

and Acellular Pertussis Vaccine Adsorbed (DTaP)

yes



Immunological Agents Tetanus and Diphtheria Toxoids Adsorbed (Td)

yes

Immunological Agents Diphtheria and Tetanus Toxoids Adsorbed (DT)

yes

Immunological Agents Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap)

yes

Diphtheria and Tetanus Toxoids and Acellular Pertussis Absorbed and Inactivated Poliovirus (DTaP-IPV) Vaccine

yes

Immunological Agents Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine (DTaP-HepB-IPV)

yes

Immunological Agents Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed, Inactivated Poliovirus and Haemophilus B Conjugate (Tetanus Toxoid Conjugate) (DTaP-IPV/Hib)

yes

Immunological Agents Haemophilus B Conjugate Vaccine (Tetanus Toxoid Conjugate)

no




yes

Immunological Agents Immunological Agents Hepatitis A Vaccine noImmunological Agents Hepatitis A and Hepatitis B

(Recombinant) Vaccine yes

Immunological Agents Immunological Agents Hepatitis B Virus Vaccine

Recombinant no


yes

Immunological Agents Hepatitis A and Hepatitis B (Recombinant) Vaccine

yes

Immunological Agents Immunological Agents Human Papillomavirus

Quadrivalent (types 6, 11, 16 and 18) Vaccine Recombinant

yes

Immunological Agents Immunological Agents Influenza Vaccine no

Influenza Vaccine Live noImmunological Agents



Immunological Agents Japanese Encephalitis Virus, Inactivated, Adsorbed

no

Immunological Agents Immunological Agents Measles, Mumps, and Rubella

Virus Vaccine Live yes

Immunological Agents Measles, Mumps, Rubella, and Varicella Virus Vaccine Live

yes

Immunological Agents Immunological Agents Meningococcal Groups (A, C, Y,

and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine

yes

Immunological Agents Meningococcal Group B Vaccine no

Immunological Agents Immunological Agents Measles, Mumps, and Rubella



yes

Immunological Agents Immunological Agents Diphtheria and Tetanus Toxoids

and Acellular Pertussis Vaccine Adsorbed (DTaP)

yes

Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap)

yes



Immunological Agents Diphtheria and Tetanus Toxoids and Acellular Pertussis Absorbed and Inactivated Poliovirus (DTaP-IPV) Vaccine

yes


yes


yes

Immunological Agents Pneumococcal 13-Valent

Conjugate Vaccine no

Immunological Agents Pneumococcal Vaccine Polyvalent no

Immunological Agents Immunological Agents Poliovirus Vaccine Inactivated noImmunological Agents Diphtheria and Tetanus Toxoids

and Acellular Pertussis Absorbed and Inactivated Poliovirus (DTaP-IPV) Vaccine

yes




yes

Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed, Inactivated Poliovirus and Haemophilus B Conjugate (Tetanus Toxoid Conjugate) (DTaP-IPV/Hib)

yes

Immunological Agents Immunological Agents Rabies Vaccine noImmunological Agents Immunological Agents Rotavirus Vaccine Live noImmunological Agents Immunological Agents Measles, Mumps, and Rubella



yes

Immunological Agents Immunological Agents Zoster Vaccine Live noImmunological Agents Zoster Vaccine Recombinant,

Adjuvanted no

Immunological Agents Varicella Virus Vaccine Live noImmunological Agents



Immunological Agents Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed (DTaP)

yes

Tetanus and Diphtheria Toxoids Adsorbed (Td)

yes

Immunological Agents Diphtheria and Tetanus Toxoids Adsorbed (DT)

yes

Immunological Agents Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap)

yes

Immunological Agents Diphtheria and Tetanus Toxoids and Acellular Pertussis Absorbed and Inactivated Poliovirus (DTaP-IPV) Vaccine

yes


yes


yes



BCG vaccine no Typhoid Vaccine Live Oral noTyphoid Vi Polysaccharide Vaccine

no

Varicella Virus Vaccine Live noMeasles, Mumps, Rubella, and Varicella Virus Vaccine Live

yes

Immunological Agents Yellow Fever Vaccine noInflammatory Bowel Disease Agents

Cat

Inflammatory Bowel Glucocorticoids ClassInflammatory Bowel Budesonide noInflammatory Bowel Cortisone Acetate noInflammatory Bowel Dexamethasone Acetate noInflammatory Bowel Dexamethasone Sodium

