marie badalamente (xiaflex) injection for ... · marie badalamente printed on: 19 may 2015 suny air...

Marie Badalamente

Printed On: 19 May 2015 SUNY AIR Abstracts 1

Development of Collagenase Clostridium Histolyticum (Xiaflex) Injection for Fibroporliferative DiseasesSUNY AIR Abstracts

Dr. Marie A Badalamente Dept. Orthopaedics, T-18, HSCStony Brook University Medical CenterStony Brook, New York 11794

[email protected]: 631 444 1489

Marie Badalamente


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Development of Collagenase Clostridium Histolyticum (Xiaflex) Injection for Fibroporliferative Diseases

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Fibroproliferative diseases are collagen based and involve excess deposition of collagen in many areas of the human body. Examples are the collagen "cords" of Dupuytren contracture (a fixed flexion contracture of the fingers), frozen shoulder (adhesive capsulitis) which is a painful condition of the shoulder joint collagen capsule and edematous fibrosclerotic panniculopathy (commonly known as cellulite) in which fine collagen "bands" form on the thigh and buttock areas, mostly in women. Collagenase Clostridium histolyticum injection therapy has been developed to treat these disorders.

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Collagenase Clostridium histolyticum (CCH) injection therapy for Dupuytren contracture was developed at Stony Brook University Medical Center "from bench to bedside". This disorder prevents patients from full extension of fingers, severly limits hand function and, prior to the injection therapy, surgery was the only option. Laboratory bench work led to an FDA investigational new drug number (IND) which allowed for FDA regulated Phase 1, 2 and 3 clinical trials (1,2,3). CCH was licensed to industry after Phase 1 and 2 and one Phase 3 clinical trial at Stony Brook University Medical Center. In 2010, CCH injection was FDA approved as "Xiaflex" in adult patients with Dupuytren contracture. Since then, many regulatory agencies around the

Marie Badalamente


world have approved this therapy, including the EU countries and Australia. It is estimated there are approximately 13-25 million Dupuytren patients worldwide.

Frozen shoulder (adhesive capsulitis) is a painful condition of the shoulder capsule which severely limits function of one or both arms and can last 2-3 years. Prolonged and painful physical therapy and/or shoulder arthroscopy are some of the present treatment options. CCH injection is currently in FDA regulated Phase 2 clinical trial study in the USA and Australia. Developed at Stony Brook Orthopaedics and licensed to industry early indications suggest that this injection therapy has merit in treating frozen shoulder and reducing recovery time from years to 2-3 months (4).

Edematous fibrosclerotic panniculopathy (cellulite), at first thought, may not seem to be a collagen based disorder but it is. Fine collagen "bands", known as septae form, mostly on the thighs and buttocks of women. Adipose or "fat" tissue protrudes through the bands giving the unsightly "mattress-like" appearance. Phase 2 FDA regulated clinical trials are now underway to investigate the safety and efficacy of CCH injection for cellulite elimination. This technology, developed at Stony Brook, has been licensed to industry.

1. Badalamente, M.A., Hurst, L.C., Hentz, V.R. Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease. Journal of Hand Surgery, 27A(5):788-798, 2002.2. Badalamente, M.A., Hurst, L.C. Efficacy and Safety of Injectable Mixed Collagenase Subtypes in the

Treatment of Dupuytren’s Contracture. Journal of Hand Surgery, 32(A) (6): 767-74, 2007.3. Hurst, L.C., Badalamente M.A., Hentz, V.R., Hotchkiss, R.N., Kaplan, T.D., Meals, R.A., Smith, T.N.,

Rodzvilla, J. Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture. New England Journal Of Medicine, 361: 968-979, 2009.

4 .Badalamente MA, Wang ED, MacKenzie S, Skyhar M, Kaufman G, Smith T, Ling Y, McCaul D, Tursi J. Phase 2a Study of the Safety and Efficacy of Collagenase Clostridium Histolyticum in Patients with Adhesive Capsulitis. Combined American Orthopaedic Association and Canadian Orthopaedic Association, Montreal, Canada, June 2014.

Curriculum Vitae or Resume* CV Badalamente.doc

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Marie Badalamente


File Attachment SummaryApplicant File Uploads• CV Badalamente.doc

1

CURRICULUM VITAE

Marie A. Badalamente, Ph.D.

I. PERSONAL BACKGROUND

Office Address: Dept. Orthopaedics, T-18, Room 052, Health Science Center SUNY@Stony Brook, NY 11794 Home Address: 29 Ashland Street

Mt. Sinai, New York 11766

Home Telephone: 631 331 3179Office Telephone: 631 444 1489E Mail: [email protected]

II. EDUCATIONAL BACKGROUND

DEGREE DATE INSTITUTION

Ph.D. 1977 Fordham University(Cell Biology/ Bronx, New YorkPhysiology)

M.S. 1973 C.W. Post College(Biology) Long Island University

Greenvale, New York

B.A. 1971 C.W. Post College(Biology) Long Island University

Greenvale, New York

III. EMPLOYMENT

YEAR EMPLOYMENT

1979 to present Department of OrthopaedicsSchool of MedicineSUNY at Stony BrookStony Brook, New York 11794-8181(516) 444-1489

1993 to Present Professor1986 to 1993 Associate Professor1979 to 1986 Assistant Professor

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1978 to 1979 Department of Anatomy & Cell BiologySUNY Downstate Medical CenterBrooklyn, New YorkAssistant Professor

1975 to 1978 Assistant Professor/Department of BiologyC.W. Post Center Long Island University

1974 to 1975 City University of New YorkBronx Center Department of Biology/Instructor

IV. PUBLICATIONS

1) Badalamente, M.A., Ultrastructure of Bertramia aerospora Fritsch, a Microsporidian parasite of the Rotifer, Branchionus plicatilis, Archiv fur Protisten Kunde, 1:1-9, 1973.

2) Badalamente, M.A., Ultrastructure Observations of the Respiratory Siphon of the Fourth Instar Culex pipiens Larve Subjected to Chemical Monolayers, Annals of the Entomological Society of America, 69(1):114-116, 1975.

3) Handelsman, J.E. and Badalamente, M.A., Neuromuscular Studies in Club Foot. J. Pediatric Orthop 1:23-32, 1982.

4) Handelsman, J.E. and Badalamente, M.A., Clubfoot: A Neuromuscular Disease. Developmental Medicine and Child Neurology, 24:3-12, 1982.

5) Badalamente, M.A. and Hurst, L.C., The Pathogenesis of Dupuytren's Contracture: Contractile Mechanisms of the Myofibroblasts. J. Hand Surg. 8(3):235-242, 1983.

6) Hurst, L.C., Badalamente, M.A., Ellstein, J. and Stracher, A., Inhibition of Neural and Muscle Degeneration After Epineural Neurorrhaphy. J. Hand Surg. 9A(3):564-571, 1984.

7) Hurst, L.C., Badalamente, M.A. and Blum, D., CO2 Laser Transection of Rat Peripheral Nerves. J. Hand Surg. 9A(3):428-433, 1984.

8) Badalamente, M.A., Dee, R. and Propper, M., Ultrastructural Study of Joint Innervation. Orthop. Rev. 13(4):212-216, 1984.

9) Halata, Z., Badalamente, M.A., Dee, R. and Propper, M., The Ultrastructure of Sensory Nerve Endings in Monkey (Macaca fasicularis) Knee Joint Capsule. J. Orthop. Res. 2(2):169-176, 1984.

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DR. MARIE A. BADALAMENTEPUBLICATIONS, cont'd

10) Badalamente, M.A., Hurst, L.C., Makowski, J. and Stracher, A., Inhibition of Neural and Muscle Regeneration After Microsurgical Repair of Severed Peripheral Nerves. Annals of N.Y. Academy of Sciences, 435:380-381, 1984.

11) Badalamente, M.A., Hurst, L.C., Ellstein, J. and McDevitt, C.A., The Pathobiology of Human Neuroma: An Electron Microscopic and Biochemical Study. Br. J. Hand Surg. 10B(1):49-53, 1985. CITATION OF THIS PAPER: 1987 Yearbook of Hand Surgery, J.H. Dobyns, R.A. Chase, P.C. Amadio (eds), Yearbook Medical Publishers, Inc., Chicago, Chapter 8, pp. 294-295.

12) Badalamente, M.A., Hurst,, L.C. and Stracher, A., Effects of Pharmacological Agents on Neuromuscular Recovery After Nerve Repair. Proceedings of the Cell Biology and Clinical Management in Functional Stimulation of Neurones and Muscles, 1:19-22, 1985.

13) Hurst, L.C., Badalamente, M.A. and Makowski, J., The Pathobiology of Dupuytren's Contracture: Effects of Prostaglandins on Myofibroblasts. J. Hand Surg. 11A(1):18-23, 1986. CITATION OF THIS PAPER: 1987 Yearbook of Hand Surgery, J.H. Dobyns, R.A. Chase, P.C. Amadio (eds), Yearbook Medical Publishers, Inc., Chicago, Chapter 14, p. 197.

14) Badalamente, M.A., Hurst, L.C., Stracher, A. and Makowski, J., The Effects of Leupeptin on Nerve Repair in Primates. Annals of the New York Academy of Sciences, 463:253-255, 1986.

15) Hurst, L.C., Badalamente, M.A., Atkins, H., Oster, Z. and Weissberg, D., Incorporation of a New Radioactive Tin Compound +4SN-117m DTPA into Normal and Burred Rat Femurs. Clin. Orthop. and Rel. Res. 206:290-295, 1986.

16) Badalamente, M.A., Hurst, L.C. and Stracher, A., Calcium-Induced Degeneration of the Cytoskeleton in Monkey and Human Peripheral Nerves. Br. J. Hand Surg. 11B(3):337-340, 1986.

17) Fromowitz, F.B., Hurst, L.C., Nathan, J. and Badalamente, M.A., Infantile (Desmoid-type) Fibromatosis with Extensive Ossification. Am. J. Surg. Pathol. 11(1):66-75, 1987.

18) Hurst, L.C., Amadio, P.C., Badalamente, M.A., Ellstein, J. and Dattwyler, R.J., Mycobacterium Marinum Infections of the Hand. J. Hand Surg. 12A(3):428-435, 1987.

