luiza handschuh karol marcinkowski university of medical sciences, department of haematology

Luiza Handschuh Karol Marcinkowski University of Medical Sciences, Department of HaematologyInstitute of Bioorganic Chemistry PAS, Center of Excellence for Nucleic Acid-based Technologies

INGRID 2008, Lacco Ameno, 11.04.2008VIRTUAL LABORATORY AND ITS APPLICATION IN GENOMICS

Virtual Laboratory - definition and advanteges The Virtual Laboratory is a distributed workgroup environment, with the main task of providing a remote access to the various kind of rare and expensive scientific laboratory equipment and computational resources (http://vlab.psnc.pl/)

A specific representative of the RIS (Remote Instrumentation Systems)

Based on grid environment, already implemented in the VLab System by Poznan Supercomputing and Networking Center (PSNC)

Independent on physical location of the instruments

Designed to cooperate with many other grid systems

Devoted to experimental and computational tasks supporting the postprocessing phase of experiment

Experiments made in other laboratories and their results can be shared enabling the workgroup

Modular architecture of the Virtual Laboratory system

Experiment execution in the Virtual LaboratoryPreparing a sample and/or input data (e.g. parameters)Measurement/computationData processing and visualizationData storage and management

Workflow managementDynamic Measurement Scenario (DMS) design:Analysis of applicationConnection diagram constructionDescription of additional dependecies Generation of applications and links descriptionGeneration of the measurement scenario descriptionan example workflow In Scenario Submission Application in NMR studies

Data storage and managementDigital Library a crucial component in most typical RIS & VL systems, a module responsible for data storage and management (DSM)unique digital collection possibility of software extentioncooperation with the library integrated systems, e.g. catalogue databasespossiblity of searching and browsing widespread access (via Internet)

Biological introduction

Functional genomics how the genom works?PROTEINRNADNA

Genomics answers the fundamental biological questions

Microarray experiment

Application of functional genomics toolsfor establishing complex model of tumor transformation. Studies on molecular mechanisms of acute myeloid leukemia pathogenesis as a part of a huge project announced by Polish Ministry of Science and Informatization in 2005:Application of functional genomics and bioinformatics for creation and characterisation of models describing biological processes of great importance in medicine and agriculture (PBZ-MNiI-2/1/2005)

Institute of Bioorganic Chemistry PAS, PoznaKarol Marcinkowski University of Medical Sciences, Department of HaematologyPozna Supercomputing and Networking CenterPozna University of Technology

Research model acute myeloid leukemia AML M1 FAB typeAML M1 is almost homogenous cell population (myeloblasts consist 90% of the whole bone marrow cell pool)Molecular determinants of this AML type are still not well described.Haematopoesis schemeBlasts from patient with FAB M1 AML(Cancer Medicine, 5th edition)

AML patients / healthy bone marrow donorsUMSCD 34+CD 34 cells isolation from blood and bone marrow samples+Transcriptome analysisusing DNA microarraysIBCHUTUMSIBCHPCNSUTIMPLICATED INSTITUTES:- Karol Marcinkowski University of Medical SciencesPozna University of Technology- Institute of Bioorganic Chemistry PAS- Pozna Supercomputing and Networking Center IBCHUTIBCHUTIBCHUTIBCHUTIBCHUTUMSUMSUT- microarray probe selection- microarray printing- RNA isolation and labeling- hybridisation- scanning and analysis- DNA microarray printing (commercial probes)- miRNA isolation- miRNA i labeling- hybridisation- scanning and analysis- total protein extraction- 2-dimensional electrophoresis- gel scanning and analysis- protein identification using mass spectrometry-miRNA analysisusing DNAmicroarraysProteome analysisStandard clinical diagnosis Biological model of leukemic transformationGenomics virtuallaboratory establishementHospitalsResearch institutesElaboration of acountry-wide data basemorphology based blood and bone marrow cell analysisimmunophenotyping, molecular biology tests- cytogeneticsElaboration of new AML diagnostic tools based on DNA microarrays & protein 2DE analysis resultsIBCHUMSIBCHUTPCNSUTPCNSUTNormalisationand bioinformatic analysisof obtained dataPCNSUTSchematic description of research

Microarray constructionMicroarray of our own design 924 oligonucleotide probes (DNA fragments, 50-70 nt) complementary to the genes involved in AML pathogenesis and control onesAROS (70 nt)

Example of preprocessed microarray images The same slide No.19HL6019sz

First step of computational work data collectionGrid adjustmentQuantitative analysis - pixels counting for each spot and background (mean and median) Signal intensity: 1- 216 (65535)

Fragment of gpr file with microarray raw data, generated by Scanarray Express

Virtual Genomics Laboratory automation of microarray data analysis I. Raw data normalizationII. Normalized data analysis

Arkusz1

NameIDHL60_szk11_MeanLH_szk11_MeanHL60_szk5_Mean4_szk5_MeanHL60_szk6_Mean5_szk6_MeanHL60_szk7_Mean8kr_szk7_MeanHL60_szk8_Mean8sz_szk7_MeanHL60_szk9_Mean9kr_szk9_MeanHL60_szk10_Mean9sz_szk10_MeanHL60_szk12_Mean10_szk12_Mean