Phosphateno

Inflammatory Bowel Hydrocortisone Sodium Succinate noInflammatory Bowel Methylprednisolone Acetate noInflammatory Bowel Methylprednisolone Sodium

S i tno

Inflammatory Bowel Prednisolone Acetate noInflammatory Bowel Prednisolone Sodium Succinate noInflammatory Bowel Prednisone noInflammatory Bowel Triamcinolone Acetonide noInflammatory Bowel Triamcinolone Diacetate no



Inflammatory Bowel Aminosalicylates Aminosalicylates and/ or Prodrugs

Class Renamed Class to add specification

Inflammatory Bowel Balsalazide Disodium noInflammatory Bowel Mesalamine noInflammatory Bowel Olsalazine Sodium no

Sulfasalazine no Added example drug from removed USP Class, "Sulfonamides."

Inflammatory Bowel Sulfonamides Class Removed USP Class, example drug moved to renamed USP Class, "Aminosalicylates and/or Prodrugs."

Inflammatory Bowel Sulfasalazine no Example drug moved to renamed USP Class, "Aminosalicylates and/or Prodrugs"

Metabolic Bone Disease A t

CatMetabolic Bone Disease

Metabolic Bone Disease Alendronate Sodium no

Metabolic Bone Disease Alendronate Sodium/ Cholecalciferol

yes Gap drug incoporated to include combination

Metabolic Bone Disease Etidronate Disodium no

Metabolic Bone Disease Ibandronate Sodium no

Metabolic Bone Disease Pamidronate Disodium no

Metabolic Bone Disease Risedronate Sodium no

Metabolic Bone Disease Zoledronic Acid no

Metabolic Bone Disease



Metabolic Bone Disease Abaloparatide no New FDA approved drug 04/28/17

Metabolic Bone Disease Calcitonin, Salmon no

Metabolic Bone Disease Parathyroid Hormone no

Metabolic Bone Disease Teriparatide no


Metabolic Bone Disease Cinacalcet Hydrochloride no

Metabolic Bone Disease Etelcalcetide no


Metabolic Bone Disease Denosumab no


Metabolic Bone Disease Calcifediol no

Metabolic Bone Disease Calcitriol no

Metabolic Bone Disease Doxercalciferol no

Metabolic Bone Disease Paricalcitol no

Romosozumab no New FDA approved drug, 4/9/19

Ophthalmic Agents Cat



Ophthalmic Agents Ophthalmic Anti-allergy Agents Class

Ophthalmic Agents Ophthalmic Agents Azelastine Hydrochloride noOphthalmic Agents Cetirizine Hydrochloride noOphthalmic Agents Emedastine Difumarate noOphthalmic Agents Epinastine Hydrochloride noOphthalmic Agents Olopatadine Hydrochloride noOphthalmic Agents Ophthalmic Agents Alcaftadine noOphthalmic Agents Bepotastine Besilate noOphthalmic Agents Ophthalmic Agents Cromolyn Sodium noOphthalmic Agents Lodoxamide Tromethamine noOphthalmic Agents Nedocromil Sodium noOphthalmic Agents Ophthalmic Antiglaucoma Agents

Intraocular Pressure Lowering Agents

Class Renamed class to broaden class name to effect rather than disease state.