19) Badalamente, M.A., Hurst, L.C., Paul, S. and Stracher, A., Enhancement of Neuromuscular Recovery After Nerve Repair in Primates. Br. J. Hand Surg. 12B:211-217, 1987. CITATION OF THIS PAPER: 1989 Yearbook of Hand Surgery.

20) Badalamente, M.A., Dee, R., Ghillani, R., Chien, P.F., Daniels, K., Mechanical Stimulation of Dorsal Root Ganglia Induces Increased Production of Substance P: A Mechanism for Pain Following Nerve Root Compromise? Spine 12(6):552-555, 1987.

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DR. MARIE A. BADALAMENTEPUBLICATIONS, cont'd

21) Badalamente, M.A., Dee, R., Ghillani, R., Chien, P.F. and Daniels, K., Compression of Lumbar Nerve Roots Induces Increase of Substance P Immunoreactivity. Annals N.Y. Academy of Sciences 494:299-301, 1987.

22) Badalamente, M.A., Hurst, L.C., Stracher, A., Localization and Inhibition of Calcium Activated Neutral Protease (CANP) in Primate Skeletal Muscle and Peripheral Nerve. Exp. Neurol. 98:357-369, 1987.

23) Hurst, L.C., Badalamente, M.A., Stracher, A., Localization of Calcium Activated Neutral Protease (CANP) in Denervated Human Skeletal Muscle and Peripheral Nerve. Neuro. Orthop. 4:55-61, 1987.

24) Badalamente, M.A,., Hurst, L.C., Sampson, S.P., Prostaglandins Influence Myofibroblast Contractility in Dupuytren's Disease. J. Hand Surg. 13A(6):867-871, 1988.

25) Badalamente, M.A., Dee, R. (Invited authorship), Muscle: Structure and Function. In: Principles of Orthopaedic Practice, R. Dee, E. Mango, L.C. Hurst (eds), N.Y. McGraw-Hill, 1989, Vol. 1, Chap. 13, pp. 110-119.

26) Hurst, L.C., Badalamente, M.A., Paul, S. (Invited authorship), Peripheral Nerve Injuries and Entrapments. Nerve Injuries in the Upper Extremity. In: Principles of Orthopaedic Practice, R. Dee, E. Mango, L.C. Hurst (eds), N.Y. McGraw-Hill, 1989, Vol. 1, Chap. 40, pp. 666-689.

27) Hurst, L.C., Badalamente, M.A., (Invited Authorship) Dupuytren's Contracture. In: Principles of Orthopaedic Practice, R. Dee, E. Mango, L.C. Hurst (eds), N.Y. McGraw-Hill, 1989, Vol. 1, Chap. 47, pp. 775-780.

28) Badalamente, M.A., Cherney, S.B., Periosteal and Vascular Innervation of the Human Patella in Degenerative Joint Disease. Seminars in Arthritis and Rheumatism 18(4):1-6, 1989.

29) Badalamente, M.A., Hurst, L.C., Stracher, A., Neuromuscular Recovery Using Calcium Protease Inhibition After Median Nerve Repair in Primates. Proceedings of the National Academy of Sciences, 86:5983-5987, 1989.

30) Hurst, L.C., Badalamente, M.A., Associated Diseases. In: Dupuytren's Disease, R. M. McFarlane, D.A. Mc Grouther, M.H. Flint (eds), Churchill Livingstone, N.Y., 1990, Volume 5, Chapter 23, pp. 253-260.

31) Hurst, L.C., Dowd, A., Sampson, S.P., Badalamente, M.A., Partial Lacerations of the Median and Ulnar Nerves. J. of Hand Surg., 16A: 207-210, 1991.

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DR. MARIE A. BADALAMENTEPUBLICATIONS, cont'd.

32) Sampson, S.P., Badalamente, M.A., Hurst, L.C., Seidman, J. The Pathobiology of the Human A1 Pulley in Trigger Finger. J. Hand Surgery,16A: 714-721, 1991. Citation of this Paper: 1993 Yearbook of Hand Surgery.

33) Hurst, L.C., Badalamente, M.A. (Invited Authorship)Biochemical Properties of Peripheral Nerve. In: Operative Nerve Repair and Reconstruction, Volume 1, R. Gelberman (ed), Lippincott Press, 1991, Chapter 4, pp. 55-72.

34) Badalamente, M.A., Hurst, L.C., Stracher, A., Prevention of Denervation Atrophy: Effects on Recovery After Nerve Repair in a Primate Model. In: The Third Vienna Muscle Symposium, G. Freilinger & M. Deutinger (eds.), 1992, Vienna, Blackwell Publishers, pp 108-116.

35) Badalamente, M.A., Hurst, L.C., Grandia, S., Sampson, S.P. Platelet Derived Growth Factor in Dupuytren’s Disease. J. Hand. Surg., 17(A): 317-323, 1992

36) Sampson, S.P. Badalamente, M.A., Hurst, L.C., Dowd, A., Sewell, C., Lehmann-Torres, J., Ferraro, M. and Semon, B. The Use of a Passive Motion Machine in the Postoperative Rehabilitation of Dupuytren's Disease. J. Hand Surg., 17A(2): 333-338, 1992.

37) Badalamente, M.A., Hurst, L.C. & Stracher, A. Recovery After Delayed Nerve Repair: Influence of a Pharmacologic Adjunct in a Primate Model. J. of Reconstructive Microsurgery, 8(5): 391-397, 1992.

38) Sampson, S.P., Wisch, D. & Badalamente, M.A. (Invited authorship), Complications of Conservative and Surgical Treatment of DeQuervain's Disease and Trigger Fingers. Hand Clinics of North America, J.M. Bednar (ed.), W.B. Saunders, Philadelphia, 10 (1): 73-82, 1994.

39) Badalamente, M.A., Hurst, L.C. & Stracher, A. Neuromuscular Recovery After Peripheral Nerve Repair: Effects of an Orally Administered Peptide in a Primate Model.J. Recon. Microsurgery, 11(6): 429-437, 1995.

40) Hurst, L.C., Starkweather, K., & Badalamente, M.A. (Invited authorship),Dupuytren's Disease. In, Surgery of the Hand and Upper Extremity, C.A. Peimer, ed.McGraw Hill, N.Y., Volume 2, Chapter 70, pp. 1601-1615, 1996.

41) Badalamente, M.A., Sampson, S.P., Hurst, L.C., Dowd, A., Myiasaka, K.The Role of Transforming Growth Factor Beta in Dupuytren's Disease. J. Hand Surg.21A: 210-215, 1996.

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42) Starkweather, K., Lattuga, S., Hurst, L.C., Badalamente, M.A., Guilak, F., Sampson, S.P., Dowd, A., Wisch, D. Collagenase in the Treatment of Dupuytren's Disease: An in vitro study. J. Hand Surg. 21A: 490-495, 1996.

43) Badalamente, M.A., Hurst, L.C. Enzyme Injection as a Nonoperative Treatment for Dupuytren's Disease. J. Drug Delivery 3 (1): 35-40, 1996.

44) Hurst, L.C., Badalamente, M.A. Dupuytren's Disease. In: Principles of Orthopaedic Practice, R. Dee, L.C. Hurst, M.A. Gruber, S. Kottmeier (eds.), 2nd Edition, McGraw Hill, Chapter 59, pp. 1145-1151, 1997.

45) Dagum, A. B., Hurst, L.C., Badalamente, M.A. Nerve Injury: Healing, Repair and Grafting In: Principles of Orthopaedic Practice, R. Dee, L.C. Hurst, M.A. Gruber, S. Kottmeier (eds), 2nd Edition, McGraw Hill, Chapter 67, pp. 1207-1214, 1997.

46) Badalamente, M.A. & Hurst, L.C. (Invited authorship), Histochemical Aids to Control Specificity of Nerve Repair. In, Management of Peripheral Nerve Problems, Second Edition, G.E. Omer, M. Spinner, A. L. Van Beek, eds., W.B. Saunders, Fl., 1998, pp. 243-247.

47) Badalamente, M.A., Hurst, L.C. (Invited authorship) The Biochemistry of Dupuytren's Disease. Hand Clinics, G.M. Rayan (ed). W.B. Saunders 15(1), 35-42 1999.

48) Hurst, L.C., Badalamente, M.A. (Invited authorship) Nonoperative Treatment of Dupuytren's Disease. Hand Clinics, G.M. Rayan (ed). W.B. Saunders 15(1), 97-107 1999.

49) Badalamente, M.A. & Stracher, A. Delay of Muscle Degeneration and Necrosis in mdx mice by Calpain Inhibition. Muscle and Nerve, 23: 106-111, 2000.

50) Hurst, L.C. & Badalamente, M.A. (Invited editors & authorship), Dupuytren's Disease, R. Tubiana, C. Leclercq, L.C. Hurst, M.A. Badalamente (eds.), Martin Dunitz Publishers, London (2000)

51) Badalamente, M.A., Hurst, L.C. Enzyme Injection as a Nonoperative Treatment of Dupuytren's Disease. J. Hand Surg. 25A(4): 629-636, 2000.

52) Ries, M.D., Badalamente, M.A. Arthrofibrosis after Total Knee Arthroplasty Clinical Orthopaedics and Related Research. 380: 177-183, 2000.

53) Khan, A.M., Ryan, M.G., Gruber, M.M., Haralabotos, S.P., Badalamente, M.A. Connective Tissue Structures in Club Foot: A Morphologic Study. Journal of Pediatric Orthopaedics, 21: 708-712, 2001.

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54) Badalamente, M.A., Hurst, L.C., Hentz, V.R. Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease. Journal of Hand Surgery, 27A(5):788-798, 2002. This paper was selected for inclusion in the Yearbook of Orthopedics, 2003.

55) Hurst, L.C., Badalamente, M.A. (Invited authorship) Dupuytren's Contracture Release and Injections. J.T. Capo and V. Tan (eds.) in Minimally Invasive Hand and Wrist Surgery. Marcel-Dekker Publishers, 2008.

56) Badalamente, M.A., Hurst, L.C. Efficacy and Safety of Injectable Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture. Journal of Hand Surgery, 32(A) (6): 767-74, 2007.

57) Hurst, L.C., Badalamente M.A., Hentz, V.R., Hotchkiss, R.N., Kaplan, T.D., Meals, R.A., Smith, T.N., Rodzvilla, J. Injectable Collagenase Clostridium Histolyticum for Dupuytren’s Contracture. New England Journal Of Medicine, 361: 968-979, 2009.

