list of manufacturers - springer978-94-011-4722-4/1.pdf · laboratory techniques in thrombosis - a...

32 List of manufacturers

Materials and reagents for the procedures and the assays below correspond with the order and the content of the assay chapters and are followed by a list of addresses.

Chapter 3: Blood collection and sample preparation: pre-analytical variation Diatube H (CTAD) Diagnostica Stago Stabilyte tubes (citrate at reduced pH) Biopool Vacutainer tubes (plain, citrate, EDTA, Becton Dickinson

CTAD) Venoject tubes (plain, citrate, EDTA) Terumo

Chapter 7: Endogenous thrombin potential Actin FS Arvin Malonyl-a-aminoisobutyryl-arginine

paranitroanilide methyl ester hydrochloride PPACK Relipidated recombinant human tissue factor (Innovin) Reptilase Substrate S2165 Substrate S2238

Chapter 8: Fibrinogen Standard 89/644

Chapter 9: Activated factor vn Bovine brain phosphatidylserine Bovine liver phosphatidylethanolamine Bovine serum albumin, fatty acid-free Egg phosphatidylcholine

293

Dade-Behring Knoll Serbio

Calbiochem Dade-Behring

Boehringer~annheim

Chromogenix

NIBSC

Calbiochem Avanti Polar Lipids

LABORATORY TECHNIQUES IN THROMBOSIS - A MANUAL

Factor VII-deficient plasma

Plasma-derived factor VIla Recombinant factor VIla Recombinant soluble tissue factor

Capture antibody of factor VIla is not commercially available

Commercially available kits Staclot VIla-rTF

Standard 89/688

Chapter 10: Factor vn activity and antigen Commercially available factor VII antigen kits Asserachrome VII:Ag

Chapter 11: Factor VIn clotting activity Automated APTT Factor VIII-depleted plasma

Commercially available kits

Standard 911666

Chapter 12: Von Willebrand factor Horseradish peroxidase o-phenylenediamine

Commercially available kits Asserachrom vWF (ELISA) Von WF:Ag (ELISA)

Standard 911666

Chapter 13: Antithrombin activity and antigen Reagents for antithrombin activity CBS 3447 (chromogenic substrate) Control plasmas (normal or pathological range)

S-2238 (chromogenic substrate) S-2765 (chromogenic substrate)

Reagents for antithrombin antigen Antithrombin antiserum Normal protein standard

Standard 93/768

294

George King Bio-Medical

American Diagnostica Diagnostica Stago

Diagnostica Stago

NIBSC

Diagnostica Stago

Organon Teknika Diagnostica Stago Ortho

Dade-Behring Chromogenix Diagnostica Stago

NIBSC

Sigma Sigma

Diagnostica Stago American Diagnostica

NIBSC

Diagnostica Stago

Chromogenix Diagnostica Stago

Chromogenix

Dade-Behring

NIBSC

LIST OF MANUFACTURERS

Chapter 14: Protein C activity and antigen Commercially available protein C activity kits Bioclot Protein C Coamatic Protein C MDA Protein C Spectrolyse Protein C Stachrom Protein C Staclot Protein C

Reagents for protein C antigen Conjugated antiprotein C immunoglobulins Coomassie Brillant Blue R 250 Gelbond Film Laurell plates

Tricine Seakem LE Agarose

Commercially available protein C antigen kits Asserachrom Protein C Technoclone Protein C Thrombonostica Protein C

Standard 93/590

Chapter 15: Protein S antigen Antibodies

Bovine serum albumin Ortho-phenylene-diamine (dihydochloride)

Commercially available kits Asserachrom free protein S (ELISA) Asserachrom total protein S (ELISA) Thromborostika protein S (ELISA)

Assera-plate protein S (Laurell) Biopool protein S EID kit (Laurell) Liatest protein S (nephelometric)

Standard 93/590

Chapter 16: Protein S activity Diluent

295

Biopool Chromogenix Organon Teknika Biopool

Diagnostica Stago

DAKO Serva FMC Bioproducts American Diagnostica Diagnostica Stago Sigma FMC Bioproducts

