MALDI-Mass Spectrometry

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• Matrices and Reagents

• Standards

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• Separation SuppliesQuality Exceeding Expectations

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Sigma-Aldrich offers a comprehensive range of reagents, standards, solvents and supplies suitable for use with high performance MALDI-MS instruments. More than 98% of our products are in stock and can typically be delivered to you within 24 h.

As a supplier of analytical reagents and standards, quality assurance is of prime importance to us. Each of our products is manufactured to clear, guaranteed specifications.

Find our products at sigma-aldrich.com/maldi

• Each set contains multiple different certified reference materials, exact values are stated on the accompanying certificate of analysis

• Certified according to DIN 55672 and ISO/EN 13885

Sigma-Aldrich offers both the Universal Proteomics Standard and the Proteomics Dynamic Range Standard as complex, well-defined, well-characterized reference standards for mass spectrometry. Both standards contain the same 48 human proteins ranging in molecular mass from 6,000 to 83,000 Da. Each constituent protein has been HPLC purified and AAA quantitated prior to formulation.

• Troubleshoot and optimize your analytical protocol

• Confirm system suitability before analyzing critical samples

• Normalize analytical results day-to-day or lab-to-lab

• Determine your limit of detection

To learn more, visit sigma-aldrich.com/ups

• Ready-to-use kits

• Suitable for calibration, tuning and sensitivity testing of MALDI-MS instruments from all manufacturers

• Features a convenient selection of pre-qualified standard analytes, matrices, and solvents

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Quality Exceeding Expectations

MALDI-MS Validation Sets (Certified Reference Materials)

Proteomics Standard Sets

ProteoMassTM Calibration Kits

Standards for Validation and Calibration

Cat. No. Product Molecular Range Mp

03598 MALDI validation set polyethylene glycol 500 – 20,000

03599 MALDI validation set poly(methyl methacrylate) 500 – 700,000

03565 MALDI validation set polystyrene 500 – 70,000

03597 MALDI validation set PS, PMMA, PDMS, PEG and PSS 5,000 – 20,000

Cat. No. Product Note

MSCAL1 ProteoMass™ Peptide and Protein MALDI-MS Calibration Kit

Configured for analyzing complex mixtures of proteins and peptides (700 to 66,000 Da), this kit is ideal for evaluating unknown samples or samples containing a broad range of molecular weights

MSCAL2 ProteoMass™ Peptide MALDI-MS Calibration Kit

Configured specifically for peptide applications (in the mass range of 700 to 3500 Da), this kit is ideal for analysis of tryptic fragments or post-source decay studies

MSCAL3 ProteoMass™ Protein MALDI-MS Calibration Kit

Configured specifically for applications in the mass range of 5 to 66 kDa, this kit is ideal for most protein studies

MSCAL4 and LTQ Hybrids useable for calibrations between m/z 50 and 4,000

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Fluka’s LC-MS and LC-MS Ultra CHROMASOLV® solvents offer high purity and low levels of alkali metal impurities, making them ideal for classical MALDI-MS sample deposition techniques and in LC-MALDI-MS coupled methods.

LC-MS Ultra grade solvents are tested specifically for UHPLC, offering extremely low baselines, high lot-to-lot reproducibility and minimal adduct formation due to high quality leaching-resistant packaging materials.

Additionally, ready-to-use blends with 0.1% of trifluoroacetic acid (TFA), ammonium actetate or formic acids are also available

Visit our solvents center at sigma-aldrich.com/solvents for more information.

