MassBio & the Massachusetts BioPharma Cluster

2

About MassBio

Our Mission: Foster a positive environment that enables each biotechnology company to achieve its full potential, making Massachusetts a world center for biotechnology.

About MassBio

About MassBioMassBio represents nearly 620 biopharma companies, service providers, academic institutions, hospitals, patient organizations, foreign agencies and other industry stakeholders.

The 410+ biopharma members are engaged in a wide spectrum of research & development in life sciences.

4,100 attendees

Savings from 20-80% on everything from lab gases, lab equipment, supplies…

MassBioEd Courses,MassBio Committee Meetings

PurchasingConsortium

Networking & Visibility

Annual EventsProfessionalDevelopment

MassBioEdFoundation

EconomicDevelopment

Policy

MassBioMembership

PurchasingConsortium

Networking & Visibility

Annual EventsProfessionalDevelopment

MassBioEdFoundation

EconomicDevelopment

State & FederalPolicy

MassBioMembership

90+ member meetings,

Savings from 20 % on everything from lab gases, lab equipment, supplies…

MassBioEd Courses,MassBio Committee Meetings

PurchasingConsortium

Networking & Visibility

Annual EventsProfessionalDevelopment

MassBioEdFoundation

EconomicDevelopment

Policy

MassBioMembership

PurchasingConsortium

Networking & Visibility

Annual EventsProfessionalDevelopment

MassBioEdFoundation

EconomicDevelopment

State & FederalPolicy

MassBio

BioReadyTM Communities Campaign

Innovation ServicesMassCONNECT

Pharma Days• Investment• Mentoring• Partnering

(March 2011)

Attleboro

Billerica

Brockton

Chicopee

Northampton

Tewksbury

Watertown

Westfield

Fall River

Chelsea

Dedham

Lynn

Newburyport

Reading

Easthampton

BurlingtonEverett

Franklin

GardnerGreenfield

Holliston

Lawrence

NorthbridgeRandolph

Salem

Sturbridge

Andover

Bedford

Beverly

Boston

Cambridge

Canton

Devens

Framingham

Grafton

Haverhill

Lexington

North Andover

Springfield

Taunton

Tri-Town (Southfield)

Waltham

Worcester

Platinum

Gold

Silver

Bronze

West Bridgewater

Marlborough

Chelmsford

Newton

Lowell

Hatfield

Norfolk

Somerville

LeominsterGloucester

Dracut

New Bedford

Pittsfield

Fitchburg

Holyoke

Mansfield

Quincy

Plymouth

Westboro

Hopkinton

Uxbridge

(March 2011)

Attleboro

Billerica

Brockton

Chicopee

Northampton

Tewksbury

Watertown

Westfield

Fall River

Chelsea

Dedham

Lynn

Newburyport

Reading

Easthampton

BurlingtonEverett

Franklin

GardnerGreenfield

Holliston

Lawrence

NorthbridgeRandolph

Salem

Sturbridge

Andover

Bedford

Beverly

Boston

Cambridge

Canton

Devens

Framingham

Grafton

Haverhill

Lexington

North Andover

Springfield

Taunton

Tri-Town (Southfield)

Waltham

Worcester

Platinum

Gold

Silver

Bronze

West Bridgewater

Marlborough

Chelmsford

Newton

Lowell

Hatfield

Norfolk

Somerville

LeominsterGloucester

Dracut

New Bedford

Pittsfield

Fitchburg

Holyoke

Mansfield

Quincy

Plymouth

Westboro

Hopkinton

Uxbridge

BioReadyCommunitiesCampaign

MassBio Services

5

Savings

MassBio negotiates a broad-based collection of contracts and services on behalf of

member companies resulting in the most competitive pricing, large volume rebate

incentives and specialized customer service

6

Access to the Network

Meet new people, learn about trends in the industry, & develop relationships with potential partners at our Forums.

Adventures in Biotech: The Series! The Billion Dollar Molecule Revisited Sex, Drugs & Rock & Roll: The story of

Viagra The Use of Social Media in FDA Regulated

Business: Impact on Patient Recruitment, Product Marketing & Regulatory Compliance

Catalyzing Innovation – The Critical Success Factors for Pharma-Academia Collaboration

Everything You Wanted to Know About Protocol Violations but were Afraid to Ask

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Access to the Network

Connect with people you have to know & increase your visibility.

Annual Events Open Houses Supplier Series Trade Shows Policy Breakfast Annual Golf Classic

Members-Only Resources

HRonline KnowledgeBase Careers Portal Member News Calendar of Events

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Business Development

Find your next partner, collaborate, and accelerate innovation.