AATK962523922292336473291524517211516559746061528N/AN/A13903017

AATK962520812085306428304535503188012406045371140N/AN/A14683155

AATK96251897224831644130155652620521154702421640N/AN/A11652242

ADRA2C152159418781772421851861916215042223854371569586837405

ADRA2C15217761624179241178188182545531249373340N/AN/A657392

ADRA2C15217411655172234177180172513551232433367N/AN/A780372

ANGTP128413601016135146171139197174664152477265N/AN/A932221

ANGTP128413458901361461721381821656091364333571504523893228

ANGTP128422671857144154182141138144402131377201N/AN/A802209

ATF346718041868196295194219188467490364430395N/AN/A930641

ATF346715902108186263190208180284486306452345N/AN/A935622

ATF3467145920671571841911471962125542314552821413511961610

BCL2L1 ?598731319410170733671080448526469015560855303464908865076514710125867

BCL2L1 ?59870311672617513333111546782770970143704346319285081062013389779526203

BCL2L1 ?5986554177491666318410554330230778753728307133268708876711245844430131

C1QTNF61149049638011311451701341621655401513752701154391815238

C1QTNF611490417991718137149180142139162308151323208N/AN/A695238

C1QTNF611490416421661142185176142156168412152354207N/AN/A714232

CBL8672114200930533026418925237512701253580476N/AN/A9981329

CBL8671705199528230524917223830610307575754491679561982841

CBL86715291561258287226166239304110091160843616695809361319

CD521043894314332252472273209489246741333817941423681112233052742485201444036967

CD521043825715262183747363214488242601214516553371441161635169634671501452639659

CD52104385731301214833879354052524173122541973854783953930542592269981434438448

CEBPD10522244244138272929941157711752949238210502324N/AN/A18503726

CEBPD10522211225535361430942955311582871236710602204N/AN/A17893883

CEBPD1052177522643295732994085211119292625209702231N/AN/A16883789

CPT1A137411551666144166170151196259521200409298N/AN/A819326

CPT1A137413071438147165177152201254545202461581N/AN/A761411

CPT1A137413021628172393177151200251594188394358N/AN/A822413

CUTL1152314171682187279201296251934753276433870176795911631126

CUTL1152313181460175249206320245912749292512807160890210223133

CUTL1152321462257204295197248223541474259443578N/AN/A9592733

DISC127185865112047143219001188304836071316179839416412017562798543221209834957

DISC127185851711211146618891257321236361313180839798446720326676034191257836730

DISC1271857711102331409177912253135347612233840910216428718969702238331227234195

EDA18961891204228748429957446516189257315721415169871716105629

EDA189618412096284494312590435164284066757711592028130715475654

EDA189613852029267459336474434161289168464120841989124115635156

ETS12113110812321491731811642232198213414534091270485757350

ETS1211319491989161190183162184205668585428338N/AN/A820353

ETS1211324022370158192180160175203713556458336N/AN/A829346

FGG22666317491586071066188728864606780939623220728537001166918512022

FGG22666111493488871267190831575159785140622719640344981434941412243

FGG22667233408984465368496832455224763339023214825149861670849012245

FUS2521261837915821196501145410523474332738481654973434073859308913417

FUS25212504345051010595801820104436633582463717021019833283138353012733

FUS2521263435554759766652108976344035334785151691093111352426508330

GNAI2277119842266144178171178169226371141329347N/AN/A700426

GNAI2277122822217149179173177170224416149348334N/AN/A781454

GNAI22771194424011461771711701662214541493573371361453777439

HIGD1A25994143723431822132012483559096103004911164N/AN/A12503390

HIGD1A25994143821021812142033273489396563035511185N/AN/A10851360

HIGD1A25994166419951902386325873429277003344961073164374312053162

HOXA1032065317751212133652718699253097915667534564635734855224025917548736619834332664773

HOXA10320652058497441282826663100513153616408549485292340025195056083946945590503827861731

HOXA1032064234846644149242950095453007516647587845004037808168645232141354405103697462630

IFNGR2346024332350138147159139192180364141322207N/AN/A678247

IFNGR23460162220891371501751381531634231363822431271456744237

IFNGR2346013591957136148169140164163441139305286N/AN/A711242

IRS28660235421731441511731371771604871343192031324458735210

IRS28660123916961451501681381921654861343461921078386810221

IRS28660143917541431471631311931595181253631771136394764204

KLF6 ?1316464589194016714651684173071684186650228081306346595392608523204

KLF6 ?13163086485059110694911822177769323927622123061060427952194585222370

KLF6 ?13165711111775349895201931199279614078684323871082129172276574222044

LPIN1 ?231751689255715621217221722082366231947079310545628122446

LPIN1 ?231751205202015821116821423484063731649793111525488062716

LPIN1 ?2317515082027157204209253235844703306444127813286667052424

MAPK355951449184420240421238226712406443684512110120911699973286

MAPK35595167621432064052053292681271661390447144912568859653119

MAPK355951379223119938821143426312477274304982266115084910153041

ABCF1233158251021124119122826977162184639890714716387331460

ABCF1232011280520122618921526979566991842892911534908271368

ABCF1231462235220221818821226068565278541998711054417321463

AGPAT11055415822981N/AN/A22133631111037358385712474147080010515579

AGPAT110554158727142232812363402839737446395832465127770010546355

AGPAT110554200526242282842313223111048769897544255412676249705597

ANXA330616721935152200165218295547542351386622102946510983481

ANXA33061392220514819617221029251960640740160590940611393287

ANXA330622922657168242174232308550494375342783150558311353321

ATP6V0C5272263272040354136983443512881590162010673519154060816502965

ATP6V0C5271689277238452836982644714261745182610703637147758716972978

ATP6V0C52721212457N/AN/A40090545614651807183510923508156588717323324

BCR61318052745245375212440668258518433658101735961627112919205593

BCR6132035293521931922147259924651783360810844210136899418705696

BCR6131535219521833022846261824101940381610223866124591320706348

CACNA2D2925411742022167192176147181183580276392258777356722416

CACNA2D29254163721311792062191701771874802763212471272469742433

CACNA2D2925416672287N/AN/A1811441851935032753442411048387720457

CCND2894165725341481781591881873025162432976191041432752611

CCND289412042183145185167189183341521261301691963475732598

CCND2894172824211421831641891842795702632977071328445744611

CD74972127622711372271561671386905073582411202777399692875

CD74972129919501372311581601476405123822651093721376720781

CD74972116720671382301561701436705153293011012696371735775

CFD167515036274638446250546520147117885298583681946324206685856615643156132512457274

CFD167518313350517098200376185142257314296423456241087218645866013230123392450158045

CFD167521366390718417262787640166568223337463650045132220396008516125178262341155903

CRYAA14091923447637711763031146615358917851934109748601487230522609446

CRYAA14091826507233410503041185614354318621926105645731291192222989933

CRYAA14091911383535211372971162578336019362020101146401297177622179203

CYBB153614822273184424184456350179889479655720301134212412203511

CYBB153616842157178407182475330170287474148621341272184412473386

CYBB1536N/AN/A20060517745935418447575995252044126358611183642

DNMT3B17891949252519122718522631463176768155712441377561906699

DNMT3B178917282982193230188226321603832638570129111235028761114

DNMT3B178917223008209266180276316619879894565127410906428421307

ELA219912047392544217984091449501221030263491148877091471238820436248

ELA219911943349942517763731331480218730683474144178751247180819247092

ELA219911716324241017974051518463218334103750150678391465255619846178

F11R ?50848N/AN/A2047167313501922272112091714546324681237978686148831154742243

F11R ?5084836454649244918931564221730911375279525111421818138531941041163043266

F11R ?5084853946961247019421425198328451273477954987479522150478936301135340717

FLOT11021115063038142159162146190191457137281226875346782260

FLOT11021113632582141161159146182186481143269365757350809257

FLOT11021117543221142160161145195187485139319232712307834256

GADD45A164717623291140142162136184178527125319205590267779213

GADD45A1647N/AN/A141144156136183170507130327203530239771212

GADD45A1647N/AN/A139145161138192175522131384189544265686207

GRB228851943253917828718227319457553333832812661135492862698

GRB22885171125731743021792791150118553435133779511164867241064

GRB22885150129421752951882742115905703533151399844396850713

HLA-DRB1 ?312313942742159212164179219569688354349749750464874622

HLA-DRB1 ?312316972657157220169179204564696507375788720397891612

HLA-DRB1 ?312314532992155214169178191569689328394545612391916643

HOXB632162815515150710915241409867535324842525156795551727273631759848

HOXB63216N/AN/A509112561416289165699277625111493843320133754325110708

HOXB63216N/AN/A58212175851607945556929032896141882331692101029578996

IL2RB356014212433150169159133196177469127300189929442751223

IL2RB356013822622129139158130193181445121276199929401774232

IL2RB356013922601130136155132195175505128275185511245852224

ITGAX ?3687961217578304210297276467164611194881791828819103894727810806119671512454807

ITGAX ?3687102021803933441168730007242443919468206613522710790499129106117321546656957

ITGAX ?3687107601631333431170730617558450219634216003504011547524288029108451321249031

LAPTM5780554144437554464559540154920973101123322753178273191461627268

LAPTM57805205331625674425795851691230629311076206227354060123964187093

LAPTM57805234333926775216026301776239936121316205627264459130060296264

LTF4057157632231493471632642653875702343683869994619711001

LTF4057171329291503681553132503985892393763815563151064772

LTF4057138626551453821563082254386112253353836773459801087

MCM5417412672730131152150135167187429144310242494237753240

MCM54174205321871321381772021771804301393012074202051052210

MCM5417416141954835555160151163175484139322206414214644214

ACADM341546258345960621624336271173965149483511645019661547

ACADM34158826842362534215683436877546814639749333789551760

ACADM3416303166247268209226334677773705N/AN/A8053959311339

AIF119914303700208287209260259263568240378543648313958550

AIF119917383401232373213312239303631253377592686331925533

AIF119916295286217359209260230291582241379581589290908535

APOC134127494584322414350757647363313198341282762716953058336513811

APOC13413015528736349941811546403384165411011510104541458184322657152

APOC1341215031504346343878197984173193613351318749914421344302811204

B3GNT619213423815059630136748710309703138397036951832589719171676362313598

B3GNT619213428086342625138454611729023017429240421872616425762868363013996

B3GNT619213429317161702152457713059043158408738671826627725673196341213005

BIRC533290801641113251975106831324443162151234823349679227263824967651332140853

BIRC533298911600512551857114833564589176211215124531656625990879989861273438524

BIRC5332105121483514352189141640774224161901248424814621525215942885071270937553

CAPG8221687412316229138161768419928101764199713998658132080870581351558646450

CAPG822N/AN/A2027326818304517301817695113314778417919640805575681412543337

CAPG822N/AN/A2764459919774940258815523102223704555427296803181371469442301

CD792497341637731196634294476263564227278656358862594066313656209801619860609

CD7924121891961833646967326882713646236739439417067284263612545211761565358131

CD79241276219483366679543340827137522473410078439971514496712599218681637661896

CDKN1A1026163731511762651782402076465273353811270476315940784

CDKN1A1026152326761852821822712186185333223581364533385826953

CDKN1A10261496277218528918830420769352132437713155434497361184

CFP5199N/AN/A169544176221211675538274338897783407900717

CFP519920563027170531178210218599564289335912716447986675

CFP51991499263816955517520824262555928832110246514831020676