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Quality Exceeding Expectations

MALDI-MS Validation Sets (Certified Reference Materials)

Solvents

Proteomics Standard Sets

ProteoMassTM Calibration Kits

Additives, Reagents and Solvents

Cat. No. Product Name Molecular Range Mp Pack Sizes

34967 Acetonitrile LC-MS CHROMASOLV 250 mL, 1 L, 2.5 L, 4 L

34972 Ethyl acetate LC-MS CHROMASOLV 1 L, 2.5 L

34966 Methanol LC-MS CHROMASOLV 1 L, 2.5 L, 4 L, 20 L

39253 Water LC-MS CHROMASOLV 1 L, 20 L

14261 Acetonitrile LC-MS Ultra CHROMASOLV 1 L, 2 L

14262 Methanol LC-MS Ultra CHROMASOLV 1 L, 2 L

14263 Water LC-MS Ultra CHROMASOLV 1 L, 2 L

Cat. No. Product Name Molecular Range Mp Pack Sizes

34669 Acetonitrile with 0.1% ammonium acetate LC-MS CHROMASOLV 2.5 L

34668 Acetonitrile with 0.1% formic acid LC-MS CHROMASOLV 2.5 L

34670 Methanol with 0.1% ammonium acetate LC-MS CHROMASOLV 2.5 L

34671 Methanol with 0.1% formic acid LC-MS CHROMASOLV 2.5 L

34674 Water with 0.1% ammonium acetate LC-MS CHROMASOLV 2.5 L

34673 Water with 0.1% formic acid LC-MS CHROMASOLV 2.5 L

34978 Water with 0.1% TFA LC-MS CHROMASOLV 2.5 L

Cat. No. Product Note

UPS1 Universal Proteomics Standard Set

Contains 48 human proteins (5 pmoles of each) ranging in molecular mass from 6,000 to 83,000 Da

UPS2 Proteomics Dynamic Range Standard Set

The same complex mixture of 48 human proteins as UPS1, but formulated into a dynamic range of concentration levels, ranging from 50 pmoles to 0.5 fmoles

The choice of the right matrix suitable for the analyte of interest is essential for the success of any MALDI-MS analysis. Sigma-Aldrich offers the most comprehensive selection of pure and ultra pure matrices for MALDI-MS, covering matrices suitable for many different analytes, such as proteins, pep-tides, polymers, lipids, oligonucleotides, and many more. Modern Ionic Liquid Matrices (ILMs) extend the unique properties of ionic liquids to MALDI-MS.

• High chemical purity to improve crystallization

• Low metal trace content to minimize adduct formation and simplify the resulting MS spectrum

• Ultra pure grades of the most popular matrix substances with extremely strict specifications concerning purity, trace metal content, appearance and solubility

For a full and up-to-date filterable product listing, please visit our Matrix Selection page at sigma-aldrich.com/maldimatrix

Matrix substances for MALDI-MS

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Cat. No. Product Purity Abbr.

Prot

eins

Pept

ides

Gly

cans

Olig

o-

nucl

eoti

des

Poly

mer

s

Lipi

ds

Other Analytes

Note Pack Sizes

92817 9-Aminoacridine ≥99.5% 9-AA √ Metabolites 1 g

89132 Aminopyrazine ≥99.0% AP Small carbohydrates 10x10 mg, 1 g

07336 3-Aminoquinoline ≥99.0% 3-AQ √ 1 g

10678 Anthranilic acid ≥99.0% 2-AA √ √ 1 g

82393 6-Aza-2-thiothymine ≥99.0% ATT √ √ √ √ Non-covalent complexes 1 g, 5 g

38368 4-Benzyloxy-α-cyanocinnamic acid

≥99.0% PAH-DNA adducts 250 mg

89063 4-Bromo-α-cyanocinnamic acid

≥95% BrCCA √ Phosphopeptides, phospholipids, chlorinated lipids, drugs, fragile analytes, ionic liquids (quantification), ME-SIMS, CID-MS/MS

