levoplant - fiapac · 2018. 10. 19. · implants nexplanon jadelle levoplant rods 1 2 2 progestin...
TRANSCRIPT
![Page 1: Levoplant - FIAPAC · 2018. 10. 19. · Implants Nexplanon Jadelle Levoplant Rods 1 2 2 Progestin Etonogestrel 68 mg Levonorgestrel 75 mg/rod Levonorgestrel 75 mg/rod Length 4 cm](https://reader036.vdocuments.site/reader036/viewer/2022071215/6045016af6b1ed06de5ab5aa/html5/thumbnails/1.jpg)
LevoplantLevonorgestrelSubdermal
ContraceptiveImplant
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WhatisLevoplant?• Twosmall,flexiblerods
• eachaboutthesizeofamatchstick• Highlyeffectivecontraceptionfor3years• canbeinsertedanytimeaslongasthewomanisnotpregnant
• WorldHealthOrganizationprequalifiedcontraceptiveimplant
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Implants
Nexplanon Jadelle Levoplant
Rods 1 2 2
Progestin Etonogestrel68 mg
Levonorgestrel75 mg/rod
Levonorgestrel75 mg/rod
Length 4 cm 4 cm 4 cmDiameter 2 mm 2.4 mm 2.4 mm
Plastic ethylene vinyl acetate Silastic* Silastic*
Approved duration of use 3 years 5 years 3 years
*Polidimetilsiloxanoycopolímero demetilvinilsiloxano
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Effectiveness• Levoplant isoneofthemosteffectivecontraceptivemethodsavailable
• Sustainedreleaseofverylowdoseoflevonorgestrelintothebloodstream
• Fewerthan1pregnancyper100women(<1%)occursinthefirstyear
• Forheavierwomen(>80kg),effectivenessofLevoplantmaydecreaseneartheendofthedurationofuse.
• ConsiderreplacingtheirLevoplant implantssoonerthan3years
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ModeofAction
Primarymodeofaction:• Productionofthickcervicalmucuswhichpreventsspermpenetration• Inhibitionofovulation– inabout50%ofmenstrualcycles
Othersecondaryactions:• Decreasenaturalprogesteroneproductionbytheovaryduringthepostovulatory(luteal)phaseeveninthosecyclesinwhichovulationoccurs
• Suppressionofendometrialgrowth(hypoplasia)
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EfficacyYear Cumulative
Pregnancy Rate
1 0.0-0.1%
2 0.2-0.3%
3 0.0-0.3%
4 0.9-1.1%
5 0.7-2.1%
Steiner, Contraception, 2010
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BenefitsofLevoplant• Long-lasting,safeandeffective• Effectivewithin24hoursofinsertion• Doesnotrequireanyfurtheractionafterinsertion• Almostimmediatereturntofertilityonceremoved• Limitedsideeffects• Convenient– doesnotinterferewithnormalactivities,sexualdesire,orintercourse
• Noroutinereturnvisitisrequireduntiltimeofremoval• Noestrogen
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Disadvantages
• Needatrainedserviceproviderforinsertionandremoval• Changesinmonthlybleedingpatterns• Implantsmaybevisibleunderskin• Doesnotpreventsexuallytransmittedinfections(STIs)
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WhocanuseLevoplant?• Levoplant issafefornearlyallwomen:
• Anyage– teenstoover40years• Withorwithoutchildren• Marriedorunmarried• Recentabortion,miscarriage,orectopicpregnancy• Smokers,regardlessofageornumberofcigarettessmoked• Breastfeeding(canuseLevoplant at6weeksafterchildbirth)• HIVpositive(whetheronantiretroviraltherapyornot)
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WhocannotuseLevoplant?
• Levoplant isNOTsuitableforwomenwho:• Maybepregnant• Haveunexplainedvaginalbleeding• Haveasevereliverinfectionortumor• Areonspecialmedication• Haveahistoryofbreastcancer• AllergytolevonorgestrelorothercomponentofLevoplant
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Precaution:DrugInteractions
Somedrugsdecreasetheeffectivenessofimplants:
• Anti-epilepsydrugs• Barbiturates(phenobarbital)
• Phenytoin• Carbamazepine• NOTvalproic acid
• Antibiotics:• Rifampin• Griseofulvin
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Sideeffects:irregularbleedingpattern
• 800mgibuprofen3timesdailyaftermealsfor5days.• Giveclientcombinedoralcontraceptiveswithethinylestradiolandlevonorgestrel.
• Onepilldailyfor21days.• Or50μg ethinyl estradioldailyfor21days
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TreatmentofBleedingEpisodes
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Sideeffectsandtheirmanagement(1)SIDEEFFECTS MANAGEMENT
Changes inmenstrualbleedingpattern
800mgibuprofen3timesdailyaftermealsfor5days.Giveclientcombinedoralcontraceptiveswiththeprogestinlevonorgestrel.Askhertotakeonepilldailyfor21days.Or50μgethinyl estradioldailyfor21days
Nausea Try localremediesHeadaches Forregular,notmigraine,headaches,suggest:
• aspirin(325–650mg)• ibuprofen(200–400mg)• paracetamol(325–1000mg)Orotherpainreliever.
Dizziness Suggestirontablets,multivitamins
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Sideeffectsandtheirmanagement(2)SIDEEFFECTS MANAGEMENT
Abdominal pain Mildabdominalpain,youcansuggest:• aspirin(325–650mg)• ibuprofen (200–400mg)• paracetamol(325–1000mg),orotherpainreliever.Forsevereabdominalpain:• Investigateforectopicpregnancy• Referatonceforimmediatediagnosisandcare.
Weightchange Reviewdietandexercisepracticesandchanges andcounselaccordingly
Breasttenderness Wearingasupportive bra(dayandnight).Suggest: aspirin(325-650mg), ibuprofen (200-400mg),paracetamol(325-1000mg),orotherpainreliever
Moodchange Ifectopic pregnancyorotherserioushealthcondition issuspected, referatonceforimmediatediagnosisandcare.
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Levoplant vsJadelle (1)Levoplant Jadelle
Activeingredient Levonorgestrel Levonorgestrel
Numberof rods 2 2
Durationofuse WHOqualified for3yearsofuse WHOqualified for5yearsofuse
Insertion Sub-dermal insertion inVshapewithtrocar Sub-dermal insertion inVshapewithtrocar
Removal Suggested touseCrile/Kellyforcepsforbothstabilizationandremoval;howeveruseofMosquito forcepsisalsoacceptable
Suggested touseMosquito forcepstostabilizeandCrile/Kellyforcepstoremovetherods
Howitworks 1. Prevents ovulation, sonoeggcanbefertilized
2. Thickenscervicalmucus(blockssperm)
1. Prevents ovulation, sonoeggcanbefertilized
2. Thickenscervicalmucus(blockssperm)
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Levoplant vsJadelle (2)Levoplant Jadelle
Howwellitworks Very effective.<1pregnancyper100usersovertimeused
Very effective.<1pregnancyper100usersovertimeused
Sideeffects Bleeding irregularities:noneatall,regular,infrequent, heavyorprolonged orirregularlasting8daysormoreespeciallyinfirstyear
Other: Headaches,abdominalpain,breasttenderness
Bleeding irregularities:noneatall,regular,infrequent, heavyorprolonged orirregularlasting8daysormoreespeciallyinfirstyear
Other: Headaches,abdominalpain,breasttenderness
Usein women>80kg Yes,though replacementbeforemaximumtimemayassurecontinuedeffectiveness
Yes,though replacementbeforemaximumtimemayassurecontinuedeffectiveness
Useduringbreastfeeding
Yes Yes
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Questions?
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LevoplantMedicalEligibilityClientScreeningandTimeofInsertion
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Objectivesofthesession
Bytheendofthesession,participantswillbeableto:• DescribemedicaleligibilityofclientsintendedtouseLevoplant• Screenclientsusingchecklist• Useclinicaljudgmentinspecialcases• AdvisewhenappropriatetoinsertLevoplant
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MedicalEligibilityinClientScreeningAsktheclientthefollowingquestions:1. Areyoubreastfeedingababylessthan6weeksold?2. Doyouhavecirrhosisoftheliver,aliverinfection,orlivertumor?3. Doyouhaveaproblemnowwithabloodclotinyourlegsorlungs?4. Doyouhavevaginalbleedingthatisunusualforyou?5. Doyouhaveorhaveyoueverhadbreastcancer?IftheanswerisNO toallofthese,thenproceedforfurtherstepsinscreening.
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ClinicalJudgmentinSpecialCasesWomenwithanyoftheconditionsbelowshouldNOTuseLevoplant:1. Breastfeedingandlessthan6weekssincechildbirth2. Severeliverdisease,infection,ortumor3. Acutebloodclotindeepveinsoflegsorlungs4. Unexplainedvaginalbleeding5. Hadbreastcancermorethan5yearsagoandithasnotreturned6. SystemicLupusErythematosuswithpositive(orunknown)anti-
phospholipidantibodies
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WhentoInsertLevoplant
IMPORTANT:AwomancanstartusingLevoplant anytimeshewantsifitisreasonablycertainsheisnotpregnant.UsethePregnancyRule-OutChecklisttobereasonablycertainsheisnotpregnant.
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Woman’ssituation Whentostart
Havingmenstrual cyclesorswitchingfromanon-hormonalmethod
Ifsheisstartingwithin7daysafterthestartofhermonthlybleeding, noneedforabackupmethod.
Ifitismorethan7daysafterthestartofhermonthlybleeding, shecanhaveLevoplant insertedifreasonablycertainsheisnotpregnant.Shewillneedabackupmethod forthefirst7daysafterinsertion.
IfswitchingfromanIUD,shecanhaveLevoplant inserted immediately.
Switchingfromahormonalmethod
Immediately,ifshehasbeenusingthehormonalmethodconsistentlyandcorrectlyorifitisotherwisereasonablycertainsheisnotpregnant.Noneedtowaitforhernextmonthlybleeding.Noneed forabackupmethod.
Ifsheisswitchingfrom injectables,shecanhaveLevoplant insertedwhentherepeatinjectionwouldhavebeengiven.Noneedforabackupmethod.
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Woman’ssituation Whentostart
Fully ornearlyfullybreastfeeding• LESS than6monthsafterchildbirth
Ifshegavebirth lessthan6weeksago,delayinsertionuntilatleast6weeksaftergivingbirth.
IfhermonthlybleedinghasNOT returned, Levoplant canbeinsertedanytimebetween6weeksand6months.Noneed forabackupmethod.
Ifhermonthlybleedinghasreturned, shecanhaveLevoplantinsertedasadvisedforwomenhavingmenstrualcycles (onpreviouspage).
Fullyornearlyfullybreastfeeding• MORE than6months afterchildbirth
IfhermonthlybleedinghasNOTreturned, shecanhaveLevoplantinsertedanytimeitisreasonablycertainsheisnotpregnant.Shewillneedabackupmethod forthefirst7daysafterinsertion
Ifhermonthlybleedinghasreturned, shecanhaveLevoplantinsertedasadvisedforwomenhavingmenstrualcycles
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PregnancyRule-OutChecklistforLevoplant
NO 1.Didyourlastmenstrual periodstartwithin thepast7days? YES
NO 2.Haveyouabstainedfrom sexualintercoursesinceyour lastmenstrualperiodordelivery? YES
NO 3.Haveyoubeenusingareliablecontraceptive methodconsistentlyandcorrectlysinceyourlastmenstrualperiodordelivery?
YES
NO 4. Haveyouhadababyinthelast4weeks? YES
NO 5.Didyouhaveababylessthan6monthsago, areyoufullyornearly-fullybreastfeeding,andhaveyouhadnomenstrualperiodsincethen?
YES
NO 6.Haveyouhadamiscarriage orabortion inthepast7days? YES
IftheclientanswerNO toallofthequestions,pregnancycannotberuledoutusingthechecklist.Ruleoutpregnancybyothermeans.
IftheclientansweredYES toatleastoneofthequestions andsheisfreeofsignsorsymptomsofpregnancy,youcanbereasonablysuresheisnotpregnant.
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Questions?
Thankyouforyourattention!
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Levoplantcontraceptive
implant
StepsforInsertionandRemoval
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BeforeYouBegin
• Alwaysusesterileglovesorforcepswhenhandlingtherods.
• IfaLevoplant rodiscontaminated(forexample,fallsonthefloor),LEAVEITforlaterdisposalandOPENANEWPACKAGEandcontinuewiththeprocedure.
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RequiredEquipment
• Anexaminationtable• Sterilesurgicalcloth/drapesandgloves• Antisepticsolution• Localanesthetic,needles,andsyringe• Trocar,forceps• Scalpel(optional)• Skinclosure,sterilegauze,andcompresses
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PropertimingforInsertion• Within7daysfromtheonsetofmenstrualbleeding
• Immediatelyorwithin7dayspost-abortion
• Immediatelyorwithin3weekspost-partumifthewomanisnotbreastfeeding
• From6weekspostpartumifthewomanisbreastfeeding
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Levoplant withDisposableTrocar&Cannula
• Levoplant isprovidedwithadisposabletrocar
• sharpenoughtopenetratetheskindirectly
• Disposabletrocarcanbeusedtopuncturetheskinandinserttherods
• Noneedforincision
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StepsofInsertion(1)1. Washthenon-dominantarm2. Allowtheclienttoliedownonthe
proceduretablewithhernon-dominantarmextendedonasterileorcleanclothontheothertable,atarightangletoherbody
3. Theimplantswillbeinsertedsub-dermallyusingthedisposabletrocar,intheshapeofanarrowV,openingtowardsthearmpit
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StepsofInsertion(2)4. Confirmtheabsenceofknownallergiestoanestheticagentor
relateddrugs5. LocatethesiteofLevoplant insertionattheinnersideoftheupper
arm,6-8cmabovetheelbow6. Useaspongeforcepstoholdacottonorgauzeswabsoakedwith
antiseptic(betadineorchlorhexidine)• Beginbywipingattheinsertionsiteandmoveoutwardinacircularmotionfor8to13cm(3to5in.).
• Ifaniodophor (e.g.,Betadine)isused,allowtoairdryforabout2minutesbeforeproceeding(iodophors requireupto2minutestocontacttimetoreleasefreeiodine).
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StepsofInsertion(3)7. Fillthesyringewith2-4mlof
1%localanestheticwithoutadrenaline
8. Anaesthetizetwoareasabout4.5cmlong,tomimictheVshapeoftheinsertionarea
9. Gentlytouchtheinsertionsitewithforcepstomakesuretheanestheticisworking
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StepsofInsertion(4)10. Introducethetrocarjustbeneath
theskinatanesthetizedarea11. Oncethetipofthetrocaris
beneaththeskin,advancethetrocaralongtheskinhorizontallytothemarkclosesttothehandleofthetrocar,pointingslightlyupwardsraisingtheskin(tenting)tokeeptheimplantinthesubdermalplane
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StepsofInsertion(5)
Note:• Donotforcethetrocar,andifyoufeelanyresistance,tryanotherdirection
• Itisimportanttokeepthetrocarsubdermalbytentingtheskinwiththetrocar,asfailuretodosomayresultindeepplacementoftheimplantscausingamoredifficultremoval
• Throughouttheinsertionprocedure,thetrocarshouldbeorientedwiththebevelup
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StepsofInsertion(6)12. Removetheplungerwhenthe
trocarisadvancedtothemarknearestthehub
13. Loadthefirstimplantintothetrocareitherwithtweezersorglovedfingers
14. Pushtheimplantgentlywiththeplungertothetipofthetrocaruntilyoufeelresistance
15. Neverforcetheplunger
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StepsofInsertion(7)
16. Holdtheplungersteadyandpullthetrocarbacktothemarknearthetip
NOTE:• Itisimportanttokeeptheplungersteadyandnottopushtheimplantintothetissue
• Thetrocariswithdrawnafterinsertionofthe1st rodonlytothemarkclosesttoitstip.DONOTwithdrawcompletely
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StepsofInsertion(8)
17. Fixthepositionofthefirstimplantwiththeleftfore-fingerandadvancethetrocartoformaVshapealongthesideofthefinger.TheVshouldbeabouta30-degreeangle.Insertthesecondimplantnexttothefirstone
NOTE:• Leave5mmbetweenthepunctureandthetipoftheimplantstoavoidspontaneousexpulsions.
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StepsofInsertion(9)18. Aftertheinsertion,presstheedges
oftheincisiontogetherandclosetheinsertionpointwithasterilebutterflyadhesive
19. Covertheinsertionareawithacompressandwrapenoughgauzearoundthearmtoensurehemostasis
20. Observethepatientattheclinicfor15minutesforsignsofsyncopeorbleedingfromtheincisionbeforesheisdischargedaftercounseling
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Removal:RequiredEquipment
• Anexaminationtable• Sterilesurgicalcloth/drapesandgloves• Antisepticsolution• Localanesthetic,needles,andsyringe• Sterile#11scalpel,forceps(twoCrile/Kellyforcepsrecommended,thoughoneCrile/KellyandoneMosquitoacceptable)
• Skinclosures,sterilegauzeandcompresses
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Removal(1)• Foroptimalreadiness,implantremovalshouldpreferablybedoneoncertainscheduleddays
• Theimplantsshallberemovedverygently,andthiswillusuallytakemoretimethantheirinsertion
• Implantsmaysometimesbenicked,cutorbrokenduringremoval.Ifremovalprovesdifficult,closetheincisionandbandagethewound,andhavethepatientreturnforanotherattempt
• Theremainingimplant(s)willbeeasiertoremoveaftertheareaishealed.Anon-hormonalmethodofcontraceptionshouldbeuseduntilbothimplanthavebeenremoved
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Removal(2) • Thepatientshallbeinasimilarposition,andasimilaraseptictechniqueshallbeappliedasforinsertion
• Locatetheimplantsbypalpation,possiblymarkingtheirpositionwithamarkerpen
• Iftheycannotbepalpated,theymaybelocatedbyultrasoundorsofttissueX-ray
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Removal(3)• Injectasmallamountoflocalanestheticundertheendsoftheimplantthatareclosertoeachother– thiswillraisetheendsoftheimplants
• Anestheticinjectedovertheimplantsmayobscuretheirpositionandmakeremovalmoredifficult
• Ifnecessary,moreanestheticcanbegiveninsmallamountsatatime
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Removal(4)