58) Badalamente, M.A., Injectable Collagenase (Clostridium Histolyticum) for Dupuytren’s Disease. In: Dupuytren’s Disease and Related Hyperproliferative Disorders, C. Eaton, M.H. Seeggenschmiedt, A. Bayat, G. Gabbiani, P. Werker, W. Wach (eds.), Springer Verlag, Berlin, Heidelberg, Chapter 43, pages 343-347, 2012.

59) Badalamente MA, Davis T, Dolmans GHCG, Eckersley R , Hovius S, Leclercq C, MacKenney E, McGrouther DA, Moermans JP, Moolenburgh JD, Nanchahal J, Peimer C, Reichert B, Seegenschmiedt H, Szabo Z, Wilbrand S. Current Strategies For Treatment Of Dupuytren’s Disease: Report From The 2011 Dupuytren’s Summit, London, December, 2011. Submitted, Journal of Hand Surgery (European Volume), 2012.

60) Hurst, L.C., Badalamente M.A., Ward, A., Parker, T., Liu, J., Tatka, J. Histology of Cords from Dupuytren’s Patients: A Comparison after Collagenase Injection/Fasciectomy, Primary Fasciectomy and Repeat Fasciectomy. Journal of Hand Surgery, 2013, in press.

61) Badalamente, M, Coffelt, L, Elfar, J, Gaston G, Hammert, W, Huang, J, Lattanza, L, Macdermid, J, Merrell, G, Netscher, D, Panthaki, Z, Rafijah, G,Trczinski, D, Graham, B. Measurement Scales in Clinical Research of the Upper Extremity, Part 1:General Principles, Measures of General Health, Pain, and Patient Satisfaction. Journal of Hand Surgery, 38A (2):401-406, 2013.

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62) Badalamente, MA, Coffelt, L, Elfar, J, Gaston G, Hammert, W, Huang, J, Lattanza, L, Macdermid, J, Merrell, G, Netscher, D, Panthaki, Z, Rafijah, G,Trczinski, D, Graham, B. Measurement Scales in Clinical Research of the Upper Extremity, Part 2: Outcome Measures of the Hand/Wrist and Shoulder/Elbow. Journal of Hand Surgery, 38A:407-412, 2013.

63) Badalamente, M.A,. Hurst, L.C., Benhaim, P, Cohen, B.M. Efficacy and Safety of Collagenase Clostridium Histolyticum in the Treatment of Proximal Interphalangeal Joints in Dupuytren Contracture: Combined Analysis of Four Phase 3 Clinical Trials. Journal of Hand Surgery Am., 40A: 975-983, 2015.64) Kaplan, FTD, Badalamente, MA, Hurst, LC, Merrell, GA, Pahk, R. Delayed Manipulation After Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture. Hand, in press.

65) Wang, E.D., Badalamente, M.A., Skyhar, M., MacKenzie, S., Kaufman, G., Smith, T., McCaul, D., Tursi, J.P. Collagenase Clostridium Histolyticum Injection in Subjects with Adhesive Capsulitis: A Randomized, Open-Label, Dose-Ranging Study. J. Bone and Joint Surgery, (in preparation).

V. ABSTRACTS AND PRESENTATIONS

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1. Aiello, E. and Badalamente, M.A., Ciliary Transport Without Metachronal Waves. Federation Proceedings, 35:369, 1976. Paper presented at Federation of American Societies for Experimental Biology, Annual Meeting, Anaheim, 1976.

2. Aiello, E. and Badalamente, M.A., Ultrastructural Observations on Mucous Distribution, Histochemistry and Transport in the Mammalian Respiratory Tract. American Zoologist 16(2):428. Paper presented at the American Society of Zoologists Meeting Tulane, 1976.

3. Handelsman, J.E. and Badalamente, M.A., Congenital Club Foot - Is It a Neuromuscular Disease? State University of New York at Stony Brook Continuing Medical Education Course, Neuromuscular Diseases in Children: Current Concepts and Treatment, Stony Brook, New York, March 1979.

4. Handelsman, J.E. and Badalamente, M.A., Etiologic Basis for Treatment of Congenital Club Foot. Eastern Long Island Chapter of the American College of Surgeons, Montauk, New York, March 1979.

5. Handelsman, J.E. and Badalamente, M.A., The Pathogenesis of Deformity in Talipes Equinovarus. Seventh Pediatric Orthopaedic International Seminar, Chicago, May 1979.

6. Handelsman, J.E. and Badalamente, M.A., Neuromuscular Abnormalities in Club Foot. Medical Society of the State of New York, Spring Continuing Medical Education Assembly Program, Rye, New York, April 1980.

7. Badalamente, M.A. and Handelsman, J.E., Annual Meeting of the American Academy for Cerebral Palsy and Developmental Medicine, Boston, October, 1980. Paper was judged to be one of the six best presented.

8. Handelsman, J.E. and Badalamente, M.A., Neuromuscular Abnormalities in Club Foot: Their Relevance in Cause and Management. Paper won the Hunterian Award of the Royal College of Surgeons, London. Paper was presented before the Royal College, March, 1981.

9. Badalamente, M.A. and Handelsman, J.E., Neuromuscular Abnormalities in Club Foot. Poster Display presented at the American Academy of Orthopaedic Surgeons Annual Meeting, Las Vegas, February 1981.

10. Handelsman, J.E. and Badalamente, M.A., Neuromuscular Studies in Club Foot. Muscular Dystrophy Abstracts, 26(7):95, 1982.

11. Handelsman, J.E. and Badalamente, M.A., Comparative Study of Muscle Structure in Neurogenic Disease and Peripheral Deformities. Presented as a poster display at the Combined Orthopaedic Meetings of the English SpeakingWorld. Cape Town, South Africa 1982. DR. MARIE A. BADALAMENTEABSTRACTS AND PRESENTATIONS, Cont'd

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12. Handelsman, J.E. and Badalamente, M.A., The Comparative Neuromuscular Pathogenesis in Club Foot, Arthrogryposis and Lumbosacral Agenesis. Presented as a poster display at Orthopaedic Research Society Meeting, January 1982, New Orleans. Transactions of the 28th Orthopaedic Research Society 7:224, 1982.

13. Badalamente, M.A. and Hurst, L.C., The Pathogenesis of Dupuytren's Contracture: Contractile Mechanisms of the Myofibroblasts. Presented at the Orthopaedic Research Society and American Society for Surgery of the Hand Annual Meetingpheral Nerve. In: Operative Nerve Repair and Reconstruction, Volume 1, R. Gelberman (ed), Lippincott Press, 1991, Chapter 4, pp. 55-72.

34) Badalamente, M.A., Hurst, L.C., Stracher, A., Prevendex Vol. 2-9-1, 1983, Orthopaedic Research and Education Foundation.

14. Stracher, A., Badalamente, M.A. and Hurst, L.C., Potential Therapeutic Application of Protease Inhibitors in Neuromuscular Degenerative Disorders. Paper presented at the International Symposium on Medical and Biological Aspects of Proteinase Inhibitors, Tokushima, Japan, August 1982.

15. Badalamente, M.A., Dee, R. and Propper, M., Joint Innervation: An Ultrastructural Study. Transactions of the 29th Orthopaedic Research Society 8:275, 1983. Presented at the Orthopaedic Research Society Annual Meeting, March 1983.

16. Badalamente, M.A., Hurst, L.C. and Stracher, A., Effects of a Protease Inhibitor After Epineural Neurorrhaphy. Transactions of the 29th Orthopaedic Research Society 8:313, 1983. Presented at the Orthopaedic Research Society and American Society for Surgery of the Hand, Annual Meetings, March 1983.

17. Badalamente, M.A., Hurst, L.C., McDevitt, C. and Ellstein, J., The Pathobiology of Human Neuroma: An Electron Microscopic and Biochemical Study. Transactions of the 29th Orthopaedic Research Society 8:276, 1983. Presented at the Orthopaedic Research Society, Annual Meetings and American Academy of Orthopaedic Surgeons Meeting, March 1983.

18. Badalamente, M.A., Hurst, L.C., Stracher, A. and Makowski, J., Inhibition of Neural and Muscle Degeneration After Microsurgical Repair of Severed Peripheral Nerves. J. Hand Surg. 8:617, 1983. Poster display presentation, N.Y. Academy of Sciences, Biological Colloquium, November 1983.

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DR. MARIE A. BADALAMENTEABSTRACTS AND PRESENTATIONS, Cont'd

19. Badalamente, M.A., Dee, R., Propper, M. and Halata, Z., The Ultrastructure of Sensory Nerve Endings in Monkey (Macaca fasicularis) Knee Joint Capsule. Transactions of the 30th Orthopaedic Research Society 9:20, 1984. Presented at the 30th Annual Meetings of the Orthopaedic Research Society, Atlanta, 1984.

20. Badalamente, M.A., Hurst, L.C. and Blum, D., CO2 Laser Transection of Peripheral Nerve. Transactions of the 30th Orthopaedic Research Society 9:21, 1984. Presented at the 30th Annual Meetings of the Orthopaedic Research Society, Atlanta, 1984.

21. Handelsman, J.E., Badalamente, M.A. and Glasser, R.A., A Comparative Study of Muscle in Peripheral Deformities. Transactions of the 30th Orthopaedic Research Society 9:275, 1984. Presented at the 30th Annual Meeting of the Orthopaedic Research Society, Atlanta, 1984. 22. Badalamente, M.A., Hurst, L.C. and Stracher, A., Effects of Leupeptin on Nerve Repair in Primates. Presented at the 2nd Biological Colloquium N.Y. Academy of Sciences, November 1984.

23. Badalamente, M.A. and Hurst, L.C., The Pathobiology of Dupuytren's Contracture: Effects of Prostaglandins on Myofibroblasts. Transactions of the 31st Orthopaedic Research Society 10:115, 1985. Presented at the 31st Annual Meeting of the Orthopaedic Research Society and American Society for Surgery of the Hand Annual Meeting, Las Vegas, January 1985.

24. Badalamente, M.A., Hurst, L.C. and Stracher, A., Adjunctive Therapy to the Microsurgical Repair of Severed Peripheral Nerves. Transactions of the 31st Orthopaedic Research Society 10:338, 1985. Presented at the 31st Annual Meeting of the Orthopaedic Research Society, Las Vegas, January 1985.

