4100607400 Rev 0.1

Speed. Versatility. Quality.

Nov, 2012

May Lee

Global Product Management

Long Pulsed Alexandrite & Nd:YAG Laser

Worldwide Revenue by Indication

Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Jan 2012

Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Jan 2012

Worldwide Procedure Fees by Indication

LASER-TISSUE ABSORPTION SPECTRUM

Oxyhemoglobin Deoxyhemoglobin Melanin Water

755 nm 805 nm

1064 nm

694 nm

* Dr. David Vasily, ASLMS 2012 Presentation on Hair Removal Lasers

Comparison of Melanin Absorption* •532 nm YAG : Higher absorption for melanin and oxyhemo, but limited penetration •755 nm alexandrite: higher melanin and oxyhemo absorption than 810 nm diode •1064 nm : deeper penetration, absorbed by oxyhemo, higher absorption for water

Hair Removal

Pigmented Lesions

Vascular Lesions

Skin Rejuvenation/Lifting

532 nm

MARKET SIZE & HIGHEST GROWTH POTENTIAL: PIGMENTED LESION

Source: BCG Research - MEDICAL LASERS: TECHNOLOGIES AND GLOBAL MARKETS, January 2010.

• Worldwide Pigmented Lesion Removal market is expected $207 mil in 2014 with highest growth rate 20.5% by year

Huge Opportunity for Hair Removal in 2012 - $266M

Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Feb 2012.

6

Alexandrite Laser demonstrates the superiority for Hair Removal.

Biggest advantage of long pulsed Nd:YAG laser is that they usually work on all types of skin, even on tanned skin in particular, and on darker skin.

Market Needs for Multiple Application Platform Europe Distributor Comments

• Candela and Cynosure introduced combination systems with Alexandrite and long pulsed Nd:YAG with an attractive pricing strategy. The dermatologists who favor treating multiple applications with one system preferred this type of system.

Source from European distributors, 2011

INDICATIONS PREFERRED BY EACH REGION FOR LONG PULSED ALEXANDRITE LASER

Source: Inputs from distributors and regional sales team, initial marketing survey, 2011-2012

•Hair Removal •Skin Rejuvenation •Pigment •Vascular •Pigment

•Skin Rejuvenation •Hair Removal •Vascular

•Hair Removal •Skin Rejuvenation •Pigment •Vascular

TESTIMONIALS FOR ALEXANDRITE FROM KOREAN KOLS

• “Alex is very effective for removal of lentingines, moles and SK. There is no bleeding, no crust. Furthermore the patients can wash their face right after the treatment. Also, it’s good for Photorejuvenation. Generally Wrinkles, pores or pigmented disorders, and so on. have been treated with different lasers but the Alexandrite can improve them all together. One treatment will not be sufficient, but after 4~6 weeks you will recognize the difference. It is also very effective for hair removal and hemangiomas.”

Dr.KT Hong, Dermatologist, Yonsei Modern Clinic, South Korea

• Alexandrite can treat pigment disease better than Nd:YAG which is better for vessel disease. Alex is popular for hair removal or pigment disease whereas overseas it is used for blood vessel disease and hair removal in Korea

• Lutronic needs the system to complete their line up for the aesthetic market. There is constant demand for the device not only in Korea, but also in the global market.

Dr.SJ Lee, Dermatologist, Yonsei Star Clinic, South Korea

Introduction

The CLARITY Family

• CLARITY LPA: Alex only • CLARITY LPY: YAG only • CLARITY LPC: Alex + YAG Combo

The choice of Cryo ICD or air cooling is available

Cryogen ICD canister

0.5 - 10 Hz

2, 3, 5, 8, 10, 12, 15, 18, 20 mm

Cryo ICD or Air Cooling*

CLARITY™ Specification

* User selected, engineer installed

Cryogen ICD canister

Air Hose connector

“U” Tip of AC model

“O” Tip of ICD model

CLARITY™ Flat Top Beam Profile at 755 nm

Source: Lutronic R&D measured. Photograph by Beam Profiler (Gentec,“Beamage”), 2012