Diagnostica Stago Technoclone Organon Teknika

NIBSC

American Diagnostica DAKO Enzyme Research Laboratories

Sigma

Diagnostica Stago Organon Teknika

Diagnostica Stago Biopool Diagnostica Stago

NIBSC

Instrumentation Laboratory


Commercially available kits IL Test Protein S assay kit

Protein S Reagent Staclot protein S

Standard 93/590

Chapter 17: Activated protein C (APC) resistance APTT reagent Activated protein C

Factor V-deficient plasma

Commercially available kits Coatest APC resistanee

Chapter 18: Tissue factor pathway inhibitor (TFPI)

Instrumentation Laboratory Dade-Behring Diagnostica Stago

NIBSC

Organon Teknika Enzyme Research Laboratories Diagnostica Stago

Chromogenix

Chromogenic substrate Chromogenix Factor VIla (human) Diagnostica Stago Factor VIla (human recombinant) Novo-Nordisk Factor X Chromogenix Factor Xa Chromogenix Polybrene Sigma Tissue factor (human recombinant) Dade-Behring

Commercially available kits Imubind free TFPI

Chapter 20: Heparin cofactor U Capture antibody (product no. 2320) Instant non-fat dried milk Substrate (Chromozyme TH) TMB Peroxidase EIA Substrate Kit

Chapter 21: Fibrinopeptide A (FPA) Anti-FPA antiserum Aprotinin (Trasylol) FPA-standard Heparin (Liquemin) Immobilized second antibody (Sac-eel. Wellcome Diagnostics) Monovette (blood collection system) PPACK Tyr-FPA

296

American Diagnostica

American Diagnostica Sigma Boehringer Mannheim Biorad

Imco Bayer Imco Roche

IDS Sarstedt Calbiochem Imco


Suppliers of reagents for the FPA radioimmunoassay Bachem

Imco Kordia Wherl

Chapter 22: Thrombin-antithrombin (TAT) complexes Commercially available kits ELISA Enzygnost TAT Dade-Behring

Chapter 23: Prothrombin fragment FI +2 PPACK

Commercially available kits ELISA Enzygnost Fl +2 micro

Calbiochem

Dade-Behring

Chapter 24: Tissue-type plasminogen activator (t-PA) activity Chromogenic substrate (S-2403) Chromogenix giu-plasminogen Chromogenix

Monoclonal t-PA antibody (B-lO) Stabilyte tubes

Commercially available kits Chromolize tPA Immuno Free t-PA

Standard 86/670

Biopool Imco Biopool

Biopool Corvas

NIBSC

Chapter 25: Tissue-type plasminogen activator antigen (t-PA Ag) Commercially available kits Asserachrom t-PA (ELISA) Coaliza t-PA (ELISA) Imulyse t-PA (ELISA) Innotest t-PA (ELISA) TintElize t-PA (ELISA) t-PA assay kit (ELISA)

Standard 86/670

Diagnostica Stago Chromogenix Biopool Innogenetics Biopool Cabru Imco Monozyme

NIBSC

Chapter 26: Plasminogen activator inhibitor-l (PAl-I) antigen Commercially available kits Asserachrom PAI-l Coaliza PAI-l Imulyse PAI-l (ELISA) PAI:Ag (ELISA) PAI-l ELISA kit

297

Diagnostica Stago Chromogenix Biopool American Diagnostica Monozyme


PAI-l antigen TintElize PAI-l (ELISA)

Standard 92/654

Chapter 27: Plasminogen activity Plasminogen free fibrinogen Streptase Streptokinase Substrate Chromozym PL Substrate S-225l

Standard (gIu-plasminogen) 78/646

Chapter 28: Plasmin inhibitor activity Abnormal control plasma

Methylamine hydrochloride Normal control plasma

Normal reference plasma

Plasmin Substrate S2403 Tween 80

Commercially available kits Actichrome <l2-antiplasmin <l2-antiplasmin

Coamatic Plasmin Inhibitor Berichrome <lrantiplasmin Chromo strate Antiplasmin Orthokrome Antiplasmin Spectrolyse <l2-antiplasmin Stachrome Antiplasmin Unitest <l2-antiplasmin