CST3147115093139170288175228256690679527404974N/AN/A8661834

CST314711599351617429417624824866869546444013105693418742012

CST314711519396766490918028323765765654939813196366308022218

CYP51A11595166132681842541842203821209648269548156565052013544775

CYP51A11595188533051792521902513791200657267535149456731914175377

CYP51A11595288333831942891952684421469605274584158480943914434501

DUSP2 ?18441925350519551819028324369462337642014957005288861820

DUSP2 ?18441511293419550318427523975068745844416836054648302356

DUSP2 ?18441719281819656518627723370170360140514705724439071969

ENSA ?202953877648290149231180674832443130120381664106161570333825406921

ENSA ?202923627729311155434092171733493119139261764120641848213525346361

ENSA ?202923217237333163136296272134323350145871675112831905206426006976

FASN2194411144617710033275957094264237365479703507613165177626166234378457823396063916

FASN2194N/AN/A10224278445901228807967495283338712513172575904044981592483287663159

FASN2194304014164910469283686593248168916523463789314289184946006943777577623203562368

FLT3LG ?232317492825151179156139186192430130250341629303855254

FLT3LG ?232318462997148172150135179194388127248200415212862237

FLT3LG ?232316343150143164145129175173418128257183401198837239

GATA1262318643142157200169186229100355219340718995473739131173

GATA126231469269815919916617822287858918241818946466328622191

GATA1262317082723162213169207242101057418339620537628449662373

GTF2E2296118163366147188165188181400444166307384579385845503

GTF2E2296117973152147180162181217342481189290349482297811562

GTF2E2296115902969150183161181226330454171297560487298870533

HMGB1314697012254711072254101343443285127157042873650552315111215134801059938263

HMGB131469931211021219252011274310375815782699392165459259481210298641094539980

HMGB13146114382253512932615117951493628153317910102655571261969914104771156141729

HSP90B17184179132443218213411196382606105233331676125855111684483016141105842252052045

HSP90B171842172828445233744162528106076790258101806228133109114585017363120982525658201

HSP90B17184N/AN/A251246192670115076918268201745926461115694533224601223162096051259

IL7R357520073972502140636212864482899138363583645641445196015145254

IL7R357519754295500140937113874763047145566679848471622336215564807

IL7R357518563895512145138214584282837143062486749441445249916085233

JAK23717N/AN/A132138149133181175427149254227356195739253

JAK2371712452944140145147142168161477152269214357189738237

JAK23717N/AN/A143152146146170162435146279218325171650239

LCP1393615172894131238153235176175413160264263669324642469

LCP13936N/AN/A136248146198158190420159268261410234767444

LCP13936N/AN/A138252154199169180415156243286412225758443

MAF4094225923480724464442373570507133227522774038849147363379320860202872368541402

MAF4094205393362529285426281655097246239032558037036128023125118690199012297140159

MAF4094217443374828595478261250536334214212242733272111212660320626196582377140479

MEF2D42091440297520834819832238910611223872866189260356913312598

MEF2D42091602281520734420034436710671260959815185051030313632860

MEF2D42091777291421837320534633282413389798061740N/AN/A14002831

ADARB1104N/AN/A176238169175169338451261300586465296760488

ADARB110419773668173239173173183336466260271908455337759515

ADARB110420003174178250180190193335458280257903453300810500

AKT120731064320370313490313981959214572117422456232753043724388

AKT120724564002453322568344952880215971317932532205150437573742

AKT120724553341499342578352951965233375516252327175357844674258

ARHGEF12233653355627125946529289570357851691182213068970775864291912560

ARHGEF12233652901762528452432510337816807188321341246886420443695279510964

ARHGEF1223365N/AN/A29353136011268737465158017371503921424784970268910638

BAK157890542721715343831185278014603181391181011705107304163211759124081777754576

BAK1578121893446217624390189280314724188281299712446113674393812133126001572350619

BAK1578137083890323915928221396305342218931498115302126985010113250138501772355374

BSG68215223332160200168196208363487235320579461296869489

BSG68216393397159202169175189419528236389515396265792509

BSG68217563008157215157177185405498247347496369254749494

CAST83127295246245465240488737366320103065111655341286151925578180

CAST83124455387256486289616768348720193225124260111561165925897924

CAST8313044435326851125647976539221847293712856067N/AN/A27148130

CD33945355663722775802806628363657172118461397841623742779312614303

CD3394530136085N/AN/A3018207623271173518501266810723992348310513936

CD33945318372423498002977657993630185921001324867822652340299113859

CDX2 ?1045346172553438073006477994000230627681396610318441640359913487

CDX2 ?1045340769173247563247458444073214725481317600218631814348412993

CDX2 ?1045306471273648823096757643997220725941513710717681878350112865

CLU119120484405134161149144163230418165285264412234691269

CLU119122923652130164147141168225419166246306415206720255

CLU119117513364133169496290172236432168249286378201720259

CTSD1509215745591993342064755996833790131663447551247221513786696

CTSD1509188849882043632024526628342779139263346511314227213676314

CTSD1509216250632154142165696498557838145755745231147223214116630

DDX6165613753223143171146147177320538210366378386232678420

DDX616561392317914317214614717430451520330437738425218721653

DDX6165624774594144183155155186298498188296383430310694419

DYRK3844419113465133134148128168161412125245194361182760227

DYRK3844422093304134136149131179161416121238173377182685218

DYRK3844414873412139142143128172164435121242169378187714220

ERBB32065230749402795812455035802067287524991228501867046422067734

ERBB32065240446582665542665745962194303126851212477877056723218075

ERBB32065221046023056622735975952179273723631111441282486223648877

FCGRT221718194682230475229454391157010371192634276560248813285210

FCGRT22172460506324853723643142517449791042664290376980514875123

FCGRT221725924614236471274522392160510781145719355362952913835117

FOXO1230820724109190288204340309130967562847722404903029582930

FOXO1230823433982201319214390280124668658347723134522849442529

FOXO1230816213520204359214405297128474165250227704472989502756

GFI1 ?26724834741229103522573766892770112946461883976215703227506236529358402144670463644

GFI1 ?26724957141668110862677856982639814440502174243817840239666335131868371784160664914

GFI1 ?26724394937146140333432267192842714207518834584819244246056240435810431354496462400

HES13280221141421591912151573536261485162277712375232799852713

HES13280241938391611881781573206231350134481614484882709582854

HES13280184134921621951711533285701429150178413594882628852737

HOXA332001319521049153532912361366470041164927251483261984653694280826692305859891

HOXA332001369320162172936891998394757711023227351473361973655226261325432295059585

HOXA332001402920422272258631761336156121005330423525511934253225289724072145755192

ID3339913332757140145149125177171453119355183299178620194

ID3339910992678167184215202197167522124403187325169622186

ID3339924354201143144562468216175500127300181363201582192

INHBE83729202236347981339148140177219405167292353373196584329

INHBE8372918023549140142154136176217421168291273364193656348

INHBE8372915953043200220284579176214419165265303351195635324

KIT381515093544191226145132188206433134300235366184738285

KIT381514933804151164147138191222457138371263350180657278

KIT381513853192144156148141171203450137387228320184663260

LGALS9396515803167149155136135183233440222306236360184590300

LGALS9396523534221139149185219171245434217285261379211658309

LGALS9396521163902139153148137186238457193267260407206625297

MAP3K127786194836771622141622112277685002703691463477288711819

MAP3K1277861880329016021516821622472853029835413354502996911542

MAP3K1277861474371816523031855921776853428035613294172837321112

MLL429712612921143151390471168278383172328302335187605347

MLL429712962773154188145148170254392186350278365181605358

MLL429713232801138150225266170269405172321278336206N/AN/A

MME431118854920183183250315189272481228315353454276605341

MME431119643967185179202201196267484240307382480251642342

MME431117643673186181228243192252451224305366453247709385

MYB460216873598676707214284183389361208272447314175644455

MYB460216724327136143157219159410366212311434300169639445

MYB460214853588142146138157164413431205309479304169693507

NDFIP1 ?8076215453444140139135127144143348119316202307156599193

NDFIP1 ?8076217443562132137168175138139338121300168290159582192

NDFIP1 ?8076223225553131511188247181164397125259179329181568190

NR3C12908212743941582202564423611239603406565177448449612454170

NR3C12908194444861652322092863461225692503566184042434012393892

NR3C12908161338241762612123313531308690498575178143835512594204

PALM506416363287157165237269172269391161300324324170655393

PALM506415963219154171242304176291407167302350328200639383

PALM506414013072151167184206172283389175362302330179620367

PKM253153431543830046633969111593081232921191448570012981023374511485

PKM253153072494928240231990311883849215619171480582518271639360811100

PKM253153532619028642736094311303637222019761453590219131678350610778

PRDM163917723492171204270348231265677970473904366202700477

PRDM1639158431331671942122342192536901180440735331193699457

PRDM1639152930921762172142122132547381176427722331185805450

PTGER2573214883700136142174192213334456286341546324180668638

PTGER2573212913327139141241302202330468273356432317175693644

PTGER257321300345913614610561178198311537273349421328196719574

RAMP310268209350831411871952962318875452593558363733767692008

RAMP310268205339676735342003092248844932263749554073596701036

RAMP310268171938421441992013282248975232493599943913067562071

ROCK1609316113572172252180201181276435134264362335175609335

ROCK1609316143959152162184239180290472135302349328166704325

ROCK1609315094053146159181208171301462136354318300172636287

SELL640213013297143150178219173201409133345229284161624313

SELL640213353585142149223275162237413137286229297167613282

SELL640218745931136150185220185257451138278242328198525307

SMAD340881916628354264172801971807144453851814883723385095308912746256031597256737

SMAD340881938830300302785521601777151744346716485801391095555710072165331727157939

SMAD34088217612893635831016919169240587649905175768768107606096111691190001665354112

SRP9672619134011153150165162183166413122323184291162682193

SRP9672615524798151146181235168173383120529309276146697182

SRP9672618123573151143202256180160372116323164294149658179

SULT1E167831830344716219819327546095919451809956222554040417884783

SULT1E16783247253601782512544355681159181117491064244850333917764707

SULT1E1678321624421170222234405608130520091862993228059650716034357

TLE17088364853642714713046491105430923441054179055491540179739449542

TLE17088457855283326043508421035394027141181178457171634153836218662

TLE170884120513738773946794212494972272012581817595792577637508584

TRAF4961815663593162169207281184283387209311433354210645435

TRAF4961813193206163164193221168290436209291408339187605430

TRAF4961812982962160163173174182260436204329370366186648425

USP44841011925471013518832345832139110791310550984330207812974

USP448410117453984132154246351300367104513846001082339235763973

USP44841011482357713415919426328433892612595571095354244780978

ZFP36753839048816475124154416931012582433614100245412571725666405317926

ZFP36753839268215461118453615721008587237174845252613139842960423318942

ZFP36753835198220509136848012869845829378448312316114889941326437320380

MPL435219364458140160188242371675174318271134280537723216803905

MPL43522001418614016818022732559016551815986245535324616334071

