Lecture 15

Maintaining blood Glc levels

Glucose is the energy source for many tissuesNeed to keep blood glucose level constantNot taking in Glc Blood glucose fallsHow to put Glc into blood?

Carbon sources for Gluconeogeneis: Cori cycle

Carbon sources for Gluconeogeneis

Gluconeogenesis

Gluconeogenesis

Reverse of glycolysis

What step/s have to be different?

Cellular compartments

Where does Glycolysis occur?

Where does TCA occur?

Compartmentalization

http://www.sabiosciences.com/pathwaymagazine/minireview/mitchondrial_energy_metabolism.php

1: How to make PEP?

Cannot directly convert Pyruvate to PEPSo, make Oxaloacetate

1: How to make PEP?

Metabolite compartmentalization must be overcome

1: How to make PEP?

2: If you don’t like it!

2: If you don’t like it!

Remember Fru 2,6-bis-PO4?

3. If you really don’t like it!

Reversing Glycolysis

Reversing Glycolysis

Avoiding “futile” cycles

Signaling cascade recap

LIVER

Example 2: Phosphofructokinase 2

Pancreas

Low Glc

?? Fru 2,6 bis-PO4

Adenylate cyclase↑? PKA?

? PFK1; ? FBPase1? GLYCOLYSIS? GLUCONEOGENESIS

Coordinating metabolism: Recap

Decreased Blood sugarMake hormone: ___________________

Effect on liver: ___________________

Effect on muscle: ___________________

Effect on adipose tissue: ___________________

Increase Blood sugarMake hormone: ___________________

Effect on liver: ___________________

Effect on muscle: ___________________

Effect on adipose tissue: ___________________