laszlo g. meszaros dept. animal physiology univ. of kaposvar , hungary argina nutraceuticals
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Cardiovascular Disease [70-80%] atherosclerosis [the disease of the arteries] endothelial dysfunction. Nutraceutical therapy. Laszlo G. Meszaros Dept. Animal Physiology Univ. of Kaposvar , Hungary Argina Nutraceuticals Hungary. - PowerPoint PPT PresentationTRANSCRIPT
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Cardiovascular Disease [70-80%]
atherosclerosis [the disease of the arteries]
endothelial dysfunction
Laszlo G. MeszarosDept. Animal PhysiologyUniv. of Kaposvar, HungaryArgina NutraceuticalsHungary
Nutraceutical therapy
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“You’re as old as your arteries…”
1. AS is responsible for more death than any other disease.
2. Not only deadly infarct and stroke, but overall well-being.
3. 6 out of 10 deadliest risk factors directly relate to AS.
4. No. 1 “risk factor” of AS is diet and life-style.
5. AS is a degenerative disease.
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AS is a degenerative disease
Error accumulation &Epigenetical changes
are likelycaused by diet and life style
Error accumulation &Epigenetical changes
are likelycaused by diet and life style
Degenerative diseases:
AS,Most types of cancer,Metabolic disease,Type-2 diabetes,Alzheimer’s,(Osteo)arthritis,…
Tomiyama H et al.: Hypertens. Res. 2004, 27:465)
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Who’s who?
Grandpa and grandson somewhere in Africa.Can you guess?
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It’s easy, when you look at their faces…
Santos PC et al.: Ethnicity and arterial stiffness in Brazil, Am. J. Hypertens, 2011, 24:278)
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So, there is hope… (age vs. disease)
Error accumulation &Epigenetical changes
are MORE THAN LIKELYcaused by diet and life style
Error accumulation &Epigenetical changes
are MORE THAN LIKELYcaused by diet and life style
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Why diet? Why physical inactivity?
Physical inactivity
Activity: beneficial effect on arterial stiffnessInactivity → obesity:dyslipidemia, metabolic syndrome,abdominal (visceral) fat as adysfunctional “immune organ”that produces inflammatorycytokines
Diet (in “developed” countries):
Junk food (in every sense),AdditivesB-type malnutrition
Waist circumference correlatesstronger with CVD and MD thanBMI.
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B-Type Malnutrition
% of RDA – USDA, 2004
Vitamin: A E C B1 B2 B4 B6Intake: 45 32 63 68 69 76 46
Only 15% of the population in the US consumes the recommended amounts of fruits and vegetables daily.More than 70% is vitamin D deficient. More than 90% is vitamin K2 deficient.Ames’s “Triage” theory
Comments: RDA values are most likely underestimated… (vitamin D) “Extra” vitamins: omega 3, flavonoids, other phytonutrients…
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B-Type Malnutrition
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Reminder…
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Problems at the beginning… (chance to treat the initial cause?)
I/1 eNOS decreases with age
I/2 NO reacts with free radicals: NO + O2
- = ONOO-
I/3 ADMA that competes with L-arg (Arginine-paradox)
II LDL-ch is VERY sensitive to oxidation by free radicals
So, one thing is for sure: we needefficient antioxidants.
And what else?
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Chance to treat the cause? An example: resveratrolJust look for the white arrows…
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(reviewing the literature)
9 papers on FMD improvements by resveratrol (1921 papers all together on resveratrol benefits)1 paper suggesting Q10 supplementation to decrease Aix11 papers to show that grape polyphenols (antho- and procyanidines) improve FMD3 papers on vitamin K2 decreasing vascular calcification3 papers on plasma vitamin D decreasing arterial stiffness21 papers to show that vitamin D improves other circulation parameters (coronary flow, for instance)
How about arterial function?
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2 x 1 daily placebo or 150 mg grape seed procyanidines + 60 mg Aronia melanocarpa anthocyanidines; test at the beginning and after 3 months
Our results…
PWV (m/s) Treated group (n=11) 0 3
12.41±1.13 9.74±0.82** significant at P < 0.05
- Also significant reduction in systolic BP- Some decrease in LDL-ch (n=7)
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Our results…
- Also significant reduction in BP- Significant increase in HDL-ch (n=5)- Significant improvement in EF
Regimen 1: 2 x 1 daily 150 mg GSE pro- + 60 mg Am anthocyanidines + 10 mg resveratrol + 50 mg Q10 (water soluble)
Regimen 2: regimen 1 + (2x1) 50 µg vitamin K2 and 1000 IU of vitamin D3)
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So, it seems that…
Thanks for listening…
Or take vitamins and dietary supplements
We have two choices: