mastergraft ® granules & mini granules medical grade polyporous resorbable ceramic granules...
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MASTERGRAFT® Granules & Mini Granules
• Medical grade polyporous resorbable ceramic granules– Each granule is composed of:
• 15% hydroxyapatite (HA)– Slow resorbing3
• 85% beta-tricalcium phosphate (β-TCP)– Fast resorbing3
• 80% interconnected porosity3
– 500 µm average pore diameter3
– 125 µm average interconnected diameter3
• 85:15 ratio chosen due to:– Long-term stability3
– Resorption rate3
3. Data On File
MASTERGRAFT® Granules in Extraction Socket Preservation – Proven Bone Formation7
• Study Design– Seven patients (ages 35 – 82
years)– Teeth extracted and
immediately grafted using MASTERGRAFT® Granules
– No primary closure– Implants placed at 4 – 5
months post-grafting
A. MASTERGRAFT® Granules placed into the extracted socket as a graft material. B. MASTERGRAFT® Granules were covered with a cellulose sponge. C. Bone core samples were taken from the grafted sites at 4 months after grafting. D. Installed implant into the grafted site at 4 months after grafting.
7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg. 2011;22(2):490-493.
• MASTERGRAFT® Granules in Human Extraction Sockets demonstrated:
• Osteoconductive scaffold for new bone formation
• Maintenance of space within the defect
• Support of new blood vessel formation
• Support of osteoclasts and osteoblasts for bone remodeling
• Effective for repairing bone defects
MASTERGRAFT® Granules in Extraction Socket Preservation Proven Bone Formation7
7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg. 2011;22(2):490-493.
Basic Bone Biology8
• Three main components
– Cells• Build, resorb and maintain
bone
– Organic Matrix• Collagen to resist fracture• Proteins (including BMP)
– Inorganic Matrix• Mineral (calcium phosphate) for
strength
Bone Tissue
Cells Matrix
Organic(DBM)
Inorganic(Mineral)
IRN7511-1.0-02
8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)
Bone Matrix8-9
Organic30%
Inorganic
Mineral70%
Composition of Bone
Type 1 Collagen
95%
Native Growth Factors
5%
Composition of Organic MatrixComposition of Inorganic Matrix
Calcium phosphate
8 Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)9. Einhorn. Biomechanics of Bone. Principles of Bone Biology (1996)
Protein Signals
Bone Grafting8
Extension of Bone Remodeling
• Assuming the right signals exist:– Osteoclasts break down old bone
• Release other signals to cells– Osteoblasts form new bone
• May reside in transplanted bone• Under right conditions, may recruit other cells
8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)
Bone Graft Incorporation10
Vascularity– Graft porosity– Vascularity of
site/hostsite preparation
Bone Formation– Bone cells
– Osteoinduction
Graft/Host Union– Stability of the
construct– Contact area-Graft quantity
10. Kalfas. Principles of Bone Healing. Neurosurg Focus 10 (4): Article 1, (2001)
MASTERGRAFT® Granules & Mini Granules
• Medical grade polyporous resorbable ceramic granules– Each granule is composed of:
• 15% hydroxyapatite (HA)– Slow resorbing3
• 85% beta-tricalcium phosphate (β-TCP)– Fast resorbing3
• 80% interconnected porosity3
– 500 µm average pore diameter3
– 125 µm average interconnected diameter3
• 85:15 ratio chosen due to:– Long-term stability3
– Resorption rate3
3. Data on File