Lecture Notes: Lymphatic System

Sec1 Lymphatic System

A) Functions:

B) Organs/Tissues 1) Lymphatic Vessels

2) Lymph Nodes

3) Spleen 4) Thymus

5) Mucosal Associated Lymphatic Tissues

Sec2 Lymphatic Vessels

A) Blood Capillaries 1) Function: a) b) Transport mechanisms:

c) *interstitial fluid

2) Blood flow thru capillary a) Enters at b) Exits at

3) Exchange occurs due to a) Blood Pressure b) Osmotic pressure

4) *Edema

B) Lymphatic Capillaries

1) Struct:

2) Fluid Movements

3) Lymph

C) Lymphatic Vessels

1) Struct:

2) Lymph movement

3) Lymph returned to

Sec3 Lymphatic Organs

A) Lymph Nodes

1) Struct:

2) Funct:

a) Macrophages b) B-cells

B) Spleen 1) Struct:

2) Funct: a) Filter

b) RBC degradation products (1) Iron

(2)

c) Blood Reservoir

3) Hemorrhage

C) Thymus

1) Endocrine Gld:

2) Lymphatic Organ:

D) Mucosal Associated Lymphatic Tissues

1) Tonsils

2) Peyer’s Patches

Sec4 Immune Response

A) *Immune Response:

B) *Antigen:

1) Large Complex Molecules

2) Bacteria: 3) Fungi: 4) Viruses:

C) Body cells have Antigens/

D) Overview

Innate Defense Mechanisms

Adaptive Defense

Mechanisms

1st Line of Defense

2nd Line of Defense 3rd Line of Defense

Sec5 Nonspecific Defense Mechanisms

A) General Characteristics: 1) Target: 2) 3) Time Frame:

B) Include: 1) 1st Line of Defense

2) 2nd Line of Defense

C) 1st Line of Defense: 1) 2) Antimicrobial Secretions

3) Filters:

D) 2nd Line of Defense 1) Cells

2) Proteins

3) 4)

E) Phagocytes: 1) Located 2) Engulf pathogen in vacuole

and fuse with lysosome

3) Examples:

F) Natural Killer Cells 1) Target:

2) Kills with

G) Inflammation

1) Triggered by

2) 4 Hallmark Signs:

3) Histamine

a) Blood vessels b) Activate c) Chemoattractant

4) Purpose:

H) Complement

1) Location 2) Function

I) Interferon 1) Viruses: a) Basic Structure:

b) Takes over host cell’s metabolic machinery

2) Interferon a) Produced by

b) Neighboring cells response

J) Fever 1) Response: 2) Hypothalamus:

a) Normal

b) Reset

3) Purpose:

Sec6 Specific Defense Mechanisms

A) Gen Chars 1) Target 2) Response:

B) Types

C) Lymphocytes

1) B-lymphocytes

a) Produced: b) Mature: c) Receptor:

d) Function:

2) T-lymphocytes

a) Produced: b) Mature: c) Receptor:

d) function

D) Antibody Mediated Immunity

1) Carried out by 2) Activated by

3) Stimulates

a) Plasma Cells

b) Memory Cells

4) Clonal Selection Theory

E) Antibodies: 1) Soluble

a) Produced by b) Identical to c) Antigen binding site

2) Functs: a) Prevents colonization

b) Neutralization

c) Agglutination

3) Immunoglobulins

a) IgG b) IgA c) IgM d) IgE e) IgD

F) Cell-Mediated Immunity

1) Carried out by 2) Activated by

3) Antigen Presenter Cell

4) Results in

5) T-lymphocytes

a)

(1)

(2) Mechanism:

c)

Sec7 Induced Immunity