The Leading Provider of Advanced Neurostimulation Products

Advanced Neurostimulation

The Magstim range of magnetic stimulation systems provide a variety of high quality solutions for researchers and clinicians working within Neurology, Neuroscience, Psychiatry and Rehabilitation.

Magstim has substantial expertise in magnetic stimulation, and is a leader in the field, offering a wide range of magnetic stimulators and stimulating coils to suit a variety of clinical and research applications.

Non-invasive Neuromodulation

Magnetic stimulation is a non-invasive and painless method of stimulating human tissue using strong, time varying magnetic fields to induce small currents in nerve tissue. These are able to stimulate the human cortex, spinal roots and peripheral nerves.

Depending on the application a variety of output waveforms may be used to excite or inhibit nerve response. These pulses can be either monophasic or biphasic, or a combination of the two.

This brochure is intended for users of TMS equipment outside of the USA.

a leader in the field “Users of Magstim Transcranial Magnetic Stimulators in the USA please note: Caution - Investigational Device. Federal (or United States law) limits device to investigational use.

Monophasic single pulse systems are favoured in neurological applications due to the accuracy of the stimulation and the low heat output. For repetitive stimulation that is used in neuroscience and psychiatry, biphasic systems are the preferred option due to their ability to produce short and efficient pulses at high frequency.

Magstim stimulators can be used in combination with equipment such as:● fMRIi ● EMG● EEGii ● Image-guided TMSiii iv ● tDCS / tACS

Magstim Magstim Magstim Magstim 200² BiStim² Rapid² Rapid² Plus¹

Output Type Monophasic Monophasic Biphasic Biphasic Twin Pulse

Maximum voltage 2.80kV 2.50kV* 1.67kV 1.67kV

Maximum repetition rates 30% 2.0s 2.0s Single PSU - 50Hz Dual PSU - 100Hz 100Hz (230V configuration) 50% 3.0s 3.0s Single PSU - 30Hz Dual PSU - 50Hz 97Hz 100% 4.0s 4.0s Single PSU - 15Hz Dual PSU - 25Hz 41Hz

Minimum Inter Stimulus Interval N/A 1.0ms N/A N/A

Minimum Inter Train Interval N/A 4.0s 0.5s 0.5s

of magnetic stimulation

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* Also available as 2.80kV

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Magstim 2002 & BiStim2 - Monophasic Magstim produce two monophasic systems; the Magstim 2002

and BiStim2, which are used extensively within the fields of

neurology and neurophysiology. For accurate single pulse

functionality, monophasic waveform systems are favoured for :

● Neurological research

● Cortical mapping and brain research

● Functional assessment of central motor pathways

● Early diagnosis, assessment and monitoring of nervous

diseases, such as Multiple Sclerosis and Motor Neurone

Disease.

Single pulse Magstim 2002 provides users with the ability to elicit cortical

evoked potentials, quickly and easily, as a routine component of

clinical and research assessment techniques, including:

● Triple Stimulation Techniquev

● Resting Motor Threshold

● Active Motor Threshold

● Central Conduction Time

● Motor Evoked Potential

● Input-Output Curve

● Cortical Silent Period

● Motor Mapping

Magstim 2002 offers complete flexibility and can be interfaced

with a wide range of commercially available EMG systems.The

monophasic waveform provides a high degree of hemispheric

accuracy, low noise and less coil heating than other pulse

waveforms.

The Magstim 2002 is backward compatible with all Magstim

stimulating coils, via the coil adaptor.

Controlled Trains Magstim BiStim2 offers the potential to combine two Magstim

2002 units to provide fully programmable paired pulse stimulation

through a single stimulating coil.The ability to change pulse

intervals and to independently control the power level of each

Magstim 2002 allows for precise sub- and supra-threshold

conditioning and test pulses.This is invaluable for the investigation

of Inter-Cortical and Intra-Cortical Inhibition and Facilitation.

The inter-stimulus interval (ISI) of the two pulses is adjustable

using either the integral stimulator controls, remote control coil or

externally via triggering software offering complete user flexibility.

Two ISI options offer maximum controllability:

● 1ms - 999ms in 1ms resolution

● 1.0ms - 99.9ms in 0.1ms resolution

BiStim2 has the added advantages of being able to sum the two

single pulses provided by the Magstim 2002 stimulators to

produce a single high power pulse equal to 113% of a single

Magstim 2002, as well as having the functionality to connect two

individual coils for interhemispheric stimulation.