CLARITY™ Flat Top Beam Profile at 1064 nm

Source: Lutronic R&D measured. Photograph by Beam Profiler (Gentec,“Beamage”), 2012

CLARITYTM User Friendly GUI

CLARITY™ FEATURES & BENEFITS

Rapid Treatment

Up to 2 Hz at 18 mm spot, 1.5 Hz at 20 mm for fast hair removal. Better staff efficiency, improved profit potential

Single Fiber Delivery for All Spot Sizes

2 to 20 mm spot sizes are available with single fiber delivery, providing convenience, saving treatment time and costs.

Wide Range Enhanced Parameter

Unique feature of CLARITY: Lower fluence is available at a smaller spot size for gentle pigment removal.

• Largest spot size: Up to 20 mm

• High repetition rate: Up to 2 Hz at 18 mm, 1.5 Hz at 20 mm for faster hair removal

• Time efficiency: Shorter treatment times for larger areas increases the clinic’s ROI

15 mm

18 mm

20 mm

CLARITYTM Faster Treatment Speeds

2mm

CLARITYTM Wide Range of Spot Sizes

Spot Size Auto-sensing

• Dual wavelength platform offers greater versatility

• Wide range of pulse widths and spot sizes for both Alex & YAG (NO limitation by wavelength)

- supports treatment convenience for a variety of indications and skin types in actual practical clinical conditions

Higher efficacy in fine hair removal with shorter pulse widths from the Alex

- Unique feature of CLARITY: lower fluence is available at a smaller spot size for gentle pigment removal

CLARITYTM Enhanced Parameters

Indication Laser Pulse Width

Hair Removal* Alex Fine: 3 ~ 5 ms Medium: 3 ~ 5 ms Thick: 5 ~ 20 ms

YAG Fine: 5 ~ 12 ms Medium: 12 ~ 40 ms Thick: 20 ~ 40 ms

Pigment* Alex 0.35 ~ 3 ms

Vascular* Alex 3 ~ 20 ms

YAG 5 ~ 60 ms

Rejuvenation Lifting

Alex 0.5 ~ 3 ms

YAG Quatro Technique: 0.35 ~ 1ms InnerLift Technique: 12 ~ 20 ms Standard Technique: 50 ~ 70 ms

CLARITYTM Wide Range of Pulse Widths by Indication

* CE marked indications

• 2 to 20 mm spots sizes are available with a single fiber delivery system

• Convenient for physicians: minimizes the treatment time, time because there is no need to change fiber during the procedure

• No need buy an optional fiber for smaller spot sizes

CLARITYTM Single Fiber Delivery for ALL Spot Sizes

Ergonomically designed fiber pole set: Automatic locks and holds the fiber without slipping

• Choice of Air Cooling or Cryogen ICD Cooling type

• ICD = Intelligent Cooling DeviceTM - Built-in cooling system

- Save time, save space

- Effective and consistent cooling during procedures

• Air Cooling - No consumables, but needs an external air cooler

- Continuously cools the epidermis throughout treatment

• An engineer is required to change the cooling method

* User selected, engineer installed

CLARITYTM User-Selectable Cooling System

CLARITYTM Memory Function: 64 Memories by Wavelength

CLARITYTM User Controlled Calibration

CLARITYTM PHYSICIAN’S TESTIMONIAL

Chong-Hyun Won, MD Dermatologist, South Korea

“ CLARITY long pulsed 755 nm Alexandrite is very effective for various pigment and photo rejuvenation without crust. Generally wrinkles, pores or skin laxity can be improved all together with this dual wavelength workhorse. Advanced features of CLARITY provides multiple treatment technique for combination. I prefer speedy hair removal feature of CLARITY, it is really efficient for fine hair removal.”

