leerink cap makts ovw
TRANSCRIPT
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April 2009
An Inside Look at the Public Capital Markets
Donald Notman
Managing Director
Equity Capital Markets
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Overview of Healthcare Financings
Examples of Successful Transactions
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U.S. Equity Mutual Fund Flows(US$ in billions)
Market Performance (1/1/08 Present)
Jan- 08 Mar -08 May-08 Jul-08 Sep- 08 Nov-08 Jan- 09 Mar -0940
45
50
55
60
65
70
75
80
85
90
95
100
105
110
DJIA
S&P 500
NASDAQ CompositeRussell 2000
2008
(33.8%)
(38.5%)
(40.5%)
(34.8%)
2009
(4.1%)
7.4%
(4.2%)
(9.3%)
Market Performance (4/17/09 Close Present))
2007
6.4%
3.5%
9.8%
(2.8%)
NBI (12.6%) (10.5%)4.6%
2008 20092007
7.7%
(1.4%)
(2.0%)
(14.5%)(19.4%)
(32.1%)
(37.0%)
(54.8%)
(1.9%)
(6.8%)
10.2%16.2%
DJ/W Medical Equip.MS HC Providers
AMEX Pharma.
MS HC Payors
DJIA
S&P 500
NASDAQ Composite
Russell 2000
% Change
(2.1%)
(0.4%)
1.3%
(0.1%)
NBI (2.6%)
DJ/W Medical Equip.
MS HC Providers
AMEX Pharma.
MS HC Payors
% Change
(3.3%)
3.6%
(4.5%)
(5.5%)
Source: FactSet, Placement Tracker, ici.org, sec.gov, company press releases
pr17 Apr 20 Apr 21 Apr 22 Apr23 Apr 2494
95
96
97
98
99
100
101
102
$(75.0)
$(65.0)
$(55.0)
$(45.0)
$(35.0)
$(25.0)
$(15.0)
$(5.0)
$5.0$15.0
$25.0
$35.0
Dec-05
Feb
-06
Apr-06
Jun-06
Aug-06
Oct-06
Dec
-06
Feb
-07
Apr-07
Jun-07
Aug-07
Oct-07
Dec
-07
Feb
-08
Apr-08
Jun-08
Aug-08
Oct-08
Dec-08
Feb
-09
PublicMarket Performance
U.S. Equity Mutual Fund Flows
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Healthcare IPOs Pricing Relative to Range
Not
:Num
rs below Healthcare IPOs Pricing Relative to Range graph represent total numberof IPOs per quarter
Source: FactSet, Placement Tracker, ici.org, sec.gov, company press releases
IPO Pricing and Performance Since 1/1/2008
Healthcare IPOs Since 1/1/2008US$ in millions, except per share Midpoint IPO Valuation Current Performance
Offer Shares of Filing Pre- Post- Market Midpoint / Offer / vs. Russ.
Company Date Filed Offer Range Price Amount Money Money Price Cap. Pricing Current 2000
CardioNet 3/18/08 6.6 4.5 $23.00 $18.00 $81.0 $333.8 $387.8 $19.79 $469.6 (21.7%) 9.9% 41.5%
MAKO Surgical 2/14/08 5.1 5.1 15.00 10.00 51.0 133.4 184.4 6.90 172.4 (33.3%) (31.0%) 2.9%
Mean 5.9 4.8 19.00 14.00 66.0 233.6 286.1 13.35 321.0 (27.5%) (10.5%) 22.2%
Note: Grey shading denotes Leerink Swann deal.