25. Badalamente, M.A., Hurst, L.C. and Stracher, A., Effects of Pharmacological Agents on Neuromuscular Recovery After Microsurgical Nerve Repair. Satellite Symposium of the XIII World Congress of Neurology, "Cell Biology and Clinical Management in Functional Stimulation of Neurones and Muscles," Abano Terme, Italy, August 1985.

26. Badalamente, M.A. (Invited lecture), Colloquium in Dupuytren's Contracture. Contractile Mechanisms of the Myofibroblasts. Victoria Hospital, University of Western Ontario, London, Ontario, Canada, October 1985.

27. Badalamente, M.A., Hurst L.C. (Invited lecture), Dupuytren's Contracture. Orthopaedic Audio-Synopsis Foundation 17(14):July 1985. Publisher of Continuing Education in Orthopaedic Surgery. Audio tape recording of current concepts in Dupuytren's Contracture for Foundation which offers CME credit.

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28. Badalamente, M.A., Hurst, L.C., Stracher, A. and Paul, S., Enhancement of Neuromuscular Recovery After Nerve Repair in Primates. The American Society for Surgery of the Hand Annual Meeting, New Orleans, La., February 1985.

29. Badalamente, M.A., Dee, R., Ghillani, R., Chien, P.F. and Daniels, K., Compression of Lumbar Nerve Roots Induces Increase of Substance P Immunoreactivity. Transactions of the 32nd Orthopaedic Research Society 11:59, 1986. Presented at the 32nd Annual Meeting of the Orthopaedic Research Society, 1986, and the 3rd Biological Colloquium of the N.Y. Academy of Science, November 1985.

30. Badalamente, M.A., Hurst, L.C., Stracher, A. and Paul, S., Protease Inhibition Enhances Neuromuscular Recovery After Nerve Repair in Primates. Transactions of the 33rd Orthopaedic Research Society 12:478, 1987. Presented at the 33rd Annual Meeting of the Orthopaedic Research Society, San Francisco, January 1987.

31. Badalamente, M.A. and Hurst, L.C., Immunohistochemical Localization of Prostaglandins in Dupuytren's Disease: Effects on Myofibroblast Contractility. Transactions of the 33rd Orthopaedic Research Society 12:330, 1987. Presented at the 33rd Annual Meeting of the Orthopaedic Research Society, San Francisco, January 1987

32. Badalamente, M.A., Hurst, L.C. and Sampson, S.P., Prostaglandins Influence Myofibroblast Contractility in Dupuytren's Disease. American Soc. for Surgery of the Hand, San Antonio, September, 1987.

33. Badalamente, M.A., Dee, R., and Daniels, K., Substance P: A Mechanism for Pain Following Nerve Root Deformation. British Orthopaedic Research Society, London, September 1987.

34. Badalamente, M.A., Hurst, L.C. and Stracher, A., Muscle and Neural Calcium Protease Localization and Inhibition: Implications on Recovery After Nerve Repair. Transactions of the 34th Orthopaedic Research Society 13:463, 1988. Presented at the 34th Annual Meeting of the Orthopaedic Research Society, Atlanta, February 1988.

35. Badalamente, M.A. and Cherney, S., The Innervation of the Human Patella in Degenerative Joint Disease: Identification of Vasoactive Neurotransmitters. Transactions of the 34th Orthopaedic Research Society 13:513, 1988. Presented at the 34th Annual Meeting of the Orthopaedic Research Society, Atlanta, February 1988.

36. Stracher, A., Badalamente, M.A. and Hurst, L.C., Localization and Function of Calcium Protease in Primate Muscle and Nerve. International Conference on Proteases and Protease Inhibitors. Tokyo, Japan, May 1988

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37. Badalamente, M.A., Hurst, L.C. and Stracher, A., Calcium Protease Localization and Inhibition After Nerve Repair in Primates. American Society for Surgery of the Hand, Baltimore, September 1988. Orthopaedic Transactions 13:8, 1989.

38. Badalamente, M.A. (Invited Speaker), Enhancement of Neuromuscular Recovery After Nerve Repair in Primates. State University of N.Y., School of Medicine at Brooklyn Health Sciences Center, November 1988.

39. Badalamente, M.A. and Hurst, L.C., Platelet Derived Growth Factor: A Cell mitogen in Dupuytren's Disease. Transactions of the 35th Orthopaedic Research Society 14:255, 1989, Orthopaedic Transactions 13:334, 1989. Presented at the 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, February 1989.

40. Badalamente, M.A., Sampson, S.P., Hurst, L.C. and Seidman, J., The Pathobiology of Stenosing Tenosynovitis of the Human A1 Pulley. Transactions of the 35th Orthopaedic Research Society 14:199, Orthopaedic Transactions 13:312, 1989. Presented at the Annual Meeting of the Orthopaedic Research Society, Las Vegas, February 1989.

41. Badalamente, M.A. (Invited Speaker), Periosteal and Subchondral Pain in Osteoarthritis. Symposium on Pain in Osteoarthritis, Cancun, Mexico, Februaryndex Vol. 2-9-1, 1983, Orthopaedic Research and Education Foundation.

14. Stracher, A., Badalamente, M.A. and Hurst, L.C., Potential Therapeutic Application of Protease Inhibitors in Nerve Repair in Primates. Second International Conference on Protease Inhibitors (Brdo Conference), Ljubljana, Yugoslavia, June 1989.

43. Badalamente, M.A. and Hurst, L.C., Platelet Derived Growth Factor in Dupuytren's Disease. The 44th Annual Meeting of the American Society for Surgery of the Hand, Seattle, September 1989.

44. Sampson, S.P., Badalamente, M.A. and Hurst, L.C., The Pathobiology of the Human A1 Pulley in Trigger Finger: Synovitis or Chondritis? The 44th Annual Meeting of the American Society for Surgery of the Hand, Seattle, September 1989.

45. Badalamente, M.A., Hurst, L.C. and Stracher, A., Maintenance of the End Organ Muscle Target: Implications on Recovery After Peripheral Nerve Repair in a Primate Model. Transactions of the 36th Orthopaedic Research Society 15(1):147, 1990. Presented at the 36th Annual Meeting of the Orthopaedic Research Society, New Orleans, February 1990.

46. Badalamente, M.A., Hurst, L.C. and Stracher, A., Prevention of Denervation Atrophy After Nerve Repair in Primates. Third Vienna Muscle Symposium, Vienna, Austria, June 1990.

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47. Badalamente, M.A., Hurst, L.C. and Stracher, A., Maintenance of the End Organ Muscle Target: Implications on Recovery After Peripheral Nerve Repair in a Primate Model. American Society for Surgery of the Hand, 45th Annual Meeting, Toronto, Canada, September, 1990.

48. Sampson, S.P., Badalamente, M.A., Hurst, L.C., Sewell, C., Lehmann-Torres, J., Ferraro, M., Semon, B. The Use of Continuous Passive Motion in the Post-Operative Rehabilitation of Dupuytren's Disease. American Society for Surgery of the Hand, 45th Annual Meeting, Toronto, Canada, September, 1990.

49. Badalamente, M.A. (Invited Speaker), Enhancement of Neuromuscular Recovery After Nerve Repair. Dept. Biological Sciences, Fordham University, October 1990.

50. Badalamente, M.A., Hurst, L.C. and Stracher, A., Enhancement of Recovery After Delayed Nerve Repair in Primates. Transactions of the 37th Orthopaedic Research Society, 16: 88, 1991. Presented at the 37th Annual Meeting of the Orthopaedic Research Society, Anaheim, Ca., March, 1991.

51. Badalamente, M.A., Sampson, S.P., Seidman, J. and Hurst, L.C. Wolff's Law Revisited in the Human A1 Pulley. American Society for Surgery of the Hand, 46th Annual Meeting, Orlando, Fl., October, 1991. 52. Sampson, S.P., Badalamente, M.A., Dowd, A. and Hurst, L.C. The Pathobiology of Cumulative Trauma Disorders/ Entrapment Syndromes: Trigger Finger, DeQuervain's Disease and Carpal Tunnel Syndrome. American Society for Surgery of the Hand, 46th Annual Meeting, Orlando, Fl., October, 1991.

53. Hurst, L.C., Badalamente, M.A. and Stracher, A. Recovery After Delayed Nerve Repair: Influence of a Pharmacologic Adjunct in a Primate Model.American Society for Reconstructive Microsurgery, 7th Annual Meeting, Orlando, October, 1991.

54. Badalamente, M.A. (Invited Speaker), Ciliary Neurotrophic Factor inPeripheral Nerve Repair. SUNY-Stony Brook, Department of Medicine, Division of Endocrinology/Metabolism Conference, January, 1992

55. Badalamente, M.A. (Invited Speaker), The Biochemistry of Peripheral Nerve Degeneration/Regeneration- Special Panel Session on "Nerve Injury and Repair". 38th Annual Meeting of the Orthopaedic Research Society, Washington, D.C., February, 1992.

56. Badalamente, M.A., Sampson, S.P., Dowd, A. and Hurst, L.C. The Pathobiology of Cumulative Trauma Disorders/ Entrapment Syndromes: Trigger Finger, DeQuervain's Disease and Carpal Tunnel Syndrome. Transactions of the 38th Orthopaedic Research Society, 17: 677, 1992. Presented at the 38th Annual Meeting of the Orthopaedic Research Society, Washington, D.C.,

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February, 1992.

57. Sampson, S.P., Badalamente, M.A., Dowd, A. & Hurst, L.C. Cumulative Trauma Disorders of the Hand and Wrist. Orthopedics Today, 12(3): 24, 1992.

58. Badalamente, M.A. (Invited Speaker), Cumulative Trauma Disorders of the Hand and Wrist. SUNY-Stony Brook, Department of Medicine, Division of Allergy/Rheumatology Conference, January, 1993.

59. Badalamente, M.A. (Invited Speaker), Peripheral Nerve Degeneration/Regeneration Special Panel Session on "Nerve Injury and Repair". 39th Annual Meeting of the Orthopaedic Research Society, San Francisco, February, 1993.

