Mapping Science and Technologywith Heterogeneous Data Analysis

Tools for strategic management of innovation – Biotech.Obs

Andrei Mogoutov | AGUIDELParis - Montreal

www.aguidel.com

Tools for strategic management of innovation

• Data collection and management « Biotech » actors using online questionnaires, publications, patents, existing databases, institutional contacts, company websites, news and press releases

• Services/applications– Positioning of companies, projects, products, patents, publications, research fields– Startup support– Early warning– Partnership network building– Advice on local promotion – Advice on foundation and management of « clusters »– Evaluation of projects– Market and technological studies– Benchmarking, competitiveness– Consultancy for valorization actors– Communication strategy development– Academic research

• Software solutions: On-line applications, off-line applications, customized solutions, integration of customers data, analytical tools

• Data analysis: Custom methods for the analysis of complex & heterogeneous datasets, text and data mining, relational analysis, GIS, scientometrics

Projects & partners• CEA (French Nuclear Energy Commission): Nano/Bio - clusters -

Dynamics of Nano-bio-technology field. • Biotech Clusters - Genopole Evry – research labs, startups & big

pharma• Public Health Canada: Clusters of Nanotechnologies in Canada,

Obesity issues and research, • Regional innovation agencies – “Technopole” Angers• INSERM: Evaluation of research laboratories, strategic analysis of

neurosciences research, • INRA/CNRS: Mapping of controversies and research fields in

genetically modified food safety• McGill University: Anticancer drugs clinical trials, Microarray R&D,

Cancer research worldwide, Cancer and genetics, Standardisation and Migraine research,

• University of Vienna: Scientometrics of Social Studies of Science Field

• Big International Foundations: Open Society Institute, WWF Ford foundation, McArthur's foundation, Govcom.org foundation various political, ecological and technological issues

• Private companies: industry, big pharma, telecoms, medical imaging• Investors, business angels

../ANALYTICAL DIMENSIONS

ANALYTICAL DIMENSIONS/DATA/METHODS/TOOLS

SPACE TIME CONTENT ACTORS & NETWORKS

X USERS Client side Apps

News RSS Feeds Client side Apps News

Client side Apps News, Web search, Blogs

SUBSCRIBED UDERS

Client/Server Apps RSS Feeds archives

Client/Server Apps News RSS Feeds archives

Client/Server Apps Client side Apps News archives, Web search, Blogs

Client/Server side Apps RSS Feeds archives + Scientometrix

SPECIAL CONTRACT

Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific GIS analysis

Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific time analysis

Client/Server side Apps + offline apps archives + Scientometrix + third party tools + specific content analysis

Client/Server side Apps + offlina apps archives + Scientometrix + third party tools + specific analysis

