med- 1 protontherapy and microdosimetry with the geant4 toolkit
DESCRIPTION
Med- 1 Protontherapy and microdosimetry with the Geant4 toolkit. Se Byeong Lee – National Cancer Center, Goyan , Korea Sébastien Incerti – IN2P3/CENBG, France o n behalf of the Med- 1 team. TYL-FKPPL Joint Workshop, Seoul, June 4-6, 2013. Outline. Context - PowerPoint PPT PresentationTRANSCRIPT
Med-1Protontherapy and
microdosimetry with the Geant4 toolkit
Se Byeong Lee – National Cancer Center, Goyan, Korea
Sébastien Incerti – IN2P3/CENBG, France
on behalf of the Med-1 team
TYL-FKPPL Joint Workshop, Seoul, June 4-6, 2013
Outline• Context
– Extend and evaluate Geant4 performance for protontherapy and
microdosimetry
in the context of protontherapy
• Proposed workplan for 2013
1. Evaluate Geant4 performance for protontherapy
2. Modelling of geometries for plasmid irradiation
3. Perform irradiation of pBR322 plasmids at NCC with 230 MeV protons
at NCC
4. Continue verification & validation of Geant4-DNA physics models
• Collaboration matters2
Med 1 triangular collaboration
NCC
Protontherapy MC simulation &
track structure modelingExperiments on proton
beam
IN2P3/CENBG
Geant4 “low energy” EM
Geant4-DNA
IN2P3/LPC Clermont
GATE/Geant4-DNA modeling for protontherapy
Biology experiments 3
Proton beam facility in National Cancer Center
IBA Proteus 235
Weight : 220 ton Height : 210 cm
Diameter : 434 cm
Energy : 230 MeV
Max. extracted beam current : 300 nA
RF frequency : 106 MHz
Evaluate for Geant4 perfomance
for protontherapy simulation• Objectives
– Deliver benchmark data for Bragg peak profiles
• in liquid water,
• longitudinal & lateral profiles, at entrance, near peak and tail
• at a selection of proton energies
– Perform monthly regression tests for the non-public monthly
releases of Geant4
• NCC joined the Geant4 collaboration in September 2012, in the
“Low Energy EM WG”
• Prior to public Geant4 releases (twice a year)
Simulation application• Simulation application based on the Geant4 electromagnetic test
#44 for Bragg peak simulations (non-public)
• Easy to modify in order to implement a simple nozzle geometry
and General Particle Source feature for the generation of incident
beam phase space
• This application will be maintained on a monthly basis from the
CERN SVN repository
• Allows to study the impact of Physics components combination
using modular physics list:
– Electromagnetic : Option_0, 3 and 4, Livermore, Penelope
– Hadronic: FTFP_BERT, QBBCInt. J. Rad. Biol. 88, 171-175 (2012)
Example of longitudinal profiles
0 20 40 60 80 100 120 140 160 1800
20
40
60
80
100
Depth along Z axis (mm)
Measurement using water phantomGeant4 simulation
Enlargement of lateral profile
Preliminary resultsGeant4 water phantom
simulation
Validation
10
Geant4MeasurementPerce
nt Depth Dose
Depth profile
Simulation of 53000 protonsPhysics:QGSP_BIC,EMstandardOpt3
,…
Using NCC proton nozzle simulation
with Geant4 9.6
Regional comparisonComparison in beam
entrance region
Comparison in Bragg peak
region
11
Measurement
Geant4
Preliminary resultsLateral dose distribution
from
water phantom measurement
2D dose distribution
comparison between
Simulation and Measurement
12
lateral profile
Percent Depth Dose
lateral profile Percent Depth Dose
Depth profile
Depth(cm)
Verification• Verification = comparison to recommendations &
other simulation software
• During Med 1 activity, we recently published CTMC
cross section models for protons and hydrogen in
liquid water and DNA bases (A, T, G, C)
– Protons : single capture, single ionization, transfer ionization (new
