male genital pathology. 62 year old male scc of the penis, spreading through the vessels of the...
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PATHOLOGY PICTURES
Male genital pathology
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62 year old male
SCC of the penis, spreading through the vessels of the corpora cavernosa
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Malignant penile carcinoma
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59 year old male with haemochromatosis and cirrhosis
Testicular atrophy
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Low power
High power
Atrophic testis
Low power: tunica albuginea (long arrow); seminiferous tubules (short arrow)
High power: Leydig cells (long arrow); atrophic tubules (short arrows); thickened basement membrane; lack of spermatogenesis
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A: normal testis
B: testicular atrophy tubules have Sertoli cells but no spermatogenesis; thickened basement membrane; apparent increase in interstitial Leydig cells
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30 year old man with dystrophia myotonica
Advanced testicular atrophy
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Epididymitis and orchitis
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71 year old male with prostatic hyperplasia
Chronic granulomatous epididymo-orchitis
Blue arrows: cream nodules comprising lipid-laden macrophages
Black arrows: hydrocoele
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Tuberculous epididymo-orchitis
Predominantly affecting the epididymis (arrows)
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Tertiary syphilis
Gumma (arrows) of the testis
Multiple irregular areas of necrosis surrounded by a zone of dense fibrosis
No recognisable testicular tissue remains
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Haemorrhagic infarction of testis due to torsion of spermatic cord
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Testis which has recently undergone infarction
Low power: tunica albuginea (long arrow); infarcted tubule (small arrow)
High power: necrotic seminiferous tubules (long arrows); oedema separating tubules (short arrows)
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Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord
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Testicular torsion
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Torsion of the testicular appendix
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Bilateral cysts of epididymis
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40 year old male
Seminoma of the testis
Homogeneous cream colour
Testicular tumours are usually a mixture of seminoma and teratoma components
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Seminoma of the testis
Fairly well circumscribed, pale, fleshy, homogeneous mass
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Embryonal carcinoma
Haemorrhagic mass
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Choriocarcinoma
Small size; marked haemorrhage and necrosis
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17 year old male
Malignant teratoma of the testis
Varied macroscopic appearance from one area to another
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Immature testicular teratoma
Low power: tunica (A); residual seminiferous tubules (B); varied picture within and between fields
High power: immature mesenchyme (A); immature cartilage (B); seminoma (C) seminoma can form a component of a mixed germ cell tumour
High power view of seminoma component: tumour cells (arrows) have large central nuclei and clear cytoplasm; fibrous connective tissue septae infiltrated with chronic inflammatory cells (arrowheads)
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Man aged 35 with ‘cannon ball’ secondaries in the lungs and a positive pregnancy test
Immature teratoma of the testis with a choriocarcinoma component
Haemorrhagic necrosis of choriocarcinoma component (characteristic due to tumour cells invading blood vessels)
Homogenous white areas: seminoma
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Teratoma of the testis
Variegated cut surface with cysts
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Mature teratoma
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Immature teratoma
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72 year old male
Hydrocoele (blue arrows) with atrophic testis (red arrows)
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6 year old male
Hydrocoele of the spermatic cord
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Chronic haematocoele (blue arrows) with testicular atrophy (red arrows)
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Man aged 58
Varicocoele (blue arrows)
Appendix of epididymis (red arrows)
Hydatid of Morgagni (black arrow) with twisted pedicle
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72 year old male with DM complicating haemochromatosis
Prostatic abscess
Blue arrows: pyogenic membrane (abscess contents removed)
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83 year old male
Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation of the bladder
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Low power
High power
Medium power
Low power: increased stroma and proliferated glands (arrows)
High power: double layer of nuclei (long arrows); regular nuclei and inconspicuous nucleoli (arrowheads)
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Prostatic hyperplasia
Hypertrophy of bladder muscle
Cystitis
Bilateral hydroureter and hydronephrosis
Suppurative pyelonephritis
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BPH
Well-define nodules compress the urethra into a slit-like lumen
Histology: nodules of hyperplastic glands on both sides of the urethra
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Carcinoma in the posterior prostate
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Low power
High power
Adenocarcinoma of the prostate
Low power: proliferation of closely-packed small glands; infiltrating into surrounding stroma
High power: glands are closely applied (long arrows); enlarged, hyperchromatic nuclei; nuclei are irregularly arranged in the cells (arrowheads)
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Poorly differentiated prostatic adenocarcinoma
Almost complete loss of the glandular architecture, pleomorphic nulei, prominent nucleoli
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Advanced carcinoma of the prostate
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Adenocarcinoma of the prostate
Lower left is posterior aspect (where carcinomatous tissue is)
Solid white tissue of cancer unlike spongy appearance of benign peripheral zone