LIMITLESS-LEDLED THERAPY LIGHT

RED LIGHT620-700NM

RED LIGHT-EMITTING DIODE (LED) TheraPhoton ASSISTED HEALING IMPROVES RESULTS OF FACIAL SKIN FRACTIONAL RESURFACING

Mario A. Trelles MD PhD, Instituto Medico Vilafortuny, FUNDACION ANTONI DE GIMBERNAT, E-43850 - Cambrils, Tarragona (SPAIN)

INTRODUCTION Laser ablative resurfacing is an effective method for rejuvenating photo- damaged facial skin but it is often associated with several weeks of burn-related sequelae. When ablative resurfacing is practised in the so-called fractional mode, the Er: YAG recovery time is shortened and there are fewer post-operative complications. TheraPhoton(LED) phototherapy is a new; proven method for the accelerated healing of wounds, post surgery (1). These beneficial effects may help to further shorten the post operative downtime after ablative fractional laser. This study looks at the effects of LED therapy on the rate of recovery time, post fractional Er:YAG resurfacing. MATERIALS & METHOD Patients Forty females mean age 52 years were treated, (4 full face, 10 periocular and 26 perioral). Skin photo types were: 5, type II; 29, type III and 6, type IV. All patients were treated in the fractional mode with the Er:YAG laser for skin resurfacing. Forty patients, matched for age, skin type and treatment location, who had previously undergone the same fractional Er: YAG laser ablative resurfacing methodology, but without using LED therapy post operatively, were retrospectively selected for comparison. Details of the treatment were explained to all patients and all signed a form of consent for surgery and use of clinical photography. Patients in the retrospective group were already covered by written informed consent. The Ethics Committee of the Antoni de Gimbernat Foundation approved the treatment protocol and method of collection of data.Er:YAG laser for fractional resurfacing The Er:YAG Pixel laser system (Alma Laser™, Israel) is equipped with a lens splitter to divide the Er:YAG 2940 nm beam into various microbeams. The area of treatment is an 11 x 11 mm square which produces 49 to 81 microbeams defining the treatment beam density. The energy programme is based on pulse length, delivering from 800 mJ/cm2 to 1400 mJ/cm2 at short and long pulse duration, respectively. Treatment can be given without the use of anaesthesia and repeated laserpasses leads to heat accumulation in tissue, which is directly correlated to pain sensation experienced at the time of laser shots. Therefore, the use of topical anaesthesia is recommended for higher energy densities or when various laser passes are planned for treatment. Long pulse programme and 8 passes were used for those skins presenting grade III wrinkles (more RTD to trigger new collagen formation), compared to between 800 mJ/cm2 and 4 passes, or 1000 mJ/cm2 and 6 passes for those presenting with grades I & II, wrinkles respectively.Phototherapy Unit Both groups were treated with the same protocol with the Er:YAG laser in fractional mode but, in one group only, patients were treated after resurfacing with the Omni lux LED based phototherapy system (Photo Therapeutics Ltd., Fazeley, Tamworth, UK) which consists of a base unit fitted with interchangeable LED array-treatment heads of different wavelengths. The panels on the head are articulated to allow the head to follow the contours of the face. Following Er:YAG laser fractional ablative resurfacing, light at 830 +/- 5 nm (near infrared) and at 633 +/- 3 nm (visible red) was alternately delivered from interchangeable heads (Omni lux plus™ and Omni lux revive™). In total 5 treatments were delivered daily, on days 1-3 and days 5 & 7.RESULTST issues healing time and post operative symptoms were recorded using an analogue scale. The scale (a standard scale used by the Instituto Medico Vilafortuny) was identical to that used in the prospective study. Healing time in the LED treatment group post Er: YAG fractional resurfacing was around 60% faster and symptoms were less apparent compared with the reference group. At the moment of skin healing, skin surface aspect was better in the LED treated group with a more natural appearance, according to the opinion given by personnel involved in and familiar with this type of treatment.

STIMULATING MITOCHONDRIAL ENERGY PRODUCTION

While the exact mechanisms are still debated, most researchers believe that nitric oxide (NO) plays a central role.

NO of course plays many vital roles in the body, but when we have too much of it, too much in the wrong place, or when our cellsdon’t have the antioxidant capacity to quell the buildup of NO, it can hinder ATP from being manufactured in the mitochondria.

How?

Well, nitric oxide begins to compete with oxygen in the mitochondria.In fact, NO binds with cytochrome c — preventing it from binding with . It basically blocks the oxygen from being used by the mitochondria. Because of this, the NO inhibits efficient ATP production.

