marchiafava-bignami disease? dec, 24th, 2003 hospital virgen de las nieves servicio de neurologia...
TRANSCRIPT
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MARCHIAFAVA-BIGNAMI DISEASE?
Dec, 24th, 2003
Hospital Virgen de las Nieves
Servicio de Neurologia
Granada. Spain
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•42 years old gentleman.
•Heavy drinker
•Subacute encephalopaty (3 weeks)
•No evidence of systemic disease
•Absence of focal or lateralizing signs (alexia and agraphia not specifically sought)
•Blood analysis normal except a high MCV and serum gammaglobulines (without monoclonal peak); chest Rx and EKG normal
•CSF acelular, normal sugar; protein 0’7 gr/l
•CT scan and MRI
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CT scan without contrast.-
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CT scan after contrast.-
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MRI sagital T1 w.-
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MRI axial T2 w and PD (1).-
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MRI axial T2 w and PD (2).- (No changes after contrast injection)
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Mild improvement after short course of metil-prednisolone
CONSIDERED DIAGNOSIS.-
Marchiafava-Bignami disease (atypical)
Others:
•Demyelinating disease (PML, ADEM,...)
•Neoplastic disease (glioma, lymphoma,...)
•Vascular
•Some zebra: Whipple disease
SUGGESTIONS ARE WELCOME!