Lecture Notes in Computer Science 8675Commenced Publication in 1973Founding and Former Series Editors:Gerhard Goos, Juris Hartmanis, and Jan van Leeuwen

Editorial Board

David HutchisonLancaster University, UK

Takeo KanadeCarnegie Mellon University, Pittsburgh, PA, USA

Josef KittlerUniversity of Surrey, Guildford, UK

Jon M. KleinbergCornell University, Ithaca, NY, USA

Alfred KobsaUniversity of California, Irvine, CA, USA

Friedemann MatternETH Zurich, Switzerland

John C. MitchellStanford University, CA, USA

Moni NaorWeizmann Institute of Science, Rehovot, Israel

Oscar NierstraszUniversity of Bern, Switzerland

C. Pandu RanganIndian Institute of Technology, Madras, India

Bernhard SteffenTU Dortmund University, Germany

Demetri TerzopoulosUniversity of California, Los Angeles, CA, USA

Doug TygarUniversity of California, Berkeley, CA, USA

Gerhard WeikumMax Planck Institute for Informatics, Saarbruecken, Germany

Polina Golland Nobuhiko HataChristian Barillot Joachim HorneggerRobert Howe (Eds.)

Medical Image Computingand Computer-AssistedIntervention – MICCAI 2014

17th International ConferenceBoston, MA, USA, September 14-18, 2014Proceedings, Part III

13

Volume Editors

Polina GollandMassachusetts Institute of TechnologyCambridge, MA, USAE-mail: polina@csail.mit.edu

Nobuhiko HataBrigham and Women’s HospitalHarvard Medical School, Boston, MA, USAE-mail: hata@bwh.harvard.edu

Christian BarillotIRISA, Rennes, FranceE-mail: christian.barillot@irisa.fr

Joachim HorneggerFriedrich-Alexander University Erlangen-NurembergErlangen, GermanyE-mail: joachim.hornegger@fau.de

Robert HoweHarvard University, Cambridge, MA, USAE-mail: howe@seas.harvard.edu

ISSN 0302-9743 e-ISSN 1611-3349ISBN 978-3-319-10442-3 e-ISBN 978-3-319-10443-0DOI 10.1007/978-3-319-10443-0Springer Cham Heidelberg New York Dordrecht London

Library of Congress Control Number: 2014946218

LNCS Sublibrary: SL 6 – Image Processing, Computer Vision, Pattern Recognition,and Graphics

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Preface

The 17th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI 2014) was held in Boston, USA, at the Mas-sachusetts Institute of Technology (MIT) and Harvard Medical School duringSeptember 14-18, 2014. We were delighted to welcome the conference back tothe location of the very first MICCAI meeting that took place on MIT campusin 1998. Over the last 16 years, the MICCAI conferences have become a premierinternational event, with papers of high standard addressing open problems inthe multidisciplinary fields of biomedical image computing, computer-assistedintervention, and medical robotics. The conference attracts leading scientists,engineers, and clinicians from a wide range of disciplines.

This year, we received a record number of 862 submissions. These coveredmedical image computing (functional and diffusion image analysis, segmentation,physical and functional modeling, shape analysis, atlases and statistical models,registration, data fusion and multiscale analysis), computer-assisted interven-tions and robotics (planning and image guidance of interventions, simulationand training systems, clinical platforms, visualization and feedback, roboticsand human–robot interaction), and clinical imaging and biomarkers (computer-aided diagnosis, organ/system specific applications, molecular and optical imag-ing and imaging biomarkers). A careful systematic review process was carriedout to create the most exciting scientific program for MICCAI 2014. The Pro-gram Committee (PC) of the conference was composed of 52 experts recognizedinternationally in the main topics of the conference. Each submission was as-signed to a primary PC member who recruited between three and four externalreviewers for each paper based on their expertise and the topic of the paper. Theexternal reviewers provided double-blind reviews of the papers. Each submissionwithout consensus among the external reviewers was assigned to two secondaryPC members and was invited to submit a rebuttal followed by discussion amongthe external reviewers. Each secondary PC member made recommendations tothe PC while taking into account the external reviews, the rebuttal, and the dis-cussion. The list of accepted papers was finalized during a two-day PC meetingheld at MIT during May 17-18, 2014, based on the scores and rankings providedby the PC members and external reviewers and on the discussion among the PCmembers. In all, we accepted 253 papers (29%) to be included in the proceedingsof MICCAI 2014 and presented as posters during the meeting. Of these, 36 wereselected for podium presentation (4%). We congratulate those who had papersaccepted and encourage those who did not to persevere and submit again nextyear. Selection of papers for MICCAI is a competitive process and with sucha strong submission pool it is inevitable that many good papers could not beincluded in the final program. We sympathize with the authors whose paperswere rejected; we had our own share of rejected papers this year!

VI Preface

In addition to the main conference, MICCAI 2014 offered a rich program ofworkshops, computational challenges, and tutorials. We received a fantastic setof proposals that resulted in an exciting, diverse, and high-quality program. Theworkshops provided a comprehensive coverage of topics not fully explored duringthe main conference and of emerging areas of MICCAI; the computational chal-lenges explored empirical solutions to hard open problems; the tutorials providededucational material for training new professionals in the field. We are gratefulto all workshop, challenge, and tutorial organizers for making these events asuccess and to the workshop chairs for creating such a great program.