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Magstim Rapid2 - BiphasicMagstim Rapid2 repetitive Transcranial Magnetic Stimulation

(rTMS) devices are highly effective non-invasive biphasic magnetic

stimulators designed to meet the exacting needs of those involved

at all levels of clinical and academic research. Highly efficient,

short duration biphasic pulses makes it very well suited to

bilateral cortical stimulation and is used in many different areas of

research, including:

Cognitive Neurosciencevi - in the investigation of learningvii viii,

memoryix, speechx, hearing, visual, perception and functional

connection

Psychiatryxi - to influence specific brain function within the

dorsolateral prefrontal cortex

Neurophysiology - used in the stimulation of the peripheral

and central nerve pathways

Rehabilitation - used in the promotion of muscle recovery and

the relief of nerve spasticity

The Magstim Rapid2 range of repetitive stimulators has been

developed to maintain a consistent pulse amplitude/frequency

during the delivery of stimulation trains through Single Pulse,

Repetitive, Burst and Session modes of operation. Rapid2

stimulators offer frequencies of up to 100Hz, with a 0.1Hz

frequency resolution for the first 30Hz.

Magstim Rapid2 has an unique inbuilt two channel EMG amplifierwith integral system acquisition software including latency andamplitude measurements. The dedicated touch screen userinterface with internal and external memory makes storage andretrieval of results straightforward. Connecting the optionalthermal printer allows for the provision of hardcopies.

Rapid2 can be used with other investigation tools such as fMRI,EMG, EEG, tDCS, tACS and Image-guided TMS over a broad rangeof protocols and is fully compatible with existing Magstim coilsthrough customised hardware.

Magstim Rapid2 Plus1 is an innovative enhancement to theRapid2 and is the only system able to offer a significantly higherrepetition rate at stimulation output of 30% and higher.This isparticularly useful in applications using protocols such as ThetaBurstxii, as the Magstim Rapid2 Plus1 is capable of up to 89% outputat 50Hz.

With the addition of a Plus1 module a single PSU Rapid2 can beeasily upgraded to dual PSU performance, whereas the addition ofthe Plus1 module to a dual PSU Rapid2 make high poweredprotocols feasible.

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Magstim Rapid2 Performance

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Stimulating coilsThere is a wide range of stimulating coils available for use with

Magstim systems, offering a great level of flexibility to both

research and clinical users: Single, Double and Placebo coils are

available in a variety of sizes for specific, targeted stimulation and

research protocols.

It is now possible to achieve prolonged periods of stimulation

with the innovative Air Film Coil, created to work in combination

with Magstim Rapid2 stimulators.

The Air Film Coil uses innovative, ambient air flow and

temperature regulated fan technology to enable the cooled coil to

run indefinitely under certain protocols.

Key features of the Air Film Coil include:

● Delivers up to 3,000 pulses at 75% stimulator output at 10Hz

stimulation (Biphasic waveform) over a 37.5 minute period

and remains within allowed temperature limits (with a starting

temperature of 22˚C).

● Extends the useful range of stimulating protocols available to

researchers and clinicians

● Unlimited running time with certain protocols

● Quiet running

● Facial nerve● Superficial peripheral nerves

● Peripheral nerves● Cortical stimulation (paediatric)

● Cortical stimulation (adult)● Cervical nerve roots● Lumbrosacral nerve roots

● Cortical stimulation (adult)● Cervical nerve roots● Lumbrosacral nerve roots

● Facial nerve● Superficial peripheral nerves● Somatosensory evoked potentials

● Peripheral nerves● Cortical stimulation (paediatric)

● Cortical stimulation (adult)● Peripheral nerves

● Cortical stimulation (adult)● Spinal roots● Peripheral nerves

● Cortical stimulation (adult)● Spinal roots● Peripheral nerves

● Cortical stimulation (adult)● Femoral nerve● Back and neck

● Central motor disorders● Spinal injuries● Urology

● Psychiatry● Cognitive neuroscience● Neurology● Neurophysiology● Rehabilitation

● Psychiatry● Cognitive neuroscience● Neurology● Neurophysiology● Rehabilitation

● Power intensive protocols● Long duration protocols

● Brain imaging research

● Specifications can be defined by the customer

Peripheral stimulation

Peripheral stimulation or paediatric and infant TMS

Adult TMS

Adult TMS - user interface on coil handle for easier control of stimulator

Accurate peripheral stimulation -handle is perpendicular to coil head

Accurate peripheral stimulation or accurate paediatric and infant TMS

Accurate adult TMS

Accurate adult TMS

Accurate adult TMS - user interface on coil handle for easier control of stimulator

Accurate adult TMS - handle is perpendicular to coil head

Deep adult TMS - elicits responses from relaxed muscles of the lower pelvic floor and lower limbs

Built-in, active cooling for long stimulation protocols

Identical to the active coil (see above) other than the stimulating output. Suitable for double-blind trials

Powerful active cooled coil with external air extraction unit

Suitable for use in MRI scanners up to 3T

Coils of various configurations and dimensions can be designed for specific customer applications

