lecture 4 bio 344 chapter 10 and 11. chapter 11 membrane transport of small molecules and the...
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Lecture 4 BIO 344
Chapter 10 and 11
Chapter 11
Membrane Transport of Small Molecules and the Electrical
Properties of Membranes
Molecule movement across lipid bilayer without proteins
Permeability across lipid bilayer
Carrier Proteins
Channel Proteins
Passive vs. Active Transport
Three Ways of Driving Active Transport
Electrochemical gradient vs. membrane potential
Can work additively or against each other
Three Ways of Driving Active Transport
Conformational Change in Carrier Protein mediates passive transport
Three Types of Carrier Mediated Transport
DVD Clip 43
Mechanism of Na+ - glucosecarrier
Binding of Na+ and glucose is cooperative
DVD Clip 44
Microvilli in the small intestine
Transcellular transport of glucose
The Na+ - K+ pump is an ATPase
DVD clip 42
Response of red blood cells to changes in osmolarity of extra cellular fluids
Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells
Few Ions are required to cause a large change in membrane potential
Electrochemical gradient vs. membrane potential
Can work additively or against each other
Selectivity of a K+ channel
DVD Clip 45
Ion Channels fluctuate between closed and open conformations
Gating of K+ channel
Gating of Ion Channels
A Typical Vertebrate Neuron
Ball and Chain Model of Rapid inactivation of ion channel
Propagation of Action Potential
Changes in Na+ channels and the action potential
Changes in Na+ channels and the action potential