CLARITYTM Alexandrite Pigment Treatment

TWIN Technique: • Small spot focus • Large spot scanning

CLARITYTM NEW Lifting Technique with the Nd:YAG

•QuatroTM Technique

•InnerLiftTM Technique

Comfortable

No Aensthetics

Speedy Procedure

Easy combination

Post Cooling Only

CLARITYTM Hair Removal with the Alex or Nd:YAG

The chromophores for the 755 nm or 1064 nm laser are • Melanin in the hair and follicle • Stem cells in the bulge • The blood supply in the papilla

Bulge

Bulb

Underside of D-E junction

Root & papilla

Subdermal fatty layer

• Selectively absorbed in the laser chromophores in the hairs and follicles, selectively heating and destroying. • The blood supply to the hair root is disrupted, the stem cells in the bulge are damaged, and the hair is forced into prolonged catagen and telogen phases, resulting in long-term hair removal.

CLARITYTM Vascular Treatment with the Alex or Nd:YAG Laser

SKIN TONE & TEXTURE IMPROVEMENT WITH ALEX

Courtesy of J.H.Won, MD, South Korea

After Before

PIGMENT REMOVAL WITH ALEX

Courtesy of B.L.Goo, MD, South Korea

After Before

PIGMENT REMOVAL WITH ALEX

After Before

Courtesy of J.H.Won, MD, South Korea

HAIR REMOVAL WITH ALEX

Courtesy of J.H.Won, MD, South Korea

After Before

HAIR REMOVAL WITH ALEX

Courtesy of J.H.Won, MD, South Korea

After Before

VASCULAR LESION WITH ALEX

Courtesy of B.L.Goo, MD, South Korea

After Before

– June, 2012 (LPC/LPA/LPY, with ICD/air cooling as optional)

– March, 2012 (LPC/LPA/LPY, with ICD/air cooling as optional)

CLARITY CLEARANCES

– TBD

– Est.Q2, 2013

CLARITY CE Mark

CLARITYTM Ad / e-Blast

CLARITYTM Ad: Medical S, Korea

CLARITYTM Brochure

• Planned & In Process

– Patient brochure: Oct, 2012 (KR)

– Marketing video: 3D animation by indication

CLARITYTM Marketing Tools:

• Planned & In Process

– Pilot Study of Dosimetry by indication: May 2012, Ongoing

– Clinical Studies: May 2012, Ongoing (T) Peer-reviewed Publication (est.2013)

– Market Preference Evaluations: July 2012, Ongoing

– Customized editorials: Q4 2012 (Asia Pacific)

– White Papers: Q4 2012

– Clinical Roundtables: Q1 2013

– Laminated Clinical Guide: Q3 2012

– eSeminar/Workshop: Q3 2012

CLARITYTM Clinical Validation Tools:

CLARITYTM Laminated Clinical Guide

CLARITY

Manufacturer Lutronic

Model name Elite MPX

Cynosure

GentleMax/Pro

Candela.

Synchro PLA:Y

DEKA

Laser Type Long pulsed Alexandrite (755 nm) / Nd:YAG (1064 nm) Laser

Pulse

Width(Alex) 0.35~300 msec 0.5~300msec 0.25~300msec 2~100msec

Spot Size

(Alex)

2/3/5/8/10/12/15/

18/20 5/7/10/12/15/18mm

6/8/10/12/15/18mm

1.5/3mm

5/10/12/14/15/16

mm

Pulse Rate Up to 10 Hz Up to 5 Hz Up to 10 Hz

Skin Cooling Air Cooling / ICD Air cooling Cyro DCD Cooling Air Cooling

Emission

Control Finger Switch or Foot Switch

CLARITYTM Comparison Table

Pulse Energy Up to 100 J (YAG)

Up to 55 J (Alex)

Up to 70J (YAG)

Up to 55J (Alex) Up to 53J (Alex) Up to 35J (Alex)

Up to 2 Hz

Specifications

Lasing Medium LP 755 Alex / 1064 Nd:YAG Combo Max.Pulse Energy (On time) 53J (Alex) Fluence Up to 150 J/cm2 Pulse Width 0.25 ms - 300 ms Spot Size 1.5, 3, 6, 8, 10, 12, 15, 18 mm