MICCAI 2014 introduced a completely new Educational Challenge, con-ceived, organized, and run by the MICCAI Student Board. The long-term goalis to create a video library of educational presentations for students enteringthe fields. The Educational Challenge was a great step in that direction, andwe hope MICCAI will continue to support this effort. Our many thanks go outto the students who organized the challenge. We would also like to thank ourinvited speaker Neville Hogan (MIT, USA) for his presentation on the use ofrobots for rehabilitation.

We thank the external reviewers and the PC for volunteering their timeand judgement to provide high-quality reviews and ensure a fair paper selectionprocess. The continued improvement in the quality of the conference dependsentirely on this tremendous effort. We thank James Stewart of precisioncon-ference.com for the efficient organization of the website and amazingly fast re-sponses to our questions and requests for changes. The conference would not bepossible without the commitment and hard work of the MIT Conference Ser-vices staff that contributed tremendous amount of effort and energy to makesure all the logistics of the meeting ran smoothly. Our special thanks go outto Amy Hansen, who singlehandedly compiled the conference proceedings andconference program brochures, spent many hours in communications with theauthors to ensure their papers are properly included in the proceedings, andhandling many other aspects of the paper submission process. We also thank allthe session chairs for managing and coordinating the presentations during theconference.

We thank the MICCAI Society for providing valuable input and supportfor the conference. We were delighted to have had a chance to organize a 10thanniversary celebration for the society. Many happy returns! Last but not least,we would like to thank all our sponsors for their kind support. Their generosityensured the highest quality of the conference and essential support to studentsand young researchers.

It was our pleasure to welcome MICCAI 2014 participants to Boston. Welook forward to seeing you all again next year in Munich, Germany!

September 2014 Polina GollandNobuhiko Hata

Christian BarillotJoachim Hornegger

Robert Howe

Organization

General Chairs

Polina Golland Massachusetts Institute of Technology, USANobuhiko Hata Harvard Medical School, USA

Program Chairs

Polina Golland Massachusetts Institute of Technology, USAChristian Barrilot IRISA, FranceJoachim Hornegger Friedrich Alexander University,

Erlangen-Nuremberg, GermanyRobert Howe Harvard Medical School, USA

Workshop/Tutorial/Challenge Chairs

Georg Langs Medical University of Vienna, AustriaMehdi Moradi University of British Columbia, CanadaSonia Pujol Harvard Medical School, USAMartin Styner University of Norther Carolina Chapel

Hill, USA

Local Arrangements

MIT Conference Services

Student Liaison

Adrian Dalca MIT, Cambridge, MA, USA

Program Committee

Purang Abolmaesumi University of British Columbia, CanadaStephen Aylward Kitware, USADean Barratt University College London, UKDorin Comaniciu Siemens, USAChristos Davatzikos University of Pennsylvania, USAMarleen de Bruijne Erasmus MC Rotterdam, The NetherlandsJames Duncan Yale University, USARandy Ellis Queen’s University, CanadaGabor Fichtinger Queen’s University, Canada

VIII Organization

James Gee University of Pennsylvania, USAGuido Gerig University of Utah, USAMiguel A. Gonzalez Ballester ICREA-Universitat Pompeu Fabra, SpainLeo Grady HeartFlow, USAHavit Greenspan Tel Aviv University, IsraelGregory D. Hager Johns Hopkins University, USAGhassan Hamameh Simon Fraser University, CanadaAmeet Jain Philips, USARon Kikinis Harvard Medical School, USAEnder Konukoglu Harvard Medical School, USAHongen Liao Tsinghua University, ChinaHuafeng Liu Zhejiang University, ChinaDimitris Metaxas Rutgers University, USAMehdi Moradi University of British Columbia, CanadaKensaku Mori Nagoya University, JapanMads Nielsen University of North Carolina Chapel Hill, USAMads Neilsen University of Copenhagen, DenmarkWiro Niessen Eramus MC Rotterdam, The NetherlandsMarc Niethammer University of North Carolina Chapel Hill, USAXenophon Papademetris Yale University, USAXavier Pennec Inria, FranceJoseine Pluim Univeristy Medical Center Utrecht,

The NetherlandsKillian Pohl SRI International, USAFrancois Rousseau CNRS, FranceDaniel Rueckert Imperial College London, UKMert Rory Sabuncu Harvard Medical School, USAYoshinobu Sato Osaka University, JapanJulia Schnabel University of Oxford, UKJulia Schnabel University of Oxford, UKDinggang Shen University of North Carolina Chapel Hill, USALi Shen Indiana University, USAKaleem Siddiqi McGill University, CanadaLawrence Staib Yale University, USADanail Stoyanov University College London, UKColin Studholme University of Washington, USAGabor Szekely ETH Zurich, SwitzerlandJunichi Tokuda Harvard Medical School, USAKoen Van Leemput Technical University of Denmark, DenmarkRene Vidal Johns Hopkins University, USASimon Warfield Harvard Medical School, USAWilliam (Sandy) Wells Harvard Medical School, USACarl-Fredrik Westin Harvard Medical School, USAAlistair Young University of Auckland, New Zealand