100 mg

68914 4-Bromo-α-cyanocinnamic acid - 4-Chloro-α-cyanocinnamic acid mixture

≥95% BrCCA: ClCCA

√ 100 mg

55841 4-Bromo-α-cyanocinnamic acid - α-Cyano-2,4-difluoro-cinnamic acid mixture

≥95% BrCCA: DiFCCA

√ 100 mg

60018 Caffeic acid ≥99.0% √ √ 1 g, 5 g

94141 4-Chloro-α-cyanocinnamic acid

≥95% ClCCA √ Phosphopeptides, phospholipids, chlorinated lipids, drugs, fragile analytes, ionic liquids (quantification), ME-SIMS, CID-MS/MS

100 mg

39379 4-Chloro-α-cyanocinnamic acid - α-Cyano-2,4-difluoro-cinnamic acid mixture

≥95% ClCCA: DiFCCA

√ 100 mg

55754 5-Chloro-2-mercaptobenzo-thiazole

≥99% CMBT √ Oligosaccharides 250 mg

77646 α-Cyano-2,4-difluorocinnamic acid

≥95% DiFCCA √ Phosphopeptides, phospholipids, chlorinated lipids, drugs, fragile analytes, ionic liquids (quantification), ME-SIMS, CID-MS/MS

100 mg

77081 α-Cyano-4-fluorocinnamic acid

≥95% FCCA √ 100 mg

70990 α-Cyano-4-hydroxycinnamic acid

≥99.0% CHCA √ √ √ 250 mg, 1 g

39468 α-Cyano-4-hydroxycinnamic acid

≥99.5%, Ultra pure

CHCA √ √ √ 10x10 mg

67336 α-Cyano-4-hydroxycinnamic acid butylamine salt

≥99.0% BA-CHCA √ √ Ionic Liquid Matrix

100 mg, 1 g

55341 α-Cyano-4-hydroxycinnamic acid diethylammonium salt

≥99.0% DEA-CHCA √ √ Ionic Liquid Matrix

1 g

18211 α-Cyano-4-hydroxycinnamic acid N-ethyl-N,N-diisopropy-lammonium salt

≥99.0% DIEA-CHCA √ √ √ √ Ionic Liquid Matrix

10x10 mg

94190 α-Cyano-4-hydroxy-cinnamic acid N-tert-butyl-N-isopropyl-N-methylammonium salt

≥99.0% IMTBA-CHCA √ √ Ionic Liquid Matrix

10x10 mg

03841 α-Cyano-4-hydroxycinnamic acid - α-Cyano-2,4-difluorocinnamic acid - α-Cyano-2,3,4,5,6-pentafluorocinnamic acid mixture

≥95% CHCA: DiFCCA: Penta FCCA

√ Phosphopeptides, phospholipids, chlorinated lipids, drugs, fragile analytes, ionic liquids (quantification), ME-SIMS, CID-MS/MS

100 mg

38419 α-Cyano-2,3,4,5,6-pentafluoro-cinnamic acid

≥95% Penta FCCA

√ 100 mg

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Cat. No. Product Purity Abbr.

Prot

eins

Pept

ides

Gly

cans

Olig

o-

nucl

eoti

des

Poly

mer

s

Lipi

ds

Other Analytes

Note Pack Sizes

89759 α-Cyano-4-phenylcinnamic acid

≥99.0% PAHs 10x10 mg

56451 1,5-Diaminonaphthalene ≥99.0% 1,5-DAN √ √ In-Source-Decay 250 mg

89415 2’,5’-Dihydroxyacetophenone ≥99.5% 2,5-DHAP √ √ √ 250 mg, 1 g

37468 2’,6’-Dihydroxyacetophenone ≥99.5% 2,6-DHAP √ √ √ √ 1 g, 5 g

85707 2,5-Dihydroxybenzoic acid ≥99.0% DHB √ √ √ √ √ Organic molecules 10 mg, 250 mg, 1 g