60. Badalamente, M.A., Hurst, L.C., Pecoraro,M. Ciliary Neurotrophic Factor as an in vivo Adjunct to Peripheral Nerve Repair. Transactions of the 39th Orthopaedic Research Society, 18: 391, 1993. Presented at the 39th Annual Meeting of the Orthopaedic Research Society, San Francisco, February, 1993.

61. Badalamente, M.A., Sampson, S.P., Schwartz, E., Hurst, L.C. Amyloid Tenosynovial Deposition in Idiopathic Carpal Tunnel Syndrome: A Histologic, Histochemical and Ultrastructural Study. Presented at the 48th Annual Meeting of the American Society for Surgery of the Hand, Kansas City, Missouri, September, 1993.

62. Sampson, S.P., Badalamente, M.A., Dowd, A., Hurst, L.C., Miyasaka, K. C. The Role of Transforming Growth Factor Beta in Dupuytren's Disease. Presented at the 48th Annual Meeting of the American Society for Surgery of the Hand, Kansas City, Missouri, September, 1993.

63. Badalamente, M.A., Davis, W., Kramer, J.M. The Pathobiology of Idiopathic Scoliosis: Dystrophin Myopathy in Paravertebral Muscles. Transactions of the 40th Annual Orthopaedic Research Society, 19: 166, 1994. 40th Annual Orthopaedic Research Society, New Orleans, February, 1994.

64. Levin, N., Badalamente, M.A., Dee, R. Clearance of Particulate Debris: A Rat Knee Joint Model Using Labeled Microspheres. Transactions of the 40th Annual Orthopaedic Research Society, 19: 846, 1994. 40th Annual Orthopaedic Research Society, New Orleans, February, 1994.

65. Badalamente, M.A. Cumulative Trauma Disorders (Repetitive Strain Injury): A Basic Science Perspective. Correspondence Newsletter 148, American Society for Surgery of the Hand, 1994 DR. MARIE A. BADALAMENTE

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ABSTRACTS AND PRESENTATIONS, Cont'd

66. Badalamente, M.A., Hurst, L.C., Stracher, A. Recovery is Enhanced After Nerve Repair and Oral Peptide Delivery in a Primate Model. 41st Annual Orthopaedic Research Society, Orlando, February, 1995, Transactions of the 41st Annual Orthopaedic Research Society, 20: 109, 1995. 50th Annual Meeting of the American Society for Surgery of the Hand, San Francisco, September, 1995.

67. Badalamente, M.A., Starkweather, K., Hurst, L.C., Guilak, F., Sampson, S.P.,Dowd, A., Wisch, D. Collagenase in the Treatment of Dupuytren's Disease. 42nd Annual Orthopaedic Research Society, Atlanta, February, 1996, Transactions of the 42nd Annual Orthopaedic Research Society, 21: 210, 1996. Combined American/JapaneseSocieties for Surgery of the Hand, Maui, Hawaii, March, 1996.

68. Linville, D., Sampson, S.P., Badalamente, M.A., Wadhwa, N.K., Sunku, V., Picot, F., Kaufman, M., Finzel, K. Edema Changes as a Cause of Carpal Tunnel Syndrome. 42nd Annual Orthopaedic Research Society, Atlanta, February, 1996.Transactions of the 42nd Annual Orthopaedic Research Society, 21: 205, 1996.

69. Healy, W., Badalamente, M.A., Hurst, L.C., Sampson, S.P., Dowd, A. Dupuytren's Disease Outcome Study. 51st Annual Meeting of the American Society for Surgery of the Hand, Nashville, September, 1996.

70. Sampson, S.P., Badalamente, M.A., Cutcliffe, D., Hurst, L.C. Idiopathic Carpal Tunnel Syndrome: In Search of the Holy Grail. 27th Annual Meeting of the American Association of Hand Surgery, Boca Raton, FL., January, 1997.

71. Badalamente, M.A., Sampson, S.P, Cutcliffe, D., Hurst, L.C., Dowd, A.The Pathobiology of Carpal Tunnel Syndrome. 43rd Annual Meeting of the Orthopaedic Research Society, San Francisco, February, 1997. Transactions of the 43rd Annual Orthopaedic Research Society, 22: 671, 1997. 72. Badalamente, M.A. (Invited Speaker) Nerve Repair in Primates. Second International Conference on Protease Inhibitors (Brdo Conference), Ljubljana, Yugoslavia, June 1989.

43. Badalamente, M.A. and Hurst, L.C., Nonoperative Treatment for Dupuytren's Disease: A Phase 2 Clinical Trial of Injectable Collagenase. 44th Annual Meeeting of the Orthopaedic Research Society, New Orleans, March, 1998. Transactions of the 44th Annual ORS, 23:1156, 1998.

74. Keller, K, Badalamente, M.A. The Inhibitory Effects of IL-4 and IL-10 on Cartilage Breakdown Induced by Synovium from Patients with Arthritis. 65th Annual Meeting American Academy of Orthopaedic Surgeons, New Orleans, March 1998.

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75. Lee, S., Badalamente, M.A., Hurst, L.C. An Outcome Score in Dupuytren's Disease. 65th Annual Meeting American Academy of Orthopaedic Surgeons, New Orleans, March 1998.

76. Badalamente, M.A. (Invited Speaker) International Federation of Societies for Sugery of the Hand, 7th Congress. Growth Factors in Dupuytren's Disease. Vancouver, May 1998.

77. Badalamente, M.A., Hurst, L.C. Enzyme Injection as a Nonoperative Treatment for Dupuytren's Disease. International Federation of Societies for Sugery of the Hand, 7th Congress. Vancouver, May 1998.

78. Badalamente, M.A. (Invited Speaker) Current Trends in Dupuytren's Disease. Department of Physical Rehabilitation. State University of New York at Stony Brook, June, 1998.

79. Badalamente, M.A. (Invited Speaker) Dupuytren's Disease: Basic Science Overview and Enzymatic Fasciotomy. General Clinical Research Center, University Hospital, State University of New York at Stony Brook, December, 1998. 80. Badalamente, M.A. (Invited Speaker) Common and Uncommon Hand Problems. Grace Presbyerian Church, Stony Brook, NY (Community Service Lecture), December, 1998.

81. Badalamente, M.A., Hurst, L.C. Collagenase Injection as a Nonoperative Treatment for Dupuytren's Disease. American Association of Hand Surgery, Hawaii, January, 1999.

82. Badalamente, M.A. (Invited Speaker) Common and Uncommon Hand Problems. First Baptist Church, Coram, NY (Community Service Lecture), March, 1999.

83. Badalamente, M.A., Hurst, L.C. Enzyme Injection as a Nonoperative Treatment in Dupuytren's Disease. American Society for Surgery of the Hand, Annual Meeting. Boston, September, 1999. Paper was awarded the Sumner L. Koch Award as one of the best papers presented.

84. Badalamente, M.A., Sampson, S.P. Hurst, L.C., Cutcliffe, D. The Pathobiology of Carpal Tunnel Syndrome: In Search Of the Holy Grail. American Society for Surgery of the Hand, Annual Meeting. Boston, September, 1999.

85. Khan, A., Ryan, M., Ruotolo, C., Gruber, M., Haralabotos, S. Badalamente M.A. The Etiology of Idiopathic Clubfoot: Does Retracting Fibrosis Play a Role? American Academy of Orthopaedic Surgeons Annual Meeting, Orlando, March 2000.

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86. Badalamente, M.A., Hurst, L.C. A Random, Placebo, Double-Blind Study of a Nonsurgical Treatment of Dupuytren's Disease. Transactions of the 46th Orthopaedic Research Society, Orlando, March 2000.

87. Badalamente, M.A., Stracher, A. Delay of Muscle Degeneration in a Dystrophic Animal Model by Calpain Inhibition. 5th International Muscle Symposium. Vienna, Austria, May, 2000.

88. Badalamente, M.A. Dupuytren's Contracture: Old Problems, New Solutions. (Invited Speaker) Instructional Course Symposium. American Society for Surgery of the Hand, Annual Meeting. Seattle, October, 2000.

89. Badalamente, M.A., Hurst, L.C. A Random, Placebo, Double-Blind ClinicalTrial of Injectable Collagenase for Dupuytren's Disease. Transactions of the 47th Annual Orthopaedic Research Society. San Francisco, 2001. 90. Badalamente, M.A., Stracher, A. Delay of Muscle Degeneration in a DystrophicAnimal Model by Calpain Inhibition. Transactions of the 47th Annual Orthopaedic Research Society. San Francisco, 2001.

91. Badalamente, M.A., Hurst, L.C., Hentz, V.R. A Random Placebo Controlled Double Blind Dose response Study of Collagenase Injection for Dupuytren's Disease. Transactions of the 48th Annual Orthopaedic Research Society. Dallas, 2002.

92. Badalamente, M.A., Hurst, L.C., Hentz, V.R. Collagen as a Clinical Target: Nonoperative Treatment of Dupuytren's Disease. American Society for Surgery of the Hand Annual meeting,. Phoenix, October, 2002.

93. Badalamente, M.A. Dupuytren's Contracture: Biochemistry/Cell Biology (Invited Speaker) Instructional Course Symposium. American Society for Surgery of the Hand, Annual Meeting. Phoenix, October, 2002.

94. Badalamente, M.A., Wang, E. Enzymatic Capsulotomy for Adhesive Capsulitis of the Shoulder. Orthopaedic Research Society, 50th Annual Meeting, San Francisco, March 2004.

95. Badalamente, M.A. Basic Science and Nonoperative Treatment of Dupuytren's Disease- Instructional Course. American Academy of Orthopaedic Surgeons, Annual Meeting, February, 2005.

96. Badalamente, M.A., Wang, E. Enzymatic Capsulotomy for Adhesive Capsulitis of the

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Shoulder. American Academy of Orthopaedic Surgeons, Annual Meeting, Chicago, March. 2006.

97. Badalamente, M.A. Basic Science and Nonoperative Treatment of Dupuytren's Disease- Instructional Course. American Academy of Orthopaedic Surgeons, Annual Meeting, Chicago, March, 2006.

98. Dagum, A.B., Badalamente, M.A. Collagenase in the Treatment of Cellulite, American Academy of Plastic Surgeons, San Francisco, October, 2006.

99. Badalamente, M.A., Hurst, L.C. Efficacy and Safety of Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture. American Association of Hand Surgery, Rio Mar, Puerto Rico, January, 2007.