Organization IX

Additional Reviewers

Abu Anas, EmranAbugharbieh, RafeefAcar, BurakAcosta-Tamayo, OscarAfacan, OnurAfsari, BijanAganj, ImanAja-Fernandez, SantiagoAkbari, HamedAkhondi-Asl, AlirezaAlavi, AbassAlberola-Lopez, CarlosAlexander, DanielAljabar, PaulAllan, MaximilianAmini, AmirAngelini, ElsaAngelopoulou, ElliAntani, SameerAnwander, AlfredArbel, TalArbelaez, PabloArdekani, SiamakArimura, HidetakaArteta, CarlosAshburner, JohnAshraf, AhmedAubert-Broche, BerengereAudette, MichelAuvray, VincentAvants, BrianAvants, BrianAwate, SuyashBach Cuadra, MeritxellBach Cuadra, MeritxellBagci, UlasBaka, NoraBalicki, MarcinBaloch, SajjadBarbu, AdrianBarmpoutis, AngelosBartoli, AdrienBassett, Danielle

Batmanghelich, KayhanBauer, StefanBaust, MaximilianBazin, Pierre-LouisBejar, BenjaminBen Ayed, IsmailBergeles, ChristosBerger, Marie-OdileBernardis, ElenaBetrouni, NacimBharat, ShyamBhatia, KanwalBhotika, RahulBilgic, BerkinBirkfellner, WolfgangBiros, GeorgeBiros, GeorgeBismuth, VincentBoctor, EmadBogunovic, HrvojeBoisvert, JonathanBossa, Matias NicolasBouix, SylvainBoukerroui, DjamalBourgeat, PierrickBovendeerd, PeterBrady, MichaelBron, EstherBrost, AlexanderBuelow, ThomasBuhmann, JoachimButakoff, ConstantineCaan, MatthanCabrera Lozoya, RocoCahill, NathanCai, WeidongCalder, JeffreyCamara, OscarCarass, AaronCardenes, RubenCardoso, Manuel JorgeCarmichael, OwenCaruyer, Emmanuel

X Organization

Castellani, UmbertoCathier, PascalCattin, Philippe C.Cepek, JeremyCeresa, MarioCetingul, Hasan ErtanChakravarty, M. MallarChang, Ping-LinChaudhry, RizwanChefd’hotel, ChristopheChen, Elvis C. S.Chen, TerrenceChen, Thomas KuiranChen, TingCheng, JianCheng, JunCheriet, FaridaChinzei, KiyoyukiChristensen, GaryChung, Albert C. S.Chung, MooCinquin, PhilippeCiompi, FrancescoCiuciu, PhilippeClancy, Neil T.Claridge, ElaClarkson, MatthewClarysse, PatrickClaus, PietClemmesen, LineCobzas, DanaCollins, D. LouisColliot, OlivierCommowick, OlivierCook, PhilipCootes, TimCordier, NicolasCorso, JasonCounsell, Serena J.Coupe, PierrickCowan, BrettCrane, JasonCriminisi, AntonioCrum, WilliamCuingnet, Remi

Daga, PankajDalca, AdrianDarkner, SuneDas, SandhitsuDauguet, JulienDawant, BenoitDe Craene, MathieuDe Raedt, SeppDehghan, EhsanDeligianni, FaniDelingette, HerveDemirci, StefanieDenney, TomDequidt, JeremieDescoteaux, MaximeDesjardins, AdrienD’hooge, JanDi Battista, AndrewDijkstra, JoukeDiMaio, SimonDing, KaiDojat, MichelDonner, ReneDrew, MarkDu Bois d’Aische, AloysDuchateau, NicolasDuchesnay, EdouardDuchesne, SimonDuda, JeffreyDuits, RemcoDuriez, ChristianDzyubachyk, OlehEavani, HariniEbrahimi, MehranEdwards, PhilipEhrhardt, JanEklund, AndersEl-Baz, AymanElson, DanielEl-Zehiry, NohaErdt, MariusErus, GurayFahrig, RebeccaFalco, AlexandreFallavollita, Pascal

Organization XI

Fang, RuoguFarag, AlyFedorov, AndriyFenster, AaronFeragen, AasaFigl, MichaelFishbaugh, JamesFitzpatrick, J. MichaelFletcher, P. ThomasFlorack, LucForoughi, PezhmanFradkin, MaximFreiman, MotiFreysinger, WolfgangFripp, JurgenFritscher, KarlFua, PascalFuerst, BernhardFunka-Lea, GarethFunke, JanGangeh, MehrdadGanz, MelanieGao, FeiGao, MingchenGao, WeiGao, YaozongGao, YiGaonkar, BilwajGarcia-Lorenzo, DanielGarvin, MonaGaser, ChristianGe, TianGeorgescu, BogdanGeremia, EzequielGhanbari, YasserGholipour, AliGhosh, AurobrataGhosh, SatrajitGhosh, SubhamGiannarou, StamatiaGibaud, BernardGibson, EliGilbert, StephenGilles, BenjaminGinsburg, Shoshana

