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INORGANIC SYNTHESIS

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• 1- Jack T. Ballinger, Gershon J. Shugar; Chemical Technicians' Ready Reference Handbook, 5th

Edition, McGraw-Hill Education: New York, 2011.

• 2- Ruren Xu, Yan Xu; Modern Inorganic Synthetic Chemistry, 2ed Edition, Elsevier: 2017.

• 3- John N. Lalena, David A. Cleary, Everett E. Carpenter, Nancy F. Dean; Inorganic Materials

Synthesis and Fabrication, Elsevier: 2017.

• 4- Sneha Mohan Bhagyaraj, Oluwatobi Samuel Oluwafemi, Nandakumar Kalarikkal, Sabu

Thomas; Synthesis of Inorganic Nanomaterials, Elsevier: 2018.

• 5- C.N.R. Rao, Kanishka Biswas; Essentials of Inorganic Materials Synthesis, Wiley: 2014.

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http://r.takjoo.profcms.um.ac.ir/

English

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• MSDS (Material Safety Data Sheet)

product safety data sheet (PSDS)

• Laboratory Health and Safety

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What is a Material Safety Data Sheet (MSDS)?

A material safety data sheet is a technical document which provides detailed

and comprehensive information on a controlled product related to:

• health effects of exposure to the product

• hazard evaluation related to the product’s handling, storage or use

• measure to protect workers at risk of exposure

• emergency procedures

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Responsibilities Related to the MSDS

• Suppliers

• Employer

• Worker

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Suppliers

1. Develop or obtain a MSDS for each controlled product imported or sold for

use in a workplace

2. Ensure the MSDS for the controlled product:

• Discloses information that is current at the time of sale or importation of the

product

• Was prepared and dated not more than three years before the date of sale or

importation

• Is available in both official languages Ferdow

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Suppliers

3. Ensure the purchaser of the controlled product has a copy of the current

MSDS at the time of or prior to the purchaser receiving the controlled product

4. Make available any information that is considered confidential (trade secret)

information and therefore exempt from disclosure to any physician or nurse

who requests that information for the purpose or making a medical diagnosis or

providing medical treatment

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Employer

1. Ensures that an up-to-date supplier MSDS is obtained from the supplier the first

time a controlled product is received in the workplace

2. Evaluates the data sheet received to determine its date of production. The data sheet

must be dated within 3 years of current date

3. Maintains up-to-date MSDSs:

- As soon as practical but no later than 90 days after new hazard information becomes

available to the employer

- At least every three years

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Employer

4. Ensures a copy of all data sheets which are required for the workplace are made

readily available at the worksite to:

Workers who may be exposed to the controlled product

The occupational health committee (OHC)

Note: The MSDSs may be made available on a computer if the employer takes all

reasonable steps to keep the terminal in working order, makes the data sheets readily

available to the employee and provides training in accessing the computer stored data

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Employer

5. Ensure that the employee who works with a controlled product or in proximity to a

controlled product is instructed in:

The content required on the MSDS

The purpose and significance of information contained in it

Instruction must ensure that employees know procedures for the safe use, storage,

handling and disposal of controlled products including procedures in the event of an

emergency involving a controlled product.

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Employer

6. Provide confidential (trade secret) information to a doctor or nurse who request this

information for purposes of making a medical diagnosis or rendering medical

treatment in an emergency

7. The employer can produce data sheets in order to provide additional information or

alter the format used as long as there is no less information provided than the original

supplier MSDS contained

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Worker

Worker Following training by the employer:

1. Follows the safe work or preventative measures as instructed by the employer

2. Knows where the sheets are located and how to find pertinent information on

safe use and first aid measures

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Material Safety Data Sheet Content

• A supplier material safety data sheet must provide at least nine categories or

sections of content and approximately sixty items of information distributed

among those categories. An MSDS must be reviewed at least every three

years. The categories must have the following similar headings:

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The LD50 is defined as the lethal dose at which 50% of the

population if killed in a given period of time; an LC50 is the

lethal concentration required to kill 50% of the population.

