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Legends for supplementary tables and figures
Supplementary table 1
Recovery rate of protein samples after ProteoMiner treatment
Supplementary table 2
Number of protein spots from fractionated plasma samples
Supplementary table 3
Number of protein spots between the ProteoMiner-treated and untreated protein samples with different
criteria
Supplementary table 4
Number of protein spots observed by mass spectrometric protein identification
Supplementary table 5
List of proteins identified by mass spectrometry
Supplementary table 6
Detailed data of identified proteins
Supplementary table 7
List of the identified proteins and their reported concentrations and references
Supplementary figure 1
Reproducibility of protein fractionation by liquid chromatography. The ultraviolet detection (280 nm) trace
for each run demonstrated consistent separation and fractionation. A. HiTrap Blue HP column ; B. HiTrap
Protein G HP column ; C. Resource Q column.
Supplementary figure 2
Two-dimensional difference gel electrophoresis images of ProteoMiner-treated and untreated protein
samples. The ProteoMiner-treated and untreated samples were labeled with Cy5 and Cy3, respectively. A.
original plasma; B. flow-through fraction of HiTrap Blue HP column; C. binding fraction of
HiTrap Blue HP column; D. flow-through fraction of HiTrap Protein G HP column; E. binding
fraction of HiTrap Protein G HP column; 0 mM fraction (F), 100 mM fraction (G), 150 mM (H),
200 mM (I), 250 mM (J), and 1 M fraction (K) of Resource Q column.
Supplementary table 1 Recovery rate of protein samples after ProteoMiner treatment
samples subjected samples purified
to ProteoMiner by ProteoMiner
fractions concentration amount concentration amount recovery rate
(μg/μl) (mg) (μg/μl) (mg) (％)
plasma 61.80 61.80 6.08 1.22 1.97
Blue FT 169.66 169.66 7.27 1.45 0.86
Blue BD 250.60 250.60 16.77 3.35 1.34
ProG FT 57.96 57.96 8.31 1.66 2.87
ProG BD 96.12 19.22 10.57 0.42 2.20
0 mM NaCl elute 56.54 11.31 4.52 0.18 1.60
100 mM NaCl elute 83.48 16.70 3.92 0.16 0.94
150 mM NaCl elute 109.70 21.94 3.15 0.13 0.57
200 mM NaCl elute 116.90 23.38 3.73 0.15 0.64
250 mM NaCl elute 20.50 4.10 4.91 0.20 4.80
1 M NaCl elute 19.60 3.92 6.20 0.25 6.33
Supplementary table 2 Number of protein spots from fractionated plasma samples
fractions number of protein spots number of protein spots
with ProteoMiner treatment without ProteoMiner treatment
plasma 697 538
Blue FT 878 698
Blue BD 786 725
Protein G FT 877 667
Protein G BD 288 284
0 mM NaCl elute 668 445
100 mM NaCl elute 556 431
150 mM NaCl elute 578 550
200 mM NaCl elute 738 598
250 mM NaCl elute 1014 670
1 M NaCl elute 950 784
total 8030 6390
Supplementary table 4 Number of protein spots observed by mass spectrometric protein identification
fractions A1) B2)
plasma 8/153) 8/8
Blue FT 8/21 8/13
Blue BD 5/9 10/12
ProG FT 10/18 13/15
ProG BD -/- -/-
0 mM 3/6 9/10
100 mM 5/10 6/7
150 mM 4/7 7/8
200 mM 5/7 7/8
250 mM 2/8 4/7
1 M 3/7 3/4
subtotal 53/108 75/92
total 128/200
1)A: Protein spots with increased intensity by ProteoMiner treatment. 2)B: Protein spots with decreased intensity by ProteoMiner treatment. 3) Protein spots with positive identification by massspectrometry / protein spots examined by mass spectrometry.
Supplementary table 5 List of proteins identified by mass spectrometry
plasma
spot number 1) accession
protein name 2) number of sequence MASCOT fold
number 2) matched peptides coverage (%) 3) score 4) difference 5)
1250 P04004 vitronectin 3 9.0 182 16.5
1266 P04004 vitronectin 2 6.5 127 20.1
1291 P04004 vitronectin 3 9.0 220 21.4
1322 P04004 vitronectin 2 5.6 117 17.7
2003 P0C0L4 complement C4-A 2 1.2 118 71.0
2664 P02768 albumin 28 41.4 1546 0.026
2670 P02768 albumin 24 37.8 1310 0.024
2703 P02768 albumin 28 40.2 1521 0.024
2715 P02768 albumin 22 36.8 1096 0.029
2923 P02768 albumin 24 38.6 1278 0.020
2936 P02768 albumin 20 33.7 1045 0.021
2937 P02768 albumin 24 38.6 1267 0.019
2938 P02768 albumin 5 10.8 259 0.023
2962 P04004 vitronectin 3 9.0 195 47.5
2963 P04004 vitronectin 3 9.0 172 52.9
2970 P01024 complement C3 13 10.4 627 20.0
Blue FT
spot number accession
protein name number of sequence MASCOT fold
number matched peptides coverage (%) score difference
775 P06727 apolipoprotein A-IV 5 15.7 237 36.4
792 P10909 clusterin 2 8.9 118 27.9
813 P27169 paraoxonase/arylesterase 1 6 24.5 347 25.5
1416 P02787 serotransferrin 11 21.2 696 0.034
1627 P00734 prothrombin 6 11.7 367 39.2
1732 P00734 prothrombin 6 11.7 326 24.3
1744 P02768 albumin 16 23.8 621 0.031
1748 P01009 alpha-1-antitrypsin 5 19.9 229 44.5
1859 P02647 apolipoprotein A-I 5 20.2 290 39.2
1893 P02787 serotransferrin 9 14.6 534 0.026
1894 P02787 serotransferrin 13 22.6 850 0.027
1895 P0C0L4 complement C4-A 2 2.0 97 44.5
1920 P02787 serotransferrin 11 16.2 661 0.021
1960 P00738 haptoglobin 12 20.9 606 0.017
2006 P00738 haptoglobin 8 16.5 426 0.028
2078 P00739 haptoglobin-related protein 2 6.3 124 0.015
Blue BD
spot number accession protein name number of sequence MASCOT fold
number matched peptides coverage (%) score difference
275 P02768 albumin 8 13.8 413 0.015
440 P02768 albumin 4 9.0 153 0.016
586 P02675 fibrinogen beta chain 16 43.2 1009 24.8
1498 P02768 albumin 18 24.6 960 0.004
1499 P02768 albumin 25 38.8 1354 0.007
1503 P02768 albumin 19 30.4 772 0.014
1511 P02768 albumin 22 28.4 1142 0.005
1514 P02768 albumin 21 25.8 1112 0.004
1519 P02768 albumin 26 29.4 1233 0.003
1520 P02768 albumin 7 12.3 430 0.007
1784 P02679 fibrinogen gamma chain 19 47.7 1164 22.3
1832 P02679 fibrinogen gamma chain 19 47.9 1078 21.4
1840 P02679 fibrinogen gamma chain 19 45.5 1109 19.0
1841 P02675 fibrinogen beta chain 15 40.7 952 19.1
1852 P02768 albumin 10 16.6 590 0.016
ProG FT
spot number accession
protein name number of sequence MASCOT fold
