macromolecules proteins lipids - amazon s3 · 2019-02-08 · folded stability, most proteins are...

Macromolecules Presenter’s Name Proteins and Lipids Sarah Maurer Associate Professor Central Connecticut State University

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Macromolecules

Presenter’s Name

Proteins and Lipids

Sarah MaurerAssociate ProfessorCentral Connecticut State University

Page 2: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

1 - 2 Amino acids

Page 3: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Page 4: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Condensation of Two Amino Acids

Page 5: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Protein function• Specifically target recognition (due to folded

structure) - lock and key mechanism• Need at least several amino acids to have

folded stability, most proteins are 50+ amino acids

• Enzymes are catalysts▪ Lower transition state energy▪ Orient and ”concentrate” reactants

Lipids• Phospholipids make up modern cell

membranes• Other amphiphilic molecules can also form

membranes

Page 7: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Fatty acid

Gly

cero

Storage lipids: triacylglycerols

Fatty acid

Gly

cero

l alkane

Fatty amide

PO4

Gly

cero

l Fatty acid

Fatty acid

Gly

cero

alkane

Fatty amide

Gly

cero

Diphytanyl

Gly

cero

Phospholipids

Glycerophospho- Sphingo-

Glycolipids

Sphingo- glacto- (sulfo-)

Archael ether lipids

Gly

cero

Membrane forming lipids

PO4

Gly

cero

lSO4

Head Group

Hydrophobic

“Backbone”

Sugar SugarCholinealcohol

glycerol

Page 8: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Structure of phospholipids

Page 9: Macromolecules proteins lipids - Amazon S3 · 2019-02-08 · folded stability, most proteins are 50+ amino acids •Enzymes are catalysts Lower transition state energy Orient and

Simpler lipids?• Single chain amphiphiles with with chemically

diverse headgroups• Less stable than phospholipids

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