MPL435228145626207301211310439827180318901242304538625516783799

MYH114629229712830423305332274168437429379202149218464119995453110363232502054651692

MYH11462922132269952117516126377593759237904209811867812360543569748201461980151314

MYH11462925279235702454578421257600752238204221611988112248526368608182551997350200

NFATC1477217063844133134254363181289425177287441301203709460

NFATC1477213693671132137454347181307417192297381308197697473

NFATC1477215603253132137173188184301419212311339358205726490

NRP1882912622262135151149156157349390163283258279209612332

NRP1882917374526133155140148159405460161248258308244556315

NRP1882917543652135153140144159384448161241276626400490311

PDE3B5140105241801972212881383654142222438012367253908949524016586231866953168

PDE3B514010299170045289431178567644272495814150290959220529636355931893553361

PDE3B5140105761525268312541013463047212695516488347679571563698418551892853362

PLCG1533515533394161181224329243827629264313763382299598709

PLCG1533514513353149171190253240841549219346832362247676675

PLCG1533517133107135152167228237789547218325749330227678961

PRKAR1B557523194970236382279482427192114342151723311139529215204100

PRKAR1B557521754201235368305537480238615502442861375739527115643969

PRKAR1B557519974065231355335700425207514872438920422838725616044008

PTP4A31115614772199751235280818103971482411139207112689912331326276196031790446692

PTP4A3111561364418194916206514813220426710123194882531712754342338028151879750551

PTP4A31115613565179991270291014543088465611426204012728411116299949029251772844654

RASSF5835931672370217321122130925883753227841312903592348241433

RASSF5835931998486817621920624524566657128642514023693238311373

RASSF58359324447565203317230573294113765129941711834652968241438

RPLP06175176635202012024396292196396024774111232342195803625

RPLP06175166338791951962334322156325965394411367337185811577

RPLP06175144538982011952263422117145985663841210319185767436

SERPING17101601367713914422831421053656029444811853361928531988

SERPING17101561346113814423429921961257833051614123371968792487

SERPING17101809340913714723929021362862834446413282821737572364

SOCS2 ?88351846350615118718223937591713411190850226932224216613969

SOCS2 ?883521995042183263220501413100213931197803192140924613923369

SOCS2 ?8835207541371672231912994341085153313761048278036023714723534

STAB12316616283398132135144136189182412135205203327186551215

STAB12316614433327131133141130158174383142209195295169566214

STAB12316613793211135137135133166171352140231206317152569226

TBL1X690719733421154168197316252712N/AN/A38010153472258591750

TBL1X6907166132881511663284342366935333604019003012218961784

TBL1X69071501431114717419926445611175153364039843322338361693

TNFRSF4729345781080217465646210251131966172376616929029481852412921741682637353

TNFRSF472934971916016185226197344721769161336368928040892858012421894640634945

TNFRSF472934737870516975415183343051754165336725969841442942714392531659336354

TRIB1102212387557722828427261873927561756261011295574685593248810612

TRIB110221229053542392832595497983136186527439954662815487247510040

TRIB110221230252582302652454756802556185824701097510462651314593043

VIL27430204543731752932445333842399101810198366144528104516596982

VIL27430199843551893673205143441995107712078316083684115117707671

VIL274302586517425260628274643332179819118145795799182116357058

bufferbuffer21684533154148N/AN/A211187610121281184377190664178



MSI212454015983993148141N/AN/A176165399118207163273159579215

MSI212454014343607139135N/AN/A179163369117288178271138591207

MSI212454014333595144141158272170163398120323179281147618205

MYL91039882881024643213515978862282487871466248530310434267818221223117268

MYL910398802511631824142487410592587523767455798612812049368329851135817932

MYL910398870410235762131165017142815584174916194604012086305124891215919472

NFKBIA4792127023605893228681140485325594057957923200736747376526491201454949429

NFKBIA4792122923830783925831259359625814137961383409738647384405483391564152073

NFKBIA47921357237825924284614364366287144775714741667391479504222122761460250037

NUP8849271461115378513841784335136601550798476867675336463477674441328948852

NUP88492716281163935088387963544397516939101937283678939945391059271473851266

NUP88492715442152445869397793620383716125104707718717541605362853801627556747

PGCP104042515486715519216219820756146522238210474133287091602

PGCP10404189742002312371621992204914682153809783823547581907

PGCP104041813451916620716121821962848523636310774093187531859

PML5371168541291883231932803041046882654518170243730811813963

PML537117883967177294N/AN/A3011047827674610219673654511883904

PML5371161439971933582023103131216894806551202540732711253610

PRSS2311098141930251351311371321811436435213289401290180633472

PRSS231109813502709129127201274163258388227289352299166610448

PRSS231109818944257161195173187171322450229280391357195521446

PTPRE5791230445851771801691542632714611522963783491739402511

PTPRE5791212942191801801641482532614931532643163381699612564

PTPRE579118203664535520152145259274N/AN/A2673233531879522609

RBPMS1103013112920131127129126161201403133250214297180562302

RBPMS1103013622744132127N/AN/A176205400135255211280167572274

RBPMS1103013682659127128N/AN/A156202377135319207285154571289

RUNX186118103339141137170158201196576135523244334169672260

RUNX186123954779184189178138235220622141357233426207582254

RUNX186122014423189167176141271213607142286236880486574242

SH3BGR645015823227155141150138188287419147258250401227542371

SH3BGR645016623193151137146139183298494148265268456238572349

SH3BGR645013413034152134147137195294492153286250365213657342

SPARC667817973528161179N/AN/A30357917021146820206640425712172782

SPARC66781590372815917618129132166015581132847211636623911112079

SPARC66781697355816618123132231360316231224773175339524913022819

STAT5A ?677612592305275095142663604925353563575522425251041342556771451192401937662073

STAT5A ?677615545302553810114472898777453903738825853287781266255497353654971890260591

STAT5A ?677614408273063786115383194867652103686324795272651287855038657282331697256319

TERT701515883342172195169197212471552291332608441270605816

TERT701515033107170191162184201437540246329576379229672610

TERT701512373151168198N/AN/A189517745517333625363226671593

TNFSF10874314973214205189237337227397558275410520454227761817

TNFSF10874313653406207192299380234417537302409511462209733699

TNFSF108743212250442272282001962513886072683575845412587391003

TUBB2030681966438523651222436649712441140895939197058942926835036

TUBB2030681990372522744221335450012611170972959202965844724985049

TUBB20306821073898227446211348522137512331038964213572656625814829

WWP2110601650424521226820922824760846832241210585353069791341

WWP2110601492384520322720522024558152534041010884983129101100

WWP211060148536472062382363942346585223794188385273757831115

MT2A450211082322232483343566239110379853454017274643199744334

MT2A450214443505270569233440236107676755551816205423639514868

MT2A450212713191258572231432243102177749353216885494799064940

NAP1L1467316823749278306258282303674803899545160081135814001800

NAP1L146731576350227328624826429868584687956115747013189011324

NAP1L14673164235502903252532592946859069761020163365538810081246

NOTCH2485315694502150143142127168167375122298190305165582224

NOTCH2485316854515145141154277163171423118328192303163579217

NOTCH2485316144636140139300416158161411126365192321156596217

OGFR11054675699751688306081711722937413374448863687318143N/AN/A1072132415

OGFR110548159111511220221370210612598354498001162878562086612149401036732795

OGFR11054823811442117022146911043301543511190914280888223902182714141186136674

PHB2113312401435818830118524840311997266577072452110176215145147

PHB2113312042422118327118624439512147566817512599102285715805301

PHB2113311860373018730018926350314728088317052513109988516275394

PPARG546818853352146169176309215365738761363629387234796972

PPARG546813762645134152296409213358700747468605414255757766

PPARG546821664457168224169171219354687957365734509300668937

PSMA6568772245496300161918105432486200353181336486839922169741119076244

PSMA6568773055118286459616465252603216367441705519843172681870121536492

PSMA65687778152053195667150753428062276754919365539462632001028126016535

PXN ?58299227119521764429212402189276183621224722454862924802165017651446743121

PXN ?5829890611401153041109621827252877681298524477887526557178522231498946288

PXN ?5829938011462169043568561835273485441409327778840524349213527401411741947

RHOB388145832821501933914152103835774303438704312627831366

RHOB3881665497816624415823621049858844333610204503086171158

RHOB3881850462017123918052420846561443337512435503365621283

S100A6627722762835201346194615331793569611545184677644512032075

S100A6627719062756203363181292335784685656535196684460313132255

S100A6627720683073200378179288347907780840550208685156812722299

SLC7A581402115354717236019934351310559723389871192463252N/AN/A

SLC7A581402065376716734429641552710611097466965127547624232476839

SLC7A581402068524817038729932354311061116420939117657837735237402

SPOCK2980693389042170921481208240439991142489717873490717097562644161328822948

SPOCK2980697118598157518551131288839381120590557705588620507522629981337123159

SPOCK2980696787952158619161009259936901077089627908558519219649733031276722416

STK17B92621495374916021010821497201197609188338262401200550369

STK17B9262N/AN/A155205192286179190573200365276400201571373

STK17B926215933502156218345480184188568212368250382191N/AN/A

THY1707015812232342085602716974672391242461135741081571553685810628231761559939920

THY1707013859211371773565114203548366441824136361034566273197312171236101855644861

THY1707015085240512854937826906682468051843180141595370893953116501383681700442176

TP537157199374931582171441624954717530497340731114822456591327

TP537157208174041542131633864804197548468372796103019386481320

TP537157198672384045041693394964743512502345774130528896301375

TXNIP106281834343022041024968641113569981389635421967563814025456

TXNIP106281979337821338642569141714299521392676421175570913705618

TXNIP106281496303421643229848639513119811570593357673174812374927

YWHAQ10971264956334508405571421489347310188578633662N/AN/A21556208

YWHAQ10971354070954829473968476905517112495492244492356322324287521

YWHAQ1097126785804475872360728542364799981294947342353209523737408

CSF1 ?143520523895149138145129180167436128322213449204540178

CSF1 ?143515363874145136170258151170405124237166418206620182

CSF1 ?143515793638251510334510147150414121242172410186617189

IL935783056191971621591006688389323109832267716125033111636882

IL9357852311895115916126627035932610262826474124543051588803

IL9357833781294516819220125737532414054966554425193561669932

IL5RA356817083901140161142174178301620145288455487259506473

IL5RA3568N/AN/A143168N/AN/A246520461209269505510242N/AN/A

IL5RA356826153494145161N/AN/A184285451206261482456247569464

CCL17636116182736148153186342213340581259312684488231661574

CCL17636113072673149151372502213315551268301565473235708580

CCL176361597821174145154504522213304548264336552474259693582

CCR712363264206584281393356640711298928942662161761791366139039109201

CCR712362726127464541442301648707292332672881187971881555154032129576

CCR71236374881556112136420791790327828422654164756421891215832168839

FCER2220816283105138135140125189170504121241206503196524177

FCER2220817992672134131137125180169536125250179682220575184

FCER2220818272553135129166191180168474125216178395180566178

Sp3_ctr 299 basesspike control 62110458420728942558023469056931042012788156019421779