• Annual Meeting: Don’t miss our signature scientific event for dynamic keynote presentations, panel discussions, interactive working sessions, poster presentations & extensive networking opportunities (April 3-4, 2014)

• MA CRO CMO Symposium: Now in its third year, the Massachusetts CRO/CMO Symposium shines a spotlight on the strength and success of the CRO and CMO communities in the Commonwealth. (May 5, 2014)

• BioPharm America: Attend this annual parterning conference & utilize partneringONE (September 2014)

Innovation ServicesPharma Days

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Innovation Services MassCONNECT

About MassBio

Innovation Services

Business Development

Access to the Network

Savings

Advocacy

Get Started

Accelerate early stage innovationIn depth gap analysis of the business model

De-risk opportunitiesDefine market needs

Create Connections within the industry

Bio/pharma networksVC and other funding networks

Collaborate with other accelerators and incubators

Strong network to identify and source start-upsReferrals to and from other accelerators

MassCONNECT mentoring model adopted by BayBio & Indiana Bio

MassCONNECT

MassCONNECT

MassChallenge

MA Tech Transfer

Center

Harvard

LabCentral

Tufts Medical Center

University of Massachusetts

MA Research Hospitals

SoPE

12

Innovation Services MassCONNECT Cycle I 2014

About MassBio

Innovation Services

Business Development

Access to the Network

Savings

Advocacy

Get Started

Aldatu Biosciences

Point of care diagnostic for HIV drug resistance

Resilience Pharma

Novel molecular pathway underlying PTSD

MGH NewCO.

Small molecule therapeutic for VHL disease

GlucoWise

Non-invasive glucometer for Diabetics

Aldatu and Resilience semi-finalists in OneStart

GlucoWise winner MIT/Sloan Building Global Innovators

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Advocacy

Policy: We are the voice of the industry on Beacon Hill & Capitol Hill.

Economic Development: We help members with:

Lab & office space Tax incentives Grants

Workforce Development: We work with our sister organization, MassBioEd on preparing the workforce and filling the pipeline.

About MassBio

Innovation Services

Business Development

Access to the Network

Savings

Advocacy

Get Started

MassBioEconomic Development

&Global Affairs

Promoting the Massachusetts Cluster

Assisting Companieslocate and grow in MA

Industry Data & Analysis

Massachusetts Biotechnology Employment, 2001-2008*

10,000

15,000

20,000

25,000

30,000

35,000

40,000

45,000

50,000

2001 2002 2003 2004 2005 2006 2007 2008

42.6%Growth

Since2001

• Marketing materials• Trade missions/BIO

• Coordination with state agencies

• BioLeads Meetings• Guidance on incentives

• Case management• 50+ active leads on average

Competitiveness

(October 2009)

Attleboro

Billerica

Brockton

Chicopee

Northampton

Tewksbury

Watertown

Westfield

Fall River

Chelsea

Dedham

Lynn

Newburyport

Reading

Easthampton

BurlingtonEverett

Franklin

GardnerGreenfield

Holliston

Lawrence

NorthbridgeRandolph

Salem

Sturbridge

Andover

Bedford

Beverly

Boston

Cambridge

Canton

Devens

Framingham

Grafton

Haverhill

Lexington

North Andover

Springfield

Taunton

Tri-Town (Southfield)

WalthamWorcester

Platinum

Gold

Silver

Bronze

West Bridgewater

Marlborough

Chelmsford

Newton

Lowell

Hatfield

Norfolk

Somerville

LeominsterGloucester

Dracut

New Bedford

Pittsfield

Fitchburg

Holyoke

Mansfield

(October 2009)

Attleboro

Billerica

Brockton

Chicopee

Northampton

Tewksbury

Watertown

Westfield

Fall River

Chelsea

Dedham

Lynn

Newburyport

Reading

Easthampton

BurlingtonEverett

Franklin

GardnerGreenfield

Holliston

Lawrence

NorthbridgeRandolph

Salem

Sturbridge

Andover

Bedford

Beverly

Boston

Cambridge

Canton

Devens

Framingham

Grafton

Haverhill

Lexington

North Andover

Springfield

Taunton

Tri-Town (Southfield)

WalthamWorcester

Platinum

Gold

Silver

Bronze

West Bridgewater

Marlborough

Chelmsford

Newton

Lowell

Hatfield

Norfolk

Somerville

LeominsterGloucester

Dracut

New Bedford

Pittsfield

Fitchburg

Holyoke

Mansfield

• EDAG Initiatives• BioReady TM Communities

Global Relationships

Advocacy Economic Development & Global Affairs

MassBio assists the growth of the biotechnology industry in Massachusetts by:

* pursuing strategies to maintain/improve the competitiveness of the cluster; and

* providing direct services to biotech companies considering entry to or expansion in Massachusetts.