Giusti, AlessandroGlocker, BenGoh, AlvinaGoksel, OrcunGoldberger, JacobGoni Cortes, JoaquinGooya, AliGraham, JimGrbic, SasaGrisan, EnricoGrova, ChristopheGuetter, ChristophGuevara, PamelaGulsun, Mehmet AkifGuo, YanrongGur, YanivGutman, BorisHacihaliloglu, IlkerHaidegger, TamasHaj-Hosseini, NedaHajnal, JosephHamamci, AndacHammers, AlexanderHan, LianghaoHaneishi, HideakiHastreiter, PeterHatt, ChuckHauta-Kasari, MarkkuHawkes, DavidHaynor, DavidHe, HuiguangHe, TianchengHeckemann, RolfHeimann, TobiasHeinrich, Mattias PaulHelmstaedter, MoritzHeng, Pheng AnnHennemuth, AnjaHermosillo, GerardoHibar, DerrekHipwell, JohnHo, HarveyHolmes, DavidHolmes, JeffHong, Byung-Woo

XII Organization

Hontani, HidekataHoogendoorn, CorneHu, ChenhuiHu, MingxingHu, YipengHu, ZhihongHua, XueHuang, HengHuang, JunzhouHuang, XiaojieHuang, XiaoleiHuisman, HenkjanIbrahim, El-SayedIglesias, Juan EugenioIngalhalikar, MadhuraIordachita, IulianJacobs, ColinJafari-Khouzani, KouroshJagadeesan, JayenderJain, SaurabhJannin, PierreJanoos, FirdausJanowczyk, AndrewJi, ShuiwangJiang, MenglinJiang, YifengJolly, Marie-PierreJomier, JulienJones, GeoffreyJordan, PetrJoshi, AnandJoshi, Gopal DattJoshi, SarangJoung, SanghyunKabus, SvenKachelrie, MarcKadoury, SamuelKahl, FredrikKainmueller, DagmarKakadiaris, IoannisKapoor, AnkurKapur, TinaKaracali, BilgeKarssemeijer, NicoKeeve, Erwin

Kelm, MichaelKerrien, ErwanKhallaghi, SiavashKhan, AliKharazmi, PegahKherif, FerathKhurd, ParmeshwarKim, BoklyeKim, MinjeongKindlmann, GordonKing, AndrewKiraly, AtillaKirisli, HortenseKitasaka, TakayukiKlein, StefanKlein, TassiloKlinder, TobiasKnutsson, HansKoizumi, NorihiroKowalewski, TimothyKrause, OswinKrieger, AxelKunz, ManuelaKwitt, RolandKwon, DongjinLotjonen, JyrkiLadikos, AlexanderLaine, AndrewLam, FanLamata, PabloLandman, BennettLang, PencillaLangerak, ThomasLangs, GeorgLapeer, RudyLarsen, Anders Boesen LindboLartizien, CaroleLasser, TobiasLasso, AndrasLauze, FrancoisLaw, Max W.K.Le, YenLecoeur, JeremyLee, JunghoonLee, Su-Lin

Organization XIII

Lefevre, JulienLefkimmiatis, StamatisLe Folgoc, LocLekadir, KarimLelieveldt, BoudewijnLendvay, ThomasLenglet, ChristopheLepore, NatashaLesage, DavidLi, ChunmingLi, FuhaiLi, GangLi, JiangLi, QuanzhengLi, YangLiao, RuiLillholm, MartinLin, HenryLindner, ClaudiaLinguraru, Marius GeorgeLinte, CristianLitjens, GeertLiu, DavidLiu, JiaminLiu, JianfeiLiu, SidongLiu, XiaoxiaoLiu, YixunLo, BennyLombaert, HerveLorenz, CristianLorenzi, MarcoLu, LeLu, ShijianLu, XiaoguangLuan, K.Lui, Lok MingLuo, XiongbiaoLyksborg, MarkMuller, HenningMachiraju, RaghuMaddah, MahnazMadooei, AliMahapatra, DwarikanathMahdavi, Seyedeh Sara

Maier-Hein, LenaMailhe, BorisMajumdar, AngshulMalandain, GregoireMalgouyres, FrancoisManduca, ArmandoManjon, Jose V.Manniesing, RashindraMansi, TommasoMarchal, MaudMarchesseau, StephanieMargeta, JanMari, Jean-MartialMariottini, Gian LucaMarsland, StephenMarti, RobertMartel, AnneMartin-Fernandez, MarcosMasamune, KenMasutani, YoshitakaMateus, DianaMattes, JulianMcClelland, JamieMcCulloch, AndrewMcIntosh, ChrisMcleod, KristinMedrano-Gracia, PauMendrik, AdrienneMenze, BjoernMetz, CoertMeyer, ChuckMichailovich, OlegMiga, MichaelMihalef, ViorelMiller, JamesMiller, KarolMirzaalian, HengamehMirzaee, HaniehModat, MarcMoghari, MehdiMohamed, AshrafMohareri, OmidMomayyez, ParyaMontillo, AlbertMoore, John