DEVICES SERVICES

DIAGNOSTICS

GENOMICS

DRUG DELIVERY

LARGE MOLECULE

SMALL MOLECULE

PROTEOMICS

RECOMBINANT DNA

ANTIBODY

MOLECULAR DIVERSITYSCREENING

GENE THERAPY

SYNTHESIS

VACCINES

GENE EXPRESSION

GENERICS OTC

CELL THERAPY

AVENTIS

GLAXO

BIOINFORMATICS

J OHNSON

ROCHE

APPLERA

PFIZER

AHP

BMS

NOVARTIS

GENE SEQUENCING

GENZYME

AMERSHAM

ABBOTT

INCYTEG

MERCK_CO

PHMACIA

CHIRON

TRANSGENICS

NIH

ELAN

BAYER

ELILILLY

AFFYMET

NUTRACEUTICALS

ASTRAZEN

GENENTEC

SCHER_AG

CELLTECH

SCHERING

MILL_PHA

PERKIN

BAXTER

NANOTECHNOLOGY

PCOP

AMGEN

MEDAREX

RATIONAL DRUG DESIGN

MERCK

BOEHRING

LEXICON

VERTEX

SEQUENOM

APP_BIOS

UN_CAL

E.I. DU

CORIXA

VALENTIS

BD MONSANTO

ARQULE

NATURAL PRODUCTS

DYAX

ABGENIX

NOVO NOR

HU_GE_SC

LION_BIO

ISIS

GENE_LOG

MDS

OXFGLYCO

CYTOGEN

MEDIMMUN

UNIV_TEX

ORCHID

INDEVUS

TREGA

BASF

GENOME

HARV_UNI

TGEN

EXELIXIS

J H_UNIV

AKZO

CARBOHYDRATE

CELL_PAT

BIOGEN

SUSM

MYRIAD

DPI

HMS

EVOTEC

TYCO_INT

SANOF_S

CAMBTECH

SANGAMO

BIOVAIL

QIAGEN

GENSET

BECKMAN

MIT

INVITROG

CHUGAI_B

OSI

MITSUB

IMMUNEX

TRIPOS

LIGAND

IMCLONE

ACAMBIS

P & G

CANC_RC

NEXSTAR

OXFBIOM

AURORA

XOMA

XENOVA

ENZON

AVANT

LYNX_USA

WATSON

E-HEALTH

MEDTRONI

MORPHOSY

THIRD_WA

GILEAD

SCIOS

DOUBLETW

HYSEQ

CURAGEN

SHIRE

SEPRACOR

CRUCELL

AMERNYCO

SKYEPH

MSKC_CEN

ANTIGENI

VICAL

THERMO_E

GENELABS

IVAX

DELTAGEN

GPC_BIOT

TULARIK

DOW_CHEM

GENVEC

PDL

NEORX

STEMCELL

CORNING

EPIMMUNE

HITACHI

BIO_TG

BAY_C_M

ALEXION

YAMANOUC

DUHS

IDEC

CUBIST

NEXELL

CEPHALON

FUJ ISAWA

TAKARA

LUDWIG_I

LIFE_TEC

GERON

NEOPROBE

PPD

ALLIANCE

SERONO

PROTSYS

TEVA

VARIAGEN

SOLVAY

CHRYSALI

DAIICHIP

DECODE

REPLIGEN

QUIDEL

SCHWARZ

TAKEDA

BIOSITE

YALE_U

UCSF

CELGENE

IMMUNOME

BIOMIRA

ROBERTS

ALLERGAN

PROGENIC

NPS

KIRIN

IMMUNOGE

ONCOR

AMRAD

DIVERSA

SCRIPPS

ICOS

ALKERMES

PITTSB_U

CURIS

POWDERJ

MYLAN

ID_BIOME

NANOGEN

BTG_PHAR

MEDIGENE

NEUR_BIO

UCSD

J TOBACCOKING

SANKYO

PEREGRIN

SUMITOM

MAXIGEN

IMMUNE

SOMATIX

SICOR

ONCORMED

BIOMERIE

HYBRIDON

UCLA

RIBOZYME

AD_POLY

NABI

AMYLIN

SUPERGEN

ICN_PHAR

IGEN

TAISHOPH

NYU

ACACIA

MGH

BIOCHEMP

U_WASH

SEQUUS

CAM_BIO

CELL_GEN

CYTRX

INHALE

RECORDAT

WASH_U

ANADYS

KYOWA

INSITE

BIO_RAD

3M

DEGUSSA

AASTROM

MAR_UN

GENTA

PROTHER

MCGILL_U

ALBANYMR

BBIOTECH

SYNCOR

AVANIR

ANTARES THERATEC

DSM_GIST

EISAI

CARDINAL

AMARINPHARMASC

PENEDERM

ALTANA

BIOGLAN

BOSTON_S

CENES

UNIV_COL

COLUMBIA

MAYO_FOU

MARTEK

COLLAGEN

LIPOSOME

IBM

MAX_PLAN

DUPONT_M

CORTECS

ADVMAG

DAINIPP

CYGNUS

MILLENN

ABSC

GENENCOR

ATRIX

UNIV_TR

BERLEX

UCB_GROU

BAUSCH

ENTREMED

OXFORD_U

CONNETIC

MGI

FISHER_S

MAYNE

ILEX

TRIANGLE

DRAXIS

VIRAGEN

TEIJ IN

MERI_BIO

ACCESS

DADEBE

GEN_EL

FOREST

TANABESE

MEDICIS

Pasteur

PHOTOTHERAPY

FRESENIU

ONO_PHAR

STERL_DR

PH_RES

QUESTCOR

AJ INOMO

MUNDIPHA

MICHIG_U

MEIJ I

DYNAGEN

SYNBIOTI

SENETEK

QUINTILE

MASS_GEN

PIERRE

NRC_CAN

NESTLE

COLLAGEX

CHIESI

AMERISB

XENOGEN

HESKA

CHEMTRAK

PHARMAS

BARR_LAB

OTSUKA

BENTLEY

PROVALIS

BTG

ASAHI

NYCOMED

SUNY

MERCKLE

GUILFORD

BEAUFOUR

ELF_AQUI

INTEG_LS

AD_TS

US_BIOSC

LUNDBECK

HSC

EPITOPE

WELLCOME

COCENSYS

SYNSORB

ALPHARMA

MEDCO_R

ORION

SMITH

KISSEI

AXCAN

AMARILLO

UNITED_T

SHIONOGI

SPECTRAL

CORNELLU

SUNTORY

AMBI

BCU

MYCOGEN

GELTEX

NCI

FERRER

BOOTS CO

PAREXEL

Information « Spaces »

• News Streams• Blog Sphere• Web Sites• E-Communication (Mailing Lists, Forums)• Scientific Information Data Bases (Publications, Patents)• Offline “Literature”• Press archives• Surveys/ Interviews• Traditional Media (TV, Radio) archives• Specific Data Bases• Etc ?

Traditions/Methods/Solutions

• Statistics / Data Mining• Textual Analysis Tools / Text Mining• Web Cartography• Scientometrics• Tools for Qualitative Data Analysis• Social / Socio-Technical Networks• GIS• Etc.

Heterogeneous Data Sets: Back Office

“Offline” Questionnaires

Sci publications

Existing Databases

Press archives

Online Data Collection

Tools

ActorLocation

ActorIdentity

ContentsClassification

Schema

Parsing & Matching System

J ohnson & J ohnson

Glaxo SmithKline plc

Aventis

Wyeth

Merck & Co. Inc.

Roche

Bristol-Myers Squibb Co.

Schering-Plough Corp.

Pfizer

Novartis

Pharmacia

Eli Lilly and Co.