Single Coils

50mm Small Coil

70mm Medium Coil

90mm High Power Coil

90mm Remote Control Coil

Double Coils

Double 25mm B.I. Coil

Double 40mm Coil

Double 50mm Coil

D702 Coil(New design)

Double 70mm Remote Control Coil

Double 70mm B.I. Coil

Double 110mm Cone Coil

Specialised Coils

Double 70mm Air Film Coil

Double 70mm Air Film Placebo Coil

Double 70mm Cooled Coil

Double 70mm MR Compatible Coil

Custom Coils

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As well as the comprehensive range of standard products,

Magstim provides a unique design service through the expertise of

the “Magstim Innovations” team. Inspired by forward thinking

researchers, the Magstim Innovations team is a dedicated group of

engineers who are able to develop to order the products required

to meet the exact needs of the research community. Magstim

Innovations helps push the boundaries of neuromodulation and

brain stimulation to new levels.

Based on 20 years experience, Magstim has developed a simple

'7 Step' pathway to successful product production.This process

ensures the product is delivered to the customer's exact

requirements and needs, when it is needed.

Customer enquiry & Specifications Feasibility evaluation

AgreementOutline design proposal Design Confirmation

Manufacturing Testing & installation

Go one step further with Magstim Innovations

the ‘7 Step’Pathway

i Combining TMS and fMRI: From 'virtual lesions' to functional-network accounts of cognition.Ruff CC, Driver J, Bestmann S.Cortex. 2008 Dec 6. [Epub ahead of print]

ii Combining TMS and EEG to study cognitive function and cortico-cortico interactions.Taylor PC, Walsh V, Eimer M.Behav Brain Res. 2008 Aug 22;191(2):141-7. Epub 2008 Apr 1.

iii Mapping of the human visual cortex using image-guided transcranial magnetic stimulation.Fernandez, E., Alfaro, A., Tormos, J.M., Climent, R., Martinez, M., Vilanova, H., Walsh, V., and Pascual-Leone, A.Brain Research Protocols 10:115-124, 2002. iv Complementary localization and lateralization of orienting and motor attention.Rushworth, Matthew F.S., Ellison, Amanda, and Walsh, Vincent.Nature Neuroscience, 4(6), June 2001.

v Triple stimulation technique (TST) in amyotrophic lateral sclerosisLeonid Komissarow, Jens D. Rollnik, Dessislava Bogdanova, Klaus Krampfl, F. A. Khabirov, Andon Kossev, Reinhard Dengler and Johannes BuflerClinical Neurophysiology, Volume 115, Issue 2, Pages 356-360 vi Transcranial magnetic stimulation and cognitive neuroscienceVincent Walsh and Alan CoweyNature Reviews – Neuroscience, Volume 1, October 2000, 73-79 vii The Contribution of Primary Motor Cortex is Essential for Probabilistic Implicit Sequence Learning: Evidence from Theta Burst Magnetic StimulationLeonora Wilkinson, James T. Teo, Ignacio Obeso, John C. Rothwell and Marjan JahanshahiJournal of Cognitive Neuroscience

viii Transcranial magnetic stimulation can measure and modulate learning and memoryJ Grafman E WassermannNeuropsychologia 37 (1999) 159-167

ix Contribution of noninvasive cortical stimulation to the study of memory functionsA. Floela, L.G. CohenBrain Research Reviews 53 (2007) 250–259

x Stimulating language: insights from TMSJoseph T. Devlin and Kate E. WatkinsBrain 130, (2007) 610–622

xi Applications of TMS to Therapy in Psychiatry. Lisanby, Sarah H.; Kinnunen, Leann H.; Crupain, Michael J. Journal of Clinical Neurophysiology. 19(4):344-360, August 2002.

xii Exploring Theta Burst Stimulation as an intervention to improve motor recovery in chronic strokeP. Talelli, R. Greenwood, J. RothwellClinical Neurophysiology, Volume 118, Issue 2, Pages 333-342

Users of Magstim Transcranial Magnetic Stimulators in the USA please note: Caution - Investigational Device. Federal (or United States law) limits device to investigational use.

All standard products carry the mark, comply with the Medical Device Directive 93/42/EEC, and are manufactured under a Quality System certified to ISO 13485.

© 2010 The Magstim Company Limited. Magstim®, and Air FilmTM are registered trademarks of The Magstim Company Limited.

All specifications are subject to change. All material in this literature is produced in good faith

The Magstim Company Ltd

Spring Gardens, Whitland

Carmarthenshire SA34 0HR

Wales UK

T: +44 (0)1994 240798

E: sales@magstim.com

www.magstim.comReferences

This brochure is intended for users outside the USA