XIV Organization

Mountney, PeterMurphy, KeelinNabavi, AryaNajman, LaurentNakamura, RyoichiNakamura, YoshihikoNasiriavanaki, MohammadrezaNavab, NassirNeumuth, ThomasNg, BernardNguyen, HianNichols, ThomasNicolau, StephaneNie, JingxinNiederer, StevenNielsen, PoulNoble, AlisonNoble, JackNoblet, VincentNolte, LutzNordsletten, DavidNouranian, SamanNugroho, HermawanOda, MasahiroO’Donnell, LaurenO’Donnell, ThomasOfli, FerdaOliver, ArnauOnofrey, JohnOrihuela-Espina, FelipeOtake, YoshitoOu, YangmingPace, DaniellePadfield, DirkPadoy, NicolasPallavaram, SrivatsanPant, SanjayParisot, SarahPark, JinHyeongParthasarathy, VijayPasternak, OferPatriciu, AlexandruPaul, PerrinePaulsen, RasmusPauly, Olivier

Pavlidis, IoannisPeitgen, Heinz-OttoPenney, GraemePernus, FranjoPeterlik, IgorPeters, JochenPeters, Terry M.Petersen, JensPetersen, JensPetersen, KerstenPetitjean, CarolinePeyrat, Jean-MarcPham, DzungPiella, GemmaPitiot, AlainPiuze, EmmanuelPizer, StephenPlenge, EsbenPoline, Jean-BaptistePoot, DirkPop, MihaelaPoulsen, CatherinePrasad, GautamPrastawa, MarcelPratt, PhilipPrevost, RaphaelPrice, BrianPrice, TruePrince, JerryPunithakumar, KumaradevanQazi, Arish A.Qi, JinyiQian, XiaoningQian, ZhenQiu, WuRadeva, PetiaRafii-Tari, HedyehRaj, AshishRajagopalan, VidyaRajchl, MartinRajpoot, NasirRaju, BalasundarRamezani, MahdiRapaka, SaikiranRathi, Yogesh

Organization XV

Ravichandran, AvinashReader, AndrewReiley, CarolReinertsen, IngeridReisert, MarcoReiter, AustinReyes, MauricioRhode, KawalRicha, RogrioRiddell, CyrillRiklin Raviv, TammyRisholm, PetterRisser, LaurentRit, SimonRivaz, HassanRiviere, DenisRobert, Jean-lucRoche, AlexisRohlfing, TorstenRohling, RobertRohr, KarlRoth, HolgerRoysam, BadrinathRussakoff, DanielSorensen, LaugeSaad, AhmedSakuma, IchiroSalcudean, TimSalvado, OlivierSan Jose Estepar, RaulSanchez, ClarisaSands, GregSarrut, DavidSarry, LaurentSarunic, MarinkoSavadjiev, PeterSchaap, MichielScheinost, DustinScherrer, BenoitSchmidt, FrankSchmidt-Richberg, AlexanderSchneider, CaitlinSchroeder, PeterSchuh, AndreasSchultz, Thomas

Schweikard, AchimSeiler, ChristofSeitel, AlexanderSermesant, MaximeSeshamani, SharmishtaaShahzad, RahilShamir, Reuben R.Sharma, PuneetShi, FengShi, KuangyuShi, WenzheShi, YonggangShi, YonghongShinohara, Russell T.Shou, GuofaSijbers, JanSimon, DuchesneSimpson, AmberSimpson, IvorSingh, NikhilSingh, VikasSingh, VivekSivaswamy, JayanthiSmeets, DirkSong, GangSong, QiSotiras, AristeidisSparks, RachelSpeidel, StefanieSporring, JonSpottiswoode, BruceStuhmer, JanStamm, AymericStaring, MariusStetten, GeorgeStewart, CharlesStewart, JamesStyles, IainStyner, MartinSu, BaiquanSubramanian, NavneethSuinesiaputra, AvanSuk, Heung-IlSummers, RonaldSundar, Hari

XVI Organization

Syeda-Mahmood, TanveerSzkulmowski, MaciejSznitman, RaphaelTahmasebi, AmirTaimouri,VahidTamaki, ToruTan, ChaoweiTanner, ChristineTaquet, MaximeTasdizen, TolgaTaylor, RussellTaylor, ZeikeTek, HuseyinThirion, BertrandThodberg, Hans HenrikThompson, StephenTiwari, PallaviTobon-Gomez, CatalinaToews, MatthewTosun, DuyguTotz, JohannesToussaint, NicolasTreeby, BradleyTroccaz, JocelyneTustison, NicholasTwining, CaroleUkwatta, ErangaUnal, GozdeUzunbas, MustafaVaillant, RegisVan Assen, HansVan de Ven, WendyVan Ginneken, BramVan Rikxoort, EvaVan Walsum, TheoVannier, MichaelVaroquaux, GaelVegas-Sanchez-Ferrero, GonzaloVemuri, BabaVenkataraman, ArchanaVercauteren, TomVialard, Francois-XavierVignon, FrancoisVik, TorbjorrnVillard, Pierre-Frederic