Bayer AG

AstraZeneca

Abbott

NETWORK ORIENTED DATABASE

Web CrawlerPatents

Design of Analytical Solution

Back Office

- data tables- web crawler- matching tools- tools for textual analysis- tools for data update and control

Front Office

Middle Office

- a layer of analytical queries - pre-defined queries for multilevel -data aggregationand synthetic analysis and indicators

- graphical/analytical interfaces (GIS, Relational Mappings, Statistical Charts)- statistical tables, indicators and textual synthesis- integrated querying tools

ON-LINEOFF-LINE

DATA UPDATE FEED-BACK

“Online” Data Collection Tool

Front Office “Desktop”

0

50

100

150

200

250

300

350

cancer familyhistory

risk factors hormonal-contraception

personalmedicalhistory

family relatives environment-tobacco

cancer genes

Scientometrix – Publications and Patents

PubMed (Medline)

ISI

Derwent

/Scientometrics/results (ReseauLu Sci_Metrix)

1

10

100

1000

1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003

20Proceedings of the National Academy of

Sciences of the United States of America

22Environmental Entomology

23Biofutur

23Current Science

26Euphytica

27Science

28Molecular Breeding

30OCL - Oleagineux, Corps Gras, Lipides

32Nature Biotechnology

32Transgenic Research

33Molecular Ecology

33Nature

37Biotechnology and Development Monitor

41Theoretical and Applied Genetics

98Journal of Economic Entomology

N. Art.Top Journals

20Proceedings of the National Academy of

Sciences of the United States of America

22Environmental Entomology

23Biofutur

23Current Science

26Euphytica

27Science

28Molecular Breeding

30OCL - Oleagineux, Corps Gras, Lipides

32Nature Biotechnology

32Transgenic Research

33Molecular Ecology

33Nature

37Biotechnology and Development Monitor

41Theoretical and Applied Genetics

98Journal of Economic Entomology

N. Art.Top Journals

selectable markers

biosafetyOil plants

rape

weeds

herbicides

herbicide resistance

gene flow

Insect pests

pest resistancegenes

gene expression

agricultural entomology

risk assessment

release

control

plant pests

glufosinate

maize

Pest control

transgenics

potatoes

reviews

resistance

interspecific hybridization

plant pathogensplant pathology

food safety

w ild relatives

polymerase chain reaction

plant diseases

tobacco

foods

DNA

stimulant plants

plant breeding

hybridization

risk

disease resistance

molecular genetics

soyabeans

Biology

pollen

entomopathogenic bacteria

root crops

genetics

toxins

glyphosate

nontarget effects

legislation

natural enemies

environmental impact

sugarbeet

Pathogenstomatoes

cereals

intergeneric hybridization

enzymes

regulations

bacterial insecticidescultivars

toxicity

rice

entomopathogensvegetables

tolerance

chemical control

pesticides

gene transfer

insect control

public opinion

coat proteins

plant genetic resources

biological control agents

dispersal

biological control

seed production

survival

genetic markers backcrossing

larvae

detection

sugar crops

weed control

phosphinothricin acetyltransferase

microbial pesticides

swede rape

pollination

parasitoids

lectins

insecticides

nucleotide sequences

trypsin inhibitors

ecology

analytical methods

volunteer plants

introgression

proteinase inhibitors

European Union

Herbicide resistant weedscrop plants as weeds

reporter genes

methodology

plant pathogenic fungi

labelling

nontarget organisms

allergens

flowering

plant parasitic nematodes

invasion

lines

evolution

food allergies safety

oilseed plants

growth

effects

promoters

plant pathogenic bacteria

agglutinins

genomes

fruitsfood products

models

leaves

consumer attitudes

contamination

marker genes

population dynamics

beta-glucuronidase

population genetics

Potyvirus

proteins

food legislation

Mol. Biol. and Virol.

Detection

Agr. entomology

Weed management - geneflow

GM Food safety

/tools (ReseauLu X2 SciMetrix)

/tools (ReseauLu X2 SciMetrix)

../Stem Cells - Counts

0

1000

2000

3000

4000

5000

6000

1960 1965 1970 1975 1980 1985 1990 1995 2000 2005 2010

STEM CELLS - AUTHORS

Name Nb Pub

WEISSMAN, IL 45

ZSEBO, KM 26

ORKIN, SH 26

OGAWA, M 25

GAGE, FH 24

JAENISCH, R 22

BRADLEY, A 22

ROSSANT, J 22

MOORE, MAS 21

EAVES, CJ 21

WILLIAMS, DA 19

LANSDORP, PM 19

NISHIKAWA, S 18

MULLIGAN, RC 18

SMITHIES, O 18

HUMPHRIES, RK 16

ALT, FW 16

DICK, JE 16

MAK, TW 15

DEXTER, TM 15

ARMITAGE, JO 15

RAJEWSKY, K 14

MORRISON, SJ 14

MoyenneDePositionName NbCit NbCitPos0,87 WEISSMAN, IL 10455 89710,83 BRADLEY, A 8217 74350,76 ROSSANT, J 7859 53980,86 MULLIGAN, RC 7029 64510,62 ZSEBO, KM 7016 5119,750,82 MAK, TW 6275 56660,95 JAENISCH, R 5798 5588,50,71 RAJEWSKY, K 5729 3963,50,84 ORKIN, SH 5471 44720,83 OGAWA, M 5368 4483,750,94 GAGE, FH 5244 4905,50,54 LANSDORP, PM 5197 2774,250,27 WAKEHAM, A 4889 1277,50,86 SMITHIES, O 4850 40740,38 GERTSENSTEIN, M 4611 1503,75

