LIPID METABOLISM

HYDROLYSIS

ADIPOSE TISSUE•90% of adipose tissue is tryglycerides

•It supplies energy.

•Insulation.

•Provides minor physical protection

•Cholestrol storage

GLYCEROLGLUCOSE

PYRUVATE

GLY

CO

LYS

IS

FATTY ACIDS

•Activation of Fatty Acid

-OXIDATION

Blue box = carbonRed box = acetyl CoA

-OXIDATION

1. Activation by addition Coenzyme-A

2. carbon oxidized from CH2 to C=O (ketone)

3. Molecule split into acetyl CoA and Fatty acid 2 carbons shorter

4. Another Coenzyme-A added to shortened Fatty acid

• Each cycle produces 1 acetyl-CoA– 18 carbon fatty acid would give 9 acetyl-CoA

• Cycles required is # of carbons/2 – 1– 18 carbon fatty acid would require 8 cycles

• Amount of energy from Fatty Acid depends on length of carbon chain– 18 carbon fatty acid would 120 ATP

LIPOGENESIS• Making triglycerides from glycerol and fatty

acids

• Anabolic process

• Fatty acids made linking 2 carbon acetyl groups (from acetyl CoA) to growing chain

• Most Fatty acids have an even number of carbons

ESSENTAIL FATTY ACIDS

•Those needed by the body, but not synthesized within the body in adequate amounts.

•Found in fish and some plants

GLUCOSE TRIGLYCERIDES

PYRUVATE

GLYCEROL

ACETYL-CoA

glycolysis

gluc

oneo

gene

sis

-ox

idat

ion

lipog

ensi

s