39319 2,5-Dihydroxybenzoic acid ≥99.5%, Ultra pure

DHB √ √ √ √ √ Organic molecules 10x10 mg

10608 Dithranol ≥98.5% DIT √ √ Dendrimers 1 g, 5 g

46278 trans-Ferulic acid ≥99.0% FA √ √ 1 g, 5 g

94155 Ferulic acid N-ethyl-N,N-diisopropylammonium salt

≥98.0% DIEA-F √ Ionic Liquid Matrix

10x10 mg

49771 Glycerol ≥99.0% √ √ √ Liquid Matrix 50 mL

53679 Harmane ≥99.5% √ √ Fullerenes 250 mg

95712 (4-Hydroxybenzylidene)malonitrile BioXtra

≥99.0% √ 10x10 mg, 250 mg

68852 3-Hydroxy-2-naphthoic acid ≥99.5% √ √ 1 g

36029 2-Hydroxy-5-(octyloxy) benzoic acid

≥98.5% √ Hydrophobic peptides 100 mg

54793 2-(4-Hydroxyphenylazo) benzoic acid

≥99.5% HABA √ √ √ √ 1 g, 5 g

56197 3-Hydroxypicolinic acid ≥99.0% 3-HPA √ Oligosaccharides 250 mg, 1 g

38472 trans-3-Indoleacrylic acid ≥98.5% IAA √ 250 mg

59927 Isovanillin ≥99.5% Small organic molecules 1 g

76154 2-Mercaptobenzothiazole ≥99.0% MBT √ √ √ 250 mg

72311 Nicotinic acid ≥99.5% √ √ √ 250 mg, 1 g

72681 4-Nitroaniline ≥99.0% √ √ √ Liquid Matrix 250 mg, 1 g

73148 3-Nitrobenzyl alcohol ≥99.5% 5 g

80362 3-Nitrobenzonitrile ≥99.0% 3-NBN Tissues via MAIV 1 g

39245 2-Picolinic acid ≥99.5% √ √ 1 g

84228 Salicylamide ≥99.0% √ 1 g

85429 Sinapic acid ≥99.0% SA √ √ Dendrimers, Fullerenes 1 g, 5 g

49508 Sinapic acid ≥99.5%, Ultra pure

SA √ √ Dendrimers, Fullerenes 10x10 mg

14078 Succinic acid ≥99.5% √ √ √ 1 g, 5 g

50862 Super-DHB ≥99.0% Super-DHB √ √ √ √ 9:1 mixture of DHB and 2-hydroxy 5-methoxy benzoic acid

10x10 mg, 1 g, 5 g

91928 2’,4’,6’-Trihydroxyacetophenone monohydrate

≥99.5% THAP √ √ √ √ 1 g, 5 g

64199 N,N,N',N'-Tetramethyl-1,8-naphthalenediamine

≥99.5% DMAN √ 1 g

50149 Universal MALDI Matrix √ √ Organic molecules 1:1 mixture of DHB and CHCA

1 g

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To improve sensitivity and reduce interferences in the mass spectrum, additives or co-matrices are often added to the sample-matrix-solvent mixture. Trifluoroacetic acid, formic acid and various ammonium salts are most commonly used in this respect.

Derivatization of sample analytes, for instance permethylation or peracetylation, can have advanta-geous effects in MALDI-MS, such as increasing analyte stability or improving the ionization efficiency.

Find our complete offering of derivatization reagents at sigma-aldrich.com/derivatization

Developed in collaboration with the Protein Quantitation Consortium, Sigma’s AQUA Peptides enable accurate, efficient mass spectrometric quantitation of protein biomarkers.

• Focus your analysis on significant protein biomarkers

• Accurately quantitate low abundance proteins

• Eliminate costly, time consuming stable isotope labeling steps

• Measure site-specific phosphorylation states

• Validate gene silencing at the protein level

Find more information at sigma-aldrich.com/aqua

Stable isotope labeling with amino acids in cell culture (SILAC) is a straightforward approach for the incorporation of a stable isotope label into cellular proteins for use with mass spectrometry-based quantitative proteomics. This method works by comparing cell cultures treated with light isotope (natural abundance) amino acids and heavy isotope (13C, 15N and/or D) labeled amino acids which produces two almost identical proteomes that only differ by their masses.

