tissue distribution. us conidia; b Macrophage (red) interaction Virus dsRNA (cyan/green) by macrophages; j macroph ages (yellow) in pancreatic ductal tico Humanitas, Rozzano, Italy); f Yolk sac tage (Microglia); i Splenic macrophage. f-i IgN, A *STAR, Singapore)

Subhra K. Biswas • Alberto Mantovani

Editors

Macrophages: Biology and Role in the Pathology of Diseases

~Springer

Preface

rious disease conditions (e.g., tumors, nmation, parasite infection, etc.) and a 1 in disease progression .

. tion and update of our understanding of is both timely and topical in presenting ls in health and disease. ave kindly contributed to this endeavor. the Springer staff who were involved in

Subhra K. Biswas, PhD Alberto Mantovani, MD

Contents

Part I Macrophage: Origin, Activation and Polarization

1 Blood Monocytes and Their Subsets in Health and Disease . . . . . . . . . . . . . . . 3 Loems Ziegler-Heitbrock

2 Polarized Activation of Macro phages .. .. .. .. .. ... .. ....... .. . . ... .. .... .. .. . .. ...... .. . 37 Maria Rosaria Galdiero, Subhra K. Biswas, and Alberto Mantovani

3 Alternative Activation of Macro phages: Concepts and Prospects.. ........... .. ......... ............. ... .... ... ... .... ............. ....... 59 Siamon Gordon, Laura Helming, and Fernando 0. Martinez Estrada

4 Regulatory Macrophages and the Maintenance of Homeostasis ...... .. 77 David M. Mosser and C. Andrew Stewart

Part II Macrophages and Their Diverse Functions

5 Phagocytosis.... .... ... .... .......... ...... ....... .. .. ....... ......... ..... ........ ... ... ..... .... ... .. .. 91 Andrea J. Wolf and David M. Underhill

6 The Antimicrobial Functions of Macrophages. ..... .. .. ... ... ........ ............ . 111 Ronald S. Flannagan

7 Vascular Modulatory Functions of Macro phages. .. ... .... ..... ... ..... .. ... ... . 131 Ioanna Keklikoglou and Michele De Palma

Part III Macrophages in Different Tissues

8 Airway Macrophages: Sentinels of Health .. . .. ...... . .. ... . . .. .. ... ... ... .. ...... .. . 171 Tracy Russell , Thomas J. Bell, and Toshifumi Fujimori

VII

viii Contents

9 Microglial Ontogeny and Functions in Shaping Brain Circuits......... 183 Guillaume Hoeffel, Paola Squarzoni, Sonia Garel, and Florent Ginhoux

10 Kupffer Cells in Health and Disease ...................... .............................. . Andrea M. Woltman, Andre Boonstra, Makoto Naito, and Pieter J.M. Leenen

11 Intestinal Macrophages: Specialized Antigen-Presenting Cells at the Front Line ............................................ .... ...... ............ ........ .. Timothy L. Denning and Bali Pulendran

Part IV Macrophages in Pathology

12 The Wound Macrophage ..... ...... ............................................................ . Meredith J. Crane and Jorge E. Albina

13 Macro phages and the Entrance of Resolution Phase Lipid Mediators ... ......................................... ......... .... ................. .. Charles N. Serhan, Nan Chiang, and Jesmond Dalli

14 Macro phages in Sepsis Progression ...................... .. .. ............................ . Eduardo L6pez-Collazo, Jean-Marc Cavaillon, and Subhra K. Biswas

15 Adaptive Characteristics of Innate Immune Responses in Macro phages ................. ........ ...... .... .............................. ... .. .. .. ....... .. ... . Mihai G. Netea and Alberto Mantovani

16 African Trypanosomiasis as Paradigm for Involvement of the Mononuclear Phagocyte System in Pathogenicity During Parasite Infection ....................................................... .... ........... . Benoit Stijlemans, Alain Beschin, Patrick De Baetselier, and Geert Raes

17 Macrophages in Obesity and Insulin Resistance ................................. . G. Chinetti-Gbaguidi and B. Staels

18 Macrophages Govern the Progression and Termination

217

249

269

287

315

339

349

375

of Inflammation in Atherosclerosis and Metabolic Diseases............... 387 Gabrielle Fredman and Ira Tabas

19 Myelomonocytic Subsets in Tumor Microenvironment........ .. .. ........... 405 Jo A. Van Ginderachter

20 Tumor-Associated Macrophages .......................... ............ ............ ... ...... 425 Antonio Sica, Laura Straus, and Paola Allavena