number matched peptides coverage (%) score difference
240 P01023 alpha-2-macroglobulin 31 28.1 1890 0.029
303 P00450 ceruloplasmin 27 36.2 1538 0.027
564 P02768 albumin 12 18.4 647 0.027
569 P02768 albumin 13 18.1 721 0.026
1084 Q15485 ficolin-2 3 10.2 195 24.4
1255 P27169 paraoxonase/arylesterase 1 5 18.3 283 45.3
1272 P00734 prothrombin 2 3.5 131 16.5
1284 P27169 paraoxonase/arylesterase 1 5 18.3 270 18.5
1285 P27169 paraoxonase/arylesterase 1 5 18.3 280 21.9
1319 P02649 apolipoprotein E 7 28.7 485 16.5
1914 P02647 apolipoprotein A-I 7 25.5 415 17.6
2165 P00738 haptoglobin 10 19.5 522 0.031
2307 P01023 alpha-2-macroglobulin 24 21.4 1488 0.032
2498 P00738 haptoglobin 9 16.0 447 0.027
2509 P27169 paraoxonase/arylesterase 1 5 18.3 309 20.4
2513 P00738 haptoglobin 4 6.9 241 0.009
2515 P00739 haptoglobin-related protein 2 3.7 82 0.022
2529 P02652 apolipoprotein A-II 3 21.0 140 25.6
2534 P00734 prothrombin 6 11.7 380 17.8
2536 P06727 apolipoprotein A-IV 12 33.1 661 0.019
2559 P00738 haptoglobin 5 10.8 306 0.025
2571 P00738 haptoglobin 10 17.5 513 0.022
2573 P00738 haptoglobin 10 15.3 543 0.021
0 mM NaCl elute
spot number accession
protein name number of sequence MASCOT fold
number matched peptides coverage (%) score difference
720 P00738 haptoglobin 5 12.1 279 12.2
745 P10909 clusterin 8 18.0 354 10.8
1205 P00738 haptoglobin 13 24.4 662 0.022
1452 P00738 haptoglobin 10 18.7 593 0.018
1509 P00738 haptoglobin 10 22.7 543 0.021
1541 P00738 haptoglobin 11 19.0 605 0.025
1543 P00738 haptoglobin 8 12.3 445 0.023
1545 P00738 haptoglobin 6 8.1 326 0.019
1549 P00739 haptoglobin-related protein 2 3.7 152 0.020
1551 P00738 haptoglobin 13 26.6 722 0.023
1562 P00738 haptoglobin 15 31.3 785 0.027
1570 P10909 clusterin 4 10.9 174 10.8
100 mM NaCl elute
spot number accession
protein name number of sequence MASCOT fold
number matched peptides coverage (%) score difference
1034 Q15848 adiponectin 3 21.7 167 20.6
1050 P01009 alpha-1-antitrypsin 8 19.6 402 22.6
1393 P02787 serotransferrin 14 21.9 874 0.027
1526 P05090 apolipoprotein D 2 12.7 87 19.8
1648 P02787 serotransferrin 16 22.3 922 0.025
1651 P02787 serotransferrin 18 28.4 1218 0.019
1657 P02787 serotransferrin 17 25.8 1064 0.022
1675 P02787 serotransferrin 18 28.4 1055 0.023
1684 P05090 apolipoprotein D 2 12.7 78 24.8
1689 P05090 apolipoprotein D 2 12.7 86 20.6
1707 P25311 zinc-alpha-2-glycoprotein 14 46.1 713 0.026
150 mM NaCl elute
spot accession protein name
number of sequence MASCOT fold
number number matched peptides coverage (%) score difference
581 P04217 alpha-1B-glycoprotein 16 29.5 774 0.038
586 P04217 alpha-1B-glycoprotein 16 23.8 565 0.031
846 P01009 alpha-1-antitrypsin 87 56.9 1587 0.043
860 P01009 alpha-1-antitrypsin 114 59.1 1709 0.032
879 P01009 alpha-1-antitrypsin 17 42.8 778 0.035
1085 P15169 carboxypeptidase N catalytic chain 4 13.1 250 22.9
1312 Q15848 adiponectin 5 29.5 222 22.6
1359 P05090 apolipoprotein D 2 12.7 92 18.7
1506 P00739 haptoglobin-related protein 6 4.3 194 0.032
1562 P00738 haptoglobin 8 6.9 201 0.042
2092 O75636 ficolin-3 5 17.7 242 22.7
200 mM NaCl elute
spot accession protein name
number of sequence MASCOT fold
number number matched peptides coverage (%) score difference
899 Q15485 ficolin-2 3 14.7 193 13.2
909 P10909 clusterin 9 18.7 465 13.2
984 Q15848 adiponectin 4 29.5 198 20.9
1470 P02766 transthyretin 7 63.3 375 0.038
1492 P10909 clusterin 8 18.5 369 13.6
1519 P10909 clusterin 9 21.8 461 15.4
1926 P02647 apolipoprotein A-I 7 32.2 465 0.020
1942 P02647 apolipoprotein A-I 7 32.2 456 0.035
1953 P02766 transthyretin 5 54.4 237 0.039
1960 P02766 transthyretin 16 65.3 568 0.035
2005 P02647 apolipoprotein A-I 3 13.5 241 0.033
2007 P02766 transthyretin 8 50.3 236 0.039
250 mM NaCl elute
spot accession protein name
number of sequence MASCOT fold
number number matched peptides coverage (%) score difference
914 P00450 ceruloplasmin 7 4.1 216 53.5
915 P00450 ceruloplasmin 7 4.1 226 32.5
983 P02768 albumin 25 24.6 1066 0.068
1192 P00738 haptoglobin 6 6.9 199 0.033
1763 P06727 apolipoprotein A-IV 16 39.1 783 0.065
1764 P00738 haptoglobin 10 18.2 441 0.055
1 M NaCl elute
spot accession protein name
number of sequence MASCOT fold
number number matched peptides coverage (%) score difference
394 P00450 ceruloplasmin 41 34.8 1648 21.1
815 P00742 coagulation factor X 8 10.2 238 0.116
1333 P00450 ceruloplasmin 6 5.5 218 212.1
1935 Q06033 inter-alpha-trypsin inhibitor
38 26.1 1135 0.042 heavy chain H3
2119 P00450 ceruloplasmin 15 13.1 599 26.2
2135 P00738 haptoglobin 2 6.2 105 0.128
1)Spot numbers refer to those in Figure 5. 2)Accession numbers of proteins and protein name were derived from Swiss-Prot and NCBI nonredundant datebases. 3)Percentage of the number of the identified amino acids per those of total ones. 4)MASCOT score for the identified proteins based on the peptide ions score (P<0.05) (http://www.matrixscience.com).
5)The ratio of intensity of protein spots between ProteoMiner treated and ProteoMiner not-treated samples.
Supplementary table 6 Detailed data of identified proteins
S
po
ts
N
o.
1)
R
an
k
Acc
essi
on
No.
2)
pr
ote
in
ID
2)
Identifie
d
protein
2)
p
I
(c
al
)
3)
M
W
(ca
l)
(D)
3)
Pr
ote
in
sco
re
4)
Pep
tide
ma
tch
es
Seq
uen
ce
cov
era
ge
(%)
5)
Io
n
ch
ar
ge
sta
te
(+)
MZ
(ob
s) 6)
Mas
s
(obs
) 7)
Mas
s
(calc
) 8)
Del
ta
9)
M
is
s
10)
Ma
sco
t
ion
s
sco
re
11)
Peptide sequence
Modi
ficati
on
12
50 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
18
2 3 9.0 2
712.
161
1
1422
.307
6
1421
.646
3
0.6
61
3
0 77.
66 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
18
2 3 9.0 2
824.
489
1
1646
.963
6
1645
.81
1.1
53
6
0 54.
82 DVWGIEGPIDAAFTR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
18
2 3 9.0 3
556.
542
2
1666
.604
8
1665
.768
2
0.8
36
6
0 52.
49 DWHGVPGQVDAAMAGR
12
66 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
12
7 2 6.5 2
824.