Chapter 29: Plasmin-arantiplasmin complexes ABTS Antibodies Aprotinin (Trasylol) Benzamidiniumchloride Bovine serum albumin PAP complex depleted plasma PAP complex standard

298

Technoclone Biopool

NIBSC

Imco Dade-Behring Chromogenix Pentapharm Chromogenix

NIBSC

Chromogenix Dade-Behring Sigma Dade-Behring Chromogenix Diagnostica Stago Organon Teknika Diagnostica Stago Biopool Chromogenix

Chromogenix Merck

American Diagnostica Instrumentation Laboratory Chromogenix Dade-Behring Organon Teknika Ortho Biopool Diagnostica Stago Unicorn

Boehringer Mannheim Technoclone Bayer Merck Dade-Behring Technoclone Technoclone


PPACK Thimerosal Tween 20

Commercially available kits PAP kits (ELISA)

Calbiochem Merck Sigma

Dade Behring Technoc1one Teijin

Chapter 30: Soluble fibrin and degradation products of fibrinogen (Fg, fibrin (FbDP; D-dimer) and total of FgDP and FbDP (TDP)

Commercially available kits Coaset Fibrin Monomer D-dimer kits

Fibrinostica soluble fibrin Fibrinostica FbDP Fibrinostica FgDP Fibrinostica TDP Soluble fibrin kit

ADDRESSES

Agen Biomedical Ltd 11 Durbell Street PO Box 391 Acacia Ridge 4110 Brisbane Australia Phone: +61 733706300 Fax: + 61 733706370 Internet: http://www.agen.com.au E-mail: [email protected]

American Biogenetic Sciences 1375 Akron Street Copiague NY 11726 USA Phone: + 1 516 789 2600 Fax: + 1 516789 1661 Internet: http://www.mabxa.com

Chromogenix Agen Biomedical American Diagnostica BioMerieux Diagnostica Stago latron Nycomed

Organon Teknika American Biogenetic Sciences

American Diagnostica Inc. 222 Railroad Avenue PO Box 1165 Greenwich CT 06836-1165 USA Phone: + 1 2036610000 Fax: + 1 203661 7784 E-mail: [email protected]

Avanti Polar Lipids Inc. 700 Industrial Park Drive Alabaster AL 35007 USA Phone: + 1 80022706511 + 1205663 2494 Fax: + 1 800 229 10041 + 1 205 663 0756 Internet: http://www.avantilipids.com E-mail: [email protected]

299


BachemAG Hauptstrasse 144 CH-4416 Bubendorf Switzerland Phone: +4161 93123 33 Fax: +41 61 931 2549 Internet: http://www.bachem.com E-mail: [email protected]

BayerAG 0-51368 Leverkusen Bayerwerk Germany Phone: +49214301 Fax: +492143066411 Internet: http://www.bayer.com

Becton Dickinson 1 Becton Drive Franklin Lakes New Jersey 07417-1885 USA Phone: + 1 201 8474500 Fax: +12018474886 Internet: http://www.bd.com

BioMerieux 376 Chem de L'orme 69280 Marcy L' etoile France Phone: +33 478 87 2000

Biopool International 6025 Nicole Street Ventura CA93003 USA Phone: + 1 805 654 0643 Fax: + 1 805 654 0681 Internet: http://www.biopool.se E-mail: [email protected]

Bio-Rad Laboratories 1000 Alfred Nobel Drive Hercules California 94547 USA Phone: + 1 510 724 7000

Fax: +15107415817 Internet: http://www.biorad.com

Boehringer Mannheim GmbH Sandhofer Strasse 116 Postfach 310120 0-68305 Mannheim Germany Phone: +49 621 759 85 68 Fax: +49 621 75940 83 Internet: http://www.boehringermannheim.com

Cabru Via Caduti per la Patria 47 20050 Lesmo (MI) Italy Phone: +39 39 698 1589 Fax: +39396065174

Calbiochem POBox 12087 San Diego CA 92112-4180 USA Phone: + 1 800 854 3417 Fax: + 1 800 776 0999 Internet: http://www.ca1biochem.com E-mail: [email protected]

