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Nutritional Management on Renal Disease
Nurpudji A Taslim, Nutrition Department
School of Medicine Hasanuddin UniversityMakassar 2005
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Renal Function1. WASTE FORMATION & HOMEOSTASIS
- UREA- REGULATION OF OSMOLALITY AND FLUID- REGULATION OF Na & K- REGULATION OF H+- REGULATION OF Ca & PO4- BALANCED
2. PROTEIN EXCRETION METABOLISM3. ENDOCRINE
- RENIN SINTHYSIS- ERYTHROPOETIN SINTHYSIS- ACTIVATIONI 25 OH CHOLECALCIFEROL- ADH ACTION- ALDOSTERON
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DIAGNOSTIC TEST
1. BLOOD- CREATININE- BUN (BALANCED URINE NITROGEN)- CCT (CREATININE CLEARANCE TEST)
2. URINALISIS- UUN ( Urea Urine Nitrogen)-PROTEIN ALBUMIN
3. VISUAL- IVP (intra venous pyelography)- ARTERIOGRAM- BIOPSI- CT-SCAN-SONOGRAM
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KLASIFIKASI
• Glomerular • Nephritic syndrom• Nephrotic syndrom
• Tubular & intertitium• ARF• Pyelonephritis• Others : others tubular or intertitium
• Progress nature of renal disease• ESRD• Nephrolithiasis
• Rheumatoid disorder
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Patofisiologi inflamation
• Osteoarthritis• Rheumatoid arthritis• Sjogren• Sistemac Lupus Erythromatosus
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NEPHRITIC SYNDROMGNA
GNA --- Inflamasi loop glom kapiler
akut, self limitimg, singkat, hematuria
infeksi sal. Nafas atas
GNC --- bila berlanjut menjadi kronis
Causa:
primer : Primer– IgA nepphropathy, hereditary nephritis
sekunder : SLE, Vasculitis, GNA associated endocarditis
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Medical nutrition therapy
AKUT :
a. Antibiotic
b. Maintain nutrition status--- resolve spontaneously
c. Reduced protein and Kalium --- uremia
d. Reduced natrium---- hipertensi
CLINICAL SYMPTOM : DECREASED OF GRF
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NEPHROTIC SYNDROMGNC
• Patogenesis• Loss of glom barrier to protein• Hipoalbuminemia• Hiperkolesterolemia• Hiperkoaguability• Abnormal bone metabolisme
• Causa:• DM, SLE, Amyloidosis• Peny utama pada ginjal
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SINDROMA NEPHROTIC
• CLINICAL SYMPTOM: Oedem, hematuri, proteinuria, hipoalbuminemia, azotemia ( NH++ >>), oligouri ( < 600cc).
• NUTRITION CARE Energi Range 35 – 60 /kg BB/hr Protein 0,8 – 1 gr Fat Moderate Na+ Moderate
K Monitoring --- Hipokalemia
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GOAL1. MAINTAIN OPTIMAL NUTRITION
2. MAINTAIN NUTRITIONAL STORES
3. MINIMIZE DISEASE METABOLISM
4. PREVENT PROGRESSIVITAS OF DISEASE
5. SLOW DIALYSIS OCCURANCE
‘high protein diet --- increased urinary
losess (Mitch, 1996)
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ACUT RENAL FAILURECausa : Sudden reduction in GFR
Renal shockdown ----- trauma or bleeding Decreased ability to excrete the daily
product of metabolic waste Clinical symptom:
a. Diuretic Phase : prod urine 450 ccb. Oligourie phase ( 7-12 hr)uremiaHigh level of K, Mg and Phospat Low level of Na, Calciumacidosis
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Medical nutrition therapy• Manage for: • uremia, metabolic acidosis, imbalanced fluid and electrolyte
• Molina (95)• Early nutritional intervention --- positive affect patient survival
• Protein• PN --- in case of vomiting and diarrhea• CHO--- not effective--- decreased breaking of protein 50%• Mixed– CHO, lipid and AA --- prevent catabolism of protein• Protein --- 0,5 – 0,8 gr/KgBB/hr• Dialysis--- 1-2gr /KgBB
• Kalium• Especially---dialyses patients• Monitoring K• Glucose, insulin, bicarbonate ---- K inside cell
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CHRONIC RENAL FAILURE• Causa : Chronic infection
Progressif glomerolus diseasesChronic Hipertension Nefrophaty DMHidronefrosis BilateralAnalgesic drug (Phenacetine)
• Symptom : uremiaAcid-base unbalanced Electrolyte unbalanced
• Clinical : anemia, anxiety, lose weight, pain (bone, joint), hypertension
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Standard Nutrition Assessment on CRF
• Parameter Normal ModerateSevere
Dry weight % RBW 85-95 75-85 < 75
• TSFmen 4-6 <4Women 8-12 <8
• ACFmen 22-24 <22Women 18-20 <18
• LABAlbumin Serum 2,8 –3,3 <2,8
Transferrin 150-180 <150
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Renal Failure DietGOAL