1 CAPECCHI, MR 4519 45190,65 REYNOLDS, BA 4487 31490,84 WILLIAMS, DA 4429 3444,5

0,7 MOORE, MAS 4301 2947,750,88 DEXTER, TM 4025 38060,91 WEISS, S 3985 3598,50,81 LI, E 3957 3335,50,47 LANGLEY, KE 3893 1782,25

0,3 BRONSON, RT 3850 1298,50,44 NISHIKAWA, S 3831 16690,78 SORIANO, P 3766 3296,5

Stem Cells Co-CitationBRAIN RES

BLOOD P NATL ACAD SCI USA

NATURE

CELL

J IMMUNOL

SCIENCE

J EXP MED

J BIOL CHEM

DEVELOPMENT

MOL CELL BIOL

EMBO J

GENE DEV

EXP HEMATOL

J CLIN INVEST

DEV BIOL

EUR J IMMUNOL

CANCER RES

J CELL BIOL

NEURONJ NEUROSCI

NEW ENGL J MED

J INVEST DERMATOL

ONCOGENE

NAT GENET

NUCLEIC ACIDS RES

BRIT J HAEMATOL

BONE MARROW TRANSPL

BIOCHEM BIOPH RES CO

IMMUNOL TODAY

LEUKEMIA

LANCET

J VIROL

J CELL PHYSIOL

ANNU REV IMMUNOL

J CLIN ONCOL

NAT MED

AM J PATHOL

IMMUNITY

EXP CELL RES

HUM GENE THER

J COMP NEUROL

ANN NY ACAD SCITRENDS GENET

J EMBRYOL EXP MORPH

MECH DEVELOP

CURR BIOL

TRANSPLANTATION

ENDOCRINOLOGY

J NATL CANCER I

USA-GLAXO INC

USA-Harvard Univ

USA-Univ Washington

USA-UNIV TEXAS

CANADA.-UNIV TORONTO

USA-Mem Sloan Kettering Canc Ctr

USA-BAYLOR COLL MED

FRANCE.-Serv Hematol

USA-UNIV CALIF LOS ANGELES

USA-FRED HUTCHINSON CANC RES CTR

USA-Stanford Univ

USA-Univ Michigan

USA-Indiana Univ

USA-Univ Penn

FRANCE.-DEPT HEMATOL

USA-J OHNS HOPKINS UNIV

USA-Duke UnivUSA-Univ Minnesota

CANADA.-UNIV BRITISH COLUMBIAUSA-UNIV CALIF SAN FRANCISCO

USA-BRIGHAM & WOMENS HOSPJ APAN.-OSAKA UNIV

USA-NCI

USA-DANA FARBER CANC INST

USA-UNIV CHICAGO

USA-Northwestern Univ

USA-UNIV NEBRASKA

USA-MED COLL WISCONSIN

FRANCE.-Hop Necker Enfants Malad

USA-Yale Univ

USA-MIT

USA-UNIV COLORADO

USA-Univ Wisconsin

USA-City Hope Natl Med Ctr

USA-CASE WESTERN RESERVE UNIV

USA-GENENTECH INC

USA-CHILDRENS HOSP

FRANCE.-HOP ST LOUIS

USA-Univ Pittsburgh

NETHERLANDS.-LEIDEN UNIV

GERMANY.-Univ Tubingen

USA-WASHINGTON UNIVJ APAN.-Univ Tokyo

USA-NHLBI

USA-NYU

USA-St J ude Childrens Hosp

USA-Univ Florida

CANADA.-HOSP SICK CHILDREN

USA-Univ Illinois

CANADA.-BRITISH COLUMBIA CANC AGCY

USA-CORNELL UNIV

USA-YESHIVA UNIV ALBERT EINSTEIN COLL MED

USA-UNIV SO CALIF

J APAN.-KYOTO UNIV

USA-AMGEN INC

USA-St J ude Childrens Res Hosp

GERMANY.-Univ Freiburg

SWEDEN.-KAROLINSKA INST

USA-VANDERBILT UNIV

CANADA.-MCGILL UNIV

ENGLAND.-UNIV CAMBRIDGE

ISRAEL.-Weizmann Inst Sci

USA-MAYO CLIN & MAYO FDN

USA-Univ Calif San Diego

FRANCE.-INST GUSTAVE ROUSSY

FRANCE.-INST J PAOLI I CALMETTES

CANADA.-Mt Sinai Hosp

USA-Univ Tennessee

ITALY.-Univ Turin

SCOTLAND.-UNIV EDINBURGH

ISRAEL.-HADASSAH UNIV HOSP

GERMANY.-UNIV HAMBURG

USA-BETH ISRAEL HOSP

GERMANY.-Univ Ulm

USA-UNIV MASSACHUSETTS

USA-NIAID

CANADA.-UNIV CALGARY

FRANCE.-HOP HENRI MONDOR

USA-Oregon Hlth Sci Univ

USA-Salk Inst Biol Studies

USA-VET ADM MED CTR

FRANCE.-Inst Pasteur

USA-MED UNIV S CAROLINA USA-COLUMBIA UNIV COLL PHYS & SURG

USA-VIRGINIA COMMONWEALTH UNIV

USA-CHILDRENS HOSP MED CTR

ITALY.-UNIV MILAN

USA-New York Med Coll

ENGLAND.-IMPERIAL CANC RES FUND

ENGLAND.-UNIV MANCHESTER

GERMANY.-UNIV COLOGNE

ENGLAND.-MRC

ISRAEL.-Technion Israel Inst Technol

NETHERLANDS.-Erasmus Univ

USA-DNAX RES INST MOLEC & CELLULAR BIOL INC

ENGLAND.-UNIV OXFORD

USA-NINDS

USA-GENET INST

AUSTRALIA.-ROYAL ADELAIDE HOSP

USA-NHGRI

STEM CELLS – Collaboration networks

Morocco.

USA

FRANCE.

GERMANY.

ITALY.

ENGLAND.

J APAN.

CANADA.

NETHERLANDS.

SPAIN.

SWEDEN.

AUSTRALIA.

SWITZERLAND.BELGIUM.

ISRAEL.

SCOTLAND.

South Korea.AUSTRIA.

FINLAND.

DENMARK.

NORWAY.

PEOPLES R CHINA.

GREECE.

Brazil.

Poland.

Czech Republic.Taiwan.

ARGENTINA.

Hungary.

Portugal.

New Zealand.

Croatia.

RUSSIA.

Singapore.

Wales.

SOUTH AFRICA.

Ireland.

North Ireland.

Turkey.

Mexico.

Saudi Arabia.

Thailand.

YUGOSLAVIA.

KUWAIT.

Luxembourg.

Egypt.

Iceland.

STEM CELLS – International Collaboration

19902000

1995

Humans

Research Support, Non-U.S. Gov't

Animal

2005

Hematopoietic

Cells, Cultured

Fibroblasts

Research Support, U.S. Gov't

Cell Differentiation

Female

Cell Division

Male

Bone Marrow

Antigens

Cell Line

Comparative Study

Adult

Gene Expression

RNA, Messenger

DNA

Middle Aged

Embryo

Polymerase Chain Reaction

Time Factors

Flow Cytometry

Neurons

Interleukin

Immunohistochemistry

Colony-Forming Units Assay

Signal Transduction

Molecular Sequence Data

Tumor Cells, Cultured

Granulocyte Colony-Stimulating Factor

Transfection

Transcription Factors

Recombinant Proteins

Base Sequence

Cell Movement

Dose-Response Relationship, Drug

Cell Separation

Aged

Skin

Cell Adhesion

Cell Count

Phenotype

Fetal Blood

Cytokines

Tumor Stem Cells

Collagen

Erythroid Progenitor Cells

Biological Markers

Transforming Growth Factor beta

Adolescent

Stem Cell Factor

Cell Cycle

Child

Proto-Oncogene Proteins

Liver

Genetic Vectors

Immunophenotyping

Culture

Membrane Proteins

Clone

Phosphorylation

Blotting, Western

T-Lymphocytes

B-Lymphocytes

In Vitro

Stem Cell Transplantation

Antibodies, Monoclonal

Pregnancy

Kinetics

Macrophages

Fetus

Amino Acid Sequence

Tumor Necrosis Factor-alpha

Retroviridae

Bone Marrow Transplantation

Trans-Activators

Transcription, Genetic

Growth Substances

Enzyme Inhibitors

Models, Biological

Extracellular Matrix

Proteins

Cell Nucleus

Spleen

Endothelium, Vascular

Mesoderm

Epithelial CellsEnzyme Activation

Actins

Lung

Neoplasm Proteins

Mutation

Granulocytes

Infant, Newborn

Erythropoietin

Microscopy, Electron

Neoplasms

Antineoplastic Agents

Fibronectins

Fluorescent Antibody Technique

Thymus Gland

Cell Transformation, Neoplastic

Monocytes

Leukemia

Cell Membrane

Chick Embryo

Lymphocytes

Erythropoiesis

Erythrocytes

Thymidine

Tritium

Colony-Stimulating Factors

Cell Lineage

Cell Culture Techniques

Apoptosis

Stromal Cells

Coculture Techniques

STEM CELLS – Emerging themes

Scientometrix: Early Warning: Strategic Diagrams of Research Scientometrix: Early Warning: Strategic Diagrams of Research Community Evolution: biosafety researchCommunity Evolution: biosafety research