Chromogenix AB Taljegardsgatan 3 S-431 53 Molndal Sweden Phone: +46 31 706 2000 Fax: +46 31 864626 Internet: http://www.chromogenix.se E-mail: [email protected]

CorvasInc. 3030 Science Park Rd. La Jolla CA92037 USA Phone: + 1 6194559800

300

Dade-Behring POBox 1149 D-35001 Marburg 1 Germany


USA

Phone: +49 642 39 8880 Fax: +49 642 131388 Internet: http:// www.dadebehring.com

DAKOAIS Produktionsvej 42 DK-2600 Glostrup Denmark Phone: +45 44 85 95 ()() Fax: +45 44 85 95 95 Internet: http://www.dako.dk

Diagnostica Stago 9, Rue des Freres Chausson F-92600 Asnieres sur Seine France Phone: +33146882020 Fax: +33 1479 10891 Internet: http://www.stago.fr E-mail: stago@stagoJr

Enzyme Research Laboratories 300 N. Michigan Street, Suite 103 South Bend IN 46601 USA Phone: + 1 2192882268 Fax: + 12192882272

FMC BioProducts 191 Thomaston Street Rockland Maine 04841 USA Phone: + 1 207 584 3400 Fax: + 1 207 594 3426 Internet: http://www.bioproducts.com E-mail: [email protected]

George King Bio-Medical Inc. 11771 West 112th St. Overland Park KS 66210-4192

Phone: + 1 913 469 5464 Fax: + 1 913 469 0871 Internet: http://kingbiomed.com E-mail: [email protected]

Iatron Laboratories Inc. 1-1, Higashi-Kanda 2-Chrome, Chiyoda-ku Tokyo 101 Japan Phone: 03 38621761 Fax: 03 38621760 Internet: http://www.sosei.coml companies/iatron.html

Immuno Diagnostic Systems Ltd (IDS) Boldon Business Park Boldon Tyne&Wear NE359PD United Kingdom Phone: +44 191 5190660 Fax: +44 191 5190760

!moo Hudiksvallsgatan 4B S-113 30 Stockholm Sweden Phone: +46 833 53 09 Fax: +46872 84 776

Innogenetics NY Industriepark 7 Box 4 B-9052 Zwijnaarde Belgium Phone: +3292410711 Fax: +329241 799 Internet: http://www.innogenetics.be

Instrumentation Laboratory SpA Viale Monza 338 20128 Milan Italy Phone: +39 225 221 Fax: +3922575250

301


KnollAG Knollstrasse 67061 Ludwigshafen Postfach 210805 67008 Ludwigshafen Germany Phone: +49 621 5890 Fax: +496215892896 Internet: http://www.knoll.de E-mail: [email protected]

Kordia bv Oude Singel158 NL-2312 RG Leiden The Netherlands Phone: +31 71 523 1050 Fax: +31 71 5221700 Internet: http://www.kordia.n1 E-mail: [email protected]

MerckKGaA D-64271 Darmstadt Germany Phone: +496151 72 0 Fax: +496151 72 2000 Internet: http://wingate.merck.de E-mail: [email protected]

Monozyme Agemalle3 DK-2970 Hersholm Denmark Phone: +4545572014 Fax:+45 45 76 57 08

National Institute for Biological Standards and Control (NIBSC) Blanche Lane South Mimms Potters Bar Hertfordshire EN6 3QG United Kingdom Phone: +44 1707 654 753 Fax: +44 1707 646 730 Internet: http://www.nibsc.ac.uk E-mail: [email protected]

Novo Nordisk A/S NovoAlle DK-2880 Bagsvaerd Denmark Phone: +45 4444 8888 Fax: +45 4449 0555 Internet: http://www.novo.dk

Nycomed Pharma A/S Sandakerveien 78 PO Box 4220 Torshov N-04010s10 Norway Phone: +4723185050 Fax: +4723186000 Internet: http://www.nycomedamersham.com

Organon Teknika Boseind 15 5281 RM Boxtel The Netherlands Phone: +31 411 6549111 Fax: +31 411 654201 Internet: http://www.akzonobel.coml home.htm

Ortho Diagnostic Systems Inc. 1001 US Highway 202 Raritan 08869-1487 N.J. USA Phone: + 1 908218 1300