• Makea4-mmincisionwiththescalpelclosetotheendsoftheimplants(belowthebottomoftheV)
• Keeptheincisionsmall
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Removal(5)• Pusheachimplantwithyourfingersgentlytowardstheincision
• Whenthetipisvisibleorneartotheincision,graspitwithCrile/Kellyforceps.Mosquitoforcepscanalsobeused
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Removal(6)• StabilizetheimplantwiththeCrile/Kellyforceps.Mosquitoforcepscanalsobeused
• Useascalpelandverygentlyopenthetissuesheatharoundtheimplant
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Removal(7)• Grasptheendoftheimplantwiththesecondforceps(Crile/Kellyforceps)
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Removal(8)
• Releasethestabilizing(first)forceps
• Usethesecondforcepsholdingtheendoftheimplanttogentlyremovetheimplant
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Removal(9)
• Repeattheprocedureforthesecondimplant
• MeasurethelengthoftheremovedimplantstomakesurethepatienthadtwoLevoplantimplantsandnotothercontraceptiveimplants
• Thelengthshouldbe44mm
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Removal(10)
• Aftertheprocedureiscompleted,closetheincisionandbandageitasafterinsertion.Thearmshouldbekeptdryforafewdays
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WishtocontinueLevoplant
• Iftheclientwishestocontinueusingthemethod,anewsetofLevoplant canbeinsertedthroughthesameincision,inthesameortheoppositedirection
• Iftheclientprefers,Levoplant canalsobeinsertedinherotherarm
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Questions?
Thankyouforyourattention!
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Levoplant
Pre&PostInsertionCareandCounseling:ClientFollow-Up
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BeforeInsertion
• Counselclientonwhattoexpect,bothduringandafterinsertionincludingcommonsideeffects
• Beclearandconcise• Reassurethatcommonsideeffectsarenotharmful• Projectprofessionalism,clinicalconfidence,andreceptivitytoquestions
• Ifpossible,alsoprovideprintedmaterials
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Managementafterinsertion• Beopentopatientquestion• Practiceactivelistening• Ruleoutothercausesofanycomplaints• Giveadviceaboutmanagingthesideeffects• Trymedicalmanagementbeforeremovalfirstforsideeffects• Honorthewishesofthewoman• Ifremovalischosen,contraceptiveand/orpregnancycounseling
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Post-insertioncare(1)• Instructclientregardingwoundcareandmakereturnvisitappointment,ifneeded
• Sheshouldkeeptheinsertionareadryfor4days.Shecantakeofftheelasticbandageorgauzeafter2daysandtheadhesivebandageafter5days.
• Seekaclinicianifanyirritationoccursatthesiteofinsertion• Aftertheanestheticwearsoff,herarmmaybesoreforafewdays.Shemayalsohaveswellingandbruisingattheinsertionsite.Thisiscommonandwillgoawaywithouttreatment.
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Post-insertioncare(2)
• Observeclientforatleast15to20minutesandaskherhowshefeelsbeforesendingherhome
• Discusswhattodoifclientexperiencesanyproblemsfollowinginsertionorsideeffects
• Asktheclienttorepeatinstructions• Answerclient’squestions
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Follow-up
“Comebackanytime”• Assureeveryclientsheiswelcometocomebackanytime– forexample,when:
• Shehasproblems,questions,orwantsanothermethod• Shehasamajorchangeinhealthstatus• Shethinksshemightbepregnant
• Remindhertobringthefollow-upcardduringeachvisittotheclinic
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WarningsignsorproblemsTheclientshouldreturntotheclinicifshehasanyofthefollowingproblems(DISCUS):• Delayedmenstrualperiodafterseveralmonthsofregularcycles(maybeasignofpregnancy)
• Infection– pusorbleedingattheinsertionside• Severelowerabdominalpain(maybeasymptomofectopicpregnancy)• Capsule(expulsionofarod)• Unexplainedheavyvaginalbleeding(eithertwiceaslong/heavyasnormal)• Severeheadache– migraine(vascular)headaches,repeatedverypainfulheadachesorblurredvision
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Questions?
Thankyouforyourattention!