medical biotechnology regenerative medicine
DESCRIPTION
Medical Biotechnology Regenerative Medicine. Muhammad Adeel Faiza Asghar Amina Shakarullah. Focus Areas. What is Regenerative Medicine? Adeel What is the Current Perspectives and Therapeutic Potential of Regenerative Medicine? Amina A case study of Regenerative Medicine. Faiza. - PowerPoint PPT PresentationTRANSCRIPT
Muhammad AdeelFaiza Asghar
Amina Shakarullah
Medical BiotechnologyRegenerative Medicine
What is Regenerative Medicine?AdeelWhat is the Current Perspectives and
Therapeutic Potential of Regenerative Medicine?
Amina• A case study of Regenerative Medicine.Faiza
Focus Areas
Focus Area 1: What is Regenerative Medicine?
A personalized form of medicine.It is the process of replacing or regenerating
human cells, tissues or organs to restore or establish normal function.
Regenerative Medicine
How do cells know into what tissue they are to mature?
How do tissues maintain their structural and functional identity?
How do tissues coordinate their activities within the body?
Why can some tissues regenerate and not others?
Why can human fetuses regenerate limbs?Why do newborn babies rarely scar?
Main Questions
GenesGrowth Factors
Main Culprits
Gatekeeper's (FDA) Opinion
Autologous Therapies (Patient’s own cells)Eg. Stem cells for liver cirrohsisHeart tissue repair (London, on-going clinical trial-
initial testing positive)• Allogenic Therapies (cells from other sources)Eg. London Project to cure blindness• Tissue Engineering (modifying cells)Eg. Claudia’s trachea• Biomedical Engineering (biomedical device
mimicing tissue/organ)Eg. Artificial Pancreas
Important Terms
Heparan sulfate analogues are polymers engineered to mimic several properties of heparan sulfates.
Heparan sulfates can sequester growth factors (GFs) and cytokines in the extracellular matrix(ECM) thereby protecting them from degradation.
However, at any site of inflammation, so also in wound areas, heparan sulfates are degraded, mainly by heparanases giving free access to protease to degrade the ECM and a subsequent loss of GFs and cytokines that disrupts the normal tissue homeostasis.
Heparan Sulfate Analogues
Heparan sulfate analogues are resistant to enzymatic reaction.
This way they strengthen the healing potential of the wound bed by repositioning GFs and cytokines back into the ECM.
Importance
Biomaterials
Click icon to add picture
A biomaterial is any material, natural or man-made, that comprises whole or part of a living structure or biomedical device which performs, auguments, or replaces a natural function.
Summary
Thank you… Any Questions.