Pentapharm Ltd Enge1gasse 109 POBox CH -4002 Basel Switzerland Phone: +41 61 706 4848 Fax: +41 61 3199619 Internet: http://www.pentapharm.ch

Roche Pharmaceuticals F. Hoffmann-La Roche Ltd CH-4070 Basel Switzerland Phone: +41 61 688 11 11 Fax: +41 61 691 93 91 Internet: http://www.roche.com

302


Sarstedt Postfach 12 20 D-51582 Niimbrecht Germany Phone: +49 2293 3050 Fax: +492293 305 122 Internet: http://www.sarstedt.com

Serbio PAE Parispace 3 125 Avenue Louis Roche 92230 Gennevilliers France Phone: +33141471500 Fax: +33 147987337

Serva Boehringer Inge1heim Bioproducts Partnership Branch Germany/Headquarters Czernyring 22/11 D-69115 Heidelberg Germany Phone: +49 6221 59 8300 Fax: +496221 598313 Internet: http://www.bibioproducts.de E-mail: [email protected]

Sigma Chemical Company PO Box 14508 St. Louis MO 63178 USA Phone: +13147715765 Fax: +13147715757 Internet: http://www.sigma.sial.com E-mail: [email protected]

Technoc1one GmbH Millinergasse 23 Postfach 158 A-1092 Vienna Austria Phone: +43 1 3422 80 Fax: +43 1 3195278

Teijin Ltd Uchisaiwai-cho 2-1-1 Chiyoda-ku Tokyo 100 Japan Phone: +81 335064892 Fax: +81 335082767

Terumo Europe NY Interleuvenlaan 40 3001 Leuven Belgium Phone: +32 16381211 Fax: +32 16229104

Unicorn Diagnostics Ltd. London United Kingdom TeVFax: +44 181 559 1006

WherlGmbH Halchtersche Strasse 49 D-38304 Wo1fenbuettel Germany Phone: +49 533195610 Fax: +49 5331956113 Internet: http://www.wherl.com E-mail: [email protected]

303

Index

accuracy 4 activated partial thromboplastin time [AP1TJ

APe resistance 163 ANT 37 blood collection 24 lupus anticoagulant 183 protein C activity and antigen 129 quality assessment 32, 35

activated protein C (APC) protein C activity and antigen 129 protein S activity 153 protein S antigen 141

activated protein C (APC) resistance APe resistance 163 prothrombin fragment Fl +2 218 quality assessment 36

acute pancreatitis 191 amyloidosis 260 angina pectoris

FPA 199 protein C activity and antigen 131 prothrombin fragment F1 +2 218 t-PA activity 227 venous occlusion test 285, 286

annexin V 183 a.-antiproteinase 130 anticardiolipin antibodies 183, 184 antiphospholipid antibodies 159, 183 a2-antiplasmin 257 antithrombin

antithrombin activity and antigen 121 quality assessement 32, 36 TAT complexes 209

arterial ischaemic events 231 arterial thrombosis 124, 142 atherosclerosis 118 autoimmune disease 183, 184

biliary obstruction 46 bleeding

ANT 38 factor VII activity and antigen 99 good medical laboratory services 9 introduction 3 PAI-1 antigen 239 plasmin-a-antiplasmin complexes 266 quality assessment 31 t-PA antigen 232

blood collection 21 blood pressure 227 blood sampling 21

C4b binding protein (C4bBP) 142, 153 cancer 159 cardiovascular disease

factor VII activity and antigen 99 fibrinogen 80,81 introduction 3

cathepsin G 189, 196 central nervous system thrombosis 130 central ophthalmic thrombosis 130 cerebral infarction 199 cerebral vein thrombosis 124 cerebrovascular diseases 164 chemotherapy 213 cholesterol 177 chronic renal failure 191 chymotrypsin 189,196 cold activation 95 coronary artery disease