ALDOC23026745370N/AN/A228337327817706382805169391866220585124

ALDOC2303435864324440224632437010177164326921824183183823854708

ALDOC2303086660025140824131937410368214838462128107183222594839

LDHC394831134291241461170202199181487125392193497223738247

LDHC394818913996159131N/AN/A187157546128370189528219722220

LDHC394820003952150136356354N/AN/A529125360190467199728211

PTGDR26388985073757735011873185102500302813854989722116474723913261643730896

PTGDR263889881438881351126925239024712994441831037724897696701512134614229608

PTGDR263889856039037374139823244027593357244801129724827744873515912602028280

IFNA134396057125486131186486114914846584314531252138882146465152596821674

IFNA1343960961082052310054141009135859512941285425371012940943603546019668

IFNA1343955361045558411374551253153571543408368126671188638164672591620850

IL12B35932186338019948037073826968369249238520545664166811972

IL12B35931712304820047930963927368966853638923445954956821948

IL12B35931743311519846925357426374460951335613395996286572135

IL12RB2359515732397147155255222182253453163307283462244679398

IL12RB2359514852261143151178244179231494159351256424248654313

IL12RB2359523143971129138139139159180429159252321974290502324

CCL226367181839021391411341261791764371302512041518254614210

CCL22636718333484137141212230175186498128247187582228630213

CCL22636718833351136140435505169177543122249227524229684199

XCR128291940351216118630647223450150721039369660540910242568

XCR128291860356015617921326523255056120335354259139111232358

XCR128291698326615617418323522653250821737952559741111072609

LysS ?93691113872524142135209283162145403116319169469189718180

LysS ?93691119813874136131135125169158423133264243612226533175

LysS ?93691115742977138136138161185154450123259187770297532180

SLITRK32286517612893219248327383253762546191280286531257642279

SLITRK32286516333140218241357431185257486209273274463240705296

SLITRK32286515332479231261285332178235494226284295532246737305

bufferbuffer21654149168151202202244197561122311189549236863195

bufferbuffer22223751171151193193211177564118389184788214864195

bufferbuffer16804199173149227267210168520120432192488226845196

PFKP5214223324512219032312902844391231219122781568732312751286

PFKP521422172660224858283428279413934185104159473833513711620

PFKP521418263321204641257385284404964199105262068439313731464

IL5B356717503516137139N/AN/A191212471141270277558257707271

IL5B356718013559136138179194188212501146279275576256677305

IL5B356717193386134136183205200236472154273258599234877253

IL1B3553264647082854252493314211592107773792632671329119415042522

IL1B35532879543627836729348142817191161799112243501846203524185396

IL1B35532912730733957935055954424311287891120953172170308829057435

IL17A360519674112147146200259184186447133259231636262595232

IL17A360520333497150149N/AN/A197195463129273257650261587226

IL17A360514402774142144215313168195456131258228523235659221

CCL1634615602913175162182157190206474144316278525219653208

CCL1634615083320176155221237240364422144316196537216716218

CCL1634615333339177166217376163179442134369197518210739192

CXCL2292018923520192224228310230286844723506562745451730580

CXCL22920511831641183259248273210260759743387494788421660556

CXCL2292024704082204288262368210273835713424589825412703567

JAK33718398313959177190N/AN/A257487713312344840745394684770

JAK33718297414273181187199284260436775318356835776408761748

JAK33718240014783181186221287263451717329349683795447750828

LHCB6838151114421088379771294518382917638571355406610015034719535941433924141

LHCB6838151117341009369362177717563226720588776267610214676745137001343522858

LHCB683815111048961615041284114022183595796886506539637115389803440541350920612

bufferbuffer325773921711712232411951865191273211901049370770196

bufferbuffer27745310175171222257223191630126300186938341782198

bufferbuffer25125089185173219232394441568123303198929325791186

GAPDH 5'259719674095217278244363360107164545750121276703939241527

GAPDH 5'259725363816231300249363253632613397473222764142910091577

GAPDH 5'2597170436412252991481117424987260047381425447795499421534

RPL1161356267686259210114652120138889324277316732312654954307142624931607

RPL1161356008778354086774334431438935742653304336630161594710023679933012

RPL11613574379605611110780526871929129004903395438313366173039762814642954

IL53567409369732663682213846602688172526051030363717381144352210313

IL53567395064142473452254816982963170426061091363216751202363610515

IL53567348959762663482593976602787167324991322510820641393370511523

PDGFB515524449834167169199245209259576194437351700301724394

PDGFB515513353441176170213259214247538180307345563290757430

PDGFB515515924032167179187168196254521209365363621302686385

CCL56352201231882152952042902296206825024017181023572818663

CCL563525438680119428123236126075467539029351413995646941167

CCL563522323433617923421834424362173042031168510045446901208

CCR3123223353809N/AN/A22022736515457921896871461109164610001803

CCR3123220493386183194217236369148472318070215291548197410351679

CCR312321723322918819621824836114997351726381467169618798781651

FASLG356394277223475733238987393022178523081583556020502001418611869

FASLG356409068373655533559846612784195125231534517523101955434711105

FASLG3563985641235755441110876722932189926461974711322611827448011490

GFP_ctr 312 basesspike control 24052670538917062713911026157538931499252121022601137752597557



