Primary tumor

Via blood

Circulatingtumor cells

Earlymetastasis

Metastasis inlymph node

Lymph node

Via lymph

Blebs

Cell shrinkage

Nuclearcondensing(pyknosis)

Tumor cells

Liver cells

MetastasisMigrating tumor cells settle in distant organs & form metastases

Lymph duct

InvasionTumor cells invade into the circulatory vessels and lymphatics via small vessels

ApoptosisSome tumor cells undergo programmed cell death which involves a series of biochemical events leading to a defined cell morphology prior to death

AngiogenesisGrowing tumor with developing blood vessels and lymphatics

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www.abcam.com/tumor_biomarkers

Tumor biomarkersVEGF antibody (ab46154)

Cytochrome C antibody [7H8.2C12] (ab13575)

cIAP2 antibody (ab23423) Survivin antibody (ab8228)

MMP1 antibody - Hemopexin domain (ab38929)

EGFR antibody [ICR10] (ab231) MUC1 antibody (ab15481)

MMP14 antibody - Hinge region (ab38971)Pan Cadherin - Plasma Membrane Marker (ab16505)

VEGF Receptor 2 antibody (ab39256)

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