Visentini-Scarzanella, MarcoViswanath, SatishVitaladevuni, ShivVitanovski, DimeVogelstein, JoshuaVoigt, IngmarVon Berg, JensVoros, SandrineVos, PieterVosburgh, KirbyVrooman, HenriVrtovec, TomazWachinger, ChristianWaelkens, PauloWan, CatherineWang, ChaohuiWang, HongzhiWang, JunchenWang, LiWang, LianshengWang, LinweiWang, QiuWang, ShijunWang, SongWang, VickyWang, YalinWang, YinhaiWang, Yu-PingWashio, ToshikatsuWassermann, DemianWee, Chong-YawWeese, JurgenWei, LiuWein, WolfgangWels, MichaelWerner, ReneWesarg, StefanWhitaker, RossWhitmarsh, TristanWiles, AndrewWilson, NathanWittek, AdamWolz, RobinWong, Ken C.L.Wong, Stephen

Organization XVII

Wright, GrahamWu, GuorongWu, John JueWu, WenWu, XiaodongXie, YuchenXing, FuyongXu, Xiao YunXu, YanwuXu, ZiyueXue, ZhongYan, PingkunYan, ZhennanYang, LiangjingYang, LinYaniv, ZivYao, JianhuaYap, Pew-ThianYaqub, MohammadYe, Dong HyeYeo, B.T. ThomasYin, YoubingYin, ZhaozhengYokota, FutoshiYoshida, HiroYushkevich, PaulZeng, HaishanZeng, Wei

Zhan, LiangZhan, YiqiangZhang, DaoqiangZhang, HuiZhang, PeiZhang, shaotingZhang, ZhijunZhao, QianZheng, GuoyanZheng, YefengZheng, YuanjieZhou, JianZhou, JinghaoZhou, KevinZhou, LupingZhou, X. SeanZhou, YanZhu, DajiangZhu, HongtuZhu, YueminZhuang, XiahaiZijdenbos, AlexZikic, DarkoZollei, LillaZuluaga, Maria A.Zwiggelaar, Reyer

XVIII Organization

MICCAI Society Board of Directors

Alison Noble (President) University of Oxford, Oxford, UKWiro Niessen (Exec. Director) Erasmus MC - University Medical Centre,

Rotterdam, The NetherlandsSebastien Ourselin (Treasurer) University College, London, UKGabor Fichtinger (Secretary) Queen’s University, Kingston, ON, CanadaStephen Aylward Kitware, Inc., NY, USAAlejandro Frangi University of Sheffield, Sheffield, UKPolina Golland MIT, Cambridge, MA, USAPierre Jannin INSERM, Rennes, FranceKensaku Mori Nagoya University, JapanNassir Navab TUM, Munich, GermanyXavier Pennec INRIA, Sophia Antipolis, FranceJosien Pluim University Medical Center Utrecht,

The NetherlandsDaniel Rueckert Imperial College, London, UKDinggang Shen UNC, Chapel Hill, NC, USA

MICCAI Society Consultants to the Board

Alan Colchester University of Kent, UKTerry Peters University of Western Ontario, London,

CanadaRichard Robb Mayo Clinic College of Medicine, USA

MICCAI Society Staff

Society Secretariat Janette Wallace, CanadaRecording Secretary Jackie Williams, Canada

Table of Contents – Part III

Shape and Population Analysis

Generalized Multiresolution Hierarchical Shape Models via AutomaticLandmark Clusterization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1

Juan J. Cerrolaza, Arantxa Villanueva, Mauricio Reyes,Rafael Cabeza, Miguel Angel Gonzalez Ballester, andMarius George Linguraru

Hierarchical Bayesian Modeling, Estimation, and Sampling forMultigroup Shape Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9

Yen-Yun Yu, P. Thomas Fletcher, and Suyash P. Awate

Depth-Based Shape-Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17Yi Hong, Yi Gao, Marc Niethammer, and Sylvain Bouix

Genus-One Surface Registration via Teichmuller Extremal Mapping . . . . 25Ka Chun Lam, Xianfeng Gu, and Lok Ming Lui

Subject-Specific Prediction Using Nonlinear Population Modeling:Application to Early Brain Maturation from DTI . . . . . . . . . . . . . . . . . . . . 33

Neda Sadeghi, P. Thomas Fletcher, Marcel Prastawa,John H. Gilmore, and Guido Gerig

BrainPrint : Identifying Subjects by Their Brain . . . . . . . . . . . . . . . . . . . . . 41Christian Wachinger, Polina Golland, and Martin Reuter

Diffeomorphic Shape Trajectories for Improved LongitudinalSegmentation and Statistics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49

Prasanna Muralidharan, James Fishbaugh, Hans J. Johnson,Stanley Durrleman, Jane S. Paulsen, Guido Gerig, andP. Thomas Fletcher

Simulating Neurodegeneration through Longitudinal PopulationAnalysis of Structural and Diffusion Weighted MRI Data . . . . . . . . . . . . . 57

Marc Modat, Ivor J.A. Simpson, Manuel Jorge Cardoso,David M. Cash, Nicolas Toussaint, Nick C. Fox, andSebastien Ourselin

The 4D Hyperspherical Diffusion Wavelet: A New Method for theDetection of Localized Anatomical Variation . . . . . . . . . . . . . . . . . . . . . . . . 65

