management model, challenges, and opportunities for core facilities in research institutes buenos...
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Management model, challenges, and
opportunities for core facilities in
research institutes
Buenos Aires March2015
• Founded in 2000
• 31 groups + 6 core facilities
• 410 staff
• 73% foreigners
• Budget: 30M€ (49% core – National and local government; 51% external)
• Position 9 worldwide Q1, Health - Scimago Reports (2007-2011)
• Severo Ochoa center of Excellence
THE CRG IN A NUTSHELL
CRG STRATEGIC GOALS
EXCELLENCE IN SCIENCE
TECHNOLOGY TRANSFER
SCIENCE & SOCIETY
FOREFRONT TECHNOLOGY
ADVANCED TRAINING
INTERNATIONAL COLLABORATION
• The Core Facilities constitute the Institute’s centralized scientific research infrastructure and allow scientists shared access to sophisticated and expensive technologies that would be hard or impossible to set up in each research group independently.
• They are meant to be a meeting point for scientists from different institutes and disciplines, to foster exchange and integration of expertise, and to create and conduct interdisciplinary projects.
CORE FACILITIES: MISSION
Provide the researchers with the BEST POSSIBLE SERVICE
1. Be state-of-the-art with respect to technologies2. Generate optimal benefit with the available resources (work
towards a larger degree of auto-sustainability and capacity to re-invest in cutting-edge technologies)
3. Provide multi-disciplinary training to the next generation of scientists
CORE FACILITIES: MISSION
Provide the researchers with the BEST POSSIBLE SERVICE
1. Be state-of-the-art with respect to technologies2. Generate optimal benefit with the available resources (work
towards a larger degree of auto-sustainability and capacity to re-invest in cutting-edge technologies)
3. Provide multi-disciplinary training to the next generation of scientists
Become a “Reference Centre for Technology”
CORE FACILITIES: MISSION
FOREFRONT TECHNOLOGIES
Histology•
Embedding/sectioning
• Pathology
Advanced Light Microscopy
• Super-resolution (STED)• Two-photon
• Confocal
Genomics• Microarray
• NGS (Illumina HiSeq2000 and 2500)
Bioinformatics• NGS data analysis• Data integration
Flow cytometry
• Becton Dickinson site• 5 analyzers and 2
sorters• Flow karyotyping
Proteomics• Orbitrap mass spec• Qtrap and Triple-
TOF mass spec
Screening / protein tech.• High content
screening• Cloning / Protein
purifcation
SIT• Storage• Computing
Core Facilities Meeting
CRG Executive Board
CRG FacultyMixed Commission
Secretary
2 Finance Officers
ORGANIZATION OF THE PROGRAMME
Board of Trustees
Director
Head of Core Facilities
SITHistologyScreening
and Protein Technologies
FACSBio-informatics
Advanced Light
MicroscopyProteomicsGenomics
Joint Facilities with the UPF
• Yearly online User Satisfaction Survey
• Individual User Advisory Committees for each Core Facility, 4-5
expert users:• Provide feedback on the quality of the service
• Guide the Facility in terms of technology development/implementation.
• Communication with the users during the facilities’ daily operations:• Initial project discussions
• Status updates during course of the projects
• Follow-up and discussion of the data
USER FEEDBACK
• Courses@CRG
• Technology Symposia
• Internal training
• Participation in UPF/CRG Masters and PhD courses
• Videoclips on website
TRAINING
FINANCIALS
Daily operations and R&D
Competitive Grants Trustees
External Users
CRG Research Groups
Competitive Grants Trustees
Core Facilities Service
• We work with two separate budgets: R&D and services
• Each core facility is given a budget for technology development and daily operations.
• CRG research groups receive an earmarked budget to be spent in Core Facilities.
FINANCIALS
• CRG core facilities operate according to full cost accounting principles. Full-cost accounting:
• Consumables
• Personnel: 80% of yearly working hours
• Equipment Depreciation:
• 5 years for laboratory equipment, 3 years for computational equipment
• 8-12 hours/day, yearly working days
• Equipment Maintenance/Repair:
• 8-12 hours/day, yearly working days
• General Structure = 20% of total cost
• 3 different prices:• Internal (PRBB) = consumables + maintenance/repair + %personnel
• External Public = full cost
• External Private = full cost + negotiation
• Keeping abreast of technologies
• Visibility / Reputation
• Avoid duplications
• Funding
CHALLENGES and OPPORTUNITIES
TECHNOLOGIES
• Keeping abreast of technologies: expensive
• Visibility / Reputation
• Avoid duplications
• Funding
TECHNOLOGIES
• Keeping abreast of technologies: VERY expensive
• Visibility / Reputation
• Avoid duplications
• Funding
• Keeping abreast of technologies
• Tech scouting and purchase
• Joint projects with providers and other
companies
• Development in-house (dedicated personnel)
TECHNOLOGIES
• Keeping abreast of technologies
• Visibility / Reputation: International collaborations
• Avoid duplications
• Funding
CHALLENGES and OPPORTUNITIES
• over 284 publications with core facility contributions
• 80 co-authored publications, 11 of them as last author
• 130 out of 206 CRG last-author research papers with core facility contributions
• Core Facilities were involved in roughly 2/3 of the CRG publications
COLLABORATIONS IN PUBLICATIONS
CRG Core FacilitiesCRG Research Groups
Bioinformatics
Genomics
Proteomics
MicroscopyBMS&PT
INTERNATIONAL COLLABORATIONS
• Reference site agreements with providers: Leica, Illumina, Thermo, ABSciex, Becton Dickinson
• International alliances: PRIME-XS, ESGI, EuroBioimaging, P4EU
• .
6 partners
• Sharing best practice• Training• Scouting new technologies• Capacity sharing• Funding
13 partners
• Promoting excellence• Integration• Attract talent, support mobility• Sharing best practise in
research and management
• Keeping abreast of technologies
• Visibility / Reputation
• Avoid duplications: Agreements with other research
centres
• Funding
CHALLENGES and OPPORTUNITIES
AGREEMENTS WITH RESEARCH CENTRES
• UPF (Joint facilities)
• VHIR (Alliance pricing)
• CCiTUB (Use of complementary facilities)
• ICFO (Super-resolution Light Nanoscopy Alliance)
• BSC (High-Performance Computing cluster)
• Spanish networks: Remoa, ProteoRed
CHALLENGES and OPPORTUNITIES
• Keeping abreast of technologies
• Visibility / Reputation
• Avoid duplications
• Funding: National funding (decreasing), H2020
(translation and innovation)
• Funding
• Partner with companies (H2020 innovation
projects)
• Collaborate with Hospitals (H2020 translation
projects)
• Negotiate with providers (discounts and
participation in projects)
• Private funding for social projects
FUNDING
ÒSCAR FORNASFACS
EDUARD SABIDÓ PROTEOMICS
HEINZ HIMMELBAUERGENOMICS
TIMO ZIMMERMANMICROSCOPY
CARLO CAROLISSCREENING andPROTEIN TECH
JULIA PONOMARENKOBIOINFORMATICS