57%
90%
73%56%
45%
33%
78%
100%
43%
50%
18%
22% 45%
33%
11%
10% 9%
22%
9% 11%
0%0%0%0%
0%
33%
50%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Q1-06 Q2-06 Q3-06 Q4-06 Q1-07 Q2-07 Q3-07 Q4-07 Q1-08 Q2-08 Q3-08 Q4-08 Q1-09
7 10 2 11 9 11 3 9 2 0 0 0 0
Priced Below Priced Within Priced Above
# IPOS
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4Source: FactSet, Placement Tracker - Includes transactions >
5MM in size
Historical PIPE and RDO Volume
Annual Healthcare RD & PIPE VolumeTotal Raised ($ in millions)
$0
$900
$1,800
$2, 00
$3, 00
$4, 00
2005 2006 2007 2008 2009 YT
B otech Spec. Pha ma edtech
2005 2009 YTD
$R
$R
C
$R
C
$R
C
$R
t
r
B
t
$2,014.7 $2,961.0 47.0% $3,173.3 7.2% $1,141.8 (64.0%) $3
1.7
Phar
a $432.4 $595.2 37.6% $208.7 (64.9%) $95.3 (54.3%) $20.0
Medtech $426.2 $827.9 94.3% $244.2 (70.5%) $226.5 (7.2%) $98.1
Total $2,873.4 $4,384.1 52.6% $3,626.2 (17.3%) $1,463.6 (59.6%) $469.8
2006 2007 2008
NumberofDeals
Sector 2005 2006 2007 2008 2009 YTD
B
otech 72 104 112 53 15
Spec. Pharma 19 26 10 4 1
Medtech 26 22 16 12 5
Total 117 152 138 69 21
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5Source: FactSet, Placement Tracker
Healthcare PIPEs and RDOs Completed Since 1/1/08
Total Raised ($ in millions) # of Transactions Completed
Pre-Offer Market Cap Ranges
3
$0
$100
$200
$300
$400
$500
$600
$300
-
2.0
4.0
6.0
8.0
10.0
12.0
14.0
16.0
18.0
Gross Proceeds Raised
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6Source: FactSet, Placement Tracker
Healthcare PIPEs and RDOs Completed Since 1/1/09
Prices as of4/!
" /!
009(1) Includes transactions # $ % & & in si
'
e(
!
)(
mountofwarrants as a percentofshares in the transaction.
(3) Exercise price ofwarrants as a percent premiumtothe transaction price.
US$ in millions, except per share Offer ) 0 Offer/ Offer 1 rice PricePerformanceP re -O ff er a % of Avg. Daily Discountto PostOffering
Units Offer Offer Market Pre-Offer Trading Warrants 10 Days Prior 2 ext 10 DaysDa te C om pa ny Industry Ticker Offered Amount Price Cap Mkt. Cap. Value Amt Prem Prior Close Close Post Today
PIPEs4/13/09 Rosetta 3 enomi4 s Biotech ROS3 2.000 8.0 4.00 38.3 20.9% 113.9x 0% NA 38.8% 43.9% (12.5%) (18.8%) (23.0%)4/9/09 Chemgenex Biotech CXSP 1.550 7.1 4.58 183.4 3.9% 34926.9x 0% NA ( 58.0%) (60.6%) 150.7% 149.4% 150.7%4 /6 /0 9 BioMimetic Therapeutics Medtech BMTI 5 .941 8.0 8.50 151.0 5.3% 16.1x 0% NA 9.7% 14.1% (10.1%) 6.4% (8.8%)3/2/09 Cardima Medtech CADM 18.519 20.0 1.08 158.1 12.6% 3465.9x 22% 16% (1.8%) (6.1%) 15.7% 4.6% 1.9%2/23/09 Opko Health Spec. Pharma OPK 20.000 20.0 1.00 235.6 8.5% 381.6x 0% NA (20.0%) (9.1%) 10.0% (9.0%) 16.0%2/19/09 EnteroMedics Medtech ETRM 13.110 15.1 1.15 54.6 27.6% 1312.7x 50% 20% (10.9%) (0.9%) (0.9%) 47.8% 95.7%2/13/09 Cadence Pharmaceuticals Biotech CADX 12.040 87.3 7.26 478.8 18.2% 158.8x 50% 8% (2.6%) (3.1%) (1.4%) (3.2%) 36.3%2/13/09 Affymax Biotech AFFY 0.652 10.0 15.33 317.6 3.1% 33.8x 65% 9% (5.5%) 0.5% 1.8% (21.7%) 11.8%2/13/09 Affymax Biotech AFFY 2.845 32.0 11.25 317.6 10.1% 147.6x 0% NA (30.7%) (26.2%) 38.7% 6.7% 52.4%1/27/09 EXACT Sciences Biotech EXAS 3.000 6.0 2.00 44.0 13.6% 39.9x 0% NA 26.6% 38.9% (18.5%) (27.5%) (24.5%)1/15/09 Re
3
en Biologics Medtech R3