Ophthalmic Agents Netarsudil noOphthalmic Agents Ophthalmic Agents Apraclonidine Hydrochloride noOphthalmic Agents Brimonidine Tartrate noOphthalmic Agents Ophthalmic Agents Betaxolol Hydrochloride noOphthalmic Agents Carteolol Hydrochloride noOphthalmic Agents Levobunolol Hydrochloride noOphthalmic Agents Metipranolol Hydrochloride noOphthalmic Agents Timolol Maleate noOphthalmic Agents Ophthalmic Agents Acetazolamide noOphthalmic Agents Brinzolamide no



Ophthalmic Agents Dorzolamide Hydrochloride noOphthalmic Agents Methazolamide noOphthalmic Agents Ophthalmic Agents Carbachol noOphthalmic Agents Echothiophate Iodide noOphthalmic Agents Pilocarpine Hydrochloride noOphthalmic Agents Pilocarpine Nitrate noOphthalmic Agents Ophthalmic Agents Bimatoprost noOphthalmic Agents Latanoprost noOphthalmic Agents Latanoprostene Bunod no New FDA approved drug, 11/02/17Ophthalmic Agents Tafluprost noOphthalmic Agents Travoprost noOphthalmic Agents Ophthalmic Agents Ophthalmic Anti-Infectives Class New class to add ophthalmic anti-infectivesOphthalmic Agents Ophthalmic Agents Azithromycin noOphthalmic Agents Bacitracin noOphthalmic Agents Besifloxacin Hydrochloride noOphthalmic Agents Ciprofloxacin noOphthalmic Agents Erythromycin noOphthalmic Agents Gatifloxacin noOphthalmic Agents Gentamicin Sulfate noOphthalmic Agents Levofloxacin noOphthalmic Agents Moxifloxacin Hydrochloride noOphthalmic Agents Ofloxacin noOphthalmic Agents Sulfacetamide Sodium noOphthalmic Agents Tobramycin noOphthalmic Agents Ophthalmic Agents Ophthalmic Agents Natamycin no



Ophthalmic Agents Ophthalmic Agents Ganciclovir Sodium noOphthalmic Agents Trifluridine noOphthalmic Agents Ophthalmic Anti-inflammatories Class

Ophthalmic Agents Ophthalmic Agents Dexamethasone noOphthalmic Agents Difluprednate noOphthalmic Agents Fluorometholone Acetate noOphthalmic Agents Loteprednol Etabonate noOphthalmic Agents Prednisolone Acetate noOphthalmic Agents Sodium Phosphate noOphthalmic Agents Rimexolone noOphthalmic Agents Triamcinolone noOphthalmic Agents Ophthalmic Agents Bromfenac Sodium noOphthalmic Agents Diclofenac Sodium noOphthalmic Agents Flurbiprofen Sodium noOphthalmic Agents Ketorolac Tromethamine noOphthalmic Agents Nepafenac no

Ophthalmic Prostaglandin and Prostamide Analogs

Class Removed class. Example drugs moved to new USP Class, "Intraocular Pressure Lowering Agents."

Ophthalmic Agents Ophthalmic Agents, Other ClassOphthalmic Agents Cenegermin no New FDA approved drug, 08/22/19Ophthalmic Agents Ophthalmic Agents Cyclopentolate Hydrochloride noOphthalmic Agents Ophthalmic Agents Hydroxypropyl Cellulose noOphthalmic Agents Ophthalmic Agents Lifitegrast noOphthalmic Agents



Cyclosporine no

Ophthalmic Agents Ophthalmic Combinations Class New class to add ophthalmic combination drug products

Ophthalmic Agents Cyclopentolate Hydrochloride/ Phenylephrine Hydrochloride

yes

Ophthalmic Agents Gentamicin Sulfate/ Prednisolone Acetate

yes

Ophthalmic Agents Hydroxyamphetamine Hydrobromide/ Tropicamide

yes

Ophthalmic Agents Loteprednol Etabonate/ T b i

yesOphthalmic Agents Neomycin/ Polymyxin B Sulfates/

Bacitracin Zinc/ Hydrocortisone Acetate

yes

Ophthalmic Agents Neomycin/ Polymyxin B Sulfates/ Dexamethasone

yes

Ophthalmic Agents Neomycin/ Polymyxin B Sulfates/ Hydrocortisone

yes

Ophthalmic Agents Phenylephrine/ Ketorolac yesOphthalmic Agents Sulfacetamide Sodium/