Therefore, in unhealthy cells, nitric oxide prevents cytochrome c from getting enough oxygen molecules. This hinders ATP production, which is a recipe for poor mitochondrial function, and thus, poor cellular function.As shown by several research groups around the world, red and near-infrared light essentially prevents this pairing of NO with

cytochrome c oxidase. It knocks the NO out and lets the oxygen in!

In essence, photobiomodulation allows oxygen into the mitochondria (and prevents NO from halting energy production).

This boosts mitochondrial function and helps improve the health of every organ and system in our body.

Technology RED THERAPY LIGHT

DISCUSSION Combined LED therapy with Er:YAG fractional resurfacing significantly reduces healing time, decreases pain and discomfort and enhances quality of skin aspect of fractional resurfaced photoaged facial skin. Fractional resurfacing stimulates collagen formation through the primary effects of RTD. RTD results in a wound repair process with repercussion son fibroblast activity and hence fibre formation. This primary effect, added to epidermis renewal due to Er:YAG fraction al ablation, is enhanced by LED therapy. Combinations of quasi monochromatic light at 633 and830 nm, have been shown to stimulate collagen formation, stimulate fibroblast and T homing cell activity and improve globalskin parameters (2- 4). Accelerated wound healing using Lowincident doses of laser energy,(LLLT) has been well documented (5-7), its transformation to LEDs, although a novel approach is becoming an exciting new application. (6). CONCLUSIONS LED therapy after Er:YAG laser fractional resurfacing accelerates skin healing controlling side effects such as pain, discomfort, fine scabbing and oedema. Erythema and skin condition seem to also benefit from this LED therapy following Er:YAG laser fractional ablative resurfacing of photoaged skin.ACKNOWLEDGEMENTST he author declares no financial or other interest in the companies and/or equipment's mentioned in this study. The preliminary conclusions of this study are registered in the academic activities of the FUNDACION ANTONI DE GIMBERNAT year 2006-2007.

TheraPhoton Application and Features

Application:•Repair and nurse the damaged skin.•Improve symptoms such as aging and loosening skin, big pore, slender wrinkles.•Improve pigmentary pathological changes, such as freckle, sunburn, senile plaques.•Improve dark complexion caused by bad metabolism or poor circulation.•Do detumescence, inflammation diminishing and scar elimination treatment for oil acne effectively.

Features:Natural beauty machine uses the LED light TheraPhoton to accelerate the skin circulation for anti-aging, no side effect, healthy and safe.A skin care tool for you, which can lighten pigmentation, fade spot, repair skin, deep nutrition.TheraPhoton technology, combines 7 colors led light which has different wave length for light treatment of skin problem, helping to regain the young look.Can effectively diminish wrinkles and sagginess, shrink pores, improve oily skin, enhance and tighten the skin, as a result of achieving the white, tender, elastic and young skin.This short-time TheraPhoton is easy to use, non-risk of burning, comfortable and painless. Exquisite appearance and also unique design, suitable for treating acne, facial red, smallpox mark, pores and removing blackheads.

TheraPhoton Device

Package Includes:

-1 x Main Machine-1 x Black eyepatch-1 x Power Adapter-1 x User Manual

Technology

LASER Vs TheraPhoton-CXX LED

Figure 1 Demonstrating histological and skin aspect changes after progressive passes of fractional Er:YAG laser. Notice progressive epidermal elimination, which increasingly produces more RTD as demonstrated in figures corresponding to 6 passes.

Full face Fractional Er:YAG resurfacing LED therapy. Central image clearly shows extensive scabbing 3 days post surgery as a result of various laser passes which result in dermal RTD.6 day image clearly demonstrates complete healing and practically no residual erythema after exposure to TheraPhoton CXX LED

TheraPhoton-C X X

Details

Type: TheraPhoton PDT Certification: CEBrand Name: LIMITLESS-LED Model Number: B-8Feature: Acne Treatment, Blood Vessels Removal, Pigment Removal, Power:120WRadiate Energy: 10000mw Light Source: LED LightLamp Number: 1080PCS Power radiate intensity: 6 Grade AdjustableLight color: 7 colors light Wavelength: Red:640n, Blue: 470 nm, Yellow: 590nm,Red And Blue: 640nm etcCapacity: ≥350j/cm2 warranty: Full 3 years

Point Size: 350*480mm

PRODUCT DETAILS

7 Colors PDF Led Light Mask Skin Rejuvenation Photon Device Acne Remover Anti-Wrinkle MaskIntroduction of PDT:Dynamical TheraPhoton is a new technology, using the photon power to do skin maintenance and treatment, transfer light energy to cell energy, then accelerate cell growth and blood circulation, stimulate fiber cells to produce collagen proteins, increase skin elasticity and take important part in rehabbing aging and acne skin, improve freckles.Promoting the growing of collagen to whiten and brighten skin and reduce fine lines or wrinkles, shrinking pores to tighten the skin and improving skin color to let skin become more smooth and elastic.Firming, lifting and tightening the skin restores elasticity, improves skin texture, smoothes wrinkles and improves pore.

How Does PDT Light WorkLED offer a totally natural, non-ablative method for skin rejuvenation. The light from the LED interacts with cells and stimulates them to produce new collagen and elastin bio light therapy (TheraPhoton). Studies confirm that the same LED energy can be used to inhibit collagen formation, By manipulating the wavelengths, cells can be turned on and off.Red light are used for photo dynamic TheraPhoton.Blue light are used in the treatment of acne.Green light reduce melanin cell, decreased pigment.Yellow light are used for photo-rejuvenation.

TheraPhoton Function and Specification

Function:To improve symptoms such as aging, loosening skin, big pore and slender wrinkles.To improve pigmentary pathological changes, such as freckle, sunburn and senile plaques.To improve dark complexion caused by bad metabolism or poor circulation. To repair and nurse the damaged skin. Do detumescence, inflammation diminishing and scar elimination treatment for oil acne effectively.Benefits: Skin Rejuvenation, reduce fine lines, black spots- removal, enhance skin elasticity, shrinking pores, clean skin deeply.

Specification:Item Type: Relaxation TheraPhoton DeviceVoltage:AC100-240VTechnology: PDT,LEDPower:100-220V 50HzInput:DC 12V 2AColor:7 colorsTime:5-60 minutes

TheraPhoton-X X X IIM

Details

Type: PDT TheraPhoton Certification: C0E, ROHS

Brand Name: LIMITLESS-LED Model Number: TheraPhoton

Feature: Skin Tightening, Pigment Removal, Acne Treatment, Skin Rejuvenation, Wrinkle Remover

Product name: 7 color led facial mask Function: Skin Care

LED Color: 7 Colors PDT Led Light

Application: Beauty Center Technology: Led Light Therapy

Net weight: 1.1 Kg Keyword: led mask

Style: Neck face Working voltage: 100~240V

Description: Skin Rejuvenation Photo facial Device

TheraPhoton-LEDBED

Type: PDT TheraPhoton Model Number: 216

Feature : Skin Tightening, Pigment Removal, Acne Treatment, Skin Rejuvenation, Wrinkle Remover, stimulates collagen growth

Color: Pearl White ( Color Option ) Function: Anti Aging

Product name: LEDBED Collagen Bed Lamp: LEDBED

Voltage: 110-380V Warranty: 3 Years

Service: OEM ODM Canopy: 16*100W

Bench:12*100W

TheraPhoton-X X X II

Model Number TheraPhoton-X X X II

Brand Name LIMITLESS-LED

Output Power 32W

Light Source Led light

Operation Modulation

Red, Blue & IR

Wave lengthRed light: 640nm; Blue light: 423nm; IR light:

830nm

Led Qty 290 pcs

Material of shell PC

Time Setting 5-60 minutes

Control Mode Button control

Input Voltage AC100-240V

Work Voltage DC12V 3A

Dimensions 473(W)*484 (D)* 343 (H) mm

Warranty Full 3 years

Weight G.W: 4.5Kg N.W:2.29Kg

TheraPhoton-HM

•Item Type: Hair Loss Product•Quantity LED: 64-68 hair growth products diode•NET WT: 1kg•Wave Lenght: 650nm•Model Ref: TheraPhoton Helmet•Brand Name : LIMITLESS-LED•Power Consumption : 15W•Warranty : Full 3 Years

TheraPhoton-Bar

Technology Wavelength Effects

Red LED 640nm/1-6mmRejuvenation & Lighten

wrinkles and acne marks

Yellow LED 583nm/1-2mm Improve erythema and redness

Green LED 523nm/0.5-2mmDeep repair & White skin

rejuvenation

Blu-ray 423nm/1mmBalanced secretion & Control

grease

White LED(Laser light) 510nmDecomposition stain & Improve

fine lines

Blue & Green LED 490nmCalming skin & Balanced

secretion

Purple LED 400nmRepairing acne & Lightening

spot

Lamp Power 600W

PDT TheraPhoton Light

LED offer a totally natural, non-ablative method for skin rejuvenation. The light from the LED interacts with cells and stimulates them to produce new collagen and elastin bio light therapy. Studies confirm that the same LED energy can be used to inhibit collagen formation, By manipulating the wavelengths, cells can be turned on and off.

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LIMITLESS-LED

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