1DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

Structural Biology in

Neurodegeneration

Markus Zweckstetter

DZNE-Göttingen &

University of Göttingen &

Max Planck Institute for Biophysical Chemistry

2DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

3DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

Intrinsically Disordered Proteins

ordered

molten globule disordered

4DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

IDPs

entropic chains recognition

transient binding permanent binding

display sites chaperones effectorsassemblers scavengers

sites of post-

translational

modifications

assist folding

modulate the

activity of a

partner molecule

assemble

complexes

store small

ligands

Formation of

membrane-less

compartments

5DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

Liquid-phase transition for myelin membrane

assembly

Aggarwal et al., PLoS Biol 2013 Libich et al.,

Biophys J 2008

Mika Simons

6DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

Phase transition of myelin basic protein

Aggarwal et al., PLoS Biol 2013

7DZNE e. V. – Structural Biology in Dementia & UMG & MPIBPC

Amyloid-like assembly of myelin basic protein

Aggarwal et al.,

PLoS Biol 2013