229
2
1646
.443
8
1645
.81
0.6
33
8
0 74 DVWGIEGPIDAAFTR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
12
7 2 6.5 3
556.
445
2
1666
.313
8
1665
.768
2
0.5
45
6
0 56 DWHGVPGQVDAAMAGR
12
91 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 2
711.
995
7
1421
.976
8
1421
.646
3
0.3
30
5
0 39 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 2
712.
228
1
1422
.441
6
1421
.646
3
0.7
95
3
0 91 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 2
824.
221
7
1646
.428
8
1645
.81
0.6
18
8
0 64 DVWGIEGPIDAAFTR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 2
824.
369
1
1646
.723
6
1645
.81
0.9
13
6
0 61 DVWGIEGPIDAAFTR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 3
556.
500
2
1666
.478
8
1665
.768
2
0.7
10
6
0 56 DWHGVPGQVDAAMAGR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 3
561.
862
2
1682
.564
8
1681
.763
1
0.8
01
7
0 68 DWHGVPGQVDAAMAGR
Oxida
tion
(M)
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
22
0 7 9.0 3
561.
881
2
1682
.621
8
1681
.763
1
0.8
58
7
0 42 DWHGVPGQVDAAMAGR
Oxida
tion
(M)
2
P10
909
CL
US Clusterin
5.
8
9
53
03
1
15
3 3 6.9 2
538.
124
1
1074
.233
6
1073
.535
3
0.6
98
4
0 38 IDSLLENDR
2
P10
909
CL
US Clusterin
5.
8
9
53
03
1
15
3 3 6.9 2
559.
436
6
1116
.858
6
1116
.602
6
0.2
56 0 46 TLLSNLEEAK
2
P10
909
CL
US Clusterin
5.
8
9
53
03
1
15
3 3 6.9 2
697.
522
6
1393
.030
6
1392
.688
5
0.3
42
2
0 75 ASSIIDELFQDR
13
22 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
11
7 2 5.6 2
712.
189
1
1422
.363
6
1421
.646
3
0.7
17
3
0 58 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
11
7 2 5.6 2
824.
434
7
1646
.854
8
1645
.81
1.0
44
8
0 62 DVWGIEGPIDAAFTR
20
03 1
P0C
0L4
CO
4A
Comple
ment
C4-A
6.
6
5
19
42
47
11
8 4 1.2 1
983.
554
982.
5467
982.
4794
0.0
67
4
0 34 TYNVLDMK
1
P0C
0L4
CO
4A
Comple
ment
C4-A
6.
6
5
19
42
47
11
8 4 1.2 2
492.
392
6
982.
7706
982.
4794
0.2
91
3
0 50 TYNVLDMK
1
P0C
0L4
CO
4A
Comple
ment
C4-A
6.
6
5
19
42
47
11
8 4 1.2 2
500.
544
6
999.
0746
998.
4743
0.6
00
4
0 37 TYNVLDMK
Oxida
tion
(M)
1
P0C
0L4
CO
4A
Comple
ment
C4-A
6.
6
5
19
42
47
11
8 4 1.2 2
719.
259
6
1436
.504
6
1435
.719
5
0.7
85
2
0 71 GLEEELQFSLGSK
1
P0C
0L5
CO
4B
Comple
ment
C4-B
6.
7
3
19
42
12
11
8 4 1.2 1
983.
554
982.
5467
982.
4794
0.0
67
4
0 34 TYNVLDMK
1
P0C
0L5
CO
4B
Comple
ment
C4-B
6.
7
3
19
42
12
11
8 4 1.2 2
492.
392
6
982.
7706
982.
4794
0.2
91
3
0 50 TYNVLDMK
1
P0C
0L5
CO
4B
Comple
ment
C4-B
6.
7
3
19
42
12
11
8 4 1.2 2
500.
544
6
999.
0746
998.
4743
0.6
00
4
0 37 TYNVLDMK
Oxida
tion
(M)
1
P0C
0L5
CO
4B
Comple
ment
C4-B
6.
7
3
19
42
12
11
8 4 1.2 2
719.
259
6
1436
.504
6
1435
.719
5
0.7
85
2
0 71 GLEEELQFSLGSK
26
64 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 1
695.
487
694.
4797
694.
3286
0.1
51
2
0 35 NYAEAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 1
880.
546
879.
5387
879.
4338
0.1
04
9
0 43 AEFAEVSK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
464.
527
1
927.
0396
926.
4861
0.5
53
5
0 36 YLYEIAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 1
940.
585
939.
5777
939.
441
0.1
36
7
0 47 DDNPNLPR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
471.
072
1
940.
1296
939.
441
0.6
88
7
0 36 DDNPNLPR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 1
951.
404
950.
3967
950.
4345
-0.
03
78
0 45 DLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
480.
853
1
959.
6916
959.
5552
0.1
36
4
0 47 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
480.
880
1
959.
7456
959.
5552
0.1
90
4
0 49 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
481.
192
1
960.
3696
959.
5552
0.8
14
4
0 62 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
481.
556
1
961.
0976
959.
5552
1.5
42
4
0 46 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
492.
807
1
983.
5996
983.
4811
0.1
18
5
0 36 TYETTLEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
15
46 101 41.4 2
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1
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5
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29
36
0 59 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
1
P02
768
AL
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9
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15
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5
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0 63 SHCIAEVENDEMPADLPSL
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Oxida
tion
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15
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2
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8
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64
83
0 52 SHCIAEVENDEMPADLPSL
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Oxida
tion
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15
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9
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9
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48
72
0 39 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
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1
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15
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5
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7
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45
54
0 35 SHCIAEVENDEMPADLPSL
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Oxida
tion
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1
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15
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5
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7
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30
24
0 59 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
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1
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768
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BU Albumin
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15
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9
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9
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92
0 41 SHCIAEVENDEMPADLPSL
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Oxida
tion
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1
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8
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6
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22
35
0 45 SHCIAEVENDEMPADLPSL
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Oxida
tion
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1
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768
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15
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7
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19
14
0 35 SHCIAEVENDEMPADLPSL
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Oxida
tion
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1
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768
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BU Albumin
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15
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5
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4
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13
66
0 39 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
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1
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9
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2
2989
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8
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0.6
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7
0 69 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
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2
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HE
M
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Hemope
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5
5
52
38
5
37
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565.
751
6
1129
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6
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HE
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HE
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Hemope
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5
52
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5
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1
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6
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5
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HE
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Hemope
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5
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6
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HE
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Hemope
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5
52
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6
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HE
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Hemope
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5
5
52
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5
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751.
163
6
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6
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5
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0 65 EWFWDLATGTMK
Oxida
tion
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HE
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O
Hemope
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5
37
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8
1836
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5
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4
0 72 SGAQATWTELPWPHEK
2
P02
790
HE
M
O
Hemope
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5
5
52
38
5
37
1 9 20.8 3
613.
562
5
1837
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7
1836
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5
0.7
86
2
0 55 SGAQATWTELPWPHEK
2
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
37
1 9 20.8 3
107
3.98
4
3218
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2
3218
.463
5
0.4
66
7
0 38 DGWHSWPIAHQWPQGPS
AVDAAFSWEEK
3
P81
605
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D
Dermcidi
n
6.
0
8
11
39
1
11
3 3 25.5 3
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660
9
1459
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9
1458
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6
1.2
04
3
1 40 LGKDAVEDLESVGK
3
P81
605
DC
D
Dermcidi
n
6.
0
8
11
39
1
11
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731.
237
2
1460
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8
1458
.756
6
1.7
03
3
1 58 LGKDAVEDLESVGK
3
P81
605
DC
D
Dermcidi
n
6.
0
8
11
39
1
11
3 3 25.5 2
734.