AAMP14200937531891722362362592507041406834181003381936269

AAMP14181835931941742131812332406591404972901054372921279

AAMP1422483832198171200149235236642138458274884357967287

LDHA3939N/AN/A204181198169227205614143473278829316996213

LDHA3939N/AN/A2051761981682131976171405682871209289834208

LDHA39392289425518317823021021820568814411184241366451986220

RPS361882797468557966664996155230241484218513443820151275726903890

RPS36188N/AN/A60071654390961032071545235813783822144473827004020

RPS361882379402556663246994256930271571220613523821138475226404016

ABCB15243129412861561571771391901665701234672871607507816217

ABCB1524310641408N/AN/A1731311991725901284642071537458748197

ABCB15243102616341551581631321971716311234542111689488671192

ADRB215499322981621551791411921725861234662021421493624180

ADRB2154100624991631581731332011836751244731861556504621180

ADRB21548922384N/AN/A1761321871606221244691971716517619179

ANPEP29033325413106212426461029874259732772966168046083436380745809791

ANPEP290306857779261066626889917279225902409142039133773354939157695

ANPEP2903061264882789479512456851986511846311413340832972191499210720

ATP2A3489120315021431531911582052156051356814711438472732257

ATP2A3489124619441461561681372072215731464262381336491721250

ATP2A3489104120651471591711362032065971314672251356471612224

BCL2L111001812582337198235190206326881N/AN/A45772115356879912193

BCL2L111001811352333185222196199334932676204528503160962011382309

BCL2L1110018116828201842291911882647676832015204781652614825808

C3AR17191020293425644622930024046096488652693612487358451747

C3AR17191393175825240721021026234412381077569126715557601002784

C3AR1719116518972062941981882382898634155907271456620806679

CBX11095130918251144231794728081119372854017627202886382024391628688423411946855643

CBX11095128837235014437849727201078669393964225316827569754208828501440001841154711

CBX110951259712227858731157331621262669854158820641691074064527926161420811503450274

CD58965N/AN/A1441501561391791835341833832401181404572213

CD5896585724392082321611501921835691874082411276434618206

CD5896584526261511511531391791715781793902101233424561203

CEBPE1053276147905641340517825744250654887118229381182521323130359418

CEBPE10532486476052113315228277902590548269082219762223933252315010031

CEBPE1053273642905001034381527744242748926686213776412230309430829638

CRADD873812692748193257N/AN/A40882413428357191203147385011522121

CRADD873814142917184249199218408817162213017581310160678812762297

CRADD873812972852184258191217371822178814088031292144676012812491

CXCL165819118733976318668304600613444524271413110845792618538623056059

CXCL165819119844539297621324662636449125611415111847732410517623486469

CXCL16581911901343232466821491521606439722851364125754072340465120885275

DLC110395167918571481631801772072596291603962671278430660257

DLC110395112925241471611761841942455841564252761006421641259

DLC110395N/AN/A1511611741862342425761504352711006391662259

EEF1G1937N/AN/A2022522062002026186811914685101075411730410

EEF1G1937102024451932252082011887336692044625901071422709411

EEF1G193789924021882162112201967196412024504481153426744426

ETS221141054240116522317720719548165018239347311604725781300

ETS2211412462343158214175200181489616169472445112249619731435

ETS22114N/AN/A1542062353101974886571724684481224488631989

FHL2227410653181167196185256227724701283409123210816386711379

FHL22274N/AN/A171194N/AN/A227754689309430102010455047681584

FHL22274N/AN/A169196188224217793702264417103110585846611418

FZR151343N/AN/A1912021901612324597191825343401198489759478

FZR151343N/AN/A18919419415724125171817844032712585158151023

FZR151343127351931811891961522334307181824413031333510703408

GNB2L1103991575268140756140769654840511412233610464376130481622375217

GNB2L110399N/AN/A39653640968453938611287226510684592124571621424799

GNB2L110399N/AN/A40154944676549639131369255010064096114767519764750

HLA-DPA131131636283518630920624439315019205876951657114574415933623

HLA-DPA13113173925441822892052703751518112811796451747114472414773961

HLA-DPA131131226265817728720725137914761167115059915371956159516014197

HOXB23212N/AN/A264602198401251101173330256216419706129413214

HOXB232121252274619029519241224994379467550215251466119710783704

HOXB232121167267420234320843525110477182475451781118665310233407

IGFBP734901315260128227230234146210259717237031086127869618202747

IGFBP73490129919622672803003734639839757867191096120068416512831

IGFBP734901107232725227731537144810539876976541031114762918573042

ITFG1815339582012220296160131186163511135376206835318634204

ITFG18153311742049150151158134186172530142319192824312646211

ITFG18153310953659144148160130193167586138314180874317632225

KLHL1155175N/AN/A164217170194224683602298322647919528722918

KLHL11551751402229615719717619720273363231982694110234576541033

KLHL11551751070164711391232181195199671647288481525941484625836

LRP140351715727830N/AN/A2992112217309541803727611555125925577323105435921862056981

LRP140351655525574449510740242490347821577913908512496132875794123510494751827955760

LRP1403517959215764620113103479131828407589723695111523124265984225124527891956858332

MBNL14154146936521702201971992875951543376370916299365279652141

MBNL14154N/AN/A17924019219424648617574294681175694551412162469

MBNL14154N/AN/A16821319322425142616974207756175588651110632162

ABCG2942913093268152169167156191260530258442446819374563430

ABCG2942911832545153168164158198291564236418427799379624378

ABCG2942910492971151170170168211308560237440378836346663377

AGTR1 ?18511871926286323160149190252442136338317677314620355

AGTR1 ?18512911993151179161160169259505136295484749336653343

AGTR1 ?18510041952150170163150192249498133297296750353636333

ANXA6309N/AN/A146153161136180221539165304269734319594289

ANXA6309N/AN/A140155159135179225553174312282691309664276

ANXA630910872623179167164142190224561159406314738321581274

ATRX54614822144209340218429459183610477576602756124488413375184

ATRX54612612412209322199503492190411018196562565122784914675461

ATRX54614042639207331196516449163510557856132688102864913205627

BCRL4 ?6169622330131129162140145146417122298170590239625191

BCRL4 ?61612152204128125142124151154428123299170673280624196

BCRL4 ?61613781625128128152125157149626145289169649262571190

CALD1800N/AN/A146166160156206519524266293635695365709564

CALD1800124122431501801661681955005762364154917454008151082

CALD1800115219371511781641682046485522424294817253906901328

CCND389612322220209539199311252241465638446012218056619281868

CCND389611552360211555N/AN/A2522348662393456136178016988531652

CCND3896149835862215922013402452396652703471130878514687781086

CD79A9731081250820839419524422982492360354115066335559651855

CD79A973109122932194172022482359401053592526139573712029031786

CD79A973218074082164221972422268281009796502142810289569311594

CFH3075296273918629244489303093447757247283278829198209725315736690378292776756270

CFH3075277223543429404511307997538309281623367130581206095295134779361992723653839

CFH307530374398483602552441281301412054404124019938796219585926334139343643086158420

CSF1R ?143613782744148152158132163193325134276221462229581297

CSF1R ?143612523033156155165134163191569248290225412241569291

CSF1R ?143610802796181197159135163188377137668548580293693284

CYFIP226999105623071551731531672234545662123363716993376741283

CYFIP226999N/AN/A149164162164N/AN/A6292253313566903747241461

CYFIP226999N/AN/A149181161177232566599182410369715361733953

DNTT17919174210501119277312488255453736748123931193264765626413923425431243563051

DNTT17919540206651219315512598957476739286134241266366565936514951431491040056363

DNTT179110136202151192294414899685551444945151121430070766129816001508431196962135

ELF420002141465456112655031355117447686742671430101204117302018412419240

ELF420002782547198017197251636110943897494762732551291016332116450020900

ELF420003053599162213254811235100341016757697832201281617312095409018652

FADD877210962796150158294224192218536194306277624293695393

FADD8772N/AN/A144163200189200237540189403312544294658393

FADD877211591942266331155141191236583170417297554284638351

FLOT22319120822071501971671952755595131953625285522848892139

FLOT22319117422631572071701932664255291873445426653149102313

FLOT2231912072070231296N/AN/A2493925431933365676093229172255

GAL51083128021042622951481541923504521743173504832666901003

GAL5108312122020154157152163184354503179307404520281694633

GAL5108313682970150171154169187395525168299362545302709949

GRN2896104831626215793442159650753102211388167136084923312169868151451141243026

GRN2896972315190165037101615503631032160982611448254503409910268122411141440711

GRN2896939915363200543871928605832642336787741458040522564211734127691093840721

HLF31312525474952812566751997107854743186480017241073623272825371817328

HLF3131235240386631702709214699551833264473216331137022993289355717425

HLF3131236245807732025714213996350463019492917101273622013348340715084

HOXB73217183740286371796597147478940614695389918191130314362455324314701

HOXB73217144128146781917599148681039744422399217151125213312000360417210

HOXB73217241349878052335672161388648514421386120531276619783309281413194

IL2RG3561594585055271090453228328681946584333488305825238831316143645641584

IL2RG3561610282165231068495258128261952885483447265820745909517546695943483

IL2RG3561664489076191257498259727151817194683767310325910855316312687042206

ITGB2 ?3689350962445501095433114473641071585196216041073831265483412919356

ITGB2 ?3689379264415471092496131174545371766220916471184430946208418920167

ITGB2 ?3689333964235391075564155299064632042262117291194934487411440820339

LAT27462N/AN/A2202122212596201114154412528751649141169323673057

LAT27462200434432352412503036231106141611178911644194190719723090

LAT27462199234482562592533076171074144211188801642184387619513024

LY6E406115352340141166138143155242385143284238446220578349

LY6E406113692428159163141145154232434139248228430209633332

LY6E4061110821451612451431521622264391452492223962241152262

MDM241931327251217418717118028563985180750782952642712001298

MDM241931109228417717918220126667687290550995858647211961599

MDM24193N/AN/A18819419520525663988880253593356335611961330

ACTG1712101105493577893286943731209111763997735641066117717155106

ACTG171297098213638033206533871376125069688331491210137218325194

ACTG1711986117153628113427404071440136873599938211261143718455461

AK2204159742872272392112062927346773314799446995349431819

AK220421045002239256220221297774726321496947699565878779

AK2204125544954124652172233188456853463836218016609841491

ARF1375119722241521621431462982808862196135174032551830791

ARF1375N/AN/A15416615516026128610472456033914102321921795

ARF1375174024811691901791844023719832458315904642811819741

BAALC ?79870133323231981901911872565415763753785945503597581024

BAALC ?79870122825692001881841962645615913863896915203767571063

BAALC ?7987013492181198197183209255561580382363582574333747837

BMI1648N/AN/A2714812445047832270328742041554523813191508311010723

BMI164828094884269501N/AN/A7762262321040071512521613331659348911467

BMI1648241745033015722745607542305387348091796582716632207345912048

CAPN1011132N/AN/A162210179232166394419296262486N/AN/A693483

CAPN101113211652698547446N/AN/A1754854172651083983457314717547

CAPN101113213982094158214163205173458468273301469N/AN/A638508

CD1993012022305143183144168161510375302225468389261607459

CD1993011752326453518156153150506377270230475385250642441

CD1993010512271140186141175177491406278264481381254641416

CDKN1B1027548711469187035723056101983430886221490536051305226453142733820313

CDKN1B102753551058145310272975891730383689251569229791030829073492801925486

CDKN1B10274454971850112414048101847399491191575730071074835954211704222220

CHI3L1111618294167221422190375361155712371367732243067185213303984

CHI3L1111616243664228423190346559163112711368665223768583513593908

CHI3L1111616813110235469179337356158012301393596203968386612534060

CST785301355226918730416922129968117183845664179744231410662580

CST785301211209519130317524627363314833727577150140932011242823

CST785301217199319634918227025162413643566522110648834710662902

DACH116021524222920626814916135892211711525649129784976113042418

DACH11602N/AN/A1642211691853681057117815595371046954122713282359

DACH11602N/AN/A1742401662414531383128918217441810891101513052251

DUSP6184812902583126155N/AN/A130175343180222334335200644323

DUSP6184811712226130156128141131167308192225306370207576308

DUSP6184811061782138179129141136180340181222335383218616322

EPHB22048169524642664222213867113833237243521144526478399122305496

EPHB22048145324062544192274017143918291343871040378183191726096063

