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MEASUREMENT OF STRESS

CONNECTED HEALTH SOLUTIONS

STRESS

€ 514B IN EUROPE

STRESS PHYSIOLOGY

4

THE FLIGHT OR FIGHT RESPONSE

Jvnkfood, CC BY-SA

ACUTE STRESS | CHRONIC STRESS

5

STRESS CONTINUUM

No stress related

complaints

Stress related complaints

< 3months

No limitation in social/professional

functioning

Overstrain3-6 stress

related complaints

Burnout

>6 months stress related complaints

HOW TO MEASURE STRESS?

A VITAL SIGN

MONITOR

IN 1 CM3

A VITAL SIGN MONITOR IN A CM3

IMEC.MUSEIC V3

A VITAL SIGN

MONITOR

IN ONE SINGLE CHIP

WEARABLE

MEDICAL

DIAGNOSTICS

Printed disposable patch – reusable electronics

TAKING

HEALTH

MONITORING

TO

YOUR

CAR

NON-CONTACT SENSING - IN OFFICE / HOSPITAL ENVIRONMENT

CardiovascularRespiratory

Cuff-less

Blood Pressure monitoring

CHF

PATIENT

MANAGEMENT

Mobile Cardiac

Outpatient Telemetry

SLEEP APNEA

imec CONNECTED HEALTH SOLUTIONSTOOLS FOR DIAGNOSTICS AND DISEASE MANAGEMENT

Nephrology

imec CONNECTED HEALTH SOLUTIONSTOOLS FOR DIAGNOSTICS AND DISEASE MANAGEMENT

NeurologyOphthalmology

Surface EEG

monitoring

Multifocal

contact lenses

(presbyopia)

BCI & NeurofeedbackGastroenterology

Orthopedics

AUGMENTED REALITY

ENHANCEMENTS

CONNECTED HEALTH SOLUTIONSCREATION OF INVESTIGATIONAL DEVICES –WITH ACCESS TO RAW DATA

Neurology

Nephrology

CardiologyPneumonology

Gastroenterology

Ophthalmology

Mental health

Orthopedics

imec CONNECTED HEALTH SOLUTIONSCOLLABORATION WITH CLINICAL PARTNERS

Neurology

Nephrology

CardiologyRespiratory

Gastroenterology

Ophthalmology

Mental health

Orthopedics

IMEC.ICHANGE

▪ PERSONALIZED ALGORITHMS TO CAPTURE BEHAVIORS

▪ INSIGHT IN OBJECTIVE AND SUBJECTIVE BEHAVIORS, MENTAL STATUS

▪ JUST-IN-TIME FEEDBACK

17

DEVELOPMENT OF PERSONALIZED TOOLS FOR COACHING PROGRAMS /

PRECISION MEDICINE / DISEASE PREVENTION

CONFIDENTIAL8

DIGITAL PHENOTYPE

For increased

PERSONALIZATION and

BEHAVIOR change

SENSOR DATA FUSIONCOMBINING MEDICAL GRADE INVESTIGATIONAL DEVICES AND CONTEXTUAL

DEVICES

Gyroscope

PERSONALIZED AND

GENERALIZED SOLUTIONS:

• PHYSIOLOGY-BASED

• MOBILE-BASED

• HYBRID

CORRELATIONS AND

CAUSALITY ANALYSIS:

• DATA MINING

• UNSUPERVISED AND SUPERVISED ML

• TIME SERIES ANALYSIS

Digital

PhenotypingPersonas/Day

types/

Routines/Triggers/

Anomalies/

context

Demographics

Activity

Diet

Genetics

Technology Usage

Others...

In traffic

@work

Clinical

Stress

detection

Quality

indicators

PPG

EEG

ECG

Others...

Energy

expenditure

Cardio

respiratory

fitness

Activity

recognition

Daily Living

Clinical

Sport

DIGITAL PHENOTYPING

TOOLBOXES

Sport

Clinical

Daily living

Daily Living

Clinical

Sport

20

HUMAN CENTERED DESIGNFOR BEHAVIOR CHANGE

INTERVENTIONS

APP IMPLEMENTATION

AND STORAGEINFRASTRUCTURE

DIGITAL PHENOTYPING DEDICATED TRIALS

ENABLING SENSOR TECHNOLOGIES

BUSINESS MODELING

AN ITERATIVE INTERDISCIPLINARY PROCESS TOWARDS

BEHAVIOR CHANGE APPLICATIONS

IMEC.ICHANGE

21

BUILDING ON IMEC HARDWARE & SOFTWARE & LIVING LABS SKILLS

Technology track

User Needs

Application track

User

interaction(MICT, SMIT,

MintLab, APT)

Business

modeling(SMIT)