305

endogenous thrombin potential 77 fibrinogen 80 plasmin-a-antiplasmin complexes 272 soluble fibrin and degradation products of

fibrinogen 282


TAT complexes 212 CTAJ) 25,26,234

D-dimer 36, 275 DDAVP 232 deep vein thrombosis

antithrombin activity and antigen 124 APTT 40 endogenous thrombin potential 77 FPA 199 protein S antigen 143 prothrombin fragment Fl +2 218 soluble fibrin and degradation products of

fibrinogen 279,282 TAT complexes 211,213 t-PA antigen 232

diabetes mellitus FPA 200 heparin cofactor II 191 protein C activity and antigen 131 protein S antigen 143 prothrombin fragment Fl +2 218 t-PA activity 227 von Willebrand factor 118

disseminated intravascular coagulation (DIC) antithrombin activity and antigen 126 APTT 40 factor VIII clotting activity 112 fibrinogen 80, 85 FPA 199 heparin cofactor II 191 plasmin inhibitor activity 260 plasmin---a-antiplasmin complexes 265,

266 protein C activity and antigen 131 prothrombin fragment Fl+2 218 TAT complexes 213 TFPI 173

DNA analysis 27 dysfibrinogenaenlia 80,277

eclampsia 282 elastase---al-antiproteinase complex 209 elastase 196, 260 EN 45001 10 EN 46001 14 EN 46002 14 evacuated tubes 24, 42, 226

factor V Leiden 25,130,213 factor VII 26, 31 factor VIII

APC resistance 163,164 APTT 43 blood col1ection 22, 23, 25, 26 factor VIII clotting activity 107 quality assessment 32, 33, 36 von Willebrand factor 117

factor VIII inhibitors 185 factor XII 3 familial thrombophilia 130 fibrin monomer 276 fibrin(ogen) degradation products 36,276 fibrinogen

fibrinogen 79 introduction 1 quality assessment 31, 36 soluble fibrin and degradation products of

fibrinogen 276 fibrinopeptide A (FPA) 199,217

good laboratory practice 3, 9 good medical laboratory services (GMLC) 9

haematocrit 22 haemophilia A

activated factor VII 91 factor VIII clotting activity 112 von Willebrand factor 118

HDL cholesterol 227 heart disease 90 heparin cofactor

antithrombin activity and antigen 121 APC resistance 165 APTT 37,38,39,43 blood collection 23 endogenous thrombin potential 67 fibrinogen 85 heparin cofactor II 189 lupus anticoagulant 186 PT 47 quality assessment 36 soluble fibrin and degradation products of

fibrinogen 277,282 TFPI 172

hepaticfailure 191 hirudin 190 histidine-rich glycoprotein 247 hormone replacement 159 human immunodeficiency 191 human leuserpin-2 189 hypercholesteroiaemia 173, 213 hyperiipaemia 85 hyperlipoproteinaemia 260 hypertension 118, 131

infections 184 inflammatory diseases 112, 118 INR 24, 35, 36, 133 insulin 286 insulin resistance 227 ischaenlic heart disease 90 international sensitivity index (lSI) 54, 59 ISO 25 11,12 ISO 9001 14 IS09002 14

306

INDEX

kallikrein 231

L-asparaginase 126,131,260 leukaemia 213, 260 lifestyle variables 22 lipids 286 ~-lipoproteinaemia 173 liver cirrhosis

antithrombin activity and antigen 125 FPA 200 soluble fibrin and degradation products of

fibrinogen 282 t-PA activity 227 von Willebrand factor 118

liver disease APTI 40 protein C activity and antigen 131 protein S activity 159 protein S antigen 143 prothrombin time 47,60 soluble fibrin and degradation products of

fibrinogen 282 TAT complexes 213

liver function 46 liver transplantation 282 lupus anticoagulant

APC resistance 165 APTT 37,38 quality assessment 36

Ilrmacroglobulin 65, 130, 260 malignancy 213,282 menopausal status 124 mesenteric vein thrombosis 124 myocardial infarction

