Laser Accelerated Proton Beams for Radiation Therapy

C-M Ma, T Tajima, B Shahine, JS Li,

MC Lee, T Guerrero and AL Boyer

Dept. of Radiation Oncology

Stanford University School of Medicine

Stanford, CA 94305, USA

Why/Why Not Proton Beams?

Advantageous dosimetry

characteristics

Expensive, cumbersome,

inflexible

Potential remains to be

explored

Laser Ion Acceleration

= 0.6 degrees

Computational and experimental proton acceleration as a function of laser intensity (Zhidkov et al. 1999).

Theoretical Results

Proton angular distribution Proton spectrum

Energy Conversion and Dose Rate

0 5 10 15 20 25 30 35 40

D epth (cm )

0.0E+0

5.0E+4

1.0E+5

1.5E+5

2.0E+5

2.5E+5

3.0E+5

3.5E+5

Ene

rgy

(MeV

)

0 5 10 15 20 25 30

D epth (cm )

0.0E+0

2.0E+4

4.0E+4

6.0E+4

Ene

rgy

(MeV

)

80 100 120 140 160 180 200

Energy (M eV)

0.0

0.4

0.8

1.2

1.6

Pro

babi

lity

Combined dose distribution Proton spectrum

Comparison of Isodose Distribution

Modulated Proton beamsPhoton IMRT

Comparison of DVHTarget DVH Rectum DVH

Current Research at Stanfordon Laser-Proton Beams

Particle-in-cell (PIC) simulations of laser-ion interactions

System design for a laser-proton therapy unit

Software development for accurate and fast dose calculation

Treatment optimization for energy-and intensity-modulated proton therapy (EIMPT)

For detailed dose calculation and IMPT treatment optimization, please see:

Jinsheng Li, et al., TU-C-BRA-06

Bilal Shahine et al, TU-C-BRA-07

The Stanford Monte Carlo Team

Charlie MaGary LuxtonDavid FindleyTodd KoumrianSteve Jiang Jinsheng LiEugene FourkalMichael LuxtonMichael LeeJasjit Jolly

Art BoyerTodd Pawlicki Ed MokSam BrainThomas GuerreroJun DengJoerg LehmannMeisong DingAjay KapurGrisel Mora