major histocompatibility complex - class i hla-a2 and presentation of herpes viral peptides
DESCRIPTION
Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides. Joshua Nord Lora Rapp Nathaniel Wanish Concordia University of Wisconsin. Big Picture. Human immune system - Cytotoxic T lymphocytes (CTL) - Viral peptide presentation - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/1.jpg)
JOSHUA NORDLORA RAPP
NATHANIEL WANISHCONCORDIA UNIVERSITY OF WISCONSIN
MAJOR HISTOCOMPATIBILITY COMPLEX - CLASS I HLA-A2 AND PRESENTATION
OF HERPES VIRAL PEPTIDES
![Page 2: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/2.jpg)
Big Picture
Human immune system- Cytotoxic T lymphocytes (CTL)- Viral peptide presentation
Major Histocompatibility Complex Class I (MHC)-structure
Human Herpesvirus-7
![Page 3: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/3.jpg)
Class I MHC Formation
Synthesis
Cnx = CalnexinHC = MHC α-chainCrt = CalreticulinTpn = Tapasin
![Page 4: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/4.jpg)
U21
Down regulation of MHC Class I
![Page 5: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/5.jpg)
The Future
X-ray crystallization of MHC & U21
Diversion of MHC to lysosomal compartments
Alternate NK cell evasion
![Page 6: Major Histocompatibility Complex - Class I HLA-A2 and Presentation of HERPES Viral Peptides](https://reader035.vdocuments.site/reader035/viewer/2022070400/568134d3550346895d9bfbfe/html5/thumbnails/6.jpg)
MHC in the Classroom
Model - interactions
- anchor residues
- peptide presentation