MALONE LA - 35

LEFOL E - 35

MICHAUD D - 36

J EFFERSON RA - 36

WILLIAMSON M - 37

RIESEBERG LH - 37

MACINTOSH SC - 37

HILDER VA - 37

CAPRIO MA - 37

LINDER CR - 40

SNOW AA - 41

SCHUBBERT R - 41

ONSTAD DW - 41

MEYER R - 42

SHELTON AM - 43

PADGETTE SR - 43

DEBLOCK M - 43

ANDOW DA - 44

ALSTAD DN - 44TAYLOR SL - 45

J OHNSON MT - 45

BARTSCH D - 45

TANG J D - 47

SAXENA D - 47

CHEVRE AM - 48

STEWART CN - 49

PILCHER CD - 49

LIU YB - 49

J ORGENSEN RB - 49

SCHEFFLER J A - 50

NIELSEN KM - 50

MIKKELSEN TR - 54KLINGER T - 54

RAYBOULD AF - 57

SIMS SR - 59

LOSEY J E - 59SCHULER TH - 64

GATEHOUSE AMR - 71

KOZIEL MG - 72CRAWLEY MJ - 76

DALE PJ - 85

DANIELL H - 89

HILBECK A - 92

ROUSH RT - 96

PERLAK FJ - 98MCGAUGHEY WH - 98

ELLSTRAND NC - 114

TABASHNIK BE - 250

GOULD F - 258

0,001

0,01

0,1

0,0001 0,001 0,01 0,1

1984-1999

2000

-200

3

Scientometrix/ Adds Heterogeneous Networks Heterogeneous NetworksCompanies & TechnologiesCompanies & Technologies