FPA 199 plasmin-a-antiplasmin complexes 266,

272 prothrombin fragment Fl +2 218 soluble fibrin and degradation products of

fibrinogen 282 TAT complexes 213 t-PA activity 227 venous occlusion test 286

nephropathy 227 nephrotic syndrome

antithrombin activity and antigen 126 heparin cofactor II 191 plasmin inhibitor activity 260 protein C activity and antigen 131 protein S activity 159 protein S antigen 143

oral anticoagulants antithrombin activity and antigen 124,

126 APC resistance 164

APTT 39 endogenous thrombin potential 77 FPA 200 heparin cofactor II 191 protein C activity and antigen 131 protein S antigen 143 prothrombin fragment FI +2 218 prothrombin time 47

plasmin 276,286 plasmin inhibitor 231,247,257 plasmin~-antiplasmin complexes 265 plasminogen 2,25,36,247 plasminogen activator (t-PA)

blood collection 25 introduction 3 PAl-l antigen 239 plasmin inhibitor activity 260 plasmin-a-antiplasmin complexes 265 t-PA activity 223 t-PA antigen 231 venous occlusion test 285, 288, 289

plasminogen activator inhibitor-I (PAl-I) blood collection 25 PAl-I antigen 239 t-PA activity 223 venous occlusion test 286, 288, 289

platelet factor 3 26 platelet factor 4 26 polybrene 47 post-infectious 159 post-surgical patients

antithrombin activity and antigen 126, 131

factor VIII clotting activity 112 plasmin inhibitor activity 260 TAT complexes 213 t-PA activity 227 von Willebrand factor 118

pre-analytical factors 4 pre-analytical variation 21 precision 4, 6 pro-urokinase system 3 proficiency testing 32 protein C 32, 36, 129 protein S 36, 141, 153 prothrombin fragment Fl +2 209,217 prothrombin time (PT)

APTT 37 factor VII activity and antigen 100, 103 fibrinogen 83 good medical laboratory services 24 introduction 2, 4 lupus anticoagulant 183 prothrombin time 45 quality assessment 32, 35 TFPI 172

PTCA 272

307


pulmonary embolism antithrombin activity and antigen 124 soluble fibrin and degradation products of

fibrinogen 279,282 TAT complexes 211,213

pulmonary thrombosis 199 purpura fulminans 130, 142

quality assessment 1, 10, 14, 18,29,30,32, 39

quality management 11,12,14,17

renal failure 191,260 respiratory distress syndrome 218 ristocetin cofactor 115

sample preparation 21 sepsis 212 Shewhart plots 10 sickle-cell disease 131 soluble fibrin 275 spontaneous abortions 184 Stabilyte 25, 226 streptokinase

plasmin-u-antiplasmin complexes 266 plasminogen activity 247 soluble fibrin and degradation products of

fibrinogen 276,282 stroke 183, 266 surgery

antithrombin activity and antigen 124 APTf 40 heparin cofactor II 191 prothrombin fragment Fl +2 211 prothrombin time 47

systemic lupus erythematosus (SLE) 183

thrombin-antithrombin (TAT) complex 209, 217

thrombin 1 thrombocytopenic purpura 118 thromboembolic disease 183 thromboembolism 286 thrombomodulin 65, 129 thrombophilia 3 thromboplastin

activated factor VII 89

AP1T 37 blood collection 21 introduction 2, 4 protein S activity 157 prothrombin time 45, 56 quality assessment 36

thrombosis antithrombin activity and antigen 125 APC resistance 167 soluble fibrin and degradation products of

fibrinogen 280 TFPI 173 t-PA antigen 232

Thrombotest 51 thrombotic diseases 90,239,276 tissue factor pathway inhibitor (TFPI) 65,

99,171 total quality management (TQM) 10 triglycerides 227

urokinase-type PA 239,260 unstable angina

TAT complexes 213 TFPI 182

uraemia plasmin-u-antiplasmin complexes 266,

270 plasminogen activity 247 soluble fibrin and degradation products of

fibrinogen 282 venous occlusion test 286 von Willebrand factor 118

venous occlusion test 285 venous thromboembolism 164 venous thrombosis

antithrombin activity and antigen 121 lupus anticoagulant 183 protein S antigen 142 venous occlusion test 285 von Willebrand factor 130

vitronectin 239 von Willebrand disease 118,232 von Willebrand factor 22, 36, 115

warfarin 47,91 Westgard rules 10

308

list of manufacturers - springer978-94-011-4722-4/1.pdf · laboratory techniques in thrombosis - a...

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