1. ADEQUATE FOOD, NOT MAKE HEAVIER RENAL FUNCTION2. DECREASED OF UREUM & CREATININ LEVEL3. MINIMIZED SALT RETENSION
REQUIREMENT1. HIGH Biologi value of Protein2. Limitation of Salt ( Heavy HT, >> K, edema, Oligo /anurie)3. Limitation of K (Glom function or prod urine << 400 cc)4. Adequate food5. >> fluid
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Others Tubular & Intertitial disease • 1. Chronic Intertitial Nephritis
• Cause : – Analgesic abuse, Sickle cel anemia, DM, Vesico urethral
reflux
• Therapy :– Increased fluid intake
• 2. Fanconi’s Syndrom• In ability to re-absorbsi proper amount of glucose, AA,
phospate, bicarbonate in proximal tubulus
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• ANAK• Polyurie• Ricketts• Growth retardation• vomiting
• GEJALA• Acidosis• Hipokalemia• Polyurie• Osteomalacia
GEJALA KLINIK
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PYELONEPHRITIS
• Infection bacteria at the kidney• Avorn et al (94) & Hovell et al (98)
• Therapy cranberry or blueberry juice will decreased bacteria
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SJOGREN’S SYNDROM
• Tabara & vara-Cristo,2000, Chronic inflammatory disorder,
characterized by poly-glandular tissue destructions leading to:
» Keratoconjunctivitis» Diminished prod of tears and saliva» Xerostomia» xeropthalmia
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Dietary Management
• Relief of symptoms and eating discomfort• Lack of appetite, weight loss, fatigue,
difficulty chewing and swallowing • Ready-to-eat food• Sweetened lemon drops• Iron, B12 and folate as well balance diet–
(Lundstom and Lindstom,2001)
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SCLERODERMA
• Escott-Stump,2002, Is a progressive characterized by deposition of fibrous connective tissue in the skin and visceral organs, including GIT
• One of manifestation of scleroderma—Raynaud’s Syndrome (ischemia or coldness in the small extremities—finger--- difficulty preparation and consumption of meal
• GIT symptoms , weight loss, renal dysfunction & multiple organ system dysfunction my result
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Medical Management
• Disease is rogessive and current treatment produces are cure
• Side effects– may results as discussion above
• Medical Nutrition Therapy• Dysphagia• Malabs of lactose, vit, FA, minerals• Need high Energy, high protein – through NGF as a
supplement • PN – diarre persistent
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SYSTEMIC LUPUS ERTHEMATOSUS (SLE)
• Etiologi tdk jelas• A genetic predisposition
• Genetic marker HLA• Human leukocyte Ag• Presence of anti-DNA ab• Environmental factors– viral infection
• Prevalence— women and childbearing age in Americans and Caucasians
• 1954– survival rate 50%, today 97%• 25% DEVELOPS SJOGREN’S SYNDROM
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MEDICAL MANAGEMENT• SLE – autoimmune disease—affects all organ system
• Steroid—used as therapy– affect nutrient metabolism, needs and excretion
• Renal function is deranged– exessive excretion of protein, Na, fluid, calcium
• DRUGTHERAPY– Corticosteroid– alter of protein, Na, fluid, calcium need– Plaquenil ( antimalaria)– effective in clearing upskin lessions ( SE—
nausea,cramping abd, diarrhea)– Immunosuppresant—azathioprine---in the event of brain or renal
involment, but GIT effects may occur
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MEDICAL NUTRITION THERAPY• No specific dietary guidelines• Diet based on individual need• Priorities—sequelae of disease and pharmacologic
effects on organ function and nutrition metabolism• Restricted---sodium and fluids intake• Limitations—fat intake• Leiba et al (2001)--- protein, calorie and diet low in
fat---reduction in immune-complex deposition in the kidney and protein urie and may prolong the lifespan
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Diet Variation
1. LOW PROTEIN DIET I : 20 gr - CCT 5-20 cc/”, ureum 100 mg
2. LOW PROTEIN DIET II 40 gr - CCT 20 – 30 cc/”, Konservatif
3. LOW PROTEIN DIET III60 gr - CCT 30-50 cc/”, MILD CRF
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PROTEIN LIMITATION BASED ON GFR
GFR PROTEIN ALLOWANCEcc/menit g/day g/kgBB/day
>25 no restriction no restriction20-25 60-90 1.315-20 50-70 1.010-15 40-55 0.7 5-10 40 u/ pria 0,5-0,6
35 u/ wanita
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MONITORING PROTEIN HOMEOSTASIS