Fiber 6 - 18 mm fiber as standard 1.5 - 3 mm fiber as optional

Rep Rate Up to 10 Hz ( Up to 2 Hz at 18 mm)

Cooling Cryo DCD

(Air cooling compatible H/P is available at Pro)

Calibration External

Electrical 200 - 240V, 50/60Hz, 30A,

4600 VA single phage Weight 155.5kg /118 kg (Pro) Size 45 x 26.5 x 38 in. (114 x 67 x 97 cm) Warranty 1Yr (Lamp life span: 250,000) Price to physician List $134,9000 to $200,000 Consumables Cryo, Lenses, Distance tips

KEY COMPETITOR: CANDELA GENTLEMAX/PRO

Air cooling compatible H/P

Pros:

•Up 2 Hz at18 mm spot size

•Wide range of pulse width

•Rapid treatment

•High brand recognition

KEY COMPETITOR: CANDELA GENTLEMAX

Cons:

•Need to change fiber for small spot size (1,5, 3 mm), additional cost and longer treatment time

•Higher minimum fluence at small spot size, not proper for pigment removal

•Not portable, very heavy system

•DCD gas loss

•Heavy service burden & expensive

•Consumable Expense (distance tips, cryo, service)

•Expensive product

Specifications

Lasing Medium LP 755 Alex/1064 Nd: YAG Combo Max.Pulse Energy (On time)

55 J (Alex) 70 J (Nd:YAG)

Fluence Up to 150 J/cm2

Pulse Width 0.5 - 300ms (Alex)/0.4 – 300 ms(Nd:YAG)

(10 - 40 ms at Multiplex)

Spot Size 5, 7, 10, 12, 15, 18 mm (Alex)

1.5,3,5,7,10,12,15,18 mm (Nd:YAG)

Rep Rate Up to 3 Hz (Alex)/5 Hz (Nd:YAG)

( Up to 1 Hz at 44J, ~5ms) Cooling Air Cooling Calibration YES Electrical 200/220V, 50/60Hz, 30A, single phage Weight 82 kg (Elite) Size 46 x 17.25 x 32.4 in. (116.8 x 43.8 x 82.3 cm)

Warranty 1Yr Price to physician Consumables NO

KEY COMPETITOR: CYNOSURE ELITE/MPX

Pros:

•No consumables

•MPX feature: blending of Alex and YAG

•Brand recognition

KEY COMPETITOR: CYNOSURE ELITE/MPX

Cons:

•Air cooling only

•Min.spot size is 5 mm in Alex mode

•1.5 mm spot size is optional

•Up to 2 Hz in Alex mode for hair removal

(MPX)

•Red aiming beam

•MPX feature not proven to be more

effective in clinical trials – ALL MARKETING

HYPE

KEY COMPETITOR: DEKA SYNCHRO PLA:Y

Specifications

Lasing Medium LP 755 Alex/1064 Nd: YAG Combo Max.Pulse Energy (On time) 35 J (Alex)

Fluence Up to 500 J/cm2 (YAG) Up to 60 J/cm2 (Alex)

Pulse Width 2 – 100 ms (Alex)

0.3 – 300 ms (Nd:YAG)

Spot Size 5, 10, 12, 14, 15, 16 mm (Alex)

2.5, 5, 7, 10, 14, 15 mm(Nd:YAG)

Rep Rate Up to 2 Hz (Alex)

Up to 7 Hz (Nd:YAG) Cooling Contact cooling Calibration External? Electrical 230V, 16A Weight 155.45 kg Size 900(H) x 480(W) x 850(D) mm Warranty 1Yr (Lamp life span:) Price to physician List $ Consumables NO

Pros:

•No consumables

•Optional IPL

•Relative inexpensive

KEY COMPETITOR: DEKA SYNCHRO PLA:Y

Cons:

•Poor beam quality and stability

•Air cooling only

•2 to 100 ms pulse with in Alex mode: no

shorter and longer pulse with as others

•Maximum spot size is only 16 mm

•Minimum spot size is 5 mm in Alex mode

•Limited pulse rate: max. 2 Hz only