EPHB2204813552056284457251477703413225014355104638651015117224885257

FBLN12192N/AN/A31477326168971132513688320513315524N/AN/A385212969

FBLN12192N/AN/A3459912587019093989338430201618638113011559341211988

FBLN121923586670736010365939548844487325928991609677215362226324011476

FOSB2354135633271592401482252661011697464400120543744710123458

FOSB2354129823641672631522092651037702434386115248843610913775

FOSB2354144423231783111502632611035712461411125848453110073550

GATA2262410518105691440500785920594064106142246525307997533712317938361791850951

GATA2262456138021166553829692325333588692152424622969234459330838191884153112

GATA22624N/AN/A17645753131330343217888924736289801073239686417447301770551575

GUCY1A3298214243321125127138128138176246161237202319167524244

GUCY1A32982N/AN/A12913211201241126169307162214200305158540233

GUCY1A3298211222952147151135127129170318168286230331176553228

HNRPA131781445415304929146182823346003172981582813532858134618614170292071252459

HNRPA131781512915507982152186124985926169131653514103790131832624673301934448201

HNRPA13178103421121811121538145232126209176131905116468893234775931295612134253981

HSPA1A3303N/AN/A167195278224203371552235347886312215719430

HSPA1A3303N/AN/A177214165175205400567247353872340222691469

HSPA1A330318505696219307182199239624583258362966358219762448

IL10RA3587N/AN/A178248172243279107259852841713314824529632768

IL10RA3587N/AN/A184272174258272101163253739913844514288782653

IL10RA3587N/AN/A189293180278272104365353243514844965179232724

JUN372518675735131136131124170190339140203199279159578213

JUN372510582861132137127126134179352131225185281356589231

JUN372511002503515574130130141172365138205185329186561218

LEF1511761315229115224518423120547682149840512823943809182997

LEF1511761162307514724913916823455880146846616253312688132728

LEF1511761412358815024525138225252982547449016005654118022312

MAFB9935N/AN/A194196171156202213448157273247N/AN/A565245

MAFB9935N/AN/A250238171156176206454159263229369191622246

MAFB993515233374186189171159187212484157256197404207624239

MEIS142115429155281481611942632374695063613255254313099481576

MEIS14211124320801461631782152134455684113237544062889331657

MEIS1421115012335142163190224220442N/AN/A3338254333112130919442

ADCY711313803436237222198171207228535199341273452211716278

ADCY711313543569228221350240222241554205330263474211617264

ADCY711312733207248236210183208220584194339264498216679282

ALB21311792366149141144130N/AN/A416138349251343192625352

ALB21313192293149143144130165252397147233184358189612361

ALB21316402078145149181188170230429145227194381209642304

ARL6IP51055011151911140143179187143210363228222299337178557300

ARL6IP51055011141826128144169178136205425187191298317176523288

ARL6IP51055012322920131153137137147222382228231325321176706235

BAX58112172841138160141133173245449147242302340190669316

BAX58114282668154178139136182253437159242283354206625316

BAX58111902415140178175196169253451152235280323196712335

BTG1694144291327013523227111944083921279421224675725924440039991182131295658561

BTG16941432812540149036221194478342763001611837789056184521610548199751310855391

BTG16941315411514155038511601539439302789412352851053673952614272271151301452712

CAT847142719631632022232572114955793143247694102866921389

CAT847131226661571981561922275345262903187193932567581306

CAT847264137181602001581912275345462763548443962527521118

CD3494713348125601616357312075254243518176639631945369379048403164921368052021

CD3494714559129751557340113235967264719778844542936511446447868136401366753454

CD3494713441119432331515717097239350926328821040576429464568543137461533156945

CEACAM64680209920121461601741832404964992553063934002908041808

CEACAM64680126118751381521681882294954762743094394403228471507

CEACAM64680165819721391551631852294375152493194984593358521816

CORO1A111511326303413618718324921097356942538923453673137863371

CORO1A1115113312708142188192258213109351651836021183373198333143

CORO1A1115114252629148205225268215117756852042425153613048623344

CTSG151114182109134242296364174351375149235221318171649465

CTSG151111201939N/AN/A162250187334427146246234327181647436

CTSG151113241812142274159243167417458151248238366199735350

DEK79133564411835991531166311056190276627281808864427653681554415600

DEK7913380645383941060395100010476061341832951876902833934020559015595

DEK7913374459484871485518170313668075356437562254921624353183526617027

E2F2187013372272144141332406149225358181245265811406822383

E2F2187011222103140142435524149254379167237255296179594430

E2F2187010992107160200203205147234415165241210315175624342

ERCC1206732088596145157171169178269420171277343355235612377

ERCC1206712711854141152170172171326452182254242334231612352

ERCC1206710941798145156172204178733475181257249346262609327

FCN12219192421281513221892212112894852362924004562496842403

FCN12219152231451492922263112163304972353013964402126602487

FCN12219123625761513474206332452964952232974444092166822558

FOXP1270861623240735046826131831363685797655915876014479942646

FOXP1270861368223220021528832432078988596445610016554319612612

FOXP12708614342356211237198227336825926106547912326684969602216

GJB1270520702497149166264287175216379277238290244166538800

GJB127051573249614516714757503164219383274272400272178579948

GJB1270511541914146171337320153215389286273419263194559811

HGF308212402116147166235243186158500124257164304162589185

HGF3082136920061381379701226190166515122247164306158571181

HGF30821208238714014721172377193161504123258157305164620176

HOXA432011697527161206363531121284980262642634332405341415354381231732732908862585

HOXA43201157082670521636721923250872502525737648459561544160867275537743191163802

HOXA432011624427183237071491224328168002482447575581491911662731468276393668164491

IER38870N/AN/A174276222298328136714271546655215749153013304014

IER3887019946740182295252322318124313641487588193559270712973208

IER3887014952672200338407557382144211061200592163489144512113227

INPP5A363212392357128129229225148201332176211244289160642296

INPP5A363238483985127129279257156205369171224237291161607292

INPP5A363215923358126132205203161202390172230216286161568277

KLF1106611599415124543028447724278458230838016785988068992664

KLF1106611557440526851325343524990158029340518646469399502455

KLF110661N/AN/A29458925953024798358730640418506789208562541

LIF3976234011788138166142173148247407166243420305194578350

LIF397614002698136173322327148298393172272353606270617423

LIF397616872994135170168179165282396181266347298178640394

MAP4K258712974677927153428748214177582243528231673706310051540593028565

MAP4K258712736651627956224248213317564257829261827822110251674654931595

MAP4K258712271540928657228154612367191296132761827864412982220630628739

MLLT142981722429832669821236453520553156294612074025468428338224364

MLLT14298N/AN/A346803167359N/AN/A3623346512654325528543391829256

MLLT14298N/AN/A3678421743645302089399738149643076670715346722947

MMP24313147235238531053229238205304495200323705360217795568

MMP2431317673560209436202208206301505204320648347223657950

MMP24313566081211431692643102142975081982986083492407001201

MYC ?46091674248622322526232347481023021845837208264252822186732

MYC ?46091922222627227526126247183025802142857219065659921656141

MYC ?46091447203426129226228643673729202567900251979767722856412

NDRG110397N/AN/A189185184189190261597301280362424255644379

NDRG110397N/AN/A189193218245209258586297353430536350632351

NDRG11039713642668180185199179204274564261336425372229718361

NR4A2492911861523154144217228157146363142273175320157635194

NR4A2492910491408150143296301165149366140268169284154634195

NR4A2492915491714153141249256161154377137272174301159639187

PAN3255967N/AN/A1321432683152065624932202504682921936871714

PAN3255967N/AN/A1321471431702078405312342485222991977461815

PAN3255967N/AN/A1301472042861965564892402534583222337421250

PLAU ?532860431782531588631998317123547973984517348134044538522685935836042

PLAU ?5328625019454385118145712962036397377601482527912726919453790759534185

PLAU ?5328603919284396116247312462106414676329395132583139524896769813137087

PRDX27001157528011511582142882524445793453386593211919181544

PRDX27001142225531481632162612484816143563346073341998541493

PRDX27001141827341471592323042454796145243366373422029231476

PTGIR573913841341127131156206153271348172202209252165482359

PTGIR573913351396126131167212135221338186199254251184536323

PTGIR573914621447921879174226129216353191209213270173524311

RARA5914584710436507154150115582239125767262817340723141010401107797939760

RARA59145315975864415305741447211611978654273593698276639661096833841211

RARA591446908473623186346713561879108837728858337972944415081942908443538

RPL5612551282594589664264292694136829133509284725630105273816376222807418504553763174

RPL561255279360446118683141424591315710920567444881635863268436361228882495475672064873

RPL561255594361439160173980027551639411401573454943937468288056430835833521874671962796

SEPT554131406187016324218724919830984713813577063753258641776

SEPT554131267181216525016421621032589714263798563853218341553

SEPT554131758300515322044351923241175412524649923122168331866

SMARCA46597238181732823005569100838795027321591920562447769478527398135281910859575

SMARCA46597N/AN/A2205560985835815384372911999866068376530918179128761744857830

SMARCA46597N/AN/A2100537486431015655377762148470368452493169880180231811755209

SSBP223635N/AN/A74318844361262116775783753381931342353422403515690926009

SSBP22363521855621109427344551350143092093940425428882275421353194719722915

SSBP22363546836162129633656222079144096974898551530642247635706778718924311

SWAP702307514201667772651157194150169349144208182288154494220

SWAP702307516223051137141205241161182330143245221309153582238

SWAP702307513282635137139246275147172328150236191283152547254

TM4SF14071247254086058384216351684343594887387499411058956925958636712

TM4SF14071N/AN/A6118793815311574344910064791140969289999987853833665

TM4SF14071N/AN/A596882273415138332711082880133227788310041048935934226

TRAF57188N/AN/A23942219544715106080272821521913598313512052774229959

TRAF57188N/AN/A28255620048517237098280821361894579512801974775830379

TRAF57188N/AN/A27752631481717106833285022371935622817122816719128173

VAMP510791331856574051018503136412516143353351031841109939921046553921636

VAMP5107913622478142411513961025119259003473503219251163711091025564621956

VAMP510791N/AN/A50614983741062112957153538517420371280711861236554020536

ZNF227570N/AN/A178177279328188342422269285377370231607399

ZNF227570N/AN/A185195192231181304426246285380381242686375

ZNF227570N/AN/A181190185208184300455266263297343216609330

MPO4353N/AN/A155223165258335953933973599205259750215414295

MPO43532025604614921817330234011379921069522309050038116634546

MPO43531865526814723020634238513299451051629358147633615364714

MYL24633189991991010902867816375555673886621029270991129850594549886722676753663

MYL24633148701573013893799726298662924512020621268711137154857575195472816561508

MYL24633150191657719055068643226161904328322558293831040655207630478912864661327

NFIA ?477440596312711161550310052930717220462271071067438023161818382275156987

NFIA ?4774N/AN/A9252088405901298175832576634536918732516147017822264554815

NFIA ?4774N/AN/A112226594491147311073543096142492970834851213026952382156445

NT5E ?4907N/AN/A154145156179204163488123245156336166778179

NT5E ?490720376196155144186189183163485123354175301148647182

NT5E ?490715182496148141187208189164476123330173258152725193

PDGFRB515941756052478161746410931666779682538131388119229914988866730326

PDGFRB51593887630845415343989161618812280688167351217838814878824230818

PDGFRB5159399960754681551380846140672688203830835361970210801223822128335

PLXNB22365414501493160171165196210233573206367555317187767765

PLXNB223654N/AN/A162173163197204234620210387641360203743409

PLXNB223654N/AN/A163178165212224294585208660631353211770604

PRKCQ558812862449134135171211164254441194328302293163680406

PRKCQ558815662192217249190246174251432191300244307158769743

PRKCQ558817241912131138187209179238433192326249275171671385

PTPN65777304253908930929694177690566813525502774317948122955388916158296672968961873

PTPN657772425334494343710668200692317361533273000519754123935937215488313873010257411

PTPN6577728275380673833120852291107316806529913213520838119675508117662345442804154097

RB159251426212213813719436325960570511293377853712507741362

RB15925296161341461611712612426177171046297630395257773769

RB159251323288113114116921126059771212204154923052058261073

RPS3A6189131826205482345365577400855899912774457847586298514912201019056

RPS3A61891355257685543943805064207578910322816051737007263114492127218525