process), double ionization (new process)
– Neutral hydrogen : single ionization, stripping
• We are now comparing
– stopping powers
– ranges
– mean deposted & transferred energies
– in liquid water and DNA material
– Once verified, the models will be made publicly available
in Geant4-DNA
15
Liquid water
Adenine
Nucl. Instrum. Meth. B in press (2013)
Validation• Validation = comparison to experimental results
• Geant4-DNA physics and physico-chemistry modelling
capabilites should be validated experimentally on ‘simple’
biological targets
– made of liquid water and/or DNA material
– in dry and hydrated conditions
• We propose to irradiate DNA plasmids at NCC
with few hundred MeV protons
– a circular double-stranded DNA purified
– grown from bacteria
• This will allow the experimental quantification of DNA
damages (SSBs & DSBs) and comparison to Geant4-DNA
simulations 16
http://sandwalk.blogspot.com
Plasmid irradiation• pBR322
• 4361 base pairs
– Fully known base sequence
• Two irradiation conditions
– Irradiation of dry DNA layers
→ direct effects
– Irradiation of DNA plasmids in water buffer
→ indirect + direct effects
• 230 MeV protons at NCC
• Irradiation protocol developed at Nuclear Physics Institute
of Prague
(M. Davidkova et al.) for the ESA AO7146 project17
Diferent plasmid conformations after irradiation can be easily separated by agarose gel electrophoresis
DNA plasmids0.5 - 10 kbp in size
Measurement of DNA damage in plasmids
Degraded
SSB DSB
SSBSSB
DSB
DSB
Supercoiled
Circularrelaxed
Linear
*SSB
*SSB
M. Davidkova, NPI
relaxedlinear
supercoiled
1
2
3
Direction of migration
1 2 3Well
relaxed
linear
supercoiled
+
-
Supercoiled
Circular relaxed
Linear
Increasing dose
Plasmid dimer
Agarose gel electrophoresisThe DNA is stained with a fluorescent dye (ethidium bromide, SYBR green)
M. Davidkova, NPI
The full biology protocol will be established on June 21st at Toulouse / Paul Sabatier
U.
Simple parametrized 300 bp circular
V. Stepan – CENBGESA BioRad II
Example of Geant4-DNA plasmid geometry
Outreach• 51th Particle Theraphy Co-
operative Group (PTCOG)
conference in Seoul on May 14-
19th, 2012
– 3 communications on GATE/Geant4 &
Geant4-DNA
• Strong support of FKPPL to the
organization of reular Geant4 and
GATE tutorials in Korea : 2009,
2010, 2011
• Recent tutorial
– Geant4 Tutorial - October 29 –
November
2, 2012 - KISTI, Seoul, S. Korea
• A new Geant4 tutorial will be
organized in 2013 in Seoul : dates
to be selected
22
KISTI, 2012
Participants
France Korea
V. Breton LPC Clermont J. H. Jeong NCC
C. Champion CENBG S. B. Lee NCC
M. Karamitros CENBG S. J. Park NCC
L. Maigne LPC Clermont J. I. Shin NCC
Y. Perrot LPC Clermont
P. Trung LPC Clermont
24
Budget request for 2013• Request from France to FKPPL
– 2 French visitors to NCC (a week)
– 1 Korean visitor to CENBG (a month)
– Participation of Dr Jeong to Geant4 2013 International Conference at the Physiqcs-
Medicine-Biology frontier in Bordeaux
• Request from Korea made to NCC
– 1 participation to the Geant4 2013 collaboration meeting (Sevilla, Spain – September
2013)
• Note: we already benefit from funding by CampusFrance PHC STAR
« PROTEUS » project (2012-2013, coord.: S. Incerti) for 3 visits of French
collaborators to Korea in 2013 (6.5 keuros).
25
Geant4 International Conference at the
Physics-Medicine-Biology frontierhttp://geant4.in2p3.fr/2013/
7-11 October 2013Bordeaux
France
Full papers in Phys.
Med. Biol.
Takashi Sasaki - KEKSe Byeong Lee – NCCRepresenting Japan and Korea