lecture 08 – second messengers ii – calcium signaling

Lecture 08 – Second Messengers II – Calcium signaling

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Transducers Second Messengers II

1. Calcium signaling • 1. Cyclic ADPribose

• 2. Inositol phosphate & other lipid signaling

• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA


CSB Fig 2:14 Basic Ca2+ signalling mechanism


CSB Fig 2:15 Ca2+ signalling dynamics


CSB Fig 2:17 Ca2+ signalling toolkit


CSB Fig 3:10 Ca2+ entry mechanisms

ROCs

• Cysteine-loop receptors• Nicotinic acetylcholine receptors (nAChRs)• 5-Hydroxytryptamine 3 (5-HT3) receptors• γ-Aminobutyric acid (GABA) receptors• Glycine receptors (GlyRs)

• Glutamate receptors• α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)

receptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors

• ATP-sensitive P2X receptors

http://www.biochemj.org/csb/003/csb003_sec005.htm%23Nicotinic_acetylcholine_receptors

http://www.biochemj.org/csb/003/csb003_sec005.htm%23Hydroxytryptamine_3_5HT3



http://www.biochemj.org/csb/003/csb003_sec005.htm%23GABA_receptors

http://www.biochemj.org/csb/003/csb003_sec005.htm%23Glycine_receptors

http://www.biochemj.org/csb/003/csb003_sec005.htm%23AMPA_receptors


http://www.biochemj.org/csb/003/csb003_sec005.htm%23NMDA_receptors


http://www.biochemj.org/csb/003/csb003_sec005.htm%23Kainate_receptors

http://www.biochemj.org/csb/003/csb003_sec005.htm%23P2X_receptors


CSB Fig 3:11 Nicotinic acetylcholine receptor

ROCs


• Glutamate receptor • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) rec

eptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors















CSB Fig 3:13 Ionotropic glutamate receptor


CSB Fig 3:14 AMPA receptor phosphorylation


CSB Fig 3:15 NMDA receptor

ROCs


• Glutamate receptors• α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)

receptors• N-methyl-D-aspartate (NMDA) receptors• Kainate receptors















CSB Fig 3:16 P2X receptor structure


CSB Fig 3: Cyclic nucleotide-gated channels


CSB Fig 3:07 CaV2 channel family


CSB Fig 3:19 Conformational coupling hypothesis


CSB Fig 3:22 STIM-induced Ca2+ entry


CSB Fig 3:46 Ryanodine receptor structure


CSB Fig 3:47 InsP3R regulation


CSB Fig 2:19 Ca2+-induced Ca2+ release


CSB Fig 2:20 Ca2+ transient mechanisms


CSB Fig 2:21 Temporal aspects

lecture 08 – second messengers ii – calcium signaling

Documents