100. Hurst, L.C., Badalamente, M.A. Efficacy and Safety of Mixed Collagenase Subtypes in the Treatment of Dupuytren’s Contracture. American Academy of Orthopaedic Surgeons, Annual Meeting, San Diego, February, 2007.

101. Badalamente, M.A. Basic Science and Nonoperative Treatment of Dupuytren's Disease- Instructional Course. American Academy of Orthopaedic Surgeons, Annual Meeting, San Diego, February, 2007.

102. Badalamente, M.A., Hurst, L.C. Long-term Efficacy of Injectable Mixed Collagenase Subtypes for Dupuytren’s Contracture: Recurrence Rates Within 2 Years in Phase III Clinical Trials. International Federation for Societies for Surgery of the Hand. Sydney, Australia, March, 2007.

103. Badalamente, M.A., Hurst, L.C. Injectable Collagenase Enzyme in Dupuytren’s Contracture: Results From Clinical Studies Stratified by Baseline Contracture Severity and Joint Type. American Society for Surgery of the Hand, Seattle, September, 2007.

104. Badalamente, M.A., Hurst, L.C. Injectable Clostridial Collagenase for Dupuytren’s Contracture: Clinical Success in Elderly Patients. Combined Meeting of the Orthopaedic Research Society. Honolulu, Hawaii, October, 2007.

105 Badalamente, M.A., Hurst, L.C. Injectable Clostridial Collagenase for Dupuytren’s Contracture: Clinical Success in Patients with Concomitant Diabetes. American Association of Hand Surgeons, Los Angeles, January, 2008.

106. Dagum AB, Hurst LC, Badalamente MA. Injectable Clostridial Collageanse in Dupuytren’s Contracture: Clinical Success in the Elderly Population. Eurohand 2008, the XIII th Federation of European Societies for Surgery of the Hand Congress, Lausanne Switzerland, June, 2008

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107. Badalamente MA, Hurst LC. Improvement in Degree of Contracture with One or More Injections of AA4500 in Patients with Dupuytren’s Contracture. American Society of Surgery of the Hand, Chicago, September, 2008.

108. Hurst LC, Badalamente MA, Kaplan, T. Baseline Characteristics of Patients Enrolled in Two Phase III Studies of Injectable Clostridial Collagenase for Dupuytren’s Contracture. American Association of Hand Surgery, Maui, January 2009.

109. Hurst LC, Badalamente MA, Wang ED. Injectable Clostridial Collagenase: Striving Towards Nonoperative Treatments for Fibroproliferative Disorders. 2009 Orthopaedic Research and Education Foundation Clinical Research Award. Presented at a joint session of the Orthopaedic Research Society and American Academy of Orthopaedic Surgeons, February 24, 2009.

110. Badalamente MA, Hurst LC, Akelman E, Coleman S, Meals R. Dupuytren’s Disease: Past Present and Future. Instructional Course Lecture, American Society for Surgery of the Hand, San Francisco, September, 2009.

111. Badalamente MA, Meals R. No Clinically Meaningful Systemic Immunologic Responses After Clostridial Collagenase Injections for Dupuytren’s Contracture. American Academy of Orthopaedic Surgeons, New Orleans, March, 2010.

112. Badalamente, MA. 4th Annual Women in Medicine Research Day. Planning Committee.Panel participant- “Stories of Success”. April 14, 2010.

113. Badalamente, MA, Hurst, LC. Dupuytren’s Disease Symposium (Co- Director)1- Presentation- Factors in Dupuytren’s Disease2- Presentation- Enzymatic Fasciotomy DevelopmentApril 16-17, 2010, SUNY Stony Brook

114. Badalamente, MA. Results of the CORD 1 Study. International Symposium in Dupuytren’s Disease, Miami, May 2010.

115. Badalamente, MA. From Bench to Bedside. Keynote Address. First Annual Inventor’s Reception, Town of Broohaven (Stony Brook University, Brookhaven National Laboratory, Cold Spring Harbor Laboratory). June 23, 2010.

116. Badalamente, MA, Project Medical Education. A two day program for NY legislators and their aides to learn how medical doctors and scientists are educated at SUNY Stony Brook. August 16, 2010.

117. Badalamente, MA, Hurst, LC. Longer Term (2 year) Follow-up of Patients Treated with Collagenase Injection for Dupuytren’s Contracture. American Academy of Orthopaedic Surgeons’ Annual Meeting, San Diego, February, 2011.

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118. Badalamente, MA (Invited Lecture). Climbing the Ladder of Success. SUNY Stony Brook Women in Medicine Program. March, 2011.

119. Badalamente, MA. The Dupuytren’s Institute: A Center of Excellence. Collagenase Development. Two-day physician training session for eight hand surgeons from Austria, March 21-22, 2011.

120. Badalamente, MA, Wang, E. Enzymatic Capsulotomy for Adhesive Capsulitis. First Annual Stony Brook University- Brookhaven National Laboratory Research Networking Day.Poster Presentation. May 13- 15, 2011.

121. Badalamente, MA, Hurst, LC. Longer Term (3 year) Followup of Patients treated with Collagenase for Dupuytren’s Contracture. American Society for Surgery of the Hand, Las Vegas, September, 2011.

122. Badalamente, MA. (Invited) Collagenase (Xiapex) Clinical Development and Use in Spain. Spanish Society for Surgery of the Hand. Seville, Spain. September, 2011.

123. Badalamente, MA. (Invited) Collagenase (Xiapex) Clinical Development and Use in the United Kingdom. The Dupuytren’s Summit. British Society for Surgery of the Hand. London, November, 2011.

124. Badalamente, MA. (Invited) Xiapex (Collagenase) Development and Use. Societe Francaise de Chirurgie de la Main, XLVIII Congress, Paris, December, 2011.

125. Badalamente, MA. (Invited) Collagenase. New Frontiers in Dupuytren’s Disease. Leuven University, Leuven, Belgium, March, 2012.

126. Badalamente, MA. Clinical Translation. Clinical Research (K30) Training Program. Stony Brook University Medical Center. April, 2012.

127. Hurst, LC, Badalamente, MA, Ward, A, Parker T, Liu, Tatka, J. Histology of Cords from Dupuytren Patients: A Comparison After Collagenase Injection/Fasciectomy, Primary Fasciectomy and Repeat Fasciectomy. American Society for Surgery of the Hand, Annual Meeting, Chicago, September, 2012.

128. Muhlrad, S, Wang, E, Badalamente, MA. Nonsurgical Injection Treatment of Trapeziometacarpal Joint Osteoarthritis (e poster). American Society for Surgery of the Hand, Annual Meeting, Chicago, September, 2012.

129. Badalamente, MA, Hurst LC, Benhaim P, Cohen B. Efficacy and safety of collagenase clostridium histolyticum (CCH) in the treatment of proximal interphalangeal joints in Dupuytren’s

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contracture: combined analysis of four phase 3 clinical trials. American Society for Surgery of the Hand Annual Meeting, San Francisco, October, 2013.

130. Grossman LB, Komatsu DE, Badalamente MA, Braunstein AM, Hurst LC. Microsurgical Simulation Exercise for Surgical Training. Award Winner, Fellows Category, Poster Presentation, Stony Brook Medical Center Annual Women in Medicine Day, April, 2013. Award Winner, Fellows Category, NY Hand Society, April 2013. American Society for Surgery of the Hand, Resident & Fellows Conference, San Francisco, October 2013, e Poster.American Association of Hand Surgery, Nassau, Bahamas, January, 2015, e Poster.

131. Badalamente MA, Wang ED, MacKenzie S, Skyhar M, Kaufman G, Smith T, Ling Y, McCaul D, Tursi J. Phase 2a Study of the Safety and Efficacy of Collagenase Clostridium Histolyticum in Patients with Adhesive Capsulitis. Combined American Orthopaedic Association and Canadian Orthopaedic Association, Montreal, Canada, June 2014.

132. Badalamente, MA, Hurst LC, Benhaim P, Cohen B. Efficacy and safety of collagenase clostridium histolyticum (CCH) in the treatment of proximal interphalangeal (PIP) joints in Dupuytren’s contracture: Combined analysis of four phase 3 clinical trials. American Association of Hand Surgery (e poster), Nassau, Bahamas, January, 2015.

133. Gould, ES, Huang, M, Badalamente, MA, Baker, KS, Wang, ED.Assessment of Shoulder MR Findings in Patients Diagnosed with Stage 2 Unilateral Adhesive Capsulitis Treated with Collagenase Clostridium Histolyticum Injection vs. Exercise-Only Controls: A Retrospective Review. The 9th Annual Women in Medicine Day,, SchoolSchool ofof Medicine,Medicine, SUNY@SUNY@Stony Brook University.

134. Badalamente MA, Wang ED, MacKenzie S, Skyhar M, Kaufman G, Smith T, Ling Y, McCaul D, Tursi J. Phase 2a Study of the Safety and Efficacy of Collagenase Clostridium Histolyticum in Patients with Adhesive Capsulitis. International Conference on Dupuytren’s and Related Diseases. Groningen, The Netherlands, May 22-23, 2015.

135. Badalamente, MA, Hurst LC, Gaston, RG, Brown, RA, Kaufman, G, Tursi, JP, Smith, T. Prospective Multicenter, Multinational Study to Evaluate the Safety and Efficacy of Concurrent Collagenase Clostridium Histolyticum Injections to Treat Two Dupuytren’s Contractures in the Same Hand. International Conference on Dupuytren’s and Related Diseases. Groningen, The Netherlands, May 22-23, 2015.