Personal

digital

Phenotyping(CHS, IBCN,

EXASCIENCE) Sensing

Innovations(CHS,

STADIUS,

IBCN, CMST)Living labs &

Trials (LL,

APT, SMIT,

CHS, MICT)

Behavior

change

application(CHS, IBCN,

SMIT,

MICT,APT )Stress

Management (CHS, IBCN)

Data backend

infrastructure(APT,

EXASCIENCE)

Wearable

Validation

Lab (CHS, LL, )

STRESS MEASUREMENT

SWEET STUDY: STRESS IN THE WORK ENVIRONMENT

23

WEARABLE AND CONTEXTUAL INFORMATION FOR STRESS DETECTION

23

CHEST PATCH

ECG

Acceleration (3 dim)

QUESTIONNAIRES

Stress

Activity

Food/beverage intake

Sleep

Gastro-intestinal symptoms

LOCATION

Continuous

During questionnaires

VOICE PHONE DATA

Proximity

Acceleration

Step count

Screen on/off

Ambient light

Temperature

Humidity

...

WEARABLES SMARTPHONE DEMOGRAPHICS

CHILLBAND

Skin conductance (SC)

Skin temperature

Acceleration (3 dim)

QUESTIONNAIRE

Age

Profession

Height

Weight

...

24

SOME SWEET NUMBERS

25

1,002 SUBJECTS 11 COMPANIES

23,500 SELF-REPORTED STRESS

RESPONSES

5 TB DATA

120,000 HOURS PHYSIOLOGICAL DATA

HOW TO PROCESS 120,000 HOURS OF PHYSIOLOGICAL DATA

RELATED TO MENTAL STRESSEC

GSC

Time

RAW DATA HIGH QUALITY DATA FEATURES

Time

Hear

tra

te(b

pm

)M

ean

SC (

µS)

Time

EC

GSC

GENDER SPORTS

DIGITAL PHENOTYPINGPERCEIVED STRESS ASSESSED BY QUESTIONNAIRE

POPULATION DYNAMICS

Medication Weekly sports hours

LINKING LIFESTYLE AND PHYSIOLOGY

No sports

Regular sports

PERSONALIZED STRESS RESPONSES REQUIRE PERSONALIZED MODELS

30

PERSON B

Skin Conductance response to a

stress test

PERSON A

Skin Conductance response to a

stress test

Rest Control Stress Rest

Rest Control Stress Rest

IMEC DATA ANALYTICS ENABLES THE CREATION OF HEALTH ALGORITHMS:

PERSONALIZED STRESS DETECTION

Sta

ndar

diz

ed H

eart

Rate

feat

ure WORKDAY

WEEKEND

Time (h)

Time (h)

LOWprobability

HIGHprobability

LOW stress

HIGH stress

NO stress

LOW stress

HIGH stress

NO stress

HIGHprobability

LOWprobability

No stress

Light stress

High stress

Self-assessment

Algorithm prediction

PERSONALIZED STRESS DETECTION ALGORITHM

TASK‐INDUCED PSYCHOPHYSIOLOGICAL RESPONSES

20 healthy participants

12 participants with stress related complaints

measurement of galvanic skin response, heart rate, and skin temperature

33

COMPARISON PARTICIPANTS WITH STRESS RELATED COMPLAINTS AND WITHOUT

patient's autonomic nervous system responses to and recovery from an acute stressor

TOWARDS INSIGHTS IN RISKS FOR BURNOUT & DEPRESSION

34

STRESS RESPONSE OF HEALTHY PERSONS VS PATIENT WITH CHRONIC STRESS

Skin Conductance stress response

35

Towards JUST-IN-TIME FEEDBACK at the

RIGHT PLACE and the RIGHT TIME

GO BEYOND MOTIVATION

36

1 .

2 .

3 .

4 .

HOW DIFFICULT IS • THE GOAL FOR YOU

• THE GOAL PERCEIVED BY YOU

FOCUS ON PERSONAL ABILITY

WHEN & WHERE SHOULD WE MOTIVATE YOU

ADD PERSONAL TRIGGERS

PERSONALIZATION

TODAY

Mister X

Demographics:

Weight: 60

Age: 38

Self-Perception:

Healthy[0,10]: 7

Sports: None

PERSONALIZATION

TOMORROW

DIGITAL PHENOTYPING

FOR

HYPER-PERSONALIZATION

45

WE ARE ALL DIFFERENT AND UNIQUE

STOP SMOKING EATING DISORDERS

+ MANY OTHER DIGITAL PHENOTYPING STUDIES

FOR CLINICAL PARTNERS START IN 2018( Borderline personality disorder, Chronic Depression, Assisted Living, Human-

Machine Interaction, prediction of injury, Stress resilience … )

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