1. Based on renal damaged indicator higher / lower of muscle mass loss
2. Creatinine clearanceGfr renal damaged– low creatinin clearance pada renal failure level of creatine serum –high
3. SUN (SERUM UREA NITROGEN) OR BUN – indicator of renal functionStabil PROTEIN DIETSUN increased increased PROTEIN INTAKE. Dehidrasion / catabolic state ( operasi, burn, infection, fracture drug catabolic: steroid
LEVEL 60- 80 mg/dl ACCEPTABLE> 80 uremia< 40 malnutrisi
4. Urea clearance filtration capability
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NUTRITION CARE
NUTRIENT OLIGOURIE DIURETIC
1. ENERGY 40-55 kcal/kg 40-55 kcal/kg (High in trauma) (high in trauma)
2. CHO 50-70% - Need supplement -
3. PROTEIN 0,5g/kg 80% HBV 0,8 g/ kg or more 1-1,5 g/kg dialysis If fasting
4. Fluid + 500 cc increasing as needed5. Na + 500-1000 mg/d replace losses6. K+ 1000 mg/d replace losses7. Fat = dialysis = dialysis
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Progresivitas of Diseases (CRF)
STAGE % LOST GFR (cc/min)
1. Decreased 55% 55-125 renal reserve
2. Renal Insuficiency 80% 30-55
3. Renal Failure 90% 12,5-30
4. Uremia / uremia >90% < 12,5 syndrome (ESRD)
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OPTIONS- THERAPY OF ESRD
1. CONSERVATIF MANAGEMENT
2. DIALYSIS A. HEMODIALISISB. PERITONEAL-DIALISIS
3. TRANSPLANTASION
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KONSERVATIF MANAGEMENT
1. LIMITATION SYMPTOM
2. PREVENT IRREVERSIBLE RENAL DAMAGED
3. MAINTAIN OF HEALTH BEFORE DIALYSIS OR TRANSPLANTASION
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TYPE OF DIALYSIS
A. HEMODIALYSBY MACHINE ( venous )3-4 hours /d, 3 – 4 x week
B. PERITONEAL DIALYSIS Intermittent ( IPD)
Continous ambulatory ( CAPD)Continous Cyclic
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NUTRITION MANAGEMENT ON RENAL TRANSPLANTASION
1. ADEQUATE FOOD
2. CHO 40 –50 % FROM TOTAL CALORIES
3. PROTEIN 1.2- 1.5 gr ADJUST TO NORMAL LEVEL (LAB
AND ELECKTROLYT BALANCE)
4. LIMITATION OF Na+ 2 - 4 gr / day
5. K+ AS NEEDED
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RENAL STONE
Causa:1. Environment Factor2. Tractus Urogenitalia 3. Matrix Organik stone
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A. ENVIRONMENTAL FACTOR
1. CALSIUM ( 96%)N eksresi 100 –175 mghipersecresion : high intake Ca, high Vit.D
long imobilisasion, hiperparathyroidrenal tubular asidosis, high calsiurie
idiopatik
2. CYSTEIN ( herediter )
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B. TRACTUS UROGENITAL
• CHANGED OF URINE PHYSICALLY
• CHANGED OF URINE CONCENTRATION
• CHANGED OF URINE BALANCED
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C. MATRIX BATU ORGANIK
• RECURRENT INFECTION• DEFICIENCY OF VITAMIN A
( DESQUAMATION OF CEL EPITHEL)
• DOT CALCIFICATIONRANDALL’S PLAQUE
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CLINICAL SYMPTOMSKOLIK, DEMAM, LEMAH
THERAPY1. High fluid2. Change pH from acid --- alkalis3. Elimination food contain nutrient---
contribute to stone development 4. Binding agent – ecretion through feses
e.g. sodium phytate --- for calsiumaluminium gel --- for phosfatGlycine --- for oksalat
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THERAPY
Susunan Kimia Modifikasi zat Gizi Diet Ash1. Calsium low calsium acid ash
Phospat low phospatOxalat low oxalat
2. As. Urat low purine alkaline ash
3. Cystine low methionine alkaline ash
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VARIATION DIET
1. LOW CALCIUM HIGH ASH CAID
2. HIGH DIET ASH ALKALIS
3. LOW PURINE DIET
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LOW CALCIUM DIET HIGH ASH ACID
• FLUID > 2500 cc/day• Low calcium• Limitation food intake contains: PROTEIN : milk, cheese, schrimp, crab, rilis, salt fish, sarden,
animal brain, ren, liver, cor CHO : potatoes, sweet potatoes, cassava, biscuit, cake contain milk VEGETABLE : Spinach, mangkok leaf, melinjo leaf, papaya
leaf, lamtoro leaf, cassava leaf, talas (taro) leaf, d.katuk leaf, kelor leaf, jtg pisang, melinjo, sawi, leunca FRUITS : All Fermented Fruits OTHERS : SOFT DRINK contains soda, alcohol, coclate, yeast
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HIGH DIET ASH ALKALIS
Especially for Cysteine stone and Uric acid
1. Fluid > 2500 cc/day
2. Low AA (contain Sulfur)
3. Vegetables < 300 gr/day
4. Fruit < 300 gr/day
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