DEVICES SERVICES

DIAGNOSTICS

GENOMICS

DRUG DELIVERY

LARGE MOLECULE

SMALL MOLECULE

PROTEOMICS

RECOMBINANT DNA

ANTIBODY

MOLECULAR DIVERSITYSCREENING

GENE THERAPY

SYNTHESIS

VACCINES

GENE EXPRESSION

GENERICS OTC

CELL THERAPY

AVENTIS

GLAXO

BIOINFORMATICS

J OHNSON

ROCHE

APPLERA

PFIZER

AHP

BMS

NOVARTIS

GENE SEQUENCING

GENZYME

AMERSHAM

ABBOTT

INCYTEG

MERCK_CO

PHMACIA

CHIRON

TRANSGENICS

NIH

ELAN

BAYER

ELILILLY

AFFYMET

NUTRACEUTICALS

ASTRAZEN

GENENTEC

SCHER_AG

CELLTECH

SCHERING

MILL_PHA

PERKIN

BAXTER

NANOTECHNOLOGY

PCOP

AMGEN

MEDAREX

RATIONAL DRUG DESIGN

MERCK

BOEHRING

LEXICON

VERTEX

SEQUENOM

APP_BIOS

UN_CAL

E.I. DU

CORIXA

VALENTIS

BD MONSANTO

ARQULE

NATURAL PRODUCTS

DYAX

ABGENIX

NOVO NOR

HU_GE_SC

LION_BIO

ISIS

GENE_LOG

MDS

OXFGLYCO

CYTOGEN

MEDIMMUN

UNIV_TEX

ORCHID

INDEVUS

TREGA

BASF

GENOME

HARV_UNI

TGEN

EXELIXIS

J H_UNIV

AKZO

CARBOHYDRATE

CELL_PAT

BIOGEN

SUSM

MYRIAD

DPI

HMS

EVOTEC

TYCO_INT

SANOF_S

CAMBTECH

SANGAMO

BIOVAIL

QIAGEN

GENSET

BECKMAN

MIT

INVITROG

CHUGAI_B

OSI

MITSUB

IMMUNEX

TRIPOS

LIGAND

IMCLONE

ACAMBIS

P & G

CANC_RC

NEXSTAR

OXFBIOM

AURORA

XOMA

XENOVA

ENZON

AVANT

LYNX_USA

WATSON

E-HEALTH

MEDTRONI

MORPHOSY

THIRD_WA

GILEAD

SCIOS

DOUBLETW

HYSEQ

CURAGEN

SHIRE

SEPRACOR

CRUCELL

AMERNYCO

SKYEPH

MSKC_CEN

ANTIGENI

VICAL

THERMO_E

GENELABS

IVAX

DELTAGEN

GPC_BIOT

TULARIK

DOW_CHEM

GENVEC

PDL

NEORX

STEMCELL

CORNING

EPIMMUNE

HITACHI

BIO_TG

BAY_C_M

ALEXION

YAMANOUC

DUHS

IDEC

CUBIST

NEXELL

CEPHALON

FUJ ISAWA

TAKARA

LUDWIG_I

LIFE_TEC

GERON

NEOPROBE

PPD

ALLIANCE

SERONO

PROTSYS

TEVA

VARIAGEN

SOLVAY

CHRYSALI

DAIICHIP

DECODE

REPLIGEN

QUIDEL

SCHWARZ

TAKEDA

BIOSITE

YALE_U

UCSF

CELGENE

IMMUNOME

BIOMIRA

ROBERTS

ALLERGAN

PROGENIC

NPS

KIRIN

IMMUNOGE

ONCOR

AMRAD

DIVERSA

SCRIPPS

ICOS

ALKERMES

PITTSB_U

CURIS

POWDERJ

MYLAN

ID_BIOME

NANOGEN

BTG_PHAR

MEDIGENE

NEUR_BIO

UCSD

J TOBACCOKING

SANKYO

PEREGRIN

SUMITOM

MAXIGEN

IMMUNE

SOMATIX

SICOR

ONCORMED

BIOMERIE

HYBRIDON

UCLA

RIBOZYME

AD_POLY

NABI

AMYLIN

SUPERGEN

ICN_PHAR

IGEN

TAISHOPH

NYU

ACACIA

MGH

BIOCHEMP

U_WASH

SEQUUS

CAM_BIO

CELL_GEN

CYTRX

INHALE

RECORDAT

WASH_U

ANADYS

KYOWA

INSITE

BIO_RAD

3M

DEGUSSA

AASTROM

MAR_UN

GENTA

PROTHER

MCGILL_U

ALBANYMR

BBIOTECH

SYNCOR

AVANIR

ANTARES THERATEC

DSM_GIST

EISAI

CARDINAL

AMARINPHARMASC

PENEDERM

ALTANA

BIOGLAN

BOSTON_S

CENES

UNIV_COL

COLUMBIA

MAYO_FOU

MARTEK

COLLAGEN

LIPOSOME

IBM

MAX_PLAN

DUPONT_M

CORTECS

ADVMAG

DAINIPP

CYGNUS

MILLENN

ABSC

GENENCOR

ATRIX

UNIV_TR

BERLEX

UCB_GROU

BAUSCH

ENTREMED

OXFORD_U

CONNETIC

MGI

FISHER_S

MAYNE

ILEX

TRIANGLE

DRAXIS

VIRAGEN

TEIJ IN

MERI_BIO