357
7
1466
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8
1465
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7
0.9
23
2
1 54 GAVHDVKDVLDSVL
26
70 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 1
695.
457
694.
4497
694.
3286
0.1
21
2
0 37 NYAEAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
464.
487
6
926.
9606
926.
4861
0.4
74
5
0 35 YLYEIAR
1
P02
768
AL
BU Albumin
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9
2
71
31
7
13
10 53 37.8 1
940.
607
939.
5997
939.
441
0.1
58
7
0 46 DDNPNLPR
1
P02
768
AL
BU Albumin
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9
2
71
31
7
13
10 53 37.8 2
471.
046
6
940.
0786
939.
441
0.6
37
7
0 40 DDNPNLPR
1
P02
768
AL
BU Albumin
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9
2
71
31
7
13
10 53 37.8 2
481.
075
6
960.
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959.
5552
0.5
81
4
0 52 FQNALLVR
1
P02
768
AL
BU Albumin
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9
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71
31
7
13
10 53 37.8 2
481.
283
6
960.
5526
959.
5552
0.9
97
4
0 46 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
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71
31
7
13
10 53 37.8 2
492.
876
6
983.
7386
983.
4811
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57
5
0 34 TYETTLEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
500.
966
1
999.
9176
999.
5964
0.3
21
2
0 50 QTALVELVK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
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302
6
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6
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7
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00
1
0 92 LVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
507.
513
6
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6
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7
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21 0 70 LVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 1
101
7.71
5
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7
1016
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1
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78
6
0 46 SLHTLFGDK
1
P02
768
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BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
509.
419
6
1016
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6
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1
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95
5
0 51 SLHTLFGDK
1
P02
768
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BU Albumin
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9
2
71
31
7
13
10 53 37.8 2
528.
564
6
1055
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6
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1
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33
6
1 50 KYLYEIAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
538.
153
7
1074
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8
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3
0.7
57
6
1 47 LDELRDEGK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
565.
051
1
1128
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6
1127
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4
0.3
96
3
1 60 KQTALVELVK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
571.
735
7
1141
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8
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6
0.7
70
2
1 69 KLVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
575.
428
6
1148
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6
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7
0.2
34
9
0 54 LVNEVTEFAK
1
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768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
575.
670
2
1149
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8
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7
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1
0 55 LVNEVTEFAK
1
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768
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BU Albumin
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9
2
71
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7
13
10 53 37.8 2
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1
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6
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89
8
1 48 FKDLGEENFK
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768
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9
2
71
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7
13
10 53 37.8 2
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693
7
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8
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1.7
75 1 47 FKDLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 1
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7
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7
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09
0 42 HPDYSVVLLLR
1
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768
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5.
9
2
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7
13
10 53 37.8 2
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660
2
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8
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7
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2
0 51 HPDYSVVLLLR
1
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768
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9
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86
0 53 AVMDDFAAFVEK
1
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768
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9
2
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31
7
13
10 53 37.8 1
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2
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7
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5
0.0
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2
0 44 AVMDDFAAFVEK
1
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768
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9
2
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2
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8
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5
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4
0 39 AVMDDFAAFVEK
1
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768
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9
2
71
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7
13
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2
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8
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5
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4
0 61 AVMDDFAAFVEK
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768
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9
2
71
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7
13
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733
6
1343
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6
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5
1.8
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2
0 69 AVMDDFAAFVEK
1
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768
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5.
9
2
71
31
7
13
10 53 37.8 2
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890
1
1357
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6
1357
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4
0.1
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2
0 75 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
680.
163
6
1358
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6
1357
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4
0.6
90
2
0 38 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 3
490.
106
2
1467
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8
1466
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8
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61 1 46 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
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9
2
71
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7
13
10 53 37.8 3
490.
123
2
1467
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8
1466
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8
0.5
12 1 49 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
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7
13
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490.
190
9
1467
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9
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8
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15
1
1 37 RHPDYSVVLLLR
1
P02
768
AL
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5.
9
2
71
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7
13
10 53 37.8 2
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6
1467
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6
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8
0.9
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9
1 36 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
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7
13
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490.
308
2
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8
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8
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67 1 41 RHPDYSVVLLLR
1
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768
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9
2
71
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7
13
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490.
331
2
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8
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8
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36 1 35 RHPDYSVVLLLR
1
P02
768
AL
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9
2
71
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7
13
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490.
354
5
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7
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8
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9
1 55 RHPDYSVVLLLR
1
P02
768
AL
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9
2
71
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7
13
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534
5
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7
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8
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9
1 46 RHPDYSVVLLLR
1
P02
768
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9
2
71
31
7
13
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756.
655
6
1511
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6
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5
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1
0 75 VPQVSTPTLVEVSR
1
P02
768
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5.
9
2
71
31
7
13
10 53 37.8 3
504.
883
5
1511
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7
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5
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1
0 38 VPQVSTPTLVEVSR
1
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768
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BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
812.
663
1
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6
1622
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3
0.5
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4
0 67 DVFLGMFLYEYAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
820.
668
2
1639
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8
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2
0.5
46
6
0 55 DVFLGMFLYEYAR
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
820.
854
7
1639
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8
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5
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4
1 82 KVPQVSTPTLVEVSR
1
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768
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9
2
71
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7
13
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742
5
1640
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7
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5
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2
1 37 KVPQVSTPTLVEVSR
1
P02
768
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9
2
71
31
7
13
10 53 37.8 3
547.
802
5
1640
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7
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5
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2
1 66 KVPQVSTPTLVEVSR
1
P02
768
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5.
9
2
71
31
7
13
10 53 37.8 2
872.
266
2
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8
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0.6
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1
0 44 HPYFYAPELLFFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 3
582.
242
2
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8
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8
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1
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768
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9
2
71
31
7
13
10 53 37.8 3
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728
5
2045
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7
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1
1.0
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6
0 37 VFDEFKPLVEEPQNLIK
1
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768
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9
2
71
31
7
13
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682.
861
1
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5
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1
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4
0 43 VFDEFKPLVEEPQNLIK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
102
3.93
3
2045
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4
2044
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1
1.7
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4
0 43 VFDEFKPLVEEPQNLIK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 2
133
3.09
5
2664
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4
2665
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6
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07
62
0 46 LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 3
889.
576
2
2665
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8
2665
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6
0.4
55
1
0 46 LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 3
997.
354
9
2989
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9
2989
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1
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28
92
0 56 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
13
10 53 37.8 3
997.
674
2
2990
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8
2989
.332
1
0.6
68
7
0 58 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
2
P02
790
HE
M
O
Hemope
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71
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tion
(M)
1
P02
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9
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TFLK
Oxida
tion
(M)
1
P02
768
AL
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9
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31
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0 34 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
1
P02
768
AL
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31
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0 37 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
2
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IG
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chain C
region
6.
0
8
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region
6.
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876
IG
HA
1
Ig
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region
6.
0
8
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505
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1
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7
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2
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876
IG
HA
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Ig
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region
6.
0
8
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48
6
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709
7
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6
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2
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876
IG
HA
1
Ig
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region
6.
0
8
38
48
6
32
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189
1
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5
1834
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5
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2
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876
IG
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1
Ig
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region
6.
0
8
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48
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8
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6
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3
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17
1 48 KGDTFSCMVGHEALPLAF
TQK
Oxida
tion
(M)
3
P01
877
IG
HA
2
Ig
alpha-2
chain C
region
5.
7
1
37
30
1
26
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region
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IG
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Ig
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region
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2
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877
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877
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TQK
Oxida
tion
(M)
4
P04
264
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264
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264
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P04
264
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4
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R
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6
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6
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EVQLVESGGGLVQPGGSL
R
6
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4
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chain
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2
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6
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R
6
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3
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chain
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0
5
13
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904
2
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R
6
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5
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0
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R
6
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7
8
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R
29
23 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 1
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384
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3767
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3286
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2
0 35 NYAEAK
1 P02 AL Albumin 5. 71 12 42 38.6 2 464. 926. 926. 0.0 0 38 YLYEIAR
768 BU 9
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31
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5416 4861 55
5
1
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768
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441
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7
0 39 DDNPNLPR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
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6
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1
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768
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31
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78 42 38.6 2
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6
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441
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1
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768
AL
BU Albumin
5.
9
2
71
31
7
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78 42 38.6 1
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477
950.
4697
950.
4345
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35
2
0 46 DLGEENFK
1
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768
AL
BU Albumin
5.
9
2
71
31
7
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78 42 38.6 2
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367
1
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950.
4345
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85
1
0 35 DLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
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78 42 38.6 2
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050
6
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959.
5552
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31
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1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
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78 42 38.6 2
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230
1
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959.
5552
0.8
90
4
0 48 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
507.
353
6
1012
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6
1012
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7
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01 0 82 LVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 1
101
7.65
6
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7
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1
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19
6
0 38 SLHTLFGDK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
509.
719
1
1017
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6
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1
0.8
94
5
0 41 SLHTLFGDK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
538.
107
7
1074
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8
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3
0.6
65
6
1 46 LDELRDEGK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
565.
014
2
1128
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8
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4
0.3
22
5
1 55 KQTALVELVK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
571.
567
7
1141
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8
1140
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6
0.4
34
2
1 68 KLVAASQAALGL
1 P02 AL Albumin 5. 71 12 42 38.6 2 575. 1149 1148 0.5 0 48 LVNEVTEFAK
768 BU 9
2
31
7
78 568
2
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8
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7
14
1
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
613.
931
2
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8
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9
0.2
5 1 53 FKDLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
614.
390
1
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6
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8
1 35 FKDLGEENFK
1
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768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
656.
578
7
1311
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8
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7
0.4
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2
0 53 HPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
671.
834
7
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8
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5
0.0
27
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0 47 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
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122
7
1342
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8
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5
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4
0 81 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
680.
177
7
1358
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8
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4
0.7
18
4
0 63 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 3
490.
016
5
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7
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8
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1 35 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
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613
6
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6
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8
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9
1 47 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
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78 42 38.6 2
756.
707
2
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8
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5
0.5
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3
0 63 VPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
812.
588
7
1623
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8
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3
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6
0 67 DVFLGMFLYEYAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
820.
601
1
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6
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2
0.4
12
4
0 76 DVFLGMFLYEYAR
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
820.
794
2
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8
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5
0.6
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1 79 KVPQVSTPTLVEVSR
1
P02
768
AL
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5.
9
2
71
31
7
12
78 42 38.6 3
547.
625
9
1639
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9
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5
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4
1 66 KVPQVSTPTLVEVSR
1 P02 AL Albumin 5. 71 12 42 38.6 2 828. 1655 1656 -1. 0 55 QNCELFEQLGEYK
768 BU 9
2
31
7
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2
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3
28
35
1
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768
AL
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5.
9
2
71
31
7
12
78 42 38.6 3
581.
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5
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7
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8
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9
0 50 HPYFYAPELLFFAK
1
P02
768
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9
2
71
31
7
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78 42 38.6 2
872.
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2
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8
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8
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1
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1
P02
768
AL
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9
2
71
31
7
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78 42 38.6 3
633.
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5
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7
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1
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768
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9
2
71
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2
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1
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768
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9
2
71
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7
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78 42 38.6 3
682.
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5
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1
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6
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1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 2
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4
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6
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87
62
0 45 LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 3
889.
442
8
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6
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6
0.0
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0 39 LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
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5.
9
2
71
31
7
12
78 42 38.6 3
889.
569
5
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7
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6
0.4
35 0 43
LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
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9
2
71
31
7
12
78 42 38.6 3
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8
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6
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2
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0 35 SHCIAEVENDEMPADLPSL
AADFVESK
1
P02
768
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9
2
71
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7
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78 42 38.6 3
997.
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9
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9
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1
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0 35 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
78 42 38.6 3
997.
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5
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7
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1
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0 37 SHCIAEVENDEMPADLPSL
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Oxida
tion
(M)
1
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768
AL
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9
2
71
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7
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78 42 38.6 3
998.
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5
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7
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1
1.8
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6
0 46 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
2
P04
264
K2
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Keratin,
type II
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tal 1
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1
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2
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264
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Keratin,
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1
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66
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517.
622
2
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8
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7
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2
P04
264
K2
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Keratin,
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1
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571.
697
1
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6
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0 44 DYQELMNTK
2
P04
264
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Keratin,
type II
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630
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.246
8
1178
.593
1
0.6
53
7
0 75 YEELQITAGR
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
633.
731
7
1265
.448
8
1264
.629
9
0.8
18
9
0 58 TNAENEFVTIK
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
651.
092
2
1300
.169
8
1299
.522
4
0.6
47
5
0 72 NMQDMVEDYR
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
652.
395
7
1302
.776
8
1301
.707
8
1.0
69 0 96 SLDLDSIIAEVK
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
671.
705
1
1341
.395
6
1339
.661
9
1.7
33
7
1 57 SKAEAESLYQSK
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
679.
740
2
1357
.465
8
1356
.688
5
0.7
77
4
0 84 LNDLEDALQQAK
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
692.
777
6
1383
.540
6
1382
.683
0.8
57
6
0 63 SLNNQFASFIDK
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
738.
684
1
1475
.353
6
1474
.778
0.5
75
7
0 78 FLEQQNQVLQTK
2
P04
264
K2
C1
Keratin,
type II
8.
1
66
17
92
9 14 31.4 2
859.
145
1716
.275
1715
.843
0.4
310 69 QISNLQQSISDAEQR
cytoskele
tal 1
5 0 1 6 8 8
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 2
119
3.00
1
2383
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4
2382
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7
1.0
42
8
0 80 GGGGGGYGSGGSSYGSG
GGSYGSGGGGGGGR
2
P04
264
K2
C1
Keratin,
type II
cytoskele
tal 1
8.
1
5
66
17
0
92
9 14 31.4 3
110
5.25
8
3312
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2
3311
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9
1.4
51
3
0 85
GSYGSGGSSYGSGGGSYG
SGGGGGGHGSYGSGSSSG
GYR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
531.
066
2
1060
.117
8
1059
.556
0.5
61
8
0 46 TLLDIDNTR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
533.
632
7
1065
.250
8
1064
.492
0.7
58
8
0 44 STMQELNSR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
561.
603
6
1121
.192
6
1120
.576
4
0.6
16
2
0 38 QEYEQLIAK
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
579.
360
7
1156
.706
8
1156
.583
6
0.1
23
2
0 60 QGVDADINGLR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
603.
987
7
1205
.960
8
1205
.596
2
0.3
64
7
0 48 QVLDNLTMEK
Oxida
tion
(M)
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
617.
175
7
1232
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8
1231
.590
6
0.7
46
3
0 63 SGGGGGGGLGSGGSIR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
618.
674
1
1235
.333
6
1234
.521
5
0.8
12
2
0 74 FSSSSGYGGGSSR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
794.
264
2
1586
.513
8
1585
.758
3
0.7
55
5
0 89 VQALEEANNDLENK
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
896.
631
2
1791
.247
8
1790
.720
5
0.5
27
4
0 99 GGSGGSYGGGGSGGGYG
GGSGSR
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 3
613.