BO 2.015 7.1 3.50 28.8 24.5% 104.9x 15% (66%) (18.6%) (7.9%) 0.0% 17.1% (15.7%)1/7/09 Infinity Pharmaceuticals Biotech INFI
6
.000 30.0 15.00 155.2 19.3% 105.9x 150% 61% 90.1% 106.3% (51.4%) (51.0%) (59.8%)
Total $7 8 0. 9
Mean $7 0. @ $9 . 7 $180.3 14% $3,400. A 7 @ % 8% (11%) ( 9 %) 10% 8% 19%Median 12. 8 4.3 156. A 13% 130. A 8% 12% (8%) (5%) (0%) 1% A %
RDOs4 /2 /09 Savient Pharmaceuticals Biotech SVNT 5.927 $31.0 $5.23 $270.4 11.5% 8x 85.0% 100% (9%) 5.9% (4.4%) (7.8%) (4.7%)3/30/09 Novavax Biotech NVAX 12.500 11.0 0.88 $64.7 17.0% 109x 0.0% NA 26% (6.4%) 15.9% (8.0%) 221.6%3/10/09 Cytori Therapeutics Biotech CYTX 4.771 10.0 2.10 $75.9 13.2% 22x 140.0% 23% (24%) (18.9%) (10.0%) (18.1%) (15.2%)3 /5 /09 Optimer Pharmaceuticals Biotech OPTR 0.458 5.0 10.93 325.0 1.5% 3x 20.0% 0% 3% (0.0%) (0.8%) 0.3% 27.5%3/5 /09 Optimer Pharmaceuticals Biotech OPTR 2.795 27.9 10.00 325.0 8.6% 18x 0.0% NA (6%) (8.5%) 8.4% 9.6% 39.3%2/20/09 Ariad Pharmaceuticals Biotech ARI A 14.379 24.3 1.69 117.6 20.7% 44x 75.0% 27% (25%) 0.0% (12.4%) (41.7%) (14.8%)1/30/09 Dexcom Medtech DXCM 15.994 48.0 3.00 92.9 51.6% 137x 0.0% NA (1%) (3.8%) 7.7% 22.7% 37.0%1/30/09 Pharmasset Biotech VRUS 4.678 45.5 9.73 244.7 18.6% 52x 0.0% NA (9%) (7.0%) 17.2% 30.3% (6.8%)1/29/09 Avi BioPharma Biotech AVII 14.224 16.5 1.16 89.0 18.5% 89x 100.0% 0% 4% (7.2%) (25.0%) (23.3%) (19.8%)
Total $219.3
Mean $24.4 $5.0 $178.3 18% $53.7 47% 30% (5%) (5%) (0%) (4%) 29%Median 24.3 3.0 117.6 17% 44.4 20% 23% (6%) (6%) (1%) (8%) (5%)
Note:3
rey denotes Leerink transactions - Rosetta3
enomics and Infinity Pharmaceuticals not included in Offer Price Discount to 10 Days Prior or Prior Close (Mean and Median)
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Current Trends
Separation ofthe haves and have-nots
Public investors remain risk adverse and are movingupstream in marketcap size
Venture investors filling some but by nomeans all ofthe void
Mostly, ifnot e clusively, participating in financings for portfoliocompanies that arealready public
Mustfund through importantmilestones
Issuers lookingmore closely at bought deals and ATM offerings
Critical deal considerations:
Marketcapitalizations less than $100 million are difficult
Later-stage programs and depthofpipeline important
Less than 12 months ofcashtakes away all leverage
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Overview of Healthcare Financings
Examples of Successful Transactions
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Leerink Swann acted as sole placement agent for Momenta Pharmaceuticals in the
Companys $25.2 million registered direct offering announced on 12/12/08
Transaction highlights:
Superior e ecution in a challengingmarket
Accomplished critical financinggoal ofCompany to e tend cash runway totwo years
Launched and priced transaction withonly four days ofmarketing
Momenta stock price traded up 30% duringthe intra-weekmarketing period; the NASDAQ
Biotechnology inde was flatoverthe period Transaction priced at a 3% premiumtothe closing price priorto launch and required no
warrants
Bookconsisted ofsignificant,high-quality new investors as well as participation by selectede isting investors
Momenta is a leader in developing bio-generics with compelling value proposition in