Prednisolone Acetate yes

Ophthalmic Agents Tobramycin/ Dexamethasone yes

Netarsudil Mesylate/ Latanoprost yes New FDA approved drug, 03/12/19

Otic Agents CatOtic Agents Class New class to add otic anti-infectivesOtic Agents Ciprofloxacin noOtic Agents Ofloxacin no



Otic Agents Class New class to add otic glucocorticoidsOtic Agents Fluocinolone Acetonide noOtic Agents Otic Combinations Class New class to add otic combination drug productsOtic Agents Ciprofloxacin/ Dexamethasone yes

Otic Agents Ciprofloxacin/ Fluocinolone Acetonide

yes

Otic Agents Ciprofloxacin Hydrochloride/ Hydrocortisone

yes

Otic Agents Hydrocortisone/ Acetic Acid yesOtic Agents Neomycin/ Polymyxin B Sulfates/

Hydrocortisone yes

Respiratory Tract/ Pulmonary Agents

Cat

Respiratory Tract Antihistamines ClassRespiratory Tract Respiratory Tract Azelastine Hydrochloride noRespiratory Tract Levocetirizine Dihydrochloride noRespiratory Tract Olopatadine Hydrochloride noRespiratory Tract Respiratory Tract Carbinoxamine Maleate noRespiratory Tract Clemastine Fumarate noRespiratory Tract Cyproheptadine Hydrochloride noRespiratory Tract Diphenhydramine Hydrochloride no

Respiratory Tract Hydroxyzine Hydrochloride noRespiratory Tract Hydroxyzine Pamoate noRespiratory Tract Promethazine Hydrochloride noRespiratory Tract Respiratory Tract Azelastine Hydrochloride/

Fluticasone Propionate yes



Respiratory Tract Anti-inflammatories, Inhaled Corticosteroids

Class

Respiratory Tract Beclomethasone Dipropionate no

Respiratory Tract Budesonide noRespiratory Tract Ciclesonide noRespiratory Tract Flunisolide noRespiratory Tract Fluticasone Propionate noRespiratory Tract Fluticasone Furoate noRespiratory Tract Mometasone Furoate noRespiratory Tract Triamcinolone Acetonide noRespiratory Tract Antileukotrienes ClassRespiratory Tract Montelukast Sodium noRespiratory Tract Zafirlukast noRespiratory Tract Zileuton noRespiratory Tract Bronchodilators, Anticholinergic Class

Respiratory Tract Aclidinium Bromide noRespiratory Tract Glycopyrrolate noRespiratory Tract Ipratropium Bromide no

Revefenacin no New FDA approved drug, 11/9/18Respiratory Tract Tiotropium Bromide noRespiratory Tract Umeclidinium noRespiratory Tract Bronchodilators, Sympathomimetic Class

Respiratory Tract Albuterol Sulfate noRespiratory Tract Arformoterol Tartrate no

Epinephrine no outpatient drug to reflect auto injection useRespiratory Tract Epinephrine Bitartrate no Removed due to OTC statusRespiratory Tract Formoterol Fumarate Dihydrate no



Respiratory Tract Indacaterol Maleate noRespiratory Tract Levalbuterol Hydrochloride noRespiratory Tract Tartrate noRespiratory Tract Metaproterenol Sulfate noRespiratory Tract Salmeterol Xinafoate noRespiratory Tract Terbutaline Sulfate noRespiratory Tract Olodaterol noRespiratory Tract Bronchodilator Combinations Class New class to add combination bronchodilator drug products

Aclidinium Bromide/ Formoterol Fumarate

yes

Respiratory Tract Budesonide/ Formoterol Fumarate Dihydrate

yes

Respiratory Tract Fluticasone Furoate/ Vilanterol Trifenatate

yes

Respiratory Tract Fluticasone Propionate/ S l t l

yesRespiratory Tract Mometasone Furoate/ Formoterol

Fumarate Dihydrate yes

Respiratory Tract Indacaterol/ Glycopyrrolate yesRespiratory Tract Umeclidinium Bromide/ Vilanterol