RPS3A61891234154555714194546574080534611106938153917181362718822129718230

SERPINI1527411931841131129152201154164371140233173282151579230

SERPINI1527412861956130127147177157162371145283227270160609221

SERPINI1527416132146131126148178160160412146228180295171559222

SOCS3902115792712192137210238206208506168335249467198779530

SOCS39021168531151881352342022082331387603398243357167750543

SOCS3902115942587182135232259214211520168398243393164822524

STAT1677213631562126128185179147146335121268163261141599197

STAT1677211301646127127225273155159366120224150267146545196

STAT1677211951616124127154205158147398123226156260150558179

TCEA1691720272934192223247383755349120744168117050031057103531889196

TCEA169172647500120124124840168130102112404810574690997108136509212

TCEA1691724994288200247259444645270221384154104749091148121235049957

TNFRSF10A8797115641526378217579602022368411532106536682809826417449956301608447254

TNFRSF10A8797104971393779616795061463377012016121097356720124861418646321587844916

TNFRSF10A87971114914143103621247621969384712837120817426798327020486059501510544255

TRRAP8295206444252182433244264731200230427891138235768664525766988

TRRAP829520643903227274231328432124423362842992206963157827047190

TRRAP8295172229493244092202944181084241727551012208374574928007496

VLDLR743613162002187163195211187207506338293209439187587446

VLDLR743613501757186163191209189204483305288203395185621423

VLDLR743615342572192168191168185225474276383215377180658441

bufferbuffer16183485162144942743201167474116416174282156786179

bufferbuffer17343513160147191212191166470112345159301156766179

bufferbuffer14282553156144262348195170517117361160288156794181

MT1G44951294220513614116224320659949347929772983905641763594

MT1G449515272211133142158217210593567466298839356224734668

MT1G449514912202132145153200207602492622297816369247673576

MYLK ?463813142310139152150205160296424147250230328209576269

MYLK ?463815303159137153342397159321440147941633305180637276

MYLK ?4638N/AN/A143157181208171319457150354251304181698279

NME14830127171327061311913369772146962068744962653032705578369831564644604

NME148301079911052597114439594227281249681946423624332585577681121690845391

NME1483013067134997671667186829043182154731087388557013382148044119351592140194

NUP98492825871769148140168243215246534169345337329173817415

NUP98492812101571144141155196213257528179352355321176823450

NUP98492813231768143137149188209252547167335330351180818366

PGDS27306456864097451556469474181545121003430339584815736597527840123173

PGDS27306N/AN/A8251679457496163441271020231608467112350578457769120616

PGDS273064201539010182061401489162243661012732608473113001639548820821695

POLA154221539204314414926135538962170225745255668649012171467

POLA154221796188014514920034039765470429043568568750412111313

POLA154221690182214715326258743568967226144370178656912741567

PRTN356571482241816931317428129710601054973624245252656314934283

PRTN356571665292517431516726731297713261227565213549554914314076

PRTN3565716934442178402438670404158413061242755276346154314704864

PTPRM579711682063133136220293182327394213320356312205698564

PTPRM5797131219291301392072821803483851993682541327200649506

PTPRM579714691832128138264328195322439214283355336209659477

RCBTB1552132794426020128731470310823637294830691407581620792391478714874

RCBTB15521327463530201283619213710723180362240871065425321272732501915199

RCBTB15521324744205207313809271511033907311133271243575124603152495615275

RUNX1T1862130123411691662003181741051502220286703478695587367

RUNX1T1862148332371681714104301611006455256372542429604606406

RUNX1T1862130227521641902152501631166488253352540366431703428

SHC1646421643657290897289532717371624813821162112120833935315512661

SHC1646422773336293895291471631329227294432160911955800903324512554

SHC164642024349631897925343461432552892465412518898727848335313007

SPI166881696291418126020031034482823526249852251447340023715822

SPI166881738241918325819328233986625516845718222849446324656225

SPI166881538233318026919827534591127817370583144052945321605590

STAT5B ?6777141622491281342873682043965183213795103832905841495

STAT5B ?6777153721571311391812642153854953034355514212757211195

STAT5B ?6777114218971311402102422133795152933774923762667451042

TFDP2702915062019N/AN/A2503432586467545524418893412198921114

TFDP2702912971807N/AN/A253340247648790618406770N/AN/A8921212

TFDP27029129217761561881772282485007556734668963822409441225

TNKS86582642368519024722944096539305005100261683838212891538481412952

TNKS86582457297318925322440298840085425108791311598712171323462412648

TNKS865829465203197291263415135857305446106632205984110901241515414684

TUBB41038215812200153161185272197381632385422822358231761630

TUBB41038213922295152167237299202373643351380835327226754818

TUBB41038214202110156180240344202416648337385986361234755554

XBP174944184791342911843527641717102526185807929432044920302796831236147

XBP174943911730443511322705911635963674191002424651809719083195791035602

XBP17494390965475181448261596163197927356974424981790217382705775736444

MT34504536136329222736464183047160499428551795306629933233296368845861637903401864819

MT345045792064729307195040297843760312385599265663335635293556487143444524113933864821

MT345045769362979252814353180944005813556600425671639642279946332749009523754124264436

NBL146812715222012290062601969782035492708915838600398815235816138295511715948151

NBL1468128325227393154687812486263441632302167396274116765722220980386881859352309

NBL1468129091226944150886015547322519937755194327398119105584826610456482302460203

NP486012401841135139155209140181313176213438284184605486

NP486013331727130131146197189206357194208412327176562509

NP486013901640127130153186146185344191231319326190549491

P2RY14993413792763143144212259133215313153276253308177590328

P2RY14993412062330128136189244140221325151336259295169638324

P2RY14993412802182124136212226143242350148346259310175636275

PIK3CG529413451828498560223294156236370235309385337184599534

PIK3CG529411951677130127220297152208336260235452339195600537

PIK3CG529411631726127123158200157222369238224415416225619502

PPIF10105144517671541971773032681589638305450213576490811814019

PPIF10105131319001572062184362651577663310473241467392710513814

PPIF101051509241115823119530629919546793208412575848129411424129

PSMC5 ?570519232643136142194264581179914232344728191199073425747276

PSMC5 ?570517492588135142209234563174414982506734219285765624575931

PSMC5 ?5705174524541401592323216241933147526198912316105185126086956

RAB13587212671783140180218319202489595554378582497416793800

RAB13587212112016138176173233193543598582356782466376729759

RAB1358721392183013818216221619051858475833464748241911551077

RHOH39915642208138155160222184492414287273428422239562449

RHOH39913783019137155171186180531430372390395417256660471

RHOH39913702398141158189249194541435387400386429242699425

S100A862794582261461536762274672116349647221150991508616716772880416422801

S100A862794126260081576622374322182358696690134611061404215113367452329427

S100A862794214238891638512214262249375408299162421361390517203773426027900

SLC25A1657616472897154153157178193203468149284207347190642239

SLC25A1657617092824225643148173180200416158249228336186631226

SLC25A1657616712988151149160205187196461150264203391204580230

SPTBN16711243057101841952322584721433617349696184879864425608258

SPTBN16711363353971751866349354871475645413643169473759824827399

SPTBN16711218655942052482322654911471711387707206580569130249045

STK32B553517954100783807803666773383597222830337491227031532206321032138447034

STK32B55351759089243446942805012700490224996367971106532936198620772064643313

STK32B5535165377942420960268433282852032517135927824424668220021451797738941

TIE1707514892434183237178221266811897921505126358547013282921

TIE1707514672442183240190272267792859763470124861548812932638

TIE1707516233221203297226266312995N/AN/A636160354842013972712

TPM1716815993005133135197237157245321209316320325193656329

TPM1716813692431132132213271150236381208420309N/AN/A664304

TPM1716815143118131131188237159234394198385274393231653297

TYK2729713872165143144167216174188449255274333288189643409

TYK27297N/AN/A140147137164173191N/AN/A2743313362001094487

TYK27297N/AN/A138153140188158198430327243333334193589457

ZAP707535N/AN/A2283242112702143605524923623656094757831290

ZAP707535195032742644222562592303946305074383644903388451278

ZAP707535270961192503582582362474265485584453275113478061141

CSF21437359614120158156216276171202525202419223452262692207

CSF21437334717123155154189242169184513175380226433226816207

CSF21437N/AN/A157150185246164173491165341213411219694239

IL103586N/AN/A138166146190211372603223337416507382718869

IL1035862764116201341691451992003455112552744215232866771011

IL103586N/AN/A133177158228198322514240270410527306682659

IL8RA3577454168731471971903363101190738306623184944537613734568

IL8RA3577166132124455452172953061136760291575128851544912634232

IL8RA3577205527771481952133242981136698277590135051640912404274

CCL18636216932357138164186238192195531132403197388195N/AN/A

CCL18636218042750134165163192200193502132367215409203658306

CCL18636220283659135165151167196206514137337219433208684280

CCR81237N/AN/A132129140188171156439120270161452194670220

CCR81237N/AN/A131127493510173162480120280166675204580228

CCR8123714532752135127182191160157430120499194349175741192

LTB4R124119183252188227227220199382575240547458516360N/AN/A

LTB4R124117783230182219N/AN/A193585627238489471505339760376

LTB4R124141517739188218222291253532617271450436498352820426



Sp9_ctr 300 basesspike control 7N/AN/A19531618137849620341209105684134981045130124478682

B2M567N/AN/A97614181572582314026011502451160397471010714002

B2M567167432991794132485162445615851458549218349425012265561

B2M567168527891843912074402315716091530493171248627410954178

NONO484118532938168185228318405841823329800132974750328035257

NONO484116852384155159186241381768930419775124569143328336206

NONO484120652764161167161203N/AN/A1032467739139884853427166175

STAT6 probe A6778N/AN/A135128135140173154430116323168402197650184

STAT6 probe A6778N/AN/A137130143197169153450120288152467203705195

STAT6 probe A6778N/AN/AN/AN/A141183163145420122383197487208614209

IFNB1345611962472141144169224185196438139503230400200768315

IFNB1345613802187142144188246174191444141462209368209732289

IFNB1345614072113142144212278176192422138423222407201765292

IL13359613652202169168202251200379493254425405459260701406

IL13359613791828365560179201180310507224331480499246679443

IL13359616931830160162165179172325472212313378545301650476

IL13RA13597N/AN/A154152157244269463735708357754799414923670

IL13RA13597N/AN/AN/AN/A1452002564256685883877567483699901194

IL13RA1359736252287160153192272244406627451481525653384889629

CCL24636913752741164151251320202181490141519202465203711189

CCL24636913732448156145195228190167479136443198561203700188

CCL24636915612705226228177188187176520137390189504202642190

FOS23532354404459514983885556021306422644282373673914491420468811710

FOS235321743980337588354524520991373040022170622512861088441210974

FOS2353256437683907422905185081039370739401854562913491165432711098

SpeA93600212401639146148144196187241486161272278565314638372

SpeA93600216282512146155170214192233507174440275479296772280

SpeA93600214462337150159192228195233483175588264487280724282

SLITRK413906528132036722623823334987310961771104112661497213595532783579

SLITRK41390652870294722124122534388511561858108812101412206292637304307

SLITRK41390653291301224025120429382511151957114510581223227489836853877

bufferbuffer27256034178154150189223165513120342168597239718193

bufferbuffer18555978176151168222220182567121369169636244725188

bufferbuffer19664534171147149178208173537124387187765257760200

PGAM1522315863915192174272306210366521170557518550282859459

PGAM1522319023850190167210210356464560197583517599333798426

PGAM1522316863626181163215223217417533186542495665338752493

emptyempty17872334190168176154235175641125625208624250941177

emptyempty16882079314278168141223181661122496197693261797184

emptyempty14461978188168240307231177626123464180718261762187

IL2 ?355812091772135133163260176384470154273381487261652690

IL2 ?355811151658134137135187185374457164252357520280684667

IL2 ?3558N/AN/A136144176236174471488173500370512281755563

IL183606N/AN/A1631841722273367907053045609

luiza handschuh karol marcinkowski university of medical sciences, department of haematology

Documents

virtual laboratorypreparing

nmr studies data storage

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fab m1 amlcancer medicine

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