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VI. PROFESSIONAL AFFILIATIONS

MICROSCOPY SOCIETY OF AMERICANEW YORK SOCIETY FOR ELECTRON MICROSCOPYSIGMA XI, THE SCIENTIFIC RESEARCH SOCIETY OF NORTH AMERICA NEW YORK ACADEMY OF SCIENCESORTHOPAEDIC RESEARCH SOCIETYBRITISH ORTHOPAEDIC RESEARCH SOCIETYAMERICAN SOCIETY FOR SURGERY OF THE HAND (FIRST Ph.D. MEMBER ELECTED)VII. EXTERNAL COMMITTEE MEMBERSHIP - EDITORIAL DUTIES DUPUYTREN'S DISEASE COMMITTEE (INVITED MEMBER)- INTERNATIONALFEDERATION OF SOCIETIES FOR SURGERY OF THE HAND, 2001

AMERICAN SOCIETY FOR SURGERY OF THE HAND-BASIC SCIENCE AND RESEARCH COMMITTEE (1994-1997, 2004-present, VICE CHAIR 2005-2006, Chair 2007-2008)

AMERICAN SOCIETY FOR SURGERY OF THE HAND- RESEARCH AND CLINICAL TRIALS ADVISORY COMMITTEE- (2005-2010)

AMERICAN SOCIETY FOR SURGERY OF THE HAND- CLINICAL TRIALS OUTCOME COMMITTEE -(2008-present)

ASSOCIATE EDITOR-JOURNAL OF HAND SURGERY (1994-2002, 2004- present)

AD HOC REVIEWER- NATURE REVIEWS RHEUMATOLOGY (2010)

AD HOC REVIEWER- CURRENT MEDICAL RESEARCH AND OPINION (2012) EDITOR- YEARBOOK OF HAND SURGERY (1995-2000)

AD HOC GRANT REVIEWER- ARTHRITIS RESEARCH FOUNDATION UK (2013)

VIII. COMMITTEE MEMBERSHIP - SUNY STONY BROOK

RESEARCH COMMITTEE------------------------(1979- present) (Chairperson 1987-1990) Dept. of Orthopaedics

RESIDENCY CURRICULUM COMMITTEE-- Dept. of Orthopaedics (1984-present) (Executive Secretary - 1989-present)

RESIDENCY SELECTION COMMITTEE-------Dept. of Orthopaedics (1980-1990; 1994- present)

FACULTY COMMITTEE---------------------------Dept. of Orthopaedics (1979-present)

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UNDERGRADUATE CURRICULUM COMMITTEE (Executive Secretary 1989) UNIVERSITY SENATE (1985-1988) UNIVERSITY LABORATORY ANIMAL USER'S COMMITTEE (1988-1989)FACULTY SENATE (School of Medicine) (1985-1991)EXECUTIVE COMMITTEE-FACULTY SENATE (School of Medicine) (1989-1991)ADVISORY COMMITTEE FOR THE UNIV. MICROSCOPY IMAGE CENTER (1992) DEAN'S RESEARCH ADVISORY COMMITTEE (School of Medicine) (1994-1997)ADVISORY COMMITTEE-UNIVERSITY HOSPITAL GENERAL CLINICAL RESEARCH CENTER (1995-2011)ADVISORY COMMITTEE-CONTINUING MEDICAL EDUCATION (1999-present)WOMEN IN MEDICINE COMMITTEE (2005-present)APPOINTMENT, PROMOTIONS AND TENURE COMMITTEE (2007-2012)FACULTY DEVELOPMENT: MENTORING PROGRAM (PEER MENTORING FOR CLINICAIN EDUCATORS) (2012-2014).

IX. HONORS AND AWARDS

- 2012 Person of the Year in Science, Times Beacon Record and Rocky Point Lions/Rotary Clubs

- Orthopaedic Research and Education Foundation/American Academy of Orthopaedic Surgeons Clinical Investigators Award, 2009. Injectable Clostridial Collagenase: Striving TowardNonoperative Treatment for Fibroporliferative Disorders.

- Neuromuscular Studies in Clubfoot- Hunterian Award Lecture, Royal College of Surgeons,London, March 1981, Co Author- JE Handelsman.

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X.GRANTS

Auxilium Pharmaceuticals, Inc. A Phase 2b, Double Blind, Placebo Controlled Study of the Safety and Efficacy of AA4500 for the Treatment of Adhesive Capsulitis (AUX-CC-871). per subject basis. E.D. Wang and M.A. Badalamente, Co-PI’s. 11/13-12/14.

Auxilium Pharmaceuticals, Inc. A Phase 2a, Randomized, Double Blind, Placebo Controlled Dose Ranging Study of Repeat Doses of AA4500 for the Treatment of Edematous Fibroscerlotic Panniculopathy” $51,992 (AUX CC 831) A.B. Dagum and M.A. Badalamente, co-PI’s. 10/13-10/14.

Auxilium Pharmaceuticals, Inc. A Phase 3b Open-Label Historically Controlled Study to Assess the Safety and Efficacy of Two Concurrent Injections of AA-4500 in Adult Subjects with Multiple Dupuytren’s Contractures with Palpable Cords (AUX-CC-867)”. ~ $150,000 on a per subject basis.LC Hurst and M.A. Badalamente, Co-PI’s. 11/12-11/14.

Auxilium Pharmaceuticals, Inc. Pilot Study to Assess the Safety and Efficacy of Two Concurrent Injections of AA-4500 in Adult Subjects with Multiple Dupuytren’s Contractures. $25,258. 10/11-10/12 LC Hurst and MA Badalamente, Co-PI’s.

Auxilium Pharmaceuticals, Inc. A phase 2a Open Label Dose Ranging Study of the Safety and Effectiveness of AA4500 for the Treatment of Adhesive Capulitis of the Shoulder. (AUX CC 870) 12/21/11-12/14/12, $136,279.

Auxilium Pharmaceuticals, Inc. A Post Market, Open Label Study of the Safety and Efficacy of Delayed Manipilation after Xiaflex Treatment in Subjects With Dupuytrens Contracture, 3/11-3/12 $67,620.

Auxilium Pharmaceuticals,Inc. Long term Studies of Dupuytren’s Subjects Treated with Collagenase. 9/09-3/13, $136,944.

General Clinical Research Center, SUNY Stony Brook. Nonsurgical Treatment of Trapeziometacarpal Joint Arthritis. 4/10-4/12. $14,000

General Clinical Research Center, SUNY Stony Brook. Multicenter Clinical Study (SUNY SB, UCLA, University of Groningen, The Netherlands) of the Genetic Origin of Dupuytren’s. 9/10-8/13. $3,500.

Auxilium Pharmaceuticals, Inc. Injection of Sterile Saline onto the Capsule of Normal Shoulders: An Ultrasound Study. 10/09-3/10, $22,920

Auxilium Pharmaceuticals, Inc. Nonoperative Treatment of Dupuytren’s Disease. CORD 1- Multicenter Phase 3 Clinical Trials, 9/07-11/08, $197,000.

26

Auxilium Pharmaceuticals, Inc. Nonoperative Treatment of Dupuytren’s Disease. Followup Data for Previous Phase 2 and Early Phase 3 Clinical Trials. $20,000. 6/06- 6/07

Ceptor Corp. Delay of Muscle Degeneration in a Murine Dystropy Model. $86,512. 5/02-4/05.

National Institutes of Health, STRR, Inhibition of Muscle Degeneration in mdx Mice by Calpain Inhibition. A. Stracher, Ph.D. and M.A. Badalamente, Ph.D.$150,000. 10/01- 10/03.

Food and Drug Administration. Collagenase in the Treatment of Dupuytren's Disease: A Phase 2 Clinical Study. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., Ph.D., Co-P.I.'s, $101,480, 10/1/2000-9/30/2004.

Food and Drug Administration. Collagenase in the Treatment of Dupuytren's Disease: A Phase 2 Clinical Study. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., Ph.D., Co-P.I.'s, $119,651, 9/29/97-9/30/00.

Advance Biofactures Corporation. Collagenase in the Treatment of Dupuytren's Disease.L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s, $40,000, 1/97-12/00.

Center for Biotechnology, SUNY Stony Brook & Advance Biofactures Corporation. Collagenase in the Treatment of Dupuytren's Disease: A Phase 2 Random Double Blind Clinical Trial. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., Ph.D., Co-P.I.'s, $69,710, 1/97-1/98. Muscular Dystrophy Association. Inhibition of Muscle Degeneration and Necrosis in mdx mice by Calpain Inhibition. M.A. Badalamente, Ph.D. P.I., $50,000, 3/96-7/97.

Advance Biofactures Corporation. Collagenase in the Treatment of Dupuytren's Disease.L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s, $27,000, 11/95-4/97.

American Society for Surgery of the Hand. Dupuytren's Disease-Outcome Study.M.A. Badalamente, Ph.D., P.I., $12,370, 10/95-9/97.

School of Medicine-SUNY Stony Brook. The Pathobiology of Idiopathic Carpal TunnelSyndrome. M.A. Badalamente, Ph.D, Sampson, S.P.& L.C. Hurst, M.D., Co-P.I.'s, $20,000, 7/95-10/96.

Center for Biotechnology, SUNY Stony Brook. Research Product Challenge Grant. Safety & Efficacy of Collagenase in the Treatment of Dupuytren's Disease. July, 1994-July, 1995. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., PI's, $ 35,000.

NYS/UUP Faculty Development Award. July, 1993. Development of Educational Computer Software for Orthopaedic Residents. $750.

Food & Drug Administration. Pharmacokinetics of Leupeptin-Development for Nerve Repair. September, 1991-September, 1995. L.C. Hurst, M.D. PI &

27

M.A. Badalamente, Ph.D., Co-P.I., $120,329.

Regeneron Pharmaceuticals, Inc., Growth Factors in Recovery After Nerve Repair. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., Co-P.I.'s, October, 1992-October, 1994,$1,683.

Biospecifics Technologies Corporation. Biomechanical and Biochemical Study of Collagenase Treatment for Dupuytren's Disease. L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.s, July 1992-Oct., 1994. $ 2860.

National Institutes of Health, Leupeptin in Recovery After Nerve Repair. L.C. Hurst, M.D. PI & M.A. Badalamente, Ph.D., Co-P.I, April 1992-March 1994, $232,771.

American Society for Surgery of the Hand, October 1991- December 1992. Transforming Growth Factor Beta in Dupuytren's Disease. M.A. Badalamente, Ph.D., L.C. Hurst, M.D. & S.P. Sampson, M.D. Co-P.I.'s, $5,510.

Regeneron Pharmaceuticals, Inc., September, 1990-June, 1991. Growth Factors in Recovery After Nerve Repair. $10,000. M.A. Badalamente, Ph.D. & L.C. Hurst, M.D., Co-P.I.'s.

National Institutes of Health, April 1, 1988-June 30, 1991, Neuromuscular Recovery After Nerve Repair. $233,888. L.C. Hurst , M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s.

National Institutes of Health, Sept. 1, 1985-Aug. 31, 1988. Effects of Leupeptin on Neuromuscular Recovery After Nerve Repair. $202,411. L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s.