ACCESS

DADEBE

GEN_EL

FOREST

TANABESE

MEDICIS

Pasteur

PHOTOTHERAPY

FRESENIU

ONO_PHAR

STERL_DR

PH_RES

QUESTCOR

AJ INOMO

MUNDIPHA

MICHIG_U

MEIJ I

DYNAGEN

SYNBIOTI

SENETEK

QUINTILE

MASS_GEN

PIERRE

NRC_CAN

NESTLE

COLLAGEX

CHIESI

AMERISB

XENOGEN

HESKA

CHEMTRAK

PHARMAS

BARR_LAB

OTSUKA

BENTLEY

PROVALIS

BTG

ASAHI

NYCOMED

SUNY

MERCKLE

GUILFORD

BEAUFOUR

ELF_AQUI

INTEG_LS

AD_TS

US_BIOSC

LUNDBECK

HSC

EPITOPE

WELLCOME

COCENSYS

SYNSORB

ALPHARMA

MEDCO_R

ORION

SMITH

KISSEI

AXCAN

AMARILLO

UNITED_T

SHIONOGI

SPECTRAL

CORNELLU

SUNTORY

AMBI

BCU

MYCOGEN

GELTEX

NCI

FERRER

BOOTS CO

PAREXEL

GENOMICS

PROTEOMICS

GENE EXPRESSION

BIOINFORMATICS

INCYTEG

MERCK_CO

AFFYMET

NANOTECHNOLOGY

LEXICON

SEQUENOM

APP_BIOS

HU_GE_SC

GENE_LOG

OXFGLYCO

ORCHID

GENOME

EXELIXIS

MYRIAD

GENSET

INVITROG

LYNX_USA

THIRD_WA

HYSEQ

CURAGEN

GPC_BIOTCORNINGHITACHI

VARIAGEN

DECODE

NANOGEN

WASH_U

MCGILL_U

IBM

MAX_PLAN

MILLENNUNIV_TR

SUNY

Scientometrix / Adds: Actor/Networks Actor/Networks

Aventis

Glaxo SmithKline plc

Johnson & Johnson

Roche

Pfizer

Novartis

Bristol-Myers Squibb Co.

Abbott

Pharmacia

Wyeth

National Institutes of Health

Eli Lilly and Co.

Genzyme Corp.

AstraZeneca

Merck & Co. Inc.Elan Corporation plc.

Applera Corporation

Chiron Corp.

Bayer AG

Amersham Pharmacia Biotech

Monsanto

Merck KGaABaxter International inc.

Schering AGSchering-Plough Corp.

Celltech Group plc

Genentech Inc.

Incyte Genomics

Boehringer Ingelheim EI DuPont de Nemours & Co. Inc.

Perkin Elmer

Amgen

Sanofi-SynthelaboBecton Dickinson and Co.

Novo NordiskShire Pharmaceuticals Group plc

Pharmacopeia Inc.

BASF

IVAX Corporation

Mitsubishi Group

Millennium Pharmaceuticals Inc.

University of California

Akzo Nobel NV

Medarex Inc.

Tyco International Ltd.

Affymetrix Inc.

Procter & Gamble Co.

Harvard University

MedImmune Inc.

Massachusetts Institute of Technology

Solvay Pharmaceuticals incChugai Biopharmaceuticals Inc.

Biogen Inc.

Mds Inc.

Johns Hopkins University

Biovail Corporation

Corixa Corp.

Stanford University School of MedicineMedtronic Inc.

Vertex Pharmaceuticals Incorporated

Watson Pharmaceuticals Inc

Harvard Medical School

Sequenom Inc.

University of Texas Interneuron

Fujisaw a Healthcare INCLigand Pharmaceuticals

ISIS Pharmaceuticals Inc.

Bio-Technology General Corp.

Lion Bioscience AG

Cytogen Corp.Schw arz Pharma AG

QUIDEL Corp.

Allergan INC.

Abgenix Inc.

Cardinal Health Inc.

Acambis plc

Teva Pharmaceutical Industries Ltd

Yamanouchi Pharmaceutical Co. Ltd.Lexicon Genetics Incorporated

Degussa AG

Cell Pathw ays Inc.

Corning Inc

Applied Biosystems Group

SankyoCephalon Inc.Takeda Chemical Industries Ltd

ICN Pharmaceuticals Inc.