• 17 Foreign agency members• Host 20 delegations annually

• Annual Industry Snapshot• Industry data for members

MassBio Leading Job Listings as % of Total Listings

0.0%

2.0%

4.0%

6.0%

8.0%

10.0%

12.0%

Biochem

istry

Biology

Chem

ist

Clinica

l

Drug D

evelo

pmen

t

Drug D

iscov

eryIS

/IT

Manu

factu

ring

Pre-C

linica

l

Proce

ss D

evelopm

ent

Quality A

ssur

ance

Quality C

ontrol

Regulato

ry

Researc

h

Feb. 08

Sept. 08

Feb. 09

Sept. 09

About MassBio

Innovation Services

Business Development

Access to the Network

Savings

Advocacy

Get Started

430+Biotech

Companies

122Colleges &Universities

Top 5NIH fundedResearchHospitals

1stin

Venture Capital & SBIR funds

per worker

1stin

Education Level of

workforce

550Biopharma

Companies

122Colleges &Universities

9 of the Top 18NIH funded

Research

Hospitals

1stin

Venture Capital & federal research

funds per worker

1stin

Education Level of

Workforce (US)

Why Massachusetts?

SupportiveLocal, State Government

Life Sciences InitiativeBiotech Caucus

The $1 Billion Massachusetts Life Sciences Initiative – Enacted in 2008

• 10 years• $1 billionInvestment$5

00 m

illio

n C

apita

l

Fund

$250 million

Tax Incentive Program

$250m Investment Fund (subject to appropriation)

Over time, the industry demonstrated its value, commitment to the region, and promise for the future . . . and state government responded.

III. History

Kendall Square, 1960

Kendall Square, 1970

60%$564 million

Beth Israel Deaconess $118,785,811

Dana Farber Cancer Institute $115,844,948

Children’s Hospital Boston $126,812,298

Brigham and Women’s $315,919,592

Harvard Medical School $200,413,466

Harvard School of Public Health$120,611,357

2013 NIH Research Funding - Longwood Medical Area - Boston

2013 World Series Champions

1980

1985

2006

Double helix of DNA explained by Watson & Crick

1978

1953

Biogen founded

U.S. Supreme Court approves patenting of recombinant life forms,Passage of Bayh-Dole Act

2000

Map of the human genome is completed

2002

Novartis locates Global Research HQ in Cambridge, MA

2008 $1 B Massachusetts Life Sciences Initiative enacted

BMS chooses to build $1b facility in Devens, MA

Genzyme founded 1981

MassBio becomes the 1st biotechnology industry association

2003

MassBio issues Biotech 2010 Report

1980

1985

2006

Double helix of DNA explained by Watson & Crick

1978

1953

Biogen founded

U.S. Supreme Court approves patenting of recombinant life forms,Passage of Bayh-Dole Act

2000

Map of the human genome is completed

2002

Novartis locates Global Research HQ in Cambridge, MA

2008 $1 B Massachusetts Life Sciences Initiative enacted

BMS chooses to build $1b facility in Devens, MA

Genzyme founded 1981

MassBio becomes the 1st biotechnology industry association

2003

MassBio issues Biotech 2010 Report

Massachusetts Biotech TimelineIndustry History

Cluster AnalysisCONFIDENTIAL — November 2013 23

— DRAFT —

Experienced Leadership: Network Effect in Industry

Note: Representative sample of previous Genzyme employees with CXO title at companies joined after Genzyme. 43 companies excluding Genzyme.

Source: Health Advances analysis, LinkedIn.

Aldexa Therapeutics

FFE Therapeutics

Novavax

Neuron Systems

OvaScience

Red Sky Partners

Declion Holdings

Antigenetics

Thrombolytic Science

International

Intercell

Columbia Laboratories

Link Medical Group

GTC Biothera-peutics

Predictive Biosciences

Verastem

Genzyme

Hydra Biosciences

Hyperion Therapeutics

Five Prime Therapeutics

PureTech Ventures

Exact Sciences

Corp

Peptimmune

Procept

Aronex

Gallus Biopharma-

ceuticals

PathoGenetix

OXiGENE

TetraLogicViscus Biologics

Proteon Therapeutics

bluebird bio

CubistGlycoSolutions

Flatley Discovery LabSarepta

Ocular TherapeutixAbazyme

CandelarEVO Biologics

CatabasisZyngenia

1st 2nd 3rd 4thCXO Position after Genzyme

Talent

Experienced Leadership : Non-profit Research

AcusphereAIRArsenalBIND BiosciencesBlend TherapeuticsEcho TherapeuticsEnzytech (Acq. by Alkermes)Gecko BiomedicaInVivo TherapeuticsKalaLiving ProofMicrochipsModernaMomentaPixarBioPervasisPulmatrixSelecta BiosciencesSeventh SenseSQZ BiotechTarisTransformT2

CompanyCreation

http://www.polarispartners.com/about/strategy/repeat-entrepreneurs/

Networks: Entrepreneurs

Bind Therapeutics Selecta Biosciences Blend Therapeutics

Associate ProfessorHarvard Medical School

Director, Laboratory of Nanomedicine and Biomaterials,Brigham & Women’s Hospital

Omid Farokhzad, M.D.