Ameer Pasha Hosseinbor, Won Hwa Kim, Nagesh Adluru,Amit Acharya, Houri K. Vorperian, and Moo K. Chung

XX Table of Contents – Part III

Brain II

Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe):Distinguishing Tumor Confounders and Molecular Subtypes on MRI . . . . 73

Prateek Prasanna, Pallavi Tiwari, and Anant Madabhushi

Automatic Clustering and Thickness Measurement of AnatomicalVariants of the Human Perirhinal Cortex . . . . . . . . . . . . . . . . . . . . . . . . . . . 81

Long Xie, John Pluta, Hongzhi Wang, Sandhitsu R. Das,Lauren Mancuso, Dasha Kliot, Brian B. Avants, Song-Lin Ding,David A. Wolk, and Paul A. Yushkevich

Constructing 4D Infant Cortical Surface Atlases Based on DynamicDevelopmental Trajectories of the Cortex . . . . . . . . . . . . . . . . . . . . . . . . . . . 89

Gang Li, Li Wang, Feng Shi, Weili Lin, and Dinggang Shen

Low-Rank to the Rescue – Atlas-Based Analyses in the Presence ofPathologies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97

Xiaoxiao Liu, Marc Niethammer, Roland Kwitt,Matthew McCormick, and Stephen Aylward

Optimized PatchMatch for Near Real Time and Accurate LabelFusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105

Vinh-Thong Ta, Remi Giraud, D. Louis Collins, and Pierrick Coupe

Functionally Driven Brain Networks Using Multi-layer GraphClustering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113

Yasser Ghanbari, Luke Bloy, Varsha Shankar, J. Christopher Edgar,Timothy P.L. Roberts, Robert T. Schultz, and Ragini Verma

Bayesian Principal Geodesic Analysis in Diffeomorphic ImageRegistration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121

Miaomiao Zhang and P. Thomas Fletcher

New Partial Volume Estimation Methods for MRI MP2RAGE . . . . . . . . . 129Quentin Duche, Parnesh Raniga, Gary F. Egan, Oscar Acosta,Giulio Gambarota, Olivier Salvado, and Herve Saint-Jalmes

Single-Subject Structural Networks with Closed-Form RotationInvariant Matching Improve Power in Developmental Studies of theCortex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137

Benjamin M. Kandel, Danny JJ Wang, James C. Gee, andBrian B. Avants

T2-Relaxometry for Myelin Water Fraction Extraction Using WaldDistribution and Extended Phase Graph . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145

Alireza Akhondi-Asl, Onur Afacan, Robert V. Mulkern, andSimon K. Warfield

Table of Contents – Part III XXI

Compact and Informative Representation of Functional Connectivityfor Predictive Modeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 153

Raif M. Rustamov, David Romano, Allan L. Reiss, andLeonidas J. Guibas

Registering Cortical Surfaces Based on Whole-Brain StructuralConnectivity and Continuous Connectivity Analysis . . . . . . . . . . . . . . . . . . 161

Boris Gutman, Cassandra Leonardo, Neda Jahanshad,Derrek Hibar, Kristian Eschenburg, Talia Nir, Julio Villalon, andPaul Thompson

Automatic Method for Thalamus Parcellation Using Multi-modalFeature Classification . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169

Joshua V. Stough, Jeffrey Glaister, Chuyang Ye, Sarah H. Ying,Jerry L. Prince, and Aaron Carass

Multiple-Network Classification of Childhood Autism Using FunctionalConnectivity Dynamics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177

True Price, Chong-Yaw Wee, Wei Gao, and Dinggang Shen

Deriving a Multi-subject Functional-Connectivity Atlas to InformConnectome Estimation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185

Ronald Phlypo, Bertrand Thirion, and Gael Varoquaux

Discriminative Sparse Connectivity Patterns for Classification of fMRIData . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193

Harini Eavani, Theodore D. Satterthwaite, Raquel E. Gur,Ruben C. Gur, and Christos Davatzikos

Diffusion MRI

MesoFT: Unifying Diffusion Modelling and Fiber Tracking . . . . . . . . . . . . 201Marco Reisert, V.G. Kiselev, Bibek Dihtal, Elias Kellner, andD.S. Novikov

Measurement Tensors in Diffusion MRI: Generalizing the Concept ofDiffusion Encoding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209

Carl-Fredrik Westin, Filip Szczepankiewicz, Ofer Pasternak,Evren Ozarslan, Daniel Topgaard, Hans Knutsson, andMarkus Nilsson

From Expected Propagator Distribution to Optimal Q-space SampleMetric . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217

Hans Knutsson and Carl-Fredrik Westin

Image Quality Transfer via Random Forest Regression: Applications inDiffusion MRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225

Daniel C. Alexander, Darko Zikic, Jiaying Zhang, Hui Zhang, andAntonio Criminisi

XXII Table of Contents – Part III

Complete Set of Invariants of a 4th Order Tensor: The 12 Tasks ofHARDI from Ternary Quartics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233

Theo Papadopoulo, Aurobrata Ghosh, and Rachid Deriche

In vivo Estimation of Dispersion Anisotropy of Neurites Using DiffusionMRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 241