Duke University Health SystemDyax Corporation

Xoma ltd.

SkyePharmaOSI Pharmaceuticals Inc.

Nycomed Amersham plc.

King Pharmaceuticals Inc

Xenova Group plc

ArQule Inc.

Genome Therapeutics Corp.

Aurora Biosciences Corp.

Valentis Inc.

0%

1%

2%

3%

4%

5%

6%

7%

8%

0% 2% 4% 6% 8% 10% Density

Cen

trality Pharma Group I

Central, Star-like hierarchical networks

Pharma Group IILess central, Less hierarchical

Platform Tech. CompaniesClique-like, complex networks

Scientometrix /GIS Spatial Network - Collaboration between Nano-Biotech Clusters

Scientometrix /GIS SpaceSpace

Biotech ClustersBiotech Clusters

01801

01801

02210

01730

01803

02451

02481

02132

02139

02118Boston

Boston Region

Scientometrix /GIS SpaceSpace

Nano-Biotech ClustersNano-Biotech Clusters

Scientometrix /GIS – Zooming InCanadian Nano-Bio publications by province and by discipline

Scientometrix /GIS – Zooming InNumber of publications by type, Montreal region

Scientometrix /GIS – Zooming InSub-clusters of the Montreal region, Note the Bio/medicine sub cluster in Laval.

Web Cartography III

IssueCrawler Project – GovCom.Org, Amsterdam (R Rogers et al)

Technology transfer: Industrial Partners of INSERM

0

50

100

150

200

250

300

350

400

450

1980 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003

0

100

200

300

400

500

600

GROUPE

PME

START-UP

Total

Industrial partners of INSERM: Emerging domains

1996-00

Biotechnologie/Médicament

2001-03

Chimie/Vaccins

1991-95

Technologie biomédicale

Diagnostic

1986-90

Epidémiologie Recherche clinique

1980-85

Nutrition

FRANCE

Médicament

Vaccins

Diagnostic

Technologie biomédicale

ETATS-UNIS

Epidemiologie

SUISSE

ROYAUME-UNI

Recherche clinique

ALLEMAGNE

BELGIQUE

ITALIE

JAPON

CANADA

Agroalimentaire

SUEDE

PAYS-BAS

DANEMARK

FINLANDE

ESPAGNE

IRAN

MONACO

LIBAN

IRLANDE

LUXEMBOURG

VENEZUELA

CHINE

ISRAEL

AUTRICHE

COREE DU SUD

ARGENTINE

AUSTRALIE

AFRIQUE DU SUD

INDE

POLOGNE

TCHECOSLOVAQUIE

CUBA

COREE DU NORD

ESTONIE

ISLANDE

R.D.A.

SINGAPOUR

HONGRIE

INSERM: international Collaboration

Technologies & Companies

Culture de cellules ou tissus

2

Génomique

Chimie combinatoire

17Zootechnie/Animalerie

11

13

Bioinformatique

5

22

14

15

21

6

Modélisation

Technologie Biomedicale

3

4

1

19

18

7

16

8

9

12

Network in Time

News

North Korea + Regime Change North Korea + Reunification

North Korea + Nuclear

North Korea + Axis of Evil

North Korea + Human Rights

North Korea + Famine

North Korea + War

MSNBC

Korea Times

New York Times

Asia Times Online

Korea Herald

Channel News Asia

Financial Times (subscription)

Frontpagemag.com

Voice of America

Washington Times

Daily Times

Taipei Times

Radio Free Asia

Reuters

San Francisco Chronicle

Chosun Ilbo

SpaceDailyFOX News

Donga

CNN Asia

Stuff.co.nz

Guardian

IranMania News

J apan Today

Minneapolis Star Tribune (subscription)

Arms Control Today

Louisville Courier J ournal

Atlanta J ournal Constitution

Washington Post

GoAsiaPacific.com

International Herald Tribune

Wired News

J apan Times

American Daily

eTaiwan News

CNN

Aljazeerah.info

Rocky Mount Telegram

Reuters AlertNet

Straits Times

Tech Central Station

CNN International

Whitehouse.gov (press release)

The Militant

Toronto Star

Newsweek

Newsday

New Zealand Herald

ABC Online

Telegraph.co.uk

The North Korean English News Space, Sept. 15 – Nov. 15, 2003.

Findings:Whitehouse.gov (press release) couches

North Korea in terms of regime change and human rights. The only other outlet that does so is Frontpagemag.org, a site which at the time of this map, extolled surfers to sign and e-petition and help “Stop the Left’s Anti-American Agenda… Help expose terrorists in our midst>”

Connecting regime change to war is done by Fox News, Newsweek, and Asia Times online. Thus it is clear that these media outlets are framing regime change in terms of military conflict.

Regime Change and Reunification are, basically, disconnected. Thus there is little talk of a German model achievement of Regime Change.

The Financial Times subscription service, a strong example of the corporate angle on the issue, presented North Korea only in terms of regime change, notably isolating the issue from conflict, reunification, famine and other issues.

Only CNN is able to connect famine and reunification, one of the more practical and meaningful associations between the issues of import in the peninsula. This finding defies conventional wisdom which would have CNN less informed by the stance of regionally located English media outlets.