Find our complete offering of SILAC reagents at sigma-aldrich.com/silac

Additives and Co-Matrices

Derivatization Reagents

AQUA™ Peptides

Stable Isotopes Labeling (SILAC)

Cat. No. Brand Product Name Specification/Grade Pack Sizes

73594 Fluka Ammonium acetate for mass spectrometry, additive for LC-MS 25 g, 100 g

09831 Fluka Ammonium citrate dibasic (Diammonium citrate)

≥99.0%, ACS reagent 100 g, 500 g

94318 Fluka Formic acid ~98%, for mass spectrometry 50 mL, 250 mL

F2252 Sigma L-(-)-Fucose ≥99.0% 10 mg, 5 g, 25 g, 100 g

64255 Sigma Methylenediphosphonic acid ≥99.0% 1 g, 5 g, 25 g

79614 Fluka Phosphoric acid ~85%, TraceSELECT® 100 mL, 500 mL

85590 Fluka Spermine ≥99.0% 5 g, 25 g

40967 Fluka Trifluoracetic acid additive for LC-MS 10 mL, 10x1 mL, 1 L

vsigma-aldrich.com/maldi

Additives and Co-Matrices

Derivatization Reagents

AQUA™ Peptides

Stable Isotopes Labeling (SILAC)

Cat. No. Brand Product Name Specification/Grade Pack Sizes

TPSC18 Supelco Supel-Tips C18 microextraction & desalting of peptides and proteins 96 ea

54227-U Supelco Supel-Tips Carbon microextraction of Oligosaccharides and other sugar containing macromolecules

96 ea

54263-U Supelco Supel-Tips Ti microextraction of Phosphopeptides and other phosphate containing molecules

96 ea

54266-U Supelco Supel-Tips Zr microextraction of Phosphopeptides and other phosphate containing molecules

96 ea

The Supel-Tips SPE product line is designed for the micro-scale extraction, concentration, and recovery of small molecules and biological macromolecules. These 10 µL polypropylene pipette tips contain a sorbent bed bonded at the working end of the tip using an inert high-purity adhesive.

• Superior recovery

• Exceptional binding capacity and enhanced affinity

• Excellent sorbent bed stability for cleaner samples

• Fast and effective analyte retention/elution

For more information, please visit our SPE portal at sigma-aldrich.com/spe

Although not as commonly connected with MS as other separation methods such as LC, thin layer chromatography is a facile and fast separation method that can quite easily be combined with subsequent MALDI-MS analysis. TLC-MALDI-MS has been successfully applied to a large variety of different sample and analyte types, including proteins, oligonucleotides and carbohydrates.

Our full selection of TLC plates can be found by visiting sigma-aldrich.com/tlc

Solid Phase Extraction (SPE)

Thin Layer Chromatography (TLC)

Separation and Extraction Supplies

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©2014 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA, SAFC, SIGMA-ALDRICH, ALDRICH and SUPELCO are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. FLUKA is a trademark of Sigma-Aldrich GmbH, registered in the US and other countries. Sigma-Aldrich, Sigma, Aldrich, Supelco, Fluka and SAFC brand products are sold by a�liated Sigma-Aldrich European distributors. Purchaser must deter-mine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on the reverse side of the invoice or packing slip.

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©2014 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA, SAFC, SIGMA-ALDRICH, ALDRICH and SUPELCO are trademarks of Sigma-Aldrich Co. LLC, registered in the US and other countries. FLUKA is a trademark of Sigma-Aldrich GmbH, registered in the US and other countries. Sigma-Aldrich, Sigma, Aldrich, Supelco, Fluka and SAFC brand products are sold by a�liated Sigma-Aldrich European distributors. Purchaser must deter-mine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on the reverse side of the invoice or packing slip.

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