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• SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

• 1.1. PRODUCT IDENTIFIER

• 1.2. RELEVANT IDENTIFIED USES OF THE SUBSTANCE OR MIXTURE AND USES ADVISED AGAINST

• 1.3. DETAILS OF THE SUPPLIER OF THE SAFETY DATA SHEET

• 1.4. EMERGENCY TELEPHONE NUMBER

• SECTION 2: HAZARDS IDENTIFICATION

• 2.1. CLASSIFICATION OF THE SUBSTANCE OR MIXTURE

• 2.2. LABEL ELEMENTS

• 2.3. OTHER HAZARDS

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• SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

• 3.1. SUBSTANCES

• 3.2. MIXTURES

• SECTION 4: FIRST AID MEASURES

• 4.1. DESCRIPTION OF FIRST AID MEASURES

• 4.2. MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED

• 4.3. INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED

• SECTION 5: FIREFIGHTING MEASURES

• 5.1. EXTINGUISHING MEDIA

• 5.2. SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE

• 5.3. ADVICE FOR FIREFIGHTERSFerdow

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• SECTION 6: ACCIDENTAL RELEASE MEASURE

• 6.1. PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES

• 6.2. ENVIRONMENTAL PRECAUTIONS

• 6.3. METHODS AND MATERIAL FOR CONTAINMENT AND CLEANING UP

• 6.4. REFERENCE TO OTHER SECTIONS

• SECTION 7: HANDLING AND STORAGE

• 7.1. PRECAUTIONS FOR SAFE HANDLING

• 7.2. CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES

• 7.3. SPECIFIC END USE(S)

• SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

• 8.1. CONTROL PARAMETERS

• 8.2. EXPOSURE CONTROLS

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• SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

• 9.1. INFORMATION ON BASIC PHYSICAL AND CHEMICAL PROPERTIES

• 9.2. OTHER INFORMATION

• SECTION 10: STABILITY AND REACTIVITY

• 10.1. REACTIVITY

• 10.2. CHEMICAL STABILITY

• 10.3. POSSIBILITY OF HAZARDOUS REACTIONS

• 10.4. CONDITIONS TO AVOID

• 10.5. INCOMPATIBLE MATERIALS

• 10.6. HAZARDOUS DECOMPOSITION PRODUCTS

• SECTION 11: TOXICOLOGICAL INFORMATION

• 11.1. INFORMATION ON TOXICOLOGICAL EFFECTS

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• SECTION 12: ECOLOGICAL INFORMATION

• 12.1. TOXICITY

• 12.2. PERSISTENCE AND DEGRADABILITY

• 12.3. BIOACCUMULATIVE POTENTIAL

• 12.4. MOBILITY IN SOIL

• 12.5. RESULTS OF PBT AND VPVB ASSESSMENT

• 12.6. OTHER ADVERSE EFFECTS

• SECTION 13: DISPOSAL CONSIDERATIONS

• 13.1. WASTE TREATMENT METHODS

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• SECTION 14: TRANSPORT INFORMATION

• 14.1. UN NUMBER

• 14.2. UN PROPER SHIPPING NAME

• 14.3. TRANSPORT HAZARD CLASS(ES)

• 14.4. PACKING GROUP

• 14.5. ENVIRONMENTAL HAZARDS

• 14.6. SPECIAL PRECAUTIONS FOR USER

• 14.7. TRANSPORT IN BULK ACCORDING TO ANNEX II OF MARPOL73/78 AND THE IBC CODE

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• SECTION 15: REGULATORY INFORMATION

• 15.1. SAFETY, HEALTH AND ENVIRONMENTAL REGULATIONS/LEGISLATION SPECIFIC FOR THE

SUBSTANCE OR MIXTURE

• 15.2. CHEMICAL SAFETY ASSESSMENT

• SECTION 16: OTHER INFORMATION

• 16.2. DATE OF THE LATEST REVISION OF THE SDS

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Laboratory Health and Safety

• Jack T. Ballinger, Gershon J. Shugar; Chemical

Technicians' Ready Reference Handbook, 5th Edition,

McGraw-Hill Education: New York, 2011.