Sutter Biomedical Co, Dec. 15, 1985-Aug. 31, 1987. The Role of Continuous Passive Motion in the Post-Operative Rehabilitation of Dupuytren's Contracture. $6,500. M.A. Badalamente, Ph.D., L.C. Hurst, M.D. & S.P. Sampson, M.D., Co-P.I.'s.

SUNY-Center for Biotechnology, July 1, 1986-June 30, 1987. The Role of Continuous Passive Motion in the Post-Operative Rehabilitation of Dupuytren's Contracture: A Cell Biological Assessment of Efficacy. $1,000. M.A. Badalamente, Ph.D., L.C. Hurst, M.D., S. P. Sampson, M.D., Co-P.I.'s.

Orthopaedic Research and Education Foundation, Jan. 1, 1985-Dec. 31, 1987. The Pathobiology of Dupuytren's Contracture: Effects of Prostaglandins on Myofibroblasts. $61,800. L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s.

Fidia Pharmaceutical Co, April 1, 1983-Sept. 30, 1985. Leupeptin-Ganglioside Treatment of Microsurgically Repaired Peripheral Nerves. $10,000. M. A. Badalamente, Ph.D., P.I.

Orthopaedic Research and Education Foundation, April 1, 1982-Sept. 30, 1984. Pathogenesis of Dupuytren's Contracture. $24,000. L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s.

Easter Seals Research Foundation, July 1, 1981-July 1, 1984. Effects of a Protease Inhibitor on

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Epineural Neurorrhaphy. $45,000. L.C. Hurst, M.D. & M.A. Badalamente, Ph.D., Co-P.I.'s.

Muscular Dystrophy Association, July 1, 1980-June 30, 1981. Light and Electron Microscopic Studies of Muscles in Human Congenital Talipes Equinovarus (Club Foot) with Special Emphasis on a Neurogenic Etiology. $15,000. M.A. Badalamente, Ph.D. & J.E. Handelsman, M.D., Co-P.I.'s.

Muscular Dystrophy Association, July 1, 1979-June 30, 1980. Electron Microscopic Studies in Muscles in Human Congenital Talipes Equinovarus (Club Foot) with Special Emphasis on a Neurogenic Etiology, $15,000. M.A. Badalamente, Ph.D. and J.E. Handelsman, M.D., Co-P.I.'s.

Research Associate with Dr. E. Aiello, Fordham University. National Institutes of Health Grant, Division of Heart and Lung, 1977-1978.

While a Ph.D. candidate, dissertation research was supported by a National Institutes of Health Grant to Dr. E. Aiello, mentor, 1973-1977.

MEETINGS ATTENDED

Gordon Conferences, Andover, New Hampshire, 1975.

Federation of American Societies for Experimental Biology, Anaheim, Ca., 1976

Preparation of Cultured Cells for Electron Microscopy, W. Alton Jones Cell Science Center, Lake Placid, N.Y., 1976

XI Congress of the International Academy of Pathology Diagnostic Electron Microscopy, Washington, D.C., 1976

Second Annual Symposium on Motor Disorders, Nassau County Medical Center, April, 1978

Neuromuscular Diseases in Children, S.U.N.Y. @ Stony Brook, March, 1979

Federation of American Societies for Experimental Biology Meeting, Anaheim, Ca., April, 1980

Medical Society of the State of New York, Spring Continuing Medical Education Assembly Program, April, 1980

Fourth Annual Symposium on Motor Disorders, Nassau County Medical Center, April, 1980

Neuromuscular Disease Update: A Postgraduate Course. Columbia University, College of Physicians and Surgeons, New York, September, 1980

American Academy for Cerebral Palsy and Developmental Medicine, Annual Meeting, Boston, October, 1980

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American Academy of Orthopaedics and Orthopaedic Research Society, Annual Meeting, Las Vegas, February, 1981

Hunterian Award Lecture, Royal College of Surgeons, London, England, March, 1981

American Academy of Orthopaedics Research Society, Annual Meeting, New Orleans, January 1982

New York Society of Electron Microscopists, Presidential Symposium, Nervous Tissue as a System for Structural Analysis, N.Y.C., May, 1982

Orthopaedic Research and American Academy of Orthopaedics Annual Meetings, Anaheim, Ca., March, 1983

New York Academy of Sciences, Biological Colloquium, New York, Nov., 1983

American Academy of Orthopaedics and Orthopaedic Research Society Annual Meeting, Atlanta, Georgia, Feb., 1984

N.Y. Academy of Sciences, 2nd biological Colloquium, N.Y., November, 1984

American Academy of Orthopaedics and Orthopaedic Research Society Annual Meeting, Atlanta, Georgia, Feb., 1984

N.Y. Academy of Sciences, 2nd Biological Colloquium, N.Y., Nov., 1984

American Academy of Orthopaedics, Orthopaedic Research Society, American Society for Surgery of the Hand, Las Vegas, Nevada, Jan., 1985

XIII World Congressscle Degeneration in a Murine Dystropy Model. M.A. Badalamente, Ph.D. $86,512. 5/02-4/05.

National Institutes of Health, STRR, Inhibition of Muscle Degeneration in mdx Mice by Calpain Inhibition, N.Y., Nov., 1985

Orthopaedic Research Society, American Society for Surgery of the Hand, American Academy of Orthopaedics, New Orleans, La., Feb., 1986

Orthopaedic Research Society, American Academy of Orthopaedics, San Francisco, Ca., Jan., 1987

British Orthopaedic Research Society, London, England, Sept., 1987

American Society for Surgery of the Hand, San Antonio, Tx., Sept., 1987

Orthopaedic Research Society, American Academy of Orthopaedic Surgeons, Atlanta, Ga., Feb.,

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1988

American Society for Surgery of the Hand, Baltimore, Md., Sept., 1988

Orthopaedic Research Society, Las Vegas, Nev., Feb., 1989

Symposium on Pain in Osteoarthritis, Cancun, Mexico, Feb., 1989

American Society for Surgery of the Hand, Seattle, Wash., Sept., 1989

Orthopaedic Research Society, New Orleans, La., Feb., 1990

Third Vienna Muscle Symposium, Vienna, Austria, June, 1990

American Society for Surgery of the Hand, Toronto, Canada, September, 1990

Orthopaedic Research Society, Anaheim, Ca., March, 1991

American Society for Surgery of the Hand, Orlando, Fl., Oct., 1991

Orthopaedic Research Society, Washington, D.C., Feb., 1992

American Society for Surgery of the Hand, Phoenix, Az., Nov. 1992

Orthopaedic Research Society, San Francisco, Ca., Feb., 1993

American Society for Surgery of the Hand, Kansas City, Mo., Sept. 1993

Orthopaedic Research Society, New Orleans, La., Feb., 1994

American Society for Surgery of the Hand, Cinncinatti, Ohio, Oct. 1994

Orthopaedic Research Society, Orlando, Fl., Feb., 1995

American Society for Surgery of the Hand, San Francisco, Ca., Sept. 1995

Orthopaedic Research Society, Atlanta, Feb, 1996

Combined Meeting of the American Society for Surgery of the Hand and the JapaneseSociety for Surgery of the Hand, Maui, Hawaii, March, 1996

American Society for Surgery of the Hand, Nashville, Sept.-Oct., 1996

Orthopaedic Research Society, San Francisco, Feb, 1997

American Society for Surgery of the Hand, Denver, September, 1997

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Orthopaedic Research Society, New Orleans, March, 1998

International Federation of Societies for Surgery of the Hand, Vancouver, Canada,May, 1998

American Association of Hand Surgery, Kona, Hawaii, January, 1999

American Society for Surgery of the Hand, Boston, September, 1999

General Clinical Research Center Bioinformatics Conference: A Technologyfor Clinical Research, San Antonio, November, 1999

Orthopaedic Research Society, Orlando, March, 2000

5th International Muscle Symposium, Vienna, Austria, May, 2000

American Society for Surgery of the Hand, Seattle, October, 2000

Orthopaedic Research Society, San Francisco, February, 2001

American Society for Surgery of the Hand, Baltimore, 2001

Orthopaedic Research Society, Dallas, 2002

FDA- Therapies for Rare Diseases: From Bench to Marketplace, Washington DC, 2002

American Society for Surgery of the Hand, Phoenix, 2002

American Society for Surgery of the Hand, Chicago, 2003

Orthopaedic Research Society, San Francisco, 2004

American Academy of Orthopaedic Surgeons, Washington DC, 2005

American Society for Surgery of the Hand, San Antonio, 2005

American Academy of Orthopaedic Surgeons, Chicago, 2006

American Society for Surgery of the Hand, Washington DC, 2006

American Association of Hand Surgery, Rio Mar, Puerto Rico, 2007

American Academy of Orthopaedic Surgeons, San Diego, 2007

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International Federation of Societies for Surgery of the Hand, Sydney, Australia, 2007

American Society for Surgery of the Hand, Seattle, September, 2007.

Combined Meeting of the Orthopaedic Research Society. Honolulu, Hawaii, October, 2007.

American Association of Hand Surgeons, Los Angeles, January, 2008.

American Society of Surgery of the Hand, Chicago, September, 2008.

American Association of Hand Surgery, Maui, January 2009.

Orthopaedic Research Society and American Academy of Orthopaedic Surgeons, Las Vegas, February, 2009.

American Society for Surgery of the Hand, San Francisco, September, 2009.

American Academy of Orthopaedic Surgeons, New Orleans, March, 2010.

International Symposium in Dupuytren’s Disease, Miami, May 2010.

American Academy of Orthopaedic Surgeons, San Diego, February, 2011.

American Society for Surgery of the Hand, Las Vegas, September, 2011.

Spanish Society for Surgery of the Hand, Seville, Spain, September, 2011.

British Society for Surgery of the Hand, London, November, 2011.

Societe Francaise de Chirurgie de la Main, XLVIII Congress, Paris, December, 2011.Leuven University, Leuven, Belgium, March, 2012.

American Society for Surgery of the Hand, Chicago, September, 2012.

American Society for Surgery of the Hand, San Francisco, September, 2013.

Combined Meeting of the American/Canadian Orthopaedic Associations, Montreal, Canada, June, 2014.

American Society for Surgery of the Hand, Boston, September, 2014.

American Association of Hand Surgery, Nassau, Bahamas, January, 2015.

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