608
2
1837
.802
8
1836
.958
1
0.8
44
7
0 54 HGVQELEIELQSQLSK
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
109
4.42
7
2186
.839
4
2186
.012
2
0.8
27
2
0 63 SDLEMQYETLQEELMALK
Oxida
tion
(M)
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
110
2.39
6
2202
.777
4
2202
.007
2
0.7
70
3
0 55 SDLEMQYETLQEELMALK
2
Oxida
tion
(M)
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 2
125
5.56
9
2509
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4
2509
.124
5
-0.
00
1
0 35 EIETYHNLLEGGQEDFESS
GAGK
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 3
837.
681
5
2510
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7
2509
.124
5
0.8
98
2
0 67 EIETYHNLLEGGQEDFESS
GAGK
3
P35
527
K1
C9
Keratin,
type I
cytoskele
tal 9
5.
1
4
62
25
5
82
9 15 32.1 3
108
9.35
9
3265
.055
2
3263
.506
6
1.5
48
6
0 94 DIENQYETQITQIEHEVSSS
GQEVQSSAK
4
P13
645
K1
C1
0
Keratin,
type I
cytoskele
tal 10
5.
0
9
59
04
6
30
3 4 10.1 2
546.
214
2
1090
.413
8
1089
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7
0.8
90
2
0 41 VTMQNLNDR
4
P13
645
K1
C1
0
Keratin,
type I
cytoskele
tal 10
5.
0
9
59
04
6
30
3 4 10.1 2
632.
147
6
1262
.280
6
1261
.589
9
0.6
90
8
0 69 SLLEGEGSSGGGGR
4
P13
645
K1
C1
0
Keratin,
type I
cytoskele
tal 10
5.
0
9
59
04
6
30
3 4 10.1 2
854.
546
1
1707
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6
1706
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9
0.3
12
7
0 11
5 GSLGGGFSSGGFSGGSFSR
4
P13
645
K1
C1
Keratin,
type I
5.
0
59
04
30
3 4 10.1 2
999.
409
1996
.803
1995
.963
0.8
400 78 ELTTEIDNNIEQISSYK
0 cytoskele
tal 10
9 6 2 8 6 2
5
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
15
1 4 8.4 2
571.
604
2
1141
.193
8
1140
.581
5
0.6
12
3
0 59 GGYTLVSGYPK
5
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
15
1 4 8.4 2
742.
974
2
1483
.933
8
1483
.680
6
0.2
53
3
0 50 EWFWDLATGTMK
5
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
15
1 4 8.4 2
751.
201
2
1500
.387
8
1499
.675
5
0.7
12
3
0 52 EWFWDLATGTMK
Oxida
tion
(M)
5
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
15
1 4 8.4 3
613.
684
1
1838
.030
5
1836
.879
5
1.1
51 0 45 SGAQATWTELPWPHEK
29
36 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 1
695.
461
694.
4537
694.
3286
0.1
25
2
0 40 NYAEAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 1
951.
659
950.
6517
950.
4345
0.2
17
2
0 35 DLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
481.
132
6
960.
2506
959.
5552
0.6
95
4
0 45 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
501.
279
1
1000
.543
6
999.
5964
0.9
47
2
0 59 QTALVELVK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
507.
650
1
1013
.285
6
1012
.591
7
0.6
94 0 79 LVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
509.
409
1
1016
.803
6
1016
.529
1
0.2
74
5
0 38 SLHTLFGDK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
538.
555
7
1075
.096
8
1073
.535
3
1.5
61
6
1 47 LDELRDEGK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
575.
775
6
1149
.536
6
1148
.607
7
0.9
28
9
0 52 LVNEVTEFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
614.
277
6
1226
.540
6
1225
.597
9
0.9
42
8
1 45 FKDLGEENFK
1 P02 AL Albumin 5. 71 10 23 33.7 2 656. 1311 1310 0.8 0 47 HPDYSVVLLLR
768 BU 9
2
31
7
45 810
2
.605
8
.734
7
71
2
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
672.
165
2
1342
.315
8
1341
.627
5
0.6
88
4
0 73 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
680.
181
6
1358
.348
6
1357
.622
4
0.7
26
2
0 59 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
490.
238
2
1467
.692
8
1466
.835
8
0.8
57 1 63 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
735.
028
1
1468
.041
6
1466
.835
8
1.2
05
9
1 48 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
756.
603
6
1511
.192
6
1510
.835
5
0.3
57
1
0 70 VPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
820.
417
7
1638
.820
8
1638
.775
2
0.0
45
6
0 74 DVFLGMFLYEYAR
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
547.
476
1
1639
.406
5
1638
.930
5
0.4
76 1 59 KVPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 2
820.
832
6
1639
.650
6
1638
.930
5
0.7
20
2
1 70 KVPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
581.
985
8
1742
.935
6
1741
.886
8
1.0
48
8
0 43 HPYFYAPELLFFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
634.
026
2
1899
.056
8
1897
.987
9
1.0
68
9
1 44 RHPYFYAPELLFFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
682.
932
9
2045
.776
9
2044
.088
1
1.6
88
8
0 46 VFDEFKPLVEEPQNLIK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
890.
004
5
2666
.991
7
2665
.251
6
1.7
4 0 53
LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
10
45 23 33.7 3
997.
800
8
2990
.380
6
2989
.332
1
1.0
48
5
0 51 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
2 P05 HE Heparin 6. 57 45 10 21.4 2 450. 899. 898. 0.5 0 43 GPLDQLEK
546 P2 cofactor
2
4
1
20
5
8 537
6
0606 476 84
7
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
466.
115
6
930.
2166
929.
4759
0.7
40
7
0 45 FAFNLYR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
515.
062
7
1028
.110
8
1027
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2
0.5
44
7
0 56 TLEAQLTPR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
540.
552
7
1079
.090
8
1078
.565
8
0.5
25 0 45 NYNLVESLK
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
540.
696
7
1079
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8
1078
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9
0.8
13 0 45 SVNDLYIQK
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
561.
124
6
1120
.234
6
1119
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8
0.6
01
8
0 37 QFPILLDFK
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
704.
558
2
1407
.101
8
1405
.735
4
1.3
66
5
0 45 YEITTIHNLFR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 3
510.
688
8
1529
.044
6
1527
.704
1
1.3
40
5
0 44 FPVEMTHNHNFR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 3
652.
039
5
1953
.096
7
1952
.030
9
1.0
65
8
0 61 FTVDRPFLFLIYEHR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
45
8 10 21.4 2
987.
217
2
1972
.419
8
1971
.892
2
0.5
27
6
0 47 GGETAQSADPQWEQLNN
K
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 2
565.
749
6
1129
.484
6
1128
.644
4
0.8
40
3
1 34 RLWWLDLK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 2
571.
667
2
1141
.319
8
1140
.581
5
0.7
38
3
0 56 GGYTLVSGYPK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 2
611.
137
1
1220
.259
6
1219
.598
6
0.6
61
1
0 44 NFPSPVDAAFR
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 2
743.
004
2
1483
.993
8
1483
.680
6
0.3
13
3
0 64 EWFWDLATGTMK
3 P02 HE Hemope 6. 52 26 7 12.6 2 750. 1499 1499 0.1 0 65 EWFWDLATGTMK Oxida
790 M
O
xin 5
5
38
5
0 923
2
.831
8
.675
5
56
3
tion
(M)
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 3
613.
585
1
1837
.733
5
1836
.879
5
0.8
54 0 56 SGAQATWTELPWPHEK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
26
0 7 12.6 2
919.
875
2
1837
.735
8
1836
.879
5
0.8
56
4
0 66 SGAQATWTELPWPHEK
29
37 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 1
789.
59
788.
5827
788.
4644
0.1
18
4
0 39 LVTDLTK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 1
880.