Maira Tariq, Torben Schneider, Daniel C. Alexander,Claudia A.M. Wheeler-Kingshott, and Hui Zhang

Diffusion of Fiber Orientation Distribution Functions with aRotation-Induced Riemannian Metric . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 249

Junning Li, Yonggang Shi, and Arthur W. Toga

Machine Learning Based Compartment Models with Permeability forWhite Matter Microstructure Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257

Gemma L. Nedjati-Gilani, Torben Schneider, Matt G. Hall,Claudia A.M. Wheeler-Kingshott, and Daniel C. Alexander

Probabilistic Shortest Path Tractography in DTI Using GaussianProcess ODE Solvers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265

Michael Schober, Niklas Kasenburg, Aasa Feragen,Philipp Hennig, and Søren Hauberg

Construct and Assess Multimodal Mouse Brain Connectomes via JointModeling of Multi-scale DTI and Neuron Tracer Data . . . . . . . . . . . . . . . . 273

Hanbo Chen, Yu Zhao, Tuo Zhang, Hongmiao Zhang, Hui Kuang,Meng Li, Joe Z. Tsien, and Tianming Liu

Designing Single- and Multiple-Shell Sampling Schemes for DiffusionMRI Using Spherical Code . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281

Jian Cheng, Dinggang Shen, and Pew-Thian Yap

A Prototype Representation to Approximate White Matter Bundleswith Weighted Currents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289

Pietro Gori, Olivier Colliot, Linda Marrakchi-Kacem,Yulia Worbe, Fabrizio De Vico Fallani, Mario Chavez,Sophie Lecomte, Cyril Poupon, Andreas Hartmann,Nicholas Ayache, and Stanley Durrleman

Machine Learning II

Hole Detection in Metabolic Connectivity of Alzheimer’s Disease Usingk -Laplacian . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297

Hyekyoung Lee, Moo K. Chung, Hyejin Kang, and Dong Soo Lee

Deep Learning Based Imaging Data Completion for Improved BrainDisease Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305

Rongjian Li, Wenlu Zhang, Heung-Il Suk, Li Wang, Jiang Li,Dinggang Shen, and Shuiwang Ji

Table of Contents – Part III XXIII

Human Connectome Module Pattern Detection Using a NewMulti-graph MinMax Cut Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313

De Wang, Yang Wang, Feiping Nie, Jingwen Yan, Weidong Cai,Andrew J. Saykin, Li Shen, and Heng Huang

Max-Margin Based Learning for Discriminative Bayesian Network fromNeuroimaging Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 321

Luping Zhou, Lei Wang, Lingqiao Liu, Philip Ogunbona, andDinggang Shen

A Novel Structure-Aware Sparse Learning Algorithm for Brain ImagingGenetics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329

Lei Du, Jingwen Yan, Sungeun Kim, Shannon L. Risacher,Heng Huang, Mark Inlow, Jason H. Moore, Andrew J. Saykin, andLi Shen

Multi-organ Localization Combining Global-to-Local Regression andConfidence Maps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337

Romane Gauriau, Remi Cuingnet, David Lesage, and Isabelle Bloch

Inter-Cluster Features for Medical Image Classification . . . . . . . . . . . . . . . 345Siyamalan Manivannan, Ruixuan Wang, and Emanuele Trucco

A Universal and Efficient Method to Compute Maps from Image-BasedPrediction Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 353

Mert R. Sabuncu

3D Spine Reconstruction of Postoperative Patients from Multi-levelManifold Ensembles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361

Samuel Kadoury, Hubert Labelle, and Stefan Parent

Scalable Histopathological Image Analysis via Active Learning . . . . . . . . . 369Yan Zhu, Shaoting Zhang, Wei Liu, and Dmitris Metaxas

Unsupervised Unstained Cell Detection by SIFT KeypointClustering and Self-labeling Algorithm . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377

Firas Mualla, Simon Scholl, Bjorn Sommerfeldt, Andreas Maier,Stefan Steidl, Rainer Buchholz, and Joachim Hornegger

Selecting Features with Group-Sparse Nonnegative SupervisedCanonical Correlation Analysis: Multimodal Prostate CancerPrognosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 385

Haibo Wang, Asha Singanamalli, Shoshana Ginsburg, andAnant Madabhushi

Clustering-Induced Multi-task Learning for AD/MCI Classification . . . . . 393Heung-Il Suk and Dinggang Shen

XXIV Table of Contents – Part III

A Novel Multi-relation Regularization Method for Regression andClassification in AD Diagnosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401

Xiaofeng Zhu, Heung-Il Suk, and Dinggang Shen

Fisher Kernel Based Task Boundary Retrieval in LaparoscopicDatabase with Single Video Query . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 409

Andru Putra Twinanda, Michel De Mathelin, and Nicolas Padoy

Multi-scale Analysis of Imaging Features and Its Use in the Study ofCOPD Exacerbation Susceptible Phenotypes . . . . . . . . . . . . . . . . . . . . . . . . 417

Felix J.S. Bragman, Jamie R. McClelland, Marc Modat,Sebastien Ourselin, John R. Hurst, and David J. Hawkes

Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 425