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• Health Safety at Work etc Act 1974

• Penalty – up to 2 year in prison &/or an unlimited fine

• The Management of Health and Safety at Work Regs 1999

• Control of Substances Hazardous to Health Regs 2004

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Workplace Hazardous Materials Information System

• 2004

• American standard: ANSI Z400.1-2004

• 16 section

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General Safety Equipment

shower

PPE

waste disposal

fire safetyeye washer

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Facilities and Safety - Module 238

Standard Safety Practices

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SAFETY SIGNS

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Research Employee Injuries (1993–1997)

Howard Hughes Medical Institute, Office of Laboratory SafetyFerdow

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Laboratory Support Injuries (1993–1997)

Howard Hughes Medical Institute, Office of Laboratory SafetyFerdow

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LABORATORY HAZARDS

•PHYSICAL

•CHEMICAL

•BIOLOGICAL

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Bites, scratches

animal or

ectoparasites

Spills, sprays

Aspiration through pipettes

broken glass, sharps

needles, syringes

Accidents,injuries

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PHYSICAL HAZARDS

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do not recap needles

always use puncture-resistant, leakproof,sharps containers

always use specific waste disposal containers

never directly handle broken glass

Needles, Broken Glass, and Sharps

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Do you see anything wrong?

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Do NOT reuse disposable injection equipment

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CHEMICAL HAZARDS

BIOSAFETY LEVEL 1 AND 2

LABORATORIES

SEPARATE CABINETS FOR STORAGE:

SPILL CONTAINMENT CABINET

HAZARDOUS WASTE STORAGE

FLAMMABLE LIQUIDS STORAGE

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MATERIAL SAFETY DATA SHEET

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50

THE RISKS FOR LABORATORY WORKERS-MOST FREQUENTLY REPORTED INFECTIONS IN US, 1979-1999

Disease or Agent No. of CasesMycobacterium tuberculosis 223

Q fever 176

Hantavirus 169

Hepatitis B virus 84

Brucella sp. 81

Salmonella sp. 66

Shigella sp. 56

Hepatitis non-A, non-B 28

Cryptosporidium sp. 27

Total 1074Ferdow

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BIOLOGICAL HAZARDS

AEROSOLS AND DROPLETS ARE THE MAIN

SOURCES OF CONTAMINATION

MODIFIED SLIDE 41->42Ferd

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Facilities and Safety - Module 2 52

SINGLE-SOURCE, MULTIPLE LABORATORY INFECTIONS

Disease Probable Source Max Distance from Source

Number Infected

Brucellosis Centrifugation Basement to 3rd

floor94

Coccidioidomycosis Culture transfer

solid media

2 building floors 13

Coxsackie

Virus infection

Spilled tube of infected mouse tissue on floor

5 feet estimated 2

Murine Typhus Intranasal inoculation

of mice

6 feet estimated 6

Tularemia 20 Petri plates dropped

70 feet 5

Venezuelan

encephalitis

9 lyophilized

ampoules dropped

4th floor stairs to 3rd or 5th floor

24

Reitman and Wedum, 1956

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CONTAMINATION ROUTES

Ocular invasion

Inhalation

Ingestion

Skin penetration

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PERSONAL PROTECTIVE EQUIPMENT

BSL 1 AND 2

LABORATORY COAT

GLOVES

GOGGLES OR FACE SHIELD

MASKS

HEARING PROTECTION

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Minor spill

Major spill

Chemical Spills anything beyond a minor spill and requiring help from outside of the laboratory group constitutes a major spill

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Biological Spills

Spill Exercises

Spill Exercises

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Learn how to operate a portable fire extinguisher

Laboratory Fire Safety

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QUESTIONS?

COMMENTS?

Organization Personnel Equipment

Purchasing

&

Inventory

Process

Control

Information

Management

Documents

&

Records

Occurrence

ManagementAssessment

Process

Improvement

Customer

Service

Facilities

&

Safety

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