464
879.
4567
879.
4338
0.0
22
9
0 34 AEFAEVSK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
464.
548
6
927.
0826
926.
4861
0.5
96
5
0 38 YLYEIAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
476.
463
6
950.
9126
950.
4345
0.4
78
1
0 36 DLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
481.
163
6
960.
3126
959.
5552
0.7
57
4
0 48 FQNALLVR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
501.
054
6
1000
.094
6
999.
5964
0.4
98
2
0 71 QTALVELVK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
507.
556
1
1013
.097
6
1012
.591
7
0.5
06 0 95 LVAASQAALGL
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 1
101
7.46
2
1016
.454
7
1016
.529
1
-0.
07
44
0 45 SLHTLFGDK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
509.
605
6
1017
.196
6
1016
.529
1
0.6
67
5
0 41 SLHTLFGDK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
528.
565
2
1055
.115
8
1054
.581
1
0.5
34
8
1 34 KYLYEIAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
537.
916
1
1073
.817
6
1073
.535
3
0.2
82
4
1 45 LDELRDEGK
1 P02 AL Albumin 5. 71 12 34 38.6 2 565. 1128 1127 0.6 1 57 KQTALVELVK
768 BU 9
2
31
7
67 182
2
.349
8
.691
4
58
5
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
575.
627
7
1149
.240
8
1148
.607
7
0.6
33
1
0 48 LVNEVTEFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
614.
187
1
1226
.359
6
1225
.597
9
0.7
61
8
1 51 FKDLGEENFK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
656.
841
2
1311
.667
8
1310
.734
7
0.9
33
2
0 50 HPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 1
134
2.78
1
1341
.773
7
1341
.627
5
0.1
46
2
0 39 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
672.
013
2
1342
.011
8
1341
.627
5
0.3
84
4
0 60 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
679.
931
6
1357
.848
6
1357
.622
4
0.2
26
2
0 69 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
734.
864
1
1467
.713
6
1466
.835
8
0.8
77
9
1 37 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
490.
355
2
1468
.043
8
1466
.835
8
1.2
08 1 63 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
756.
585
6
1511
.156
6
1510
.835
5
0.3
21
1
0 73 VPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
504.
981
5
1511
.922
7
1510
.835
5
1.0
87
1
0 43 VPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
813.
201
2
1624
.387
8
1622
.780
3
1.6
07
6
0 69 DVFLGMFLYEYAR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
820.
689
6
1639
.364
6
1638
.775
2
0.5
89
4
0 76 DVFLGMFLYEYAR
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
547.
554
1
1639
.640
5
1638
.930
5
0.7
1 1 68 KVPQVSTPTLVEVSR
1 P02 AL Albumin 5. 71 12 34 38.6 3 547. 1640 1638 1.1 1 62 KVPQVSTPTLVEVSR
768 BU 9
2
31
7
67 696
2
.066
8
.930
5
36
3
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
821.
418
6
1640
.822
6
1638
.930
5
1.8
92
2
1 75 KVPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
828.
386
2
1654
.757
8
1656
.745
3
-1.
98
75
0 41 QNCELFEQLGEYK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
872.
191
7
1742
.368
8
1741
.886
8
0.4
82
1
0 50 HPYFYAPELLFFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
581.
912
5
1742
.715
7
1741
.886
8
0.8
28
9
0 62 HPYFYAPELLFFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
682.
892
5
2045
.655
7
2044
.088
1
1.5
67
6
0 37 VFDEFKPLVEEPQNLIK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
888.
824
5
2663
.451
7
2665
.251
6
-1.
8 0 48
LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 2
133
2.88
1
2663
.747
4
2665
.251
6
-1.
50
42
0 48 LVRPEVDVMCTAFHDNEE
TFLK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
12
67 34 38.6 3
996.
837
8
2987
.491
6
2989
.332
1
-1.
84
05
0 46 SHCIAEVENDEMPADLPSL
AADFVESK
Oxida
tion
(M)
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
450.
551
1
899.
0876
898.
476
0.6
11
7
0 52 GPLDQLEK
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
466.
189
6
930.
3646
929.
4759
0.8
88
7
0 46 FAFNLYR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
515.
022
2
1028
.029
8
1027
.566
2
0.4
63
7
0 53 TLEAQLTPR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
540.
548
6
1079
.082
6
1078
.565
9
0.5
16
8
0 56 SVNDLYIQK
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
561.
443
2
1120
.871
8
1119
.632
8
1.2
39 0 39 QFPILLDFK
2 P05 HE Heparin 6. 57 54 11 25.7 2 704. 1406 1405 0.5 0 49 YEITTIHNLFR
546 P2 cofactor
2
4
1
20
5
0 169
2
.323
8
.735
4
88
5
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 3
510.
538
5
1528
.593
7
1527
.704
1
0.8
89
6
0 47 FPVEMTHNHNFR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 3
652.
231
9
1953
.673
9
1952
.030
9
1.6
43 0 74 FTVDRPFLFLIYEHR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 2
987.
268
2
1972
.521
8
1971
.892
2
0.6
29
6
0 72 GGETAQSADPQWEQLNN
K
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 3
106
8.58
3
3202
.727
2
3202
.592
9
0.1
34
3
0 48 HQGTITVNEEGTQATTVT
TVGFMPLSTQVR
2
P05
546
HE
P2
Heparin
cofactor
2
6.
4
1
57
20
5
54
0 11 25.7 3
107
4.47
7
3220
.409
2
3218
.587
8
1.8
21
4
0 58 HQGTITVNEEGTQATTVT
TVGFMPLSTQVR
Oxida
tion
(M)
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
565.
755
7
1129
.496
8
1128
.644
4
0.8
52
5
1 44 RLWWLDLK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 1
114
1.54
1
1140
.533
7
1140
.581
5
-0.
04
78
0 43 GGYTLVSGYPK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
571.
436
2
1140
.857
8
1141
.624
4
-0.
76
65
0 46 QGHNSVFLIK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
571.
637
6
1141
.260
6
1140
.581
5
0.6
79
1
0 64 GGYTLVSGYPK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
611.
107
2
1220
.199
8
1219
.598
6
0.6
01
3
0 37 NFPSPVDAAFR
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
743.
159
7
1484
.304
8
1483
.680
6
0.6
24
3
0 64 EWFWDLATGTMK
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
750.
984
7
1499
.954
8
1499
.675
5
0.2
79
3
0 76 EWFWDLATGTMK
Oxida
tion
(M)
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
886.
767
6
1771
.520
6
1770
.992
0.5
28
6
0 96 LYLVQGTQVYVFLTK
3 P02 HE Hemope 6. 52 41 10 18.0 3 613. 1837 1836 0.5 0 50 SGAQATWTELPWPHEK
790 M
O
xin 5
5
38
5
9 475
8
.405
6
.879
5
26
1
3
P02
790
HE
M
O
Hemope
xin
6.
5
5
52
38
5
41
9 10 18.0 2
919.
847
7
1837
.680
8
1836
.879
5
0.8
01
4
0 66 SGAQATWTELPWPHEK
29
38 1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 2
575.
617
2
1149
.219
8
1148
.607
7
0.6
12
1
0 47 LVNEVTEFAK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 2
672.
205
7
1342
.396
8
1341
.627
5
0.7
69
4
0 68 AVMDDFAAFVEK
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 2
680.
323
7
1358
.632
8
1357
.622
4
1.0
10
4
0 54 AVMDDFAAFVEK
Oxida
tion
(M)
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 3
490.
450
9
1468
.330
9
1466
.835
8
1.4
95
1
1 63 RHPDYSVVLLLR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 3
547.
577
8
1639
.711
6
1638
.930
5
0.7
81
1
1 51 KVPQVSTPTLVEVSR
1
P02
768
AL
BU Albumin
5.
9
2
71
31
7
25
9 6 10.8 2
102
3.35
3
2044
.691
4
2044
.088
1
0.6
03
4
0 36 VFDEFKPLVEEPQNLIK
2
P00
739
HP
TR
Haptoglo
bin-relat
ed
protein
6.
4
2
39
49
6
16
1 4 4.3 2
656.
629
6
1311
.244
6
1310
.599
0.6
45
6
0 69 TEGDGVYTLNDK
2
P00
739
HP
TR
Haptoglo
bin-relat
ed
protein
6.
4
2
39
49
6
16
1 4 4.3 2
720.
712
6
1439
.410
6
1438
.694
0.7
16
7
1 51 TEGDGVYTLNDKK
2
P00
739
HP
TR
Haptoglo
bin-relat
ed
protein
6.
4
2
39
49
6
16
1 4 4.3 2
720.
802
7
1439
.590
8
1438
.694
0.8
96
9
1 35 TEGDGVYTLNDKK
29
62 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 2
711.
854
2
1421
.693
8
1421
.646
3
0.0
47
5
0 65 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 2
712.
007
1
1421
.999
6
1421
.646
3
0.3
53
3
0 62 FEDGVLDPDYPR
1 P04 VT Vitronect 5. 55 19 7 9.0 2 824. 1646 1645 0.5 0 82 DVWGIEGPIDAAFTR
004 NC in 5
5
06
9
5 173
6
.332
6
.81 22
6
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 3
556.
506
8
1666
.498
6
1665
.768
2
0.7
30
4
0 39 DWHGVPGQVDAAMAGR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 2
834.
815
7
1667
.616
8
1665
.768
2
1.8
48
7
0 51 DWHGVPGQVDAAMAGR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 3
561.
414
2
1681
.220
8
1681
.763
1
-0.
54
23
0 34 DWHGVPGQVDAAMAGR
Oxida
tion
(M)
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
19
5 7 9.0 3
561.
944
5
1682
.811
7
1681
.763
1
1.0
48
6
0 52 DWHGVPGQVDAAMAGR
Oxida
tion
(M)
29
63 1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
17
2 5 9.0 2
712.
221
2
1422
.427
8
1421
.646
3
0.7
81
5
0 48 FEDGVLDPDYPR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
17
2 5 9.0 2
824.
885
7
1647
.756
8
1645
.81
1.9
46
8
0 67 DVWGIEGPIDAAFTR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
17
2 5 9.0 2
833.
989
7
1665
.964
8
1665
.768
2
0.1
96
7
0 60 DWHGVPGQVDAAMAGR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
17
2 5 9.0 3
556.
421
2
1666
.241
8
1665
.768
2
0.4
73
6
0 55 DWHGVPGQVDAAMAGR
1
P04
004
VT
NC
Vitronect
in
5.
5
5
55
06
9
17
2 5 9.0 3
561.
660
2
1681
.958
8
1681
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Supplemental Table 7 Reported concentration of identified proteins and references normal concentration References
protein name μg/ml
adiponectin 2-17 [1] albumin 35000-52000 [2]
alpha-1-antitrypsin 900-2000 [3] alpha-1B-glycoprotein 150-300 [2] alpha-2-macroglobulin 1300-3000 [3]
apolipoprotein A-I 1000-2000 [2] apolipoprotein A-II 190-300 [4] apolipoprotein A-IV 110-220 [5]
apolipoprotein D 60-90 [6] apolipoprotein E 30-60 [7]
carboxypeptidase N 30 [8] ceruloplasmin 190-370 [9]
clusterin 250-420 [10] coagulation factor X 10 [11]
complement C3 900-1800 [2] complement C4-A 25-90 [3]
fibrinogen beta chain 520-1420 [3] fibrinogen gamma chain 490-1340 [3]
ficolin-2 1-12 [12] ficolin-3 3-54 [13]
haptoglobin 200-2000 [14] haptoglobin-related protein 32-41 [14]
inter-alpha-trypsin inhibitor (heavy chain H3) 100-200 [3] paraoxonase/arylesterase 1 58-61 [15]
prothrombin 100 [3] serotransferrin 2000-3600 [2] transthyretin 200-400 [2] vitronectin 240-530 [10]
zinc-alpha-2-glycoprotein 60-80 [16]
References [1] Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., et al., Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 1999, 257, 79-83. [2] Hortin, G. L., The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clinical Chemistry 2006, 52, 1223-1237. [3] Hortin, G. L., Sviridov, D., Anderson, N. L., High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance. Clinical Chemistry 2008, 54, 1608-1616. [4] Luo, J., Liu, B., [ELISA for measurement of human serum apolipoprotein A II]. Hua Xi Yi Ke Da Xue Xue Bao 1994, 25, 229-232.
[5] Kondo, K., Allan, C., Fidge, N., QUANTITATION OF APOLIPOPROTEIN-A-IV IN HUMAN-PLASMA USING A COMPETITIVE ENZYME-LINKED IMMUNOSORBENT-ASSAY. Journal of Lipid Research 1989, 30, 939-944. [6] Cheung, M. C., Albers, J. J., CHARACTERIZATION OF LIPOPROTEIN PARTICLES ISOLATED BY IMMUNOAFFINITY CHROMATOGRAPHY - PARTICLES CONTAINING A-I AND A-II AND PARTICLES CONTAINING A-I BUT NO A-II. Journal of Biological Chemistry 1984, 259, 2201-2209. [7] Schiele, F., De Bacquer, D., Vincent-Viry, M., Beisiegel, U., et al., Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project. Atherosclerosis 2000, 152, 475-488. [8] Matthews, K. W., Mueller-Ortiz, S. L., Wetsel, R. A., Carboxypeptidase N: a pleiotropic regulator of inflammation. Molecular Immunology 2004, 40, 785-793. [9] Kim, C. H., Park, J. Y., Kim, J. Y., Choi, C. S., et al., Elevated serum ceruloplasmin levels in subjects with metabolic syndrome: A population-based study. Metabolism-Clinical and Experimental 2002, 51, 838-842. [10] Hogasen, K., Mollnes, T. E., Tschopp, J., Harboe, M., QUANTITATION OF VITRONECTIN AND CLUSTERIN - PITFALLS AND SOLUTIONS IN ENZYME IMMUNOASSAYS FOR ADHESIVE PROTEINS. Journal of Immunological Methods 1993, 160, 107-115. [11] Kalafatis, M., Egan, J. O., VantVeer, C., Cawthern, K. M., Mann, K. G., The regulation of clotting factors. Critical Reviews in Eukaryotic Gene Expression 1997, 7, 241-280. [12] Munthe-Fog, L., Hummelshoj, T., Hansen, B. E., Koch, C., et al., The impact of FCN2 polymorphisms and haplotypes on the ficolin-2 serum levels. Scandinavian Journal of Immunology 2007, 65, 383-392. [13] Munthe-Fog, L., Hummelshoj, T., Ma, Y. J., Hansen, B. E., et al., Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state. Molecular Immunology 2008, 45, 2660-2666. [14] Kujiraoka, T., Oka, T., Ishihara, M., Egashira, T., et al., A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration. Journal of Lipid Research 2000, 41, 1358-1363. [15] Kujiraoka, T., Oka, T., Ishihara, M., Egashira, T., et al., A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration. Journal of Lipid Research 2000, 41, 1358-1363. [16] Yilmaz, Y., Yonal, O., Eren, F., Kurt, R., et al., Serum zinc-α2-glycoprotein concentrations in patients with non-alcoholic fatty liver disease. Clin Chem Lab Med 2011, 49, 93-97.
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