Contents

Part V Transcriptional ar

21 Role of NF -KB Activat Toby Lawrence

22 Interferon Regulatory Regulation of Macro pi H.L. Eames and I.A. U~

23 Kruppei-Like Factors Lalitha Nayak, Derin T1

24 Regulation of Macrop by the STAT- SOCS Si Sandra E. Nicholson an

25 Functions of the Large and Macro phages ....... Michito Hamada and S1

26 The Control of Gene I Renato Ostuni and Gio1

27 Role of Micro RNA in Graziella Curtale and

Part VI Systems Biology

28 The Macrophage Tra Ronny Milde, Matthiey and Fernando 0. Marti1

29 Omics Approaches to Shakti Gupta, Ashok R Mano Ram Maurya, an

Contents

in Shaping Brain Circuits... .. .... 183 )onia Garel,

Makoto Naito,

Antigen-Presenting

lil

esolution

!smond Dalli

lVaillon,

mmune Responses

m for Involvement m in Pathogenicity

ick De Baetselier,

217

249

269

287

315

339

349

Resistance..... .. ..... .. ....... ... ......... . 375

n and Termination nd Metabolic Diseases....... ... ..... 387

1icroenvironment............... .. .. . ... 405

425 Allavena

Contents ix

Part V Transcriptional and Epigenetic Mechanisms

21 Role of NF -KB Activation in Macrophages.... ..... ............ ...... .............. .. 447 Toby Lawrence

22 Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation .......... ..... ....... .... 463 H.L. Eames and I.A. Udalova

23 Kruppei-Like Factors in Monocyte- Macrophage Biology.................. 487 Lalitha Nayak, Deiin Tugal, and Mukesh K. Jain

24 Regulation of Macrophage Polarization by the STAT - SOCS Signaling Axis .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 497 Sandra E. Nicholson and Peter J. Murray

25 Functions of the Large Maf Transcription Factors and Macro phages .. .. .. . .. .. .. . .. .. . .. . . . .. .. .. . .. .. .. . .. .. .. .. . .. .. .. .. . .. . .. .. . .. .. .. .... . .. .. . .. .. 509 Michito Hamada and Satoru Takahashi

26 The Control of Gene Expression in Macro phages .. .. .. .. .. .. .. .. .. .. .. .. .. . .. .. 5 19 Renato Ostuni and Gioacchino Natoli

27 Role of MicroRNA in Macrophage Activation and Polarization........ 545 Graziella Curtale and Massimo Locati

Part VI Systems Biology of Macrophages

28 The Macrophage Transcriptome .... ........ .. .......... .... ...... .. ............ .... ..... .. 559 Ronny Milde, Matthieu Pesant, Massimo Locati, and Fernando 0. Martinez Estrada

29 Omics Approaches to Macrophage Biology .......... .... .............. ............. . Shakti Gupta, Ashok Reddy Dinasarapu, Merril J. Gersten, Marro Ram Maurya, and Shankar Subramaniam

587

Contents

in Shaping Brain Circuits......... 183 :onia Garel,

Makoto Naito,

Antigen-Presenting

tn

esolution

:smond Dalli

tvaillon,

mmune Responses

m for Involvement m in Pathogenicity

ick De Baetselier,

Resistance .. ............... ... ........ .... . .

n and Termination nd Metabolic Diseases ......... .... ..

Iicroenvironment. ... ......... ...... ... .

AJ.lavena

217

249

269

287

315

339

349

375

387

405

425

Contents ix

Part V Transcriptional and Epigenetic Mechanisms

21 Role of NF-KB Activation in Macrophages............................ .... ........... 447 Toby Lawrence

22 Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation.................. ..... ... 463 H.L. Eames and I.A. Udalova

23 Kruppel-Like Factors in Monocyte- Macrophage Biology... ... .... ........ 487 Lalitha Nayak, Derin Tugal, and Mukesh K. Jain

24 Regulation of Macrophage Polarization by the STAT - SOCS Signaling Axis .. .. .. .. .. .. .. .. . .. .. . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 497 Sandra E. Nicholson and Peter J. Murray

25 Functions of the Large Maf Transcription Factors and Macro phages .. .. . .. . . . . .. .. .. .. .. . .. . . .. . .. .. . . . .. .. .. . . .. . .. .. . .. .. .. . .. . .. .. .. .. ... .. .. . .. .. . . 509 Michito Hamada and Satoru Takahashi

26 The Control of Gene Expression in Macro phages .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . 5 19 Renato Ostuni and Gioacchino Natoli

27 Role of MicroRNA in Macrophage Activation and Polarization........ 545 Graziella Curtale and Massimo Locati

Part VI Systems Biology of Macrophages

28 The Macrophage Transcriptome .... ........ ............ .... .... .. ........ ........ .. ....... 559 Ronny Milde, Matthieu Pesant, Massimo Locati, and Fernando 0. Martinez Estrada

29 Omics Approaches to Macrophage Biology.................................... .. .... 587 Shakti Gupta, Ashok Reddy Dinasarapu, Merril J. Gersten, Mano Ram Maurya, and Shankar Subramaniam