Trifenatate yes

Respiratory Tract Fluticasone Furoate/ Umeclidinium Bromide/ Vilanterol Trifenatate

yes

Respiratory Tract Glycopyrrolate/ Formoterol F t

yesRespiratory Tract Ipratropium Bromide/ Albuterol

Sulfate yes

Respiratory Tract Tiotropium Bromide/ Olodaterol yesRespiratory Tract Cystic Fibrosis Agents ClassRespiratory Tract Respiratory Tract Ivacaftor no



Respiratory Tract Lumacaftor/ Ivacaftor yesRespiratory Tract Tezacaftor/ Ivacaftor yesRespiratory Tract Respiratory Tract Tobramycin noRespiratory Tract Aztreonam noRespiratory Tract Respiratory Tract Dornase Alfa noRespiratory Tract Mast Cell Stabilizers ClassRespiratory Tract Cromolyn Sodium noRespiratory Tract Phosphodiesterase Inhibitors,

Airways Disease Class

Respiratory Tract Aminophylline noRespiratory Tract Theophylline noRespiratory Tract Respiratory Tract Roflumilast noRespiratory Tract Pulmonary Antihypertensives ClassRespiratory Tract Respiratory Tract Ambrisentan noRespiratory Tract Bosentan noRespiratory Tract Macitentan noRespiratory Tract Respiratory Tract Sildenafil Citrate noRespiratory Tract Tadalafil noRespiratory Tract Respiratory Tract Epoprostenol noRespiratory Tract Iloprost noRespiratory Tract Treprostinil noRespiratory Tract Respiratory Tract Riociguat noRespiratory Tract Respiratory Tract Selexipag no



Respiratory Tract Respiratory Tract Agents, Other Class

Respiratory Tract Acetylcysteine noRespiratory Tract Respiratory Tract Benralizumab no New FDA approved drug, 11/14/17Respiratory Tract Mepolizumab noRespiratory Tract Pulmonary Fibrosis Agents ClassRespiratory Tract Nintedanib noRespiratory Tract Pirfenidone noSkeletal Muscle Relaxants Cat

Skeletal Muscle Relaxants Cyclobenzaprine Hydrochloride no

Skeletal Muscle Relaxants Metaxalone no

Skeletal Muscle Relaxants Methocarbamol no

Skeletal Muscle Relaxants Orphenadrine Citrate no

Skeletal Muscle Relaxants Carisoprodol no

Skeletal Muscle Relaxants Carisoprodol/ Aspirin yes

Skeletal Muscle Relaxants Carisoprodol/ Aspirin/ Codeine Phosphate

yes

Skeletal Muscle Relaxants Chlorzoxazone no

Skeletal Muscle Relaxants Orphenadrine Hydrochloride no

Skeletal Muscle Relaxants Orphenadrine Citrate/ Aspirin/ Caffeine

yes



Skeletal Muscle Relaxants

Skeletal Muscle Relaxants Abobotulinum Toxin A no

Skeletal Muscle Relaxants Incobotulinum Toxin A no

Skeletal Muscle Relaxants Rimabotulinum Toxin B no

Sleep Disorder Agents CatSleep Disorder Agents GABA Receptor Modulators ClassSleep Disorder Agents Sleep Disorder Agents Estazolam noSleep Disorder Agents Flurazepam noSleep Disorder Agents Temazepam noSleep Disorder Agents Quazepam noSleep Disorder Agents Sleep Disorder Agents Eszopiclone noSleep Disorder Agents Zaleplon noSleep Disorder Agents Zolpidem Tartrate noSleep Disorder Agents Sleep Disorders, Other ClassSleep Disorder Agents Armodafinil noSleep Disorder Agents Doxepin Hydrochloride noSleep Disorder Agents Modafinil no

PitolisantSleep Disorder Agents Sodium Oxybate no

Solriamfetol no New FDA approved drug, 03/20/19Sleep Disorder Agents Sleep Disorder Agents Suvorexant noSleep Disorder Agents Sleep Disorder Agents Tasimelteon noSleep Disorder Agents Ramelteon no


medicare model guidelines draft v8.0 1 of 97...anti-inflammatory agents diclofenac sodium/...

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