current environment
Near-term value catalyst in potential approval ofM-Enoxaparin,genericofSanofis Lovenoxwith$3.6 billion ofglobal sales in 2007
Significanttechnical hurdles forcompetitors Amphastar, Hospira, and Teva
Momenta technology and scientists helped resolve global heparin contamination crisis
ANDA filed for M356,generic version ofTevas Copaxone,with$1.4 billion ofglobal sales in2007
Majorcollaboration with industry leaderNovartis / Sandoz
Proprietary follow-on biologics capabilities and pipeline
$25.2 million
Registered DirectOffering
Sole Placement
Agent
December 2008
Case Example: Momenta Registered Direct Offering
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Leerink Swann LLC acted as sole placement agent in the 1/30/09 announced Pharmasset
(Nasdaq: VRUS) $45.5 million registered direct offering
Superior execution
Accomplished critical financinggoal ofCompany, removingfinancingoverhang
Achieved maximum deal size withoversubscribed book and stocktradingup on announcement
Tight, intra-weekmarketingwithminimal share price impact
Priced at a 7% discounttothe prior days closing price and required nowarrants
World-class bookwith significant participation from both new and existing blue chip healthcareinvestors
Sales and tradingcoordinated with researchtoorganize several high quality non-deal marketing events
MEDACorp resources were used tocraft selling and positioning points to investors
Pharmasset is a world-class company developing blockbuster potential anti-viral drugs
R7128 represents a multi-billion dollar blockbuster drugcandidate forthe treatmentofHCV
Clevudine represents a late-stage potential paradigm-shiftingtherapy for HBV
Pharmassethas the leading nucleoside analogue development platform, a key strategic asset
Managementhas consistently delivered on data and timelines attracting a leadinghealthcareinstitutional investor base
Case Example: Pharmasset Registered Direct
$45.5 million
Registered DirectOffering
Sole PlacementAgent
January 2009
10
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Background:
Market Cap:$286.7 mm
Market Price:$5.24(H - $28.42 ; L - $2.80)
PDUFA on July 30, 2009 for lead product
Transaction:
$31 million
Unit Offering:
1 share ofcommon 1 warrantto buy 0.85 common share
Price - $5.23 perunit
Warrant Pricing: Initial strike at$10.46 with adjustable pricing and expiration based on FDA outcome(PDUFA 7/30/09)
Pricing:
Approval, strike of$10.46
IfComplete Response Letter(CRL):
Repriced based on 5-day VWAP at T + 11-15 days
Floorof$1.56
Expiration:
Approval or rejection 9 months post CRL
Ifneither approval nor rejection, earlierof:
15 months after CRL
9 months post Company Response
Ifno CRL, 7 years
Case Example: Savient Pharmaceuticals (SVNT)
$ 1 million
Registered DirectOffering
April 2009
11
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Factors For a Successful PIPE / RDO
Non-Deal Roadshows are important in this environment
Identification ofanchororder is critical
Anchor is 10% - 20%ofdeal
Prior validation ofstrategic supportor interest
Existing base ofsolid institutions attracts more